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Chem."},{"key":"10.1016\/j.intimp.2026.117519_bb0395","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.celrep.2014.04.046","article-title":"Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity","volume":"7","author":"Yokoyama","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2026.117519_bb0400","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1038\/onc.2016.477","article-title":"6-Phosphofructo-2-kinase\/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells","volume":"36","author":"Ros","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2026.117519_bb0405","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. 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