{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:53:53Z","timestamp":1792252433174,"version":"4.4.0"},"reference-count":124,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Liaoning Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024-MS-048"],"award-info":[{"award-number":["2024-MS-048"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.intimp.2026.117537","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:45:14Z","timestamp":1792014314000},"page":"117537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Advancing early detection of Alzheimer's disease: from established biomarkers to future innovations"],"prefix":"10.1016","volume":"190","author":[{"given":"Le","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8 Suppl","key":"10.1016\/j.intimp.2026.117537_bb0005","first-page":"S177","article-title":"Economic burden of Alzheimer disease and managed care considerations","volume":"26","author":"Wong","year":"2020","journal-title":"Am. J. Manag. Care"},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0010","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"The Lancet Neurology"},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0015","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the global burden of Alzheimer's disease","volume":"3","author":"Brookmeyer","year":"2007","journal-title":"Alzheimers Dement."},{"issue":"7","key":"10.1016\/j.intimp.2026.117537_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076518","article-title":"Inflammatory processes in Alzheimer's disease-Pathomechanism, diagnosis and treatment: a review","volume":"24","author":"Twarowski","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0025","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3233\/JAD-190220","article-title":"18F-FDG is a superior Indicator of cognitive performance compared to 18F-Florbetapir in Alzheimer's disease and mild cognitive impairment evaluation: a global quantitative analysis","volume":"70","author":"Khosravi","year":"2019","journal-title":"Journal of Alzheimer's disease : JAD"},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70086","article-title":"Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease","volume":"21","author":"Fertan","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0035","doi-asserted-by":"crossref","first-page":"e282","DOI":"10.1212\/WNL.0000000000004860","article-title":"Associations between [(18)F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample","volume":"90","author":"La Joie","year":"2018","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0040","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/brain\/awac329","article-title":"Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals","volume":"146","author":"Groot","year":"2023","journal-title":"Brain J. Neurol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117537_bb0045","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3233\/JAD-170327","article-title":"The cerebrospinal fluid A\u03b21-42\/A\u03b21-40 ratio improves concordance with amyloid-PET for diagnosing Alzheimer's disease in a clinical setting","volume":"60","author":"Niemantsverdriet","year":"2017","journal-title":"Journal of Alzheimer's disease : JAD"},{"issue":"13","key":"10.1016\/j.intimp.2026.117537_bb0050","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm3088","article-title":"Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer's disease","volume":"10","author":"Hu","year":"2024","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jalz.2016.09.014","article-title":"Blood-based biomarkers in Alzheimer disease: current state of the science and a novel collaborative paradigm for advancing from discovery to clinic","volume":"13","author":"O'Bryant","year":"2017","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0060","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13195-023-01314-6","article-title":"Biomarkers in Alzheimer's disease: role in early and differential diagnosis and recognition of atypical variants","volume":"15","author":"Dubois","year":"2023","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.intimp.2026.117537_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cca.2026.121046","article-title":"Bridging the gaps in Alzheimer's disease biomarker research: from multi-omics integration to point-of-care diagnostics, a comprehensive review","volume":"589","author":"Khasanov","year":"2026","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0070","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","volume":"18","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.intimp.2026.117537_bb0125","doi-asserted-by":"crossref","DOI":"10.2196\/76981","article-title":"Comparative diagnostic accuracy of AI-assisted Fluorine-18 Fluorodeoxyglucose positron emission tomography versus structural magnetic resonance imaging in Alzheimer disease: systematic review and Meta-analysis","volume":"8","author":"Wang","year":"2025","journal-title":"JMIR Aging"},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0095","doi-asserted-by":"crossref","first-page":"437","DOI":"10.2967\/jnumed.122.264279","article-title":"A head-to-head comparison between plasma pTau181 and tau PET along the Alzheimer's disease continuum","volume":"64","author":"Coomans","year":"2023","journal-title":"J. Nucl. Med."