{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T08:26:54Z","timestamp":1794212814898,"version":"4.8.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019091","name":"Key Research and Development Program of Hunan Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572335"],"award-info":[{"award-number":["82572335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.intimp.2026.117504","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:44:38Z","timestamp":1790970278000},"page":"117504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rapamycin attenuates ferroptotic stress and improves macrophage efferocytosis in experimental atherosclerosis"],"prefix":"10.1016","volume":"190","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0005","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/STROKEAHA.123.043633","article-title":"Optimal medical Management of Atherosclerotic Intracranial Stenosis","volume":"55","author":"Wabnitz","year":"2024","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","article-title":"Inflammation and atherosclerosis: signaling pathways and therapeutic intervention","volume":"7","author":"Kong","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2026.117504_bb0015","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s12325-020-01291-4","article-title":"Intracranial atherosclerotic Stenoses: pathophysiology, epidemiology, risk factors and current therapy options","volume":"37","author":"Krasteva","year":"2020","journal-title":"Adv. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2026.117504_bb0020","doi-asserted-by":"crossref","DOI":"10.1172\/JCI157011","article-title":"Through the layers: how macrophages drive atherosclerosis across the vessel wall","volume":"132","author":"Susser","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.intimp.2026.117504_bb0025","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41569-023-00957-0","article-title":"Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets","volume":"21","author":"De Meyer","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117504_bb0030","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","article-title":"The clearance of dead cells by efferocytosis","volume":"21","author":"Boada-Romero","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0035","doi-asserted-by":"crossref","DOI":"10.1007\/s11883-026-01394-3","article-title":"From inflammation to targeted therapy: leveraging neutrophil, platelet, RBC, and macrophage biology for nanocarrier in atherosclerosis","volume":"28","author":"Heydari","year":"2026","journal-title":"Curr. Atheroscler. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2026.117504_bb0040","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/s41569-024-01037-7","article-title":"Efferocytosis in atherosclerosis","volume":"21","author":"Adkar","year":"2024","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.intimp.2026.117504_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102763","article-title":"NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK\/PI3K\/AKT pathway","volume":"64","author":"Wang","year":"2023","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.intimp.2026.117504_bb0050","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.acvd.2023.07.007","article-title":"Interplay between efferocytosis and atherosclerosis","volume":"116","author":"Rochette","year":"2023","journal-title":"Arch. Cardiovasc. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0055","doi-asserted-by":"crossref","first-page":"20220722","DOI":"10.1515\/biol-2022-0722","article-title":"Ferroptosis: a potential target of macrophages in plaque vulnerability","volume":"18","author":"Li","year":"2023","journal-title":"Open Life Sci."},{"key":"10.1016\/j.intimp.2026.117504_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116112","article-title":"The mechanisms of ferroptosis and its role in atherosclerosis","volume":"171","author":"Xu","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2026.117504_bb0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.intimp.2026.117504_bb0070","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159498","article-title":"Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction","volume":"133","author":"Cai","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.intimp.2026.117504_bb0075","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCRESAHA.121.320704","article-title":"Myeloid cell PKM2 deletion enhances efferocytosis and reduces atherosclerosis","volume":"130","author":"Doddapattar","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2026.117504_bb0080","article-title":"Intercellular mitochondrial transfer and mitochondrial transplantation in cardiovascular disease","author":"Farhid","year":"2026","journal-title":"Can. J. Cardiol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117504_bb0085","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nchembio.2079","article-title":"Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis","volume":"12","author":"Shimada","year":"2016","journal-title":"Nat. Chem. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0090","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1161\/STROKEAHA.123.045513","article-title":"Focused update on intracranial atherosclerosis: introduction, highlights, and knowledge gaps","volume":"55","author":"Hoh","year":"2024","journal-title":"Stroke"},{"issue":"e3","key":"10.1016\/j.intimp.2026.117504_bb0095","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1136\/jnis-2022-019685","article-title":"Comparison of drug-coated balloon with conventional balloon for angioplasty in symptomatic intracranial atherosclerotic stenosis","volume":"15","author":"Tang","year":"2023","journal-title":"J. Neurointerv. Surg."