{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:53:23Z","timestamp":1790787203227,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Indian Pacing and Electrophysiology Journal"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.ipej.2021.12.001","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T02:00:59Z","timestamp":1639620059000},"page":"77-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy and safety of leadless pacemaker: A systematic review, pooled analysis and meta-analysis"],"prefix":"10.1016","volume":"22","author":[{"given":"Daniel","family":"Darlington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Bourne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Patwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-1586","authenticated-orcid":false,"given":"Chun Shing","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ipej.2021.12.001_bib1","first-page":"691","article-title":"Survival in patients with permanent pacemakers","volume":"10","author":"Rosenqvist","year":"1992","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.ipej.2021.12.001_bib2","first-page":"1186","article-title":"Complications after cardiac implantable electronic device implantation: an analysis of a complete, nationwide cohort in Demark","volume":"18","author":"Kirkfeldt","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ipej.2021.12.001_bib3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.hrthm.2011.12.014","article-title":"Incidence and predictors of short- and long-term complications in pacemaker therapy: the FOLLOWPACE study","volume":"9","author":"Udo","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ipej.2021.12.001_bib4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.hrthm.2006.10.009","article-title":"Clinical experience with pacemaker pulse generators and transvenous leads: an 8-year prospective multicentre study","volume":"4","author":"Hauser","year":"2007","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ipej.2021.12.001_bib5","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/europace\/euv053","article-title":"Risk factors for cardiac implantable electronic device infection: a systematic review and meta-analysis","volume":"17","author":"Polyzos","year":"2015","journal-title":"Europace"},{"key":"10.1016\/j.ipej.2021.12.001_bib6","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1161\/01.CIR.95.8.2098","article-title":"Systemic infection related to endocarditis on pacemaker leads","volume":"95","author":"Klug","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.ipej.2021.12.001_bib7","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jacc.2016.01.009","article-title":"Clinical significant pocket hematoma increases long-term risk of device infection","volume":"67","author":"Essebag","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.ipej.2021.12.001_bib8","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.hrthm.2017.05.017","article-title":"A\u00a0leadless pacemaker in the real-world setting: the micra transcatheter pacing system post-approval registry","volume":"14","author":"Roberts","year":"2017","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ipej.2021.12.001_bib9","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1056\/NEJMoa1507192","article-title":"Percutaneous implantation of an entirely intracardiac leadless pacemaker","volume":"373","author":"Reddy","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ipej.2021.12.001_bib10","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.ipej.2021.12.001_bib11","author":"Wells"},{"key":"10.1016\/j.ipej.2021.12.001_bib12","unstructured":"Deeks JJ, Higgins JPT, Altman DG. Analysing data and undertaking meta-analyses. 9.5.2. Identifying and measuring heterogeneity. Available at: 9.5.2 Identifying and measuring heterogeneity (cochrane.org)."},{"key":"10.1016\/j.ipej.2021.12.001_bib13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2133.2011.10218.x","article-title":"Efficacy of topical treatments for cutaneous warts: a meta-analysis and pooled analysis of randomized controlled trials","volume":"165","author":"Kwok","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ipej.2021.12.001_bib14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/europace\/euy116","article-title":"Feasibility and long-term effectiveness of a non-apical Micra pacemaker implantation in a referral centre for lead extraction","volume":"21","author":"Bongiorni","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.ipej.2021.12.001_bib15","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.hlc.2018.09.014","article-title":"Leadless permanent pacing: a single centre Australian experience","volume":"28","author":"Denman","year":"2019","journal-title":"Heart Lung Circ"},{"key":"10.1016\/j.ipej.2021.12.001_bib16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.recesp.2019.06.008","article-title":"Performance of the Micra cardiac pacemaker in nonagenarians","volume":"73","author":"El Amrani","year":"2020","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.ipej.2021.12.001_bib17","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1016\/j.hrthm.2018.08.005","article-title":"Updated performance of the Micra transcatheter pacemaker in the real-world setting: a comparison to the