{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:33:31Z","timestamp":1793799211660,"version":"4.6.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.intimp.2026.117588","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:17:52Z","timestamp":1792675072000},"page":"117588","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["DOTMP induces nephrotoxicity via the Hsp90\u03b2\/PI3K signaling axis"],"prefix":"10.1016","volume":"191","author":[{"given":"Xiaoke","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2026.117588_bb0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMoa1213755","article-title":"ALSYMPCA Investigators. Alpha emitter radium-223 and survival in metastatic prostate cancer","volume":"369","author":"Parker","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.intimp.2026.117588_bb0010","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/S1470-2045(14)70474-7","volume":"15","author":"Hoskin","year":"2014","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.intimp.2026.117588_bb0015","first-page":"252","article-title":"Targeting of osseous sites with alpha-emitting 223Ra: comparison with the beta-emitter 89Sr in mice","volume":"44","author":"Henriksen","year":"2003","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.intimp.2026.117588_bb0020","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.radonc.2005.03.003","article-title":"Radiopharmaceuticals for the palliation of painful bone metastasis-a systemic review","volume":"75","author":"Bauman","year":"2005","journal-title":"Radiother. Oncol."},{"issue":"4 Suppl","key":"10.1016\/j.intimp.2026.117588_bb0025","first-page":"71","article-title":"Radionuclide therapy with bone seeking radionuclides in palliation of painful bone metastases","volume":"22","author":"Maini","year":"2003","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.intimp.2026.117588_bb0030","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jlcr.3517","article-title":"A \"mix-and-use\" approach for formulation of human clinical doses of 177Lu-DOTMP at hospital radiopharmacy for management of pain arising from skeletal metastases","volume":"60","author":"Chakraborty","year":"2017","journal-title":"J Labelled Comp Radiopharm."},{"key":"10.1016\/j.intimp.2026.117588_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2022.110246","article-title":"Dosimetric implications of the potential radionuclidic impurities in 153Sm-DOTMP","volume":"185","author":"Wendt","year":"2022","journal-title":"Appl. Radiat. Isot."},{"issue":"1","key":"10.1016\/j.intimp.2026.117588_bb0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2967\/jnmt.108.054700","article-title":"Comparison of systemic toxicities of 177Lu-DOTMP and 153Sm-EDTMP administered intravenously at equivalent skeletal doses to normal dogs","volume":"37","author":"Bryan","year":"2009","journal-title":"J. Nucl. Med. Technol."},{"issue":"5","key":"10.1016\/j.intimp.2026.117588_bb0045","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.intimp.2026.117588_bb0050","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s11096-025-01988-y","article-title":"Incidence and risk factors of acute kidney injury in patients with polypharmacy: a systematic review and meta-analysis","volume":"47","author":"Yang","year":"2025","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2026.117588_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113993","article-title":"Iridium cluster\/hafnium-porphyrin framework heterojunctions for biocatalytic ROS-scavenging and acute kidney injury alleviation","volume":"385","author":"Luo","year":"2025","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.intimp.2026.117588_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/toxins17030145","article-title":"Nafamostat mesylate regulates glycosylation to alleviate aristolochic acid induced kidney injury","volume":"17","author":"Xie","year":"2025","journal-title":"Toxins (Basel)."},{"issue":"5","key":"10.1016\/j.intimp.2026.117588_bb0065","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41581-022-00658-w","article-title":"Role of necroptosis in kidney health and disease","volume":"19","author":"Kolbrink","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2026.117588_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-24712-6","article-title":"Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury","volume":"12","author":"Tonnus","year":"2021","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.intimp.2026.117588_bb0075","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.ccell.2022.11.001","article-title":"Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer","volume":"40","author":"Li","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2026.117588_bb0080","article-title":"Investigating the relationship of co-exposure to multiple metals with chronic kidney disease: an integrated perspective from epidemiology and adverse outcome pathways","volume":"480","author":"Wang","year":"2024","journal-title":"J. Hazard. Mater."},{"issue":"3","key":"10.1016\/j.intimp.2026.117588_bb0085","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00204-023-03637-7","article-title":"Development of an adverse outcome pathway network for nephrotoxicity","volume":"98","author":"Barnes","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.intimp.2026.117588_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124675","article-title":"Multi-omics integration analysis: tools and applications in environmental toxicology","volume":"360","author":"Shi","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.intimp.2026.117588_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119480","article-title":"Application and development trends of network toxicology in the safety assessment of traditional Chinese medicine","volume":"343","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"D1","key":"10.1016\/j.intimp.2026.117588_bb0100","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.intimp.2026.117588_bb0105","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.intimp.2026.117588_bb0110","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.intimp.2026.117588_bb0115","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2026.117588_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.170036","article-title":"Aptamer-engineered multivalent camptothecin conjugates synergistically orchestrate immunosuppressive microenvironment and DNA damage cascades in colorectal carcinoma","volume":"525","author":"Zuo","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"29","key":"10.1016\/j.intimp.2026.117588_bb0125","article-title":"Responsive ROS-augmented prodrug hybridization nanoassemblies for multidimensionally synergitic treatment of hepatocellular carcinoma in cascade assaults","volume":"12","author":"Zeng","year":"2025","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.intimp.2026.117588_bb0130","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1016\/j.apsb.2025.11.011","article-title":"Engineering selective PI3K\u03b3 inhibitors with antitumor and immunomodulatory potentials","volume":"16","author":"Zuo","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2026.117588_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156859","article-title":"Voacamine initiates the PI3K\/mTOR\/Beclin1 pathway to induce autophagy and potentiate apoptosis in acute myeloid leukemia","volume":"143","author":"Cao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2026.117588_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114654","article-title":"Self-assembled multicomponent prodrugs with GSH\/ROS site-responsiveness enable spatiotemporally controlled release for treating resistant NSCLC","volume":"391","author":"Zhang","year":"2026","journal-title":"J. Control. Release"},{"issue":"9","key":"10.1016\/j.intimp.2026.117588_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cells13090781","article-title":"Nuclear mTOR signaling orchestrates transcriptional programs underlying cellular growth and metabolism","volume":"13","author":"Zhao","year":"2024","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.intimp.2026.117588_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2022.151240","article-title":"Amino acids control blood glucose levels through mTOR signaling","volume":"101","author":"Fan","year":"2022","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.intimp.2026.117588_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2026.1771707","article-title":"Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species","volume":"17","author":"Fan","year":"2026","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.intimp.2026.117588_bb0160","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ki.2013.559","article-title":"Rictor\/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury","volume":"86","author":"Li","year":"2014","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.intimp.2026.117588_bb0165","doi-asserted-by":"crossref","first-page":"F267","DOI":"10.1152\/ajprenal.00629.2014","article-title":"mTOR contributes to ER stress and associated apoptosis in renal tubular cells","volume":"308","author":"Dong","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926014360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576926014360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T13:18:29Z","timestamp":1793798309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576926014360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":33,"alternative-id":["S1567576926014360"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117588","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DOTMP induces nephrotoxicity via the Hsp90\u03b2\/PI3K signaling axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2026.117588","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117588"}}