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/jnis-2023-021177","article-title":"First-in-human experience of sirolimus coated balloon for symptomatic intracranial artery stenosis","volume":"17","author":"Luo","year":"2025","journal-title":"J. Neurointerv. Surg."},{"issue":"5","key":"10.1016\/j.intimp.2026.117504_bb0105","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.92.5.1355","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association","volume":"92","author":"Stary","year":"1995","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0110","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2025.2498105","article-title":"Is uric acid a true antioxidant? Identification of uric acid oxidation products and their biological effects","volume":"30","author":"Pinz","year":"2025","journal-title":"Redox Rep."},{"key":"10.1016\/j.intimp.2026.117504_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103039","article-title":"SPTBN2 suppresses ferroptosis in NSCLC cells by facilitating SLC7A11 membrane trafficking and localization","volume":"70","author":"Deng","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0120","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41420-021-00716-5","article-title":"Gasdermin D mediates host cell death but not interleukin-1\u03b2 secretion in mycobacterium tuberculosis-infected macrophages","volume":"7","author":"Theobald","year":"2021","journal-title":"Cell Death Discov."},{"issue":"8","key":"10.1016\/j.intimp.2026.117504_bb0125","doi-asserted-by":"crossref","DOI":"10.1172\/JCI145275","article-title":"Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis","volume":"131","author":"Kasikara","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"11","key":"10.1016\/j.intimp.2026.117504_bb0130","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1172\/JCI94735","article-title":"CAMKII\u03b3 suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis","volume":"127","author":"Doran","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0135","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12951-024-02463-y","article-title":"Targeted delivery of MerTK protein via cell membrane engineered nanoparticle enhances efferocytosis and attenuates atherosclerosis in diabetic ApoE\u2212\/\u2212 mice","volume":"22","author":"Qiu","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"24","key":"10.1016\/j.intimp.2026.117504_bb0140","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4903","article-title":"In vitro assessment of efferocytic capacity of human macrophages using flow cytometry","volume":"13","author":"Salina","year":"2023","journal-title":"Bio-Protoc."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0145","doi-asserted-by":"crossref","first-page":"11319","DOI":"10.1038\/s41598-026-41381-x","article-title":"The Caspase-1-EGR4 axis regulates macrophage repolarization in acute myeloid leukemia cells","volume":"16","author":"Qian","year":"2026","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.intimp.2026.117504_bb0150","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0155","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.intimp.2026.117504_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2024.102027","article-title":"Mediation of Ferroptosis suppressor protein 1 expression via 4-Hydroxy-2-Nonenal accumulation contributes to acquisition of resistance to apoptosis and Ferroptosis in diffuse large B-cell lymphoma","volume":"104","author":"Kawade","year":"2024","journal-title":"Lab. Invest."},{"issue":"5","key":"10.1016\/j.intimp.2026.117504_bb0165","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0170","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2026.117504_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110622","article-title":"MMP9 drives ferroptosis by regulating GPX4 and iron signaling","volume":"27","author":"Gawargi","year":"2024","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0180","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0185","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1038\/s41467-024-46971-9","article-title":"Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation","volume":"15","author":"Tsutsumi","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0190","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41467-017-02733-4","article-title":"Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin","volume":"9","author":"DeWaal","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0195","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41419-025-07394-6","article-title":"LDHA-mediated glycolysis in stria vascularis endothelial cells regulates macrophages function through CX3CL1-CX3CR1 pathway in noise-induced oxidative stress","volume":"16","author":"Yi","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0200","doi-asserted-by":"crossref","first-page":"8624","DOI":"10.1038\/s41467-024-53006-w","article-title":"MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1\u03b1 pathways in mice","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.105637","article-title":"Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression","volume":"300","author":"Chiou","year":"2024","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111941","article-title":"Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation","volume":"42","author":"Meyers","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0215","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/ATVBAHA.121.317735","article-title":"Endogenous