investigational study and a transvenous historical control","volume":"15","author":"El-Chami","year":"2018","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ipej.2021.12.001_bib18","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/europace\/euaa097","article-title":"Leadless pacemaker implantation quality: importance of the operator's experience","volume":"22","author":"Haeberlin","year":"2020","journal-title":"Europace"},{"key":"10.1016\/j.ipej.2021.12.001_bib19","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.hrthm.2018.12.007","article-title":"Safety and feasibility of a midseptal implantation technique of a leadless pacemaker","volume":"16","author":"Hai","year":"2019","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ipej.2021.12.001_bib20","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.recesp.2016.09.011","article-title":"The Micra leadless transcatheter pacemaker. Implantation and mid-term follow-up results in a single center","volume":"70","author":"Mart\u00ednez-Sande","year":"2017","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"10.1016\/j.ipej.2021.12.001_bib21","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.hrthm.2020.05.022","article-title":"Safety of leadless pacemaker implantation in the very elderly","volume":"17","author":"Pagan","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ipej.2021.12.001_bib22","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCULATIONAHA.113.006987","article-title":"Permanent leadless cardiac pacing: results of the LEADLESS trial","volume":"129","author":"Reddy","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ipej.2021.12.001_bib23","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMoa1511643","article-title":"A\u00a0leadless intracardiac transcatheter pacing system","volume":"374","author":"Reynolds","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ipej.2021.12.001_bib24","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1093\/eurheartj\/ehv214","article-title":"Early performance of a miniaturized leadless cardiac pacemaker: the Micra Transcatheter Pacing Study","volume":"36","author":"Ritter","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ipej.2021.12.001_bib25","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/europace\/eux359","article-title":"Primary safety results from the LEADLESS observational study","volume":"20","author":"Sperzel","year":"2018","journal-title":"Europace"},{"key":"10.1016\/j.ipej.2021.12.001_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/pace.13894","article-title":"The feasibility of leadless pacemaker implantation for superelderly patients","volume":"43","author":"Tachibana","year":"2020","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.ipej.2021.12.001_bib27","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/jce.14360","article-title":"Very high pacing thresholds during long-term follow-up predicted by a combination of implant pacing threshold and impedance in leadless transcatheter pacemakers","volume":"31","author":"Tolosana","year":"2020","journal-title":"J\u00a0Cardiovasc Electrophysiol"},{"key":"10.1016\/j.ipej.2021.12.001_bib28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/pace.13601","article-title":"Real-world experience with leadless cardiac pacing","volume":"42","author":"Vaidya","year":"2019","journal-title":"Pacing Clin Electrophysiol"},{"key":"10.1016\/j.ipej.2021.12.001_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/europace\/euy195","article-title":"Leadless pacing using the transcatheter pacing system (Micra TPS) in the real world: initial Swiss experience from the Romandie region","volume":"21","author":"Valiton","year":"2019","journal-title":"Europace"},{"key":"10.1016\/j.ipej.2021.12.001_bib30","first-page":"1","article-title":"Comparison between leadless and transvenous single-chamber pacemaker therapy in a referral centre for lead extraction","author":"Zucchelli","year":"2020","journal-title":"J\u00a0Interv Card Electrophysiol"},{"key":"10.1016\/j.ipej.2021.12.001_bib31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.hrthm.2004.02.020","article-title":"Patient, procedural, and hardware factors associated with pacemaker lead failures in pediatrics and congenital heart disease","volume":"1","author":"Fortescue","year":"2004","journal-title":"Heart Rhythm"}],"container-title":["Indian Pacing and Electrophysiology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972629221001790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0972629221001790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:43:37Z","timestamp":1760852617000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0972629221001790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0972629221001790"],"URL":"https:\/\/doi.org\/10.1016\/j.ipej.2021.12.001","relation":{},"ISSN":["0972-6292"],"issn-type":[{"value":"0972-6292","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of leadless pacemaker: A systematic review, pooled analysis and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Indian Pacing and Electrophysiology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ipej.2021.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Indian Heart Rhythm Society. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}