},{"issue":"11","key":"10.1016\/j.intimp.2026.117537_bb0105","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"11","key":"10.1016\/j.intimp.2026.117537_bb0080","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1016\/j.neurobiolaging.2011.12.032","article-title":"Dispersible amyloid \u03b2-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice","volume":"33","author":"Rijal Upadhaya","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0170","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/alz.12301","article-title":"Plasma p-tau181, p-tau217, and other blood-based Alzheimer's disease biomarkers in a multi-ethnic, community study","volume":"17","author":"Brickman","year":"2021","journal-title":"Alzheimers Dement."},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0175","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13910","article-title":"Clinical usefulness of cerebrospinal fluid biomarkers in Alzheimer's disease","volume":"53","author":"Pe\u00f1a-Bautista","year":"2023","journal-title":"Eur. J. Clin. Investig."},{"issue":"6","key":"10.1016\/j.intimp.2026.117537_bb0180","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1002\/alz.13777","article-title":"Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease","volume":"20","author":"Cousins","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"12","key":"10.1016\/j.intimp.2026.117537_bb0185","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.45862","article-title":"Longitudinal blood-based biomarkers and clinical progression in subjective cognitive decline","volume":"8","author":"Trieu","year":"2025","journal-title":"JAMA Netw. Open"},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0200","doi-asserted-by":"crossref","first-page":"426","DOI":"10.14283\/jpad.2023.43","article-title":"Diagnostic biomarkers of amyloid and tau pathology in Alzheimer's disease: An overview of tests for clinical practice in the United States and Europe","volume":"10","author":"Iaccarino","year":"2023","journal-title":"J. Prev Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0205","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.2020.12134","article-title":"Discriminative accuracy of plasma Phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders","volume":"324","author":"Palmqvist","year":"2020","journal-title":"Jama"},{"issue":"5","key":"10.1016\/j.intimp.2026.117537_bb0210","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","article-title":"Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology","volume":"141","author":"Ashton","year":"2021","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117537_bb0215","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","article-title":"Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts","volume":"19","author":"Karikari","year":"2020","journal-title":"The Lancet Neurology"},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0230","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamaneurol.2023.5319","article-title":"Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for Alzheimer disease pathology","volume":"81","author":"Ashton","year":"2024","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0235","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41398-024-03220-3","article-title":"Associations of plasma biomarkers with cerebral perfusion and structure in Alzheimer's disease","volume":"15","author":"He","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.intimp.2026.117537_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/s44321-026-00483-9","article-title":"Predictive value of plasma p-tau217 for Alzheimer's dementia compared to other blood-based biomarkers","author":"Trares","year":"2026","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.intimp.2026.117537_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1426700","article-title":"CNS cell-derived exosome signatures as blood-based biomarkers of neurodegenerative diseases","volume":"18","author":"Park","year":"2024","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0460","doi-asserted-by":"crossref","first-page":"230","DOI":"10.14283\/jpad.2023.99","article-title":"Association of Blood MicroRNA expression and polymorphisms with cognitive and biomarker changes in older adults","volume":"11","author":"Sadlon","year":"2024","journal-title":"J. Prev Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.intimp.2026.117537_bb0465","first-page":"59","article-title":"MiRNA \u2212483-5p as a potential noninvasive biomarker for early detection of Alzheimer's disease","volume":"27","author":"Sabry","year":"2020","journal-title":"Egypt. J. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjpad.2025.100257","article-title":"Early detection of Alzheimer's disease using small RNAs. Results from the EPAD cohort","volume":"12","author":"Sikosek","year":"2025","journal-title":"J. Prev. Alzheimers Dis."