{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:00:58Z","timestamp":1791468058554,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400405"],"award-info":[{"award-number":["82400405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20240601023RC"],"award-info":[{"award-number":["20240601023RC"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.intimp.2026.117495","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:28:42Z","timestamp":1790587722000},"page":"117495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Beyond anticoagulation: Rivaroxaban attenuates acute myocardial inflammatory injury through the PAR2-mROS-TXNIP-NLRP3 pyroptosis axis"],"prefix":"10.1016","volume":"190","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maralmaa","family":"Tsagaankhuu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haikuo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2026.117495_bb0005","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1160\/TH16-10-0807","article-title":"New developments in anticoagulants: past, present and future","volume":"117","author":"Weitz","year":"2017","journal-title":"Thromb. Haemost."},{"issue":"22","key":"10.1016\/j.intimp.2026.117495_bb0010","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.125.041993","article-title":"Reduction of thrombus burden with short-term, low-dose rivaroxaban use in acute myocardial infarction: the ARISE-ARMYDA 7 randomized trial","volume":"14","author":"Mennuni","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"7","key":"10.1016\/j.intimp.2026.117495_bb0015","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/jamainternmed.2025.1109","article-title":"Oral anticoagulation and risk of adverse clinical outcomes in venous thromboembolism","volume":"185","author":"Bea","year":"2025","journal-title":"JAMA Intern. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.117495_bb0020","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.atherosclerosis.2015.03.023","article-title":"Rivaroxaban, a novel oral anticoagulant, attenuates atherosclerotic plaque progression and destabilization in ApoE-deficient mice","volume":"242","author":"Hara","year":"2015","journal-title":"Atherosclerosis"},{"issue":"12","key":"10.1016\/j.intimp.2026.117495_bb0025","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jacbts.2021.09.010","article-title":"Rivaroxaban, a direct Oral factor xa inhibitor, attenuates atherosclerosis by alleviating factor xa-PAR2-mediated autophagy suppression","volume":"6","author":"Ito","year":"2021","journal-title":"JACC Basic Transl Sci"},{"issue":"16","key":"10.1016\/j.intimp.2026.117495_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25168727","article-title":"Beyond anticoagulation: a comprehensive review of non-vitamin K Oral anticoagulants (NOACs) in inflammation and protease-activated receptor Signaling","volume":"25","author":"Jannati","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.intimp.2026.117495_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70418","article-title":"Acute myocardial infarction: molecular pathogenesis, diagnosis, and clinical management","volume":"6","author":"Zhu","year":"2025","journal-title":"MedComm"},{"issue":"15","key":"10.1016\/j.intimp.2026.117495_bb0040","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jacc.2025.07.064","article-title":"Targeting inflammation after acute myocardial infarction","volume":"86","author":"Imbesi","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117495_bb0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","article-title":"Inflammation in acute myocardial infarction: the good, the bad and the ugly","volume":"45","author":"Matter","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.intimp.2026.117495_bb0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","article-title":"Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities","volume":"186","author":"Ong","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117495_bb0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2026.117495_bb0060","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.intimp.2018.12.028","article-title":"Role of pyroptosis in cardiovascular diseases","volume":"67","author":"Jia","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117495_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70878","article-title":"The role of inflammation and immunity in cardiovascular disease: molecular mechanisms and therapeutic targets","volume":"7","author":"Rong","year":"2026","journal-title":"MedComm"},{"issue":"3","key":"10.1016\/j.intimp.2026.117495_bb0070","article-title":"The NLRP3 inflammasome: mechanisms of activation, regulation, and therapeutic opportunities","volume":"7","author":"Zou","year":"2026","journal-title":"MedComm (2020)"},{"key":"10.1016\/j.intimp.2026.117495_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2025.09.006","article-title":"Targeting the NLRP3 inflammasome-Gasdermin D axis to combat cardiovascular diseases","volume":"209","author":"Choi","year":"2025","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117495_bb0080","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"19","key":"10.1016\/j.intimp.2026.117495_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/cells14191509","article-title":"Myocardial ischemia\/reperfusion injury: molecular insights, forensic perspectives, and therapeutic horizons","volume":"14","author":"Fede","year":"2025","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.intimp.2026.117495_bb0090","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117495_bb0095","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41569-021-00552-1","article-title":"Interplay between inflammation and thrombosis in cardiovascular pathology","volume":"18","author":"Stark","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"Suppl 1(0 1)","key":"10.1016\/j.intimp.2026.117495_bb0100","doi-asserted-by":"crossref","first-page":"S92","DOI":"10.1111\/jth.12896","article-title":"Polyphosphate as modulator of hemostasis, thrombosis, and inflammation","volume":"13","author":"Morrissey","year":"2015","journal-title":"J. Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.intimp.2026.117495_bb0105","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1111\/jth.15894","article-title":"Protease- and cell type-specific activation of protease-activated receptor 2 in cutaneous inflammation","volume":"20","author":"Fleischer","year":"2022","journal-title":"J. Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.intimp.2026.117495_bb0110","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1093\/cvr\/cvaa263","article-title":"Pleiotropic actions of factor xa inhibition in cardiovascular prevention: mechanistic insights and implications for anti-thrombotic treatment","volume":"117","author":"Ten Cate","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.intimp.2026.117495_bb0115","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1161\/HYPERTENSIONAHA.121.18477","article-title":"DPP4 promotes human endothelial cell senescence and dysfunction via the PAR2-COX-2-TP Axis and NLRP3 inflammasome activation","volume":"79","author":"Valencia","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.intimp.2026.117495_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2025.02.011","article-title":"A short history of the atrial NLRP3 inflammasome and its distinct role in atrial fibrillation","volume":"202","author":"Poppenborg","year":"2025","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.intimp.2026.117495_bb0125","article-title":"Permanent ligation of the left anterior descending coronary artery in mice: a model of post-myocardial infarction remodelling and heart failure","volume":"94","author":"Muthuramu","year":"2014","journal-title":"J. Vis. Exp."},{"issue":"6","key":"10.1016\/j.intimp.2026.117495_bb0130","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/SHK.0000000000001412","article-title":"Direct rivaroxaban-induced factor XA inhibition proves to be cardioprotective in rats","volume":"53","author":"Guillou","year":"2020","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.intimp.2026.117495_bb0135","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00395-007-0653-4","article-title":"SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia\/reperfusion injury in rat hearts","volume":"102","author":"Strande","year":"2007","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.intimp.2026.117495_bb0140","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16097","article-title":"Rivaroxaban, a direct inhibitor of coagulation factor xa, attenuates adverse cardiac remodeling in rats by regulating the PAR-2 and TGF-\u03b21 signaling pathways","volume":"11","author":"Zhang","year":"2023","journal-title":"PeerJ"},{"issue":"12","key":"10.1016\/j.intimp.2026.117495_bb0145","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.jacbts.2023.05.008","article-title":"TAK1 activation by NLRP3 deficiency confers Cardioprotection against pressure overload-induced cardiomyocyte Pyroptosis and hypertrophy","volume":"8","author":"Li","year":"2023","journal-title":"JACC Basic Transl Sci"},{"issue":"22","key":"10.1016\/j.intimp.2026.117495_bb0150","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022011","article-title":"Retinol-binding protein 4 promotes cardiac injury after myocardial infarction via inducing cardiomyocyte pyroptosis through an interaction with NLRP3","volume":"10","author":"Zhang","year":"2021","journal-title":"J. Am. Heart Assoc."},{"issue":"7","key":"10.1016\/j.intimp.2026.117495_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12071396","article-title":"Inhibitors of NLRP3 inflammasome in ischemic heart disease: focus on functional and redox aspects","volume":"12","author":"Pagliaro","year":"2023","journal-title":"Antioxidants"},{"issue":"10\u221212","key":"10.1016\/j.intimp.2026.117495_bb0160","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop between NLRP3 inflammasome and reactive oxygen species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2026.117495_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114543","article-title":"\u03b2-Sitosterol suppresses NLRP3 inflammasome activation and Pyroptosis in myocardial ischemia\/reperfusion injury via inhibition of PPAR\u03b32","volume":"154","author":"Wu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1\u20133","key":"10.1016\/j.intimp.2026.117495_bb0170","first-page":"103","article-title":"3\u2032-Methoxypuerarin ameliorates myocardial ischemia\/reperfusion-induced pyroptosis via regulating IGF2BP1\/m6A\/NLRP3 pathway","volume":"44","author":"Zhou","year":"2026","journal-title":"Antioxid. Redox Signal."},{"issue":"7","key":"10.1016\/j.intimp.2026.117495_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14070889","article-title":"Cardioprotection reloaded: reflections on 40 years of research","volume":"14","author":"Pagliaro","year":"2025","journal-title":"Antioxidants"},{"issue":"4","key":"10.1016\/j.intimp.2026.117495_bb0180","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","article-title":"The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases","volume":"21","author":"Toldo","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.intimp.2026.117495_bb0185","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phrs.2015.05.012","article-title":"Ilexgenin a inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP\/NLRP3 inflammasome activation in an AMPK dependent manner","volume":"99","author":"Li","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"8","key":"10.1016\/j.intimp.2026.117495_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.70082","article-title":"Exploring thioredoxin-interacting protein (TXNIP) as a therapeutic target for cardiovascular diseases","volume":"358","author":"Date","year":"2025","journal-title":"Arch Pharm (Weinheim)"},{"issue":"7","key":"10.1016\/j.intimp.2026.117495_bb0195","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","article-title":"TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target","volume":"55","author":"Choi","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117495_bb0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1161\/ATVBAHA.118.311655","article-title":"Roles of coagulation proteases and PARs (protease-activated receptors) in mouse models of inflammatory diseases","volume":"39","author":"Posma","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.intimp.2026.117495_bb0205","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2024.06.011","article-title":"Activation of the ROS\/TXNIP\/NLRP3 pathway disrupts insulin-dependent glucose uptake in skeletal muscle of insulin-resistant obese mice","volume":"222","author":"Russell-Guzm\u00e1n","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"13","key":"10.1016\/j.intimp.2026.117495_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/cells14130994","article-title":"NLRP3 inflammasome and inflammatory response in aging disorders: the entanglement of redox modulation in different outcomes","volume":"14","author":"Chhunchha","year":"2025","journal-title":"Cells"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:22:32Z","timestamp":1791465752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926013433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":42,"alternative-id":["S1567576926013433"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117495","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beyond anticoagulation: Rivaroxaban attenuates acute myocardial inflammatory injury through the PAR2-mROS-TXNIP-NLRP3 pyroptosis axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117495"}}