SOD2 (superoxide dismutase) regulates platelet-dependent thrombin generation and thrombosis during aging","volume":"43","author":"Sonkar","year":"2023","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117504_bb0220","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.devcel.2024.12.011","article-title":"HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis","volume":"60","author":"Peng","year":"2025","journal-title":"Dev. Cell"},{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0225","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1172\/JCI90520","article-title":"MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis","volume":"127","author":"Cai","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2026.117504_bb0230","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jot.2022.04.002","article-title":"MFG-E8 promotes tendon-bone healing by regualting macrophage efferocytosis and M2 polarization after anterior cruciate ligament reconstruction","volume":"34","author":"Geng","year":"2022","journal-title":"J. Orthop. Translat."},{"key":"10.1016\/j.intimp.2026.117504_bb0235","doi-asserted-by":"crossref","DOI":"10.1155\/cdr\/9549175","article-title":"Astragaloside IV alleviates H2O2-induced mitochondrial dysfunction and inhibits mitophagy via PI3K\/AKT\/mTOR pathway","volume":"2025","author":"Qi","year":"2025","journal-title":"Cardiovasc. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0240","article-title":"SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0245","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12964-025-02075-5","article-title":"IRG1\/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con a induced autoimmune liver injury","volume":"23","author":"Zeng","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0250","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1161\/CIRCRESAHA.123.323223","article-title":"CD147 Sparks atherosclerosis by driving M1 phenotype and impairing Efferocytosis","volume":"134","author":"Lv","year":"2024","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.intimp.2026.117504_bb0255","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.4049\/jimmunol.2200351","article-title":"cGAS mediates inflammation by polarizing macrophages to M1 phenotype via the mTORC1 pathway","volume":"210","author":"Shen","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2026.117504_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156373","article-title":"Kushenol O regulates GALNT7\/NF-\u03baB axis-mediated macrophage M2 polarization and Efferocytosis in papillary thyroid carcinoma","volume":"138","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0265","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/imr.13214","article-title":"The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation","volume":"319","author":"Schilperoort","year":"2023","journal-title":"Immunol. Rev."},{"issue":"18","key":"10.1016\/j.intimp.2026.117504_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e37727","article-title":"Vascular smooth muscle cell phenotypic switching in atherosclerosis","volume":"10","author":"Yu","year":"2024","journal-title":"Heliyon"},{"issue":"20","key":"10.1016\/j.intimp.2026.117504_bb0275","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031121","article-title":"Phenotypic switching of vascular smooth muscle cells in atherosclerosis","volume":"12","author":"Chen","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.intimp.2026.117504_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.engmed.2024.100043","article-title":"Shedding new light on atherosclerosis therapeutics: nanomedicines targeting atherosclerotic immune microenvironment","volume":"1","author":"Wang","year":"2024","journal-title":"EngMedicine"},{"issue":"25","key":"10.1016\/j.intimp.2026.117504_bb0285","doi-asserted-by":"crossref","first-page":"36542","DOI":"10.1021\/acsami.5c07617","article-title":"An atorvastatin\/Ferrostatin-1 Codelivered hybrid exosome\/liposome system for combinational Ferroptosis inhibition, inflammation suppression, Efferocytosis promotion, and macrophage reprogramming in atherosclerosis treatment","volume":"17","author":"Feng","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"22","key":"10.1016\/j.intimp.2026.117504_bb0290","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1161\/CIRCULATIONAHA.125.075352","article-title":"IRF5 siRNA Nanoimmunotherapy: restoring macrophage Efferocytosis in atherosclerosis","volume":"152","author":"He","year":"2025","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.intimp.2026.117504_bb0295","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.cmet.2021.08.001","article-title":"First we eat, then we do everything else: the dynamic metabolic regulation of efferocytosis","volume":"33","author":"Trzeciak","year":"2021","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0300","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/imr.12218","article-title":"Macrophage phenotypes in atherosclerosis","volume":"262","author":"Colin","year":"2014","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.intimp.2026.117504_bb0305","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/ATVBAHA.121.316233","article-title":"Crosstalk between macrophages and vascular smooth muscle cells in atherosclerotic plaque stability","volume":"42","author":"Yurdagul","year":"2022","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.intimp.2026.117504_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2026.116848","article-title":"CXCL16 promotes macrophage-driven inflammation and vascular smooth muscle cell phenotypic switching during carotid plaque destabilization","volume":"182","author":"Yao","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0315","doi-asserted-by":"crossref","DOI":"10.1186\/s12645-026-00375-0","article-title":"Targeting glycoprotein VI (GPVI) in cancer: mechanistic insights and therapeutic strategies to suppress metastasis and thrombosis","volume":"17","author":"Heydari","year":"2026","journal-title":"Cancer Nanotechnol."