},{"issue":"7","key":"10.1016\/j.intimp.2026.117537_bb0380","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1002\/alz.13863","article-title":"Neurofilaments and progranulin are related to atrophy in frontotemporal lobar degeneration - a transdiagnostic study cross-validating atrophy and fluid biomarkers","volume":"20","author":"H\u00fcper","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0385","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1002\/alz.13889","article-title":"Joint effect of testosterone and neurofilament light chain on cognitive decline in men: the Shanghai aging study","volume":"20","author":"Tang","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0390","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/alz.12724","article-title":"Plasma A\u03b242\/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: a cross-sectional and longitudinal study in the AIBL cohort","volume":"19","author":"Chatterjee","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"5","key":"10.1016\/j.intimp.2026.117537_bb0395","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1002\/alz.13713","article-title":"Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer's disease","volume":"20","author":"Sintini","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0455","doi-asserted-by":"crossref","first-page":"15589","DOI":"10.1038\/s41598-022-19862-6","article-title":"Plasma microRNAs as potential biomarkers in early Alzheimer disease expression","volume":"12","author":"Pe\u00f1a-Bautista","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2026.117537_bb0360","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.210013","article-title":"Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease","volume":"11","author":"Balendra","year":"2021","journal-title":"Open Biol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0365","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209806","article-title":"Association of Neurogranin and BACE1 with clinical cognitive decline in individuals with subjective cognitive decline","volume":"103","author":"Wang","year":"2024","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2026.117537_bb0370","doi-asserted-by":"crossref","DOI":"10.1017\/S0033583525100048","article-title":"Using multiscale molecular dynamics simulations to explore the fusion machinery underlying neurotransmitter release","volume":"58","author":"An","year":"2025","journal-title":"Q. Rev. Biophys."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0375","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13195-025-01685-y","article-title":"Evaluation of cerebrospinal fluid levels of VAMP-2 and SNAP-25 in a dementia with Lewy bodies clinical cohort stratified by Alzheimer's pathophysiological biomarkers","volume":"17","author":"Gonz\u00e1lez","year":"2025","journal-title":"Alzheimer's Res. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bcp.2013.11.009","article-title":"Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: a long-range point of view beyond 2020","volume":"88","author":"Hampel","year":"2014","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40644-016-0092-2","article-title":"Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents: (18)F-FAU, (18)F-FMAU, and (18)F-FLT","volume":"16","author":"McHugh","year":"2016","journal-title":"Cancer imaging : the official publication of the International Cancer Imaging Society"},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0090","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2850","article-title":"Amyloid-\u03b2 PET in Alzheimer's disease: a systematic review and Bayesian meta-analysis","volume":"13","author":"Ruan","year":"2023","journal-title":"Brain Behav."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0100","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41582-024-00942-2","article-title":"Biomarker-based staging of Alzheimer disease: rationale and clinical applications","volume":"20","author":"Therriault","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0110","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"issue":"9","key":"10.1016\/j.intimp.2026.117537_bb0115","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.molmed.2022.05.008","article-title":"Staging of Alzheimer's disease: past, present, and future perspectives","volume":"28","author":"Therriault","year":"2022","journal-title":"Trends Mol. Med."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/alzrt47","article-title":"Role of structural MRI in Alzheimer's disease","volume":"2","author":"Vemuri","year":"2010","journal-title":"Alzheimer's Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0130","article-title":"Association of CSF biomarkers with MRI brain changes in Alzheimer's disease","volume":"16","author":"Seidu","year":"2024","journal-title":"Alzheimer's & dementia (Amsterdam, Netherlands)"},{"key":"10.1016\/j.intimp.2026.117537_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.859492","article-title":"AD resemblance atrophy index of brain magnetic resonance imaging in predicting the progression of mild cognitive impairment carrying apolipoprotein E-\u03b54 allele","volume":"14","author":"Mai","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"2","key":"10.1016\/j.intimp.2026.117537_bb0140","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3233\/JAD-221023","article-title":"Differentiation of Alzheimer's disease from frontotemporal dementia and mild cognitive impairment based on arterial spin labeling magnetic resonance imaging: a pilot cross-sectional study from PUMCH dementia cohort","volume":"93","author":"Mao","year":"2023","journal-title":"Journal of Alzheimer's disease : JAD"},{"issue":"2","key":"10.1016\/j.intimp.2026.117537_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14484","article-title":"Choroid plexus cysts on 7T MRI: relationship to aging and neurodegenerative diseases","volume":"21","author":"Zhen","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"12","key":"10.1016\/j.intimp.2026.117537_bb0150","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.1002\/alz.14318","article-title":"Plasma p-tau181 and GFAP reflect 7T MR-derived changes in Alzheimer's disease: a longitudinal study of structural and functional MRI and