{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T05:25:22Z","timestamp":1793856322449,"version":"4.6.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["HDHY2024009"],"award-info":[{"award-number":["HDHY2024009"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,170,240"],"award-info":[{"award-number":["82,170,240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,404,724"],"award-info":[{"award-number":["82,404,724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.intimp.2026.117507","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:53:23Z","timestamp":1791402803000},"page":"117507","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction"],"prefix":"10.1016","volume":"190","author":[{"given":"Zheyu","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaorun","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41574-023-00898-1","article-title":"Inter-organ crosstalk during development and progression of type 2 diabetes mellitus","volume":"20","author":"Xourafa","year":"2024","journal-title":"Nat. Rev. Endocrinol."},{"issue":"723","key":"10.1016\/j.intimp.2026.117507_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf9382","article-title":"Metaflammation in obesity and its therapeutic targeting","volume":"15","author":"Schleh","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"12","key":"10.1016\/j.intimp.2026.117507_bb0020","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.120.046464","article-title":"Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis","volume":"144","author":"Edgar","year":"2021","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.intimp.2026.117507_bb0025","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2337\/dc15-1990","article-title":"Intensive diabetes treatment and cardiovascular outcomes in type 1 diabetes: the DCCT\/EDIC study 30-year follow-up","volume":"39","author":"Diabetes C, Complications Trial \/Epidemiology of Diabetes I, Complications Study Research G","year":"2016","journal-title":"Diabetes Care"},{"issue":"7258","key":"10.1016\/j.intimp.2026.117507_bb0030","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0035","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41581-022-00633-5","article-title":"Trained immunity - basic concepts and contributions to immunopathology","volume":"19","author":"Ochando","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0040","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41392-024-01755-x","article-title":"Metabolic memory: mechanisms and diseases","volume":"9","author":"Dong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2026.117507_bb0045","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cmet.2015.07.013","article-title":"S-adenosylmethionine levels govern innate immunity through distinct methylation-dependent pathways","volume":"22","author":"Ding","year":"2015","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.intimp.2026.117507_bb0050","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"de Vos","year":"2022","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.intimp.2026.117507_bb0055","doi-asserted-by":"crossref","DOI":"10.2174\/1573399819666221121104542","article-title":"Association of gut microbiota and diabetes mellitus","volume":"19","author":"Sowmiya","year":"2023","journal-title":"Curr. Diabetes Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12974-025-03352-3","article-title":"Probiotics alleviate painful diabetic neuropathy by modulating the microbiota-gut-nerve axis in rats","volume":"22","author":"Jiang","year":"2025","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0065","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00125-020-05295-1","article-title":"The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis","volume":"64","author":"Bock","year":"2021","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0070","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-physiol-051524-094728","article-title":"Managing glucose homeostasis through the gut microbiome","volume":"88","author":"Weninger","year":"2026","journal-title":"Annu. Rev. Physiol."},{"issue":"18","key":"10.1016\/j.intimp.2026.117507_bb0075","doi-asserted-by":"crossref","first-page":"8504","DOI":"10.1039\/D3FO01701J","article-title":"Lactobacillus gasseri CKCC1913 mediated modulation of the gut-liver axis alleviated insulin resistance and liver damage induced by type 2 diabetes","volume":"14","author":"Jiang","year":"2023","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.intimp.2026.117507_bb0080","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3168\/jds.2018-15203","article-title":"Probiotic Lactobacillus gasseri SBT2055 improves insulin secretion in a diabetic rat model","volume":"102","author":"Niibo","year":"2019","journal-title":"J. Dairy Sci."},{"issue":"8","key":"10.1016\/j.intimp.2026.117507_bb0085","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/gutjnl-2019-320204","article-title":"Interaction between drugs and the gut microbiome","volume":"69","author":"Weersma","year":"2020","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cmet.2017.09.019","article-title":"Metformin alters upper small intestinal microbiota that impact a glucose-SGLT1-sensing glucoregulatory pathway","volume":"27","author":"Bauer","year":"2018","journal-title":"Cell Metab."},{"issue":"6284","key":"10.1016\/j.intimp.2026.117507_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.intimp.2026.117507_bb0100","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2026.117507_bb0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S","article-title":"Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation","volume":"15","author":"Alberti","year":"1998","journal-title":"Diabet. Med."},{"key":"10.1016\/j.intimp.2026.117507_bb0110","doi-asserted-by":"crossref","first-page":"416254","DOI":"10.1155\/2011\/416254","article-title":"Development of a nongenetic mouse model of type 2 diabetes","volume":"2011","author":"Gilbert","year":"2011","journal-title":"Exp. Diabetes Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory mechanisms linking obesity and metabolic disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2026.117507_bb0120","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41392-023-01333-7","article-title":"Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2026.117507_bb0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tcb.2024.06.001","article-title":"Roles of H3K4 methylation in biology and disease","volume":"35","author":"Wang","year":"2025","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.intimp.2026.117507_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111837","article-title":"S-adenosylmethionine (SAM) diet promotes innate immunity via histone H3K4me3 complex","volume":"131","author":"Xiao","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"D1","key":"10.1016\/j.intimp.2026.117507_bb0135","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkae973","article-title":"Generic diagramming platform (GDP): a comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692601355X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692601355X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:43:38Z","timestamp":1793853818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692601355X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":27,"alternative-id":["S156757692601355X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117507","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117507","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117507"}}