},{"key":"10.1016\/j.intimp.2026.117504_bb0320","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2026.10047","article-title":"When GPVI Goes rogue: pathogenesis and therapeutic horizons in ITP","volume":"28","author":"Naghinezhad","year":"2026","journal-title":"Expert Rev. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0325","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00395-024-01033-5","article-title":"The interplay of collagen, macrophages, and microcalcification in atherosclerotic plaque cap rupture mechanics","volume":"119","author":"Jansen","year":"2024","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.intimp.2026.117504_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114333","article-title":"Autophagy inhibition and ferroptosis activation during atherosclerosis: hypoxia-inducible factor 1\u03b1 inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages","volume":"161","author":"Hu","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.intimp.2026.117504_bb0335","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.chembiol.2022.10.006","article-title":"Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein","volume":"29","author":"Armenta","year":"2022","journal-title":"Cell Chem. Biol."},{"issue":"6","key":"10.1016\/j.intimp.2026.117504_bb0340","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41589-021-00751-4","article-title":"A compendium of kinetic modulatory profiles identifies ferroptosis regulators","volume":"17","author":"Conlon","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0345","article-title":"mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"issue":"49","key":"10.1016\/j.intimp.2026.117504_bb0350","doi-asserted-by":"crossref","first-page":"31189","DOI":"10.1073\/pnas.2017152117","article-title":"Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis","volume":"117","author":"Yi","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.intimp.2026.117504_bb0355","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41418-020-00728-1","article-title":"Cellular degradation systems in ferroptosis","volume":"28","author":"Chen","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2026.117504_bb0360","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2026.10043","article-title":"The tumor-platelet-immune Interface: driving metastasis, pre-metastatic niche formation and therapeutic vulnerabilities","volume":"28","author":"Naghinezhad","year":"2026","journal-title":"Expert Rev. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0365","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41392-024-01840-1","article-title":"Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0370","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00395-023-01023-z","article-title":"Macrophage profiling in atherosclerosis: understanding the unstable plaque","volume":"119","author":"Gianopoulos","year":"2024","journal-title":"Basic Res. Cardiol."},{"issue":"10","key":"10.1016\/j.intimp.2026.117504_bb0375","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: a dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2026.117504_bb0380","article-title":"Macrophage polarization, metabolic reprogramming, and inflammatory effects in ischemic heart disease","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117504_bb0385","doi-asserted-by":"crossref","DOI":"10.1136\/svn-2024-003259","article-title":"DRug-coated balloon for endovascular treatment of sYmptOmatic intracraNial stenotic disease (DR. BEYOND): the protocol of a multicentre randomised trial","volume":"10","author":"Mo","year":"2025","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.intimp.2026.117504_bb0390","doi-asserted-by":"crossref","DOI":"10.1186\/s12645-026-00423-9","article-title":"Platelet\u2013neutrophil cooperation in premetastatic niche formation: from NETosis and stromal conditioning to nanotherapeutic interception","author":"Heydari","year":"2026","journal-title":"Cancer Nanotechnol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0395","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-026-00957-5","article-title":"Guided immunotherapy for residual solid tumor: integrating platelets and CAR T cells to reduce post-surgical recurrence","volume":"14","author":"Heydari","year":"2026","journal-title":"Biomark. Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117504_bb0400","doi-asserted-by":"crossref","DOI":"10.1186\/s12645-025-00340-3","article-title":"Nanodrug-based modulation of platelet\u2013leukocyte interactions in ovarian cancer: a new frontier in targeted therapy","volume":"16","author":"Naghinezhad","year":"2025","journal-title":"Cancer Nanotechnol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T08:15:56Z","timestamp":1794212156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926013524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":80,"alternative-id":["S1567576926013524"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117504","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapamycin attenuates ferroptotic stress and improves macrophage efferocytosis in experimental atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117504","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117504"}}