MRS","volume":"20","author":"G\u00f6schel","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0155","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/acn3.274","article-title":"CSF A\u03b242\/A\u03b240 and A\u03b242\/A\u03b238 ratios: better diagnostic markers of Alzheimer disease","volume":"3","author":"Janelidze","year":"2016","journal-title":"Annals of Clinical and Translational Neurology"},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0160","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12883-019-1591-0","article-title":"Cerebro-spinal fluid biomarker levels: phosphorylated tau (T) and total tau (N) as markers for rate of progression in Alzheimer's disease","volume":"20","author":"Wattmo","year":"2020","journal-title":"BMC Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0165","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3233\/JAD-170927","article-title":"Added diagnostic value of cerebrospinal fluid biomarkers for differential dementia diagnosis in an autopsy-confirmed cohort","volume":"63","author":"Niemantsverdriet","year":"2018","journal-title":"Journal of Alzheimer's Disease : JAD"},{"issue":"10510","key":"10.1016\/j.intimp.2026.117537_bb0190","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(25)01294-2","article-title":"New landscape of the diagnosis of Alzheimer's disease","volume":"406","author":"Frisoni","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2026.117537_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101446","article-title":"Diagnostic accuracy of blood biomarkers for Alzheimer's disease and amnestic mild cognitive impairment: a meta-analysis","volume":"71","author":"Chen","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0220","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","article-title":"Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia","volume":"26","author":"Janelidze","year":"2020","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.117537_bb0225","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202217123","article-title":"Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads","volume":"15","author":"Salvad\u00f3","year":"2023","journal-title":"EMBO Mol. Med."},{"issue":"11","key":"10.1016\/j.intimp.2026.117537_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70881","article-title":"Combining CSF MTBR-tau243 and plasma pTau217 ratio enhances the prediction of continuous regional tau PET burden in early Alzheimer's disease","volume":"21","author":"Devanarayan","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"9","key":"10.1016\/j.intimp.2026.117537_bb0245","first-page":"1797","article-title":"Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer's disease","volume":"28","author":"Mil\u00e0-Alom\u00e0","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2026.117537_bb0250","doi-asserted-by":"crossref","DOI":"10.2174\/0115672050477953260623073513","article-title":"Diagnostic accuracy of plasma p-tau181 measured using automated chemiluminescent immunoassays for Alzheimer's disease: a systematic review and Meta-analysis","author":"Hu","year":"2026","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0265","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40035-024-00418-9","article-title":"Central nervous system-derived extracellular vesicles: the next generation of neural circulating biomarkers?","volume":"13","author":"Bravo-Miana","year":"2024","journal-title":"Transl. Neurodegener."},{"issue":"17","key":"10.1016\/j.intimp.2026.117537_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26175113","article-title":"RNA dynamics in Alzheimer's disease","volume":"26","author":"Rybak-Wolf","year":"2021","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0275","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jalz.2019.05.002","article-title":"Concordance between the assessment of A\u03b242, T-tau, and P-T181-tau in peripheral blood neuronal-derived exosomes and cerebrospinal fluid","volume":"15","author":"Jia","year":"2019","journal-title":"Alzheimers Dement."},{"issue":"17","key":"10.1016\/j.intimp.2026.117537_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26178246","article-title":"Exosomal non-coding RNAs as potential biomarkers for Alzheimer's disease: advances and perspectives in translational research","volume":"26","author":"Titze-de-Almeida","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.117537_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105800","article-title":"MicroRNA-29c-3p in dual-labeled exosome is a potential diagnostic marker of subjective cognitive decline","volume":"171","author":"Li","year":"2022","journal-title":"Neurobiol. Dis."},{"issue":"Suppl. 1","key":"10.1016\/j.intimp.2026.117537_bb0290","doi-asserted-by":"crossref","first-page":"S204","DOI":"10.1016\/j.neuroimage.2010.06.020","article-title":"Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model","volume":"54","author":"Koronyo-Hamaoui","year":"2011","journal-title":"NeuroImage"},{"issue":"13","key":"10.1016\/j.intimp.2026.117537_bb0295","doi-asserted-by":"crossref","first-page":"e1158","DOI":"10.1212\/WNL.0000000000005205","article-title":"Retinal signs and 20-year cognitive decline in the atherosclerosis risk in communities study","volume":"90","author":"Deal","year":"2018","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0300","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/WNO.0000000000000580","article-title":"Altered macular microvasculature in mild cognitive impairment and Alzheimer disease","volume":"38","author":"Jiang","year":"2018","journal-title":"Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society"},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0305","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-023-02548-2","article-title":"Retinal pathological features and proteome signatures of Alzheimer's disease","volume":"145","author":"Koronyo","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.intimp.2026.117537_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101273","article-title":"Alzheimer's disease pathophysiology in the retina","volume":"101","author":"Gaire","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"issue":"6","key":"10.1016\/j.intimp.2026.117537_bb0315","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1111\/aos.14381","article-title":"Retinal microvascular attenuation in mental cognitive impairment and Alzheimer's disease by optical coherence tomography angiography","volume":"98","author":"Wu","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.intimp.2026.117537_bb0320","article-title":"Unveiling immune-related feature genes for Alzheimer's disease based on machine learning","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2026.117537_bb0325","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","article-title":"Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the Alzheimer disease continuum","volume":"78","author":"Benedet","year":"2021","journal-title":"JAMA Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0330","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s41398-020-0801-2","article-title":"Neurogranin as a cognitive biomarker in cerebrospinal fluid and blood exosomes for Alzheimer's disease and mild cognitive impairment","volume":"10","author":"Liu","year":"2020","journal-title":"Transl. Psychiatry"},{"issue":"21","key":"10.1016\/j.intimp.2026.117537_bb0335","doi-asserted-by":"crossref","first-page":"e2065","DOI":"10.1212\/WNL.0000000000012853","article-title":"CSF synaptic biomarkers in the preclinical stage of Alzheimer disease and their association with MRI and PET: a cross-sectional study","volume":"97","author":"Mil\u00e0-Alom\u00e0","year":"2021","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0340","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00277-023-05478-x","article-title":"Integrative analyses reveal outcome-associated and targetable molecular partnerships between TP53, BRD4, TNFRSF10B, and CDKN1A in diffuse large B-cell lymphoma","volume":"103","author":"Forberg","year":"2024","journal-title":"Ann. Hematol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117537_bb0345","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/brain\/awae329","article-title":"Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes","volume":"148","author":"Al-Diwani","year":"2025","journal-title":"Brain J. Neurol."},{"issue":"7858","key":"10.1016\/j.intimp.2026.117537_bb0350","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41586-021-03489-0","article-title":"Meningeal lymphatics affect microglia responses and anti-a\u03b2 immunotherapy","volume":"593","author":"Da Mesquita","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0355","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-026-01973-1","article-title":"Longitudinal changes of blood \u03b2-synuclein in cognitively unimpaired, mild cognitive impairment and sporadic Alzheimer's disease","volume":"18","author":"Oeckl","year":"2026","journal-title":"Alzheimer's Res. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2026.117537_bb0400","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/clinchem\/hvad018","article-title":"Plasma glial fibrillary acidic protein in the Alzheimer disease continuum: relationship to other biomarkers, differential diagnosis, and prediction of clinical progression","volume":"69","author":"Shen","year":"2023","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0405","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12974-020-01935-w","article-title":"Astrocyte remodeling in the beneficial effects of long-term voluntary exercise in Alzheimer's disease","volume":"17","author":"Belaya","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2026.117537_bb0410","doi-asserted-by":"crossref","DOI":"10.1007\/s00406-026-02253-7","article-title":"Comparison of TDP-43, NfL, and GFAP in cerebrospinal fluid and serum in Alzheimer's disease","author":"Manco","year":"2026","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0415","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1212\/WNL.0000000000012174","article-title":"Primary progressive aphasia associated with GRN mutations: new insights into the nonamyloid Logopenic variant","volume":"97","author":"Saracino","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.intimp.2026.117537_bb0420","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02780","article-title":"Heterozygous CX3CR1 deficiency in microglia restores neuronal \u03b2-amyloid clearance pathways and slows progression of Alzheimer's like-disease in PS1-APP mice","volume":"10","author":"Hickman","year":"2019","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.intimp.2026.117537_bb0425","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm5667","article-title":"Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer's disease","volume":"8","author":"Bu","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2026.117537_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112736","article-title":"Expression patterns of blood-based biomarkers of neurodegeneration and inflammation across adulthood in rhesus macaques","volume":"203","author":"Metzler","year":"2025","journal-title":"Exp. Gerontol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117537_bb0435","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1002\/alz.13485","article-title":"Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort","volume":"20","author":"Foley","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0440","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"6","key":"10.1016\/j.intimp.2026.117537_bb0445","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1038\/s41591-025-03617-7","article-title":"Plasma MTBR-tau243 biomarker identifies tau tangle pathology in Alzheimer's disease","volume":"31","author":"Horie","year":"2025","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.intimp.2026.117537_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.tjpad.2026.100544","article-title":"Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology and is associated with increased risk of clinical progression in early Alzheimer's disease","volume":"13","author":"Cetindag","year":"2026","journal-title":"J. Prev Alzheimers Dis."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0475","doi-asserted-by":"crossref","first-page":"10201","DOI":"10.1007\/s12035-025-04895-5","article-title":"Amyloid-\u03b2-induced neurotoxicity modulates miR-98 and miR-200 expression in SH-SY5Y cells: a step toward Alzheimer's biomarker discovery","volume":"62","author":"Keske","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2026.117537_bb0480","article-title":"ACOT7, a candidate and novel serum biomarker of Alzheimer's disease","volume":"16","author":"Wang","year":"2024","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0485","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-026-46738-w","article-title":"Association of tear fluid glutathione synthetase and glutathione levels with amyloid positivity","volume":"16","author":"van de Sande","year":"2026","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2026.117537_bb0490","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neuroscience.2018.10.001","article-title":"Study on urine metabolic profile of A\u03b225-35-induced Alzheimer's disease using UHPLC-Q-TOF-MS","volume":"394","author":"Liu","year":"2018","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0495","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032590","article-title":"Beta-amyloid peptide in tears: an early diagnostic marker of Alzheimer's disease correlated with choroidal thickness","volume":"24","author":"Gharbiya","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2026.117537_bb0500","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-026-02104-6","article-title":"Plasma p-tau as a biomarker for the differential diagnosis of Alzheimer's disease: a systematic review and meta-analysis","author":"Chai","year":"2026","journal-title":"Alzheimer's Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0505","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-026-01974-0","article-title":"Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort","volume":"18","author":"Orellana","year":"2026","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.intimp.2026.117537_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102290","article-title":"A critical appraisal of blood-based biomarkers for Alzheimer's disease","volume":"96","author":"Lista","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0515","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13195-024-01630-5","article-title":"Analytical and clinical performance of eight Simoa(\u00ae) and Lumipulse(\u00ae) assays for automated measurement of plasma p-tau181 and p-tau217","volume":"16","author":"Wojda\u0142a","year":"2024","journal-title":"Alzheimer's Res. Ther."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0520","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70478","article-title":"The clinical translation of blood biomarkers for Alzheimer's disease: timing and challenges","volume":"21","author":"Huang","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0525","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3233\/ADR-230029","article-title":"Plasma biomarkers of Alzheimer's disease: a review of available assays, recent developments, and implications for clinical practice","volume":"7","author":"Pais","year":"2023","journal-title":"J Alzheimers Dis Rep"},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0530","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s13195-024-01647-w","article-title":"Blood-based biomarkers and plasma a\u03b2 assays in the differential diagnosis of Alzheimer's disease and behavioral-variant frontotemporal dementia","volume":"16","author":"Mohaupt","year":"2024","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.intimp.2026.117537_bb0535","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ymeth.2018.10.018","article-title":"Quantitation of low abundant soluble biomarkers using high sensitivity single molecule counting technology","volume":"158","author":"Hwang","year":"2019","journal-title":"Methods"},{"key":"10.1016\/j.intimp.2026.117537_bb0540","article-title":"Millipore xMap\u00ae Luminex (HATMAG-68K): An accurate and cost-effective method for evaluating Alzheimer's biomarkers in cerebrospinal fluid","volume":"12","author":"Hansen","year":"2021","journal-title":"Front. Psychol."},{"issue":"3","key":"10.1016\/j.intimp.2026.117537_bb0545","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/alz.12706","article-title":"Test-retest variability of plasma biomarkers in Alzheimer's disease and its effects on clinical prediction models","volume":"19","author":"Cullen","year":"2023","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0550","doi-asserted-by":"crossref","DOI":"10.1063\/1.5087122","article-title":"Challenges and opportunities in exosome research-perspectives from biology, engineering, and cancer therapy","volume":"3","author":"Li","year":"2019","journal-title":"APL Bioeng"},{"issue":"6","key":"10.1016\/j.intimp.2026.117537_bb0555","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41592-021-01174-8","article-title":"L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma","volume":"18","author":"Norman","year":"2021","journal-title":"Nat. Methods"},{"issue":"5","key":"10.1016\/j.intimp.2026.117537_bb0560","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/jamaneurol.2025.0142","article-title":"Cognitive phenotyping and interpretation of Alzheimer blood biomarkers","volume":"82","author":"Bouteloup","year":"2025","journal-title":"JAMA Neurol."},{"issue":"8","key":"10.1016\/j.intimp.2026.117537_bb0565","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/alz.12510","article-title":"Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease-related blood-based biomarkers: results from the standardization of Alzheimer's blood biomarkers (SABB) working group","volume":"18","author":"Verberk","year":"2022","journal-title":"Alzheimers Dement."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0570","doi-asserted-by":"crossref","first-page":"7407","DOI":"10.1038\/s41467-025-62590-4","article-title":"AI-driven fusion of multimodal data for Alzheimer's disease biomarker assessment","volume":"16","author":"Jasodanand","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2026.117537_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102497","article-title":"AI-driven innovations in Alzheimer's disease: integrating early diagnosis, personalized treatment, and prognostic modelling","volume":"101","author":"Kale","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2026.117537_bb0580","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14600","article-title":"Machine learning prediction of tau-PET in Alzheimer's disease using plasma, MRI, and clinical data","volume":"21","author":"Karlsson","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"Suppl. 2","key":"10.1016\/j.intimp.2026.117537_bb0585","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.2967\/jnumed.125.270152","article-title":"Imaging and fluid biomarkers of Alzheimer disease: complementation rather than competition","volume":"66","author":"Drzezga","year":"2025","journal-title":"J. Nucl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0590","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41746-025-01640-z","article-title":"Alzheimer's disease digital biomarkers multidimensional landscape and AI model scoping review","volume":"8","author":"Qi","year":"2025","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.intimp.2026.117537_bb0595","series-title":"Empirical evaluation of pre-trained transformers for human-level NLP: the role of sample size and dimensionality","first-page":"4515","author":"Ganesan","year":"2021"},{"key":"10.1016\/j.intimp.2026.117537_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.bspc.2020.102249","article-title":"Detection of mild cognitive impairment and Alzheimer's disease using dual-task gait assessments and machine learning","volume":"64","author":"Ghoraani","year":"2021","journal-title":"Biomed. Signal Process. Control"},{"key":"10.1016\/j.intimp.2026.117537_bb0605","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1333894","article-title":"Distinct eye movement patterns to complex scenes in Alzheimer's disease and Lewy body disease","volume":"18","author":"Yamada","year":"2024","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2026.117537_bb0610","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13024-020-00395-3","article-title":"Neuroimaging advances regarding subjective cognitive decline in preclinical Alzheimer's disease","volume":"15","author":"Wang","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"5","key":"10.1016\/j.intimp.2026.117537_bb0615","doi-asserted-by":"crossref","DOI":"10.3390\/cells10050993","article-title":"Neuronal and astrocytic extracellular vesicle biomarkers in blood reflect brain pathology in mouse models of Alzheimer's disease","volume":"10","author":"Delgado-Peraza","year":"2021","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.intimp.2026.117537_bb0620","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071618","article-title":"Astrocyte- and neuron-derived extracellular vesicles from Alzheimer's disease patients effect complement-mediated neurotoxicity","volume":"9","author":"Nogueras-Ortiz","year":"2020","journal-title":"Cells"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926013858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:33:02Z","timestamp":1792251182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926013858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":124,"alternative-id":["S1567576926013858"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117537","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancing early detection of Alzheimer's disease: from established biomarkers to future innovations","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117537"}}