{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:50:01Z","timestamp":1777600201518,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2021\/13997-0"],"award-info":[{"award-number":["2021\/13997-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2022\/00770-0"],"award-info":[{"award-number":["2022\/00770-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["304707\/2023\\u20136"],"award-info":[{"award-number":["304707\/2023\\u20136"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["ISA Transactions"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.isatra.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:24:36Z","timestamp":1762597476000},"page":"199-210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Reduced chattering target-tracking sliding mode control for intraprocedural propofol control"],"prefix":"10.1016","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-2572","authenticated-orcid":false,"given":"Roberto","family":"Costa Ceccato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0153-6686","authenticated-orcid":false,"given":"Jos\u00e9 Roberto","family":"Castilho Piqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isatra.2025.11.005_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.compchemeng.2022.107747","article-title":"Linear MPC for anesthesia process with external predictor","volume":"161","author":"Pawlowski","year":"2022","journal-title":"Comput Chem Eng"},{"key":"10.1016\/j.isatra.2025.11.005_bib0010","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1109\/LCSYS.2024.3399093","article-title":"Human-imitating control of depth of hypnosis combining MPC and event-based PID strategies","volume":"8","author":"Milanesi","year":"2024","journal-title":"IEEE Control Syst Lett"},{"issue":"1","key":"10.1016\/j.isatra.2025.11.005_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/bja\/67.1.41","article-title":"Pharmacokinetic model driven infusion of propofol in children","volume":"67","author":"Marsh","year":"1991","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.isatra.2025.11.005_bib0020","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/00000542-199805000-00006","article-title":"The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers","volume":"88","author":"Schnider","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.isatra.2025.11.005_bib0025","year":"2018"},{"issue":"3","key":"10.1016\/j.isatra.2025.11.005_bib0030","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11071-018-4095-3","article-title":"A computationally efficient hill curve adaptation strategy during continuous monitoring of dose\u2013effect relation in anaesthesia","volume":"92","author":"Ionescu","year":"2018","journal-title":"Nonlinear Dyn"},{"key":"10.1016\/j.isatra.2025.11.005_bib0035","series-title":"IFAC-papersonline","first-page":"6490","article-title":"Towards closing the loop in depth-of-hypnosis control: connecting Matlab-Simulink to medical devices","volume":"vol. 56","author":"Karer","year":"2023"},{"issue":"1","key":"10.1016\/j.isatra.2025.11.005_bib0040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s10877-010-9266-9","article-title":"Dynamic behavior of BIS, m-entropy and neurosense brain function monitors","volume":"25","author":"Bibian","year":"2011","journal-title":"J Clin Monit Comput"},{"key":"10.1016\/j.isatra.2025.11.005_bib0045","series-title":"IFAC-papersonline","first-page":"496","article-title":"A minimum time-to-target MPC approach for depth of hypnosis in total intravenous anesthesia","volume":"vol. 58","author":"Milanesi","year":"2024"},{"key":"10.1016\/j.isatra.2025.11.005_bib0050","doi-asserted-by":"crossref","first-page":"206264","DOI":"10.1109\/ACCESS.2020.3037725","article-title":"Closed-loop control of anesthesia: survey on actual trends, challenges and perspectives","volume":"8","author":"Ghita","year":"2020","journal-title":"IEEE Access"},{"issue":"18","key":"10.1016\/j.isatra.2025.11.005_bib0055","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3182\/20120829-3-HU-2029.00102","article-title":"Closed-loop control of anesthesia - a review","volume":"45","author":"Dumont","year":"2012","journal-title":"IFAC Proc Volumes"},{"issue":"5","key":"10.1016\/j.isatra.2025.11.005_bib0060","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/acs.1087","article-title":"Robust control of depth of anesthesia","volume":"23","author":"Dumont","year":"2009","journal-title":"Int J Adapt Control Signal Process"},{"issue":"6","key":"10.1016\/j.isatra.2025.11.005_bib0065","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.bspc.2013.04.005","article-title":"Individualized closed-loop control of propofol anesthesia: a preliminary study","volume":"8","author":"Soltesz","year":"2013","journal-title":"Biomed Signal Process Control"},{"issue":"3","key":"10.1016\/j.isatra.2025.11.005_bib0070","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1109\/TBME.2008.915670","article-title":"A model-predictive hypnosis control system under total intravenous anesthesia","volume":"55","author":"Sawaguchi","year":"2008","journal-title":"IEEE Trans Biomed Eng"},{"issue":"18","key":"10.1016\/j.isatra.2025.11.005_bib0075","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3182\/20120829-3-HU-2029.00009","article-title":"Towards a multivariable model for controlling the depth of anaesthesia using propofol and remifentanil","volume":"45","author":"Ionescu","year":"2012","journal-title":"IFAC Proc Volumes"},{"issue":"5","key":"10.1016\/j.isatra.2025.11.005_bib0080","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.bspc.2011.09.001","article-title":"Robust closed-loop control of hypnosis with propofol using WAVCNS index as the controlled variable","volume":"7","author":"Hahn","year":"2012","journal-title":"Biomed Signal Process Control"},{"issue":"18","key":"10.1016\/j.isatra.2025.11.005_bib0085","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3182\/20120829-3-HU-2029.00094","article-title":"Control of patient response to anesthesia using l1 adaptive methods","volume":"45","author":"Kharisov","year":"2012","journal-title":"IFAC Proc Vol"},{"issue":"2","key":"10.1016\/j.isatra.2025.11.005_bib0090","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1049\/iet-syb.2018.5080","article-title":"Hypnosis regulation in propofol anaesthesia employing super-twisting sliding mode control to compensate variability dynamics","volume":"14","author":"Ilyas","year":"2020","journal-title":"IET Syst Biol"},{"key":"10.1016\/j.isatra.2025.11.005_bib0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bspc.2024.107489","article-title":"Regulation of depth of hypnosis through optimized AI-based robust nonlinear controller","volume":"104","author":"Imam","year":"2025","journal-title":"Biomed Signal Process Control"},{"key":"10.1016\/j.isatra.2025.11.005_bib0100","series-title":"IFAC-papersonline","first-page":"3015","article-title":"On the use of the Eleveld pk\/pd model for the design of PID control of anesthesia","volume":"vol. 56","author":"Paolino","year":"2023"},{"issue":"17","key":"10.1016\/j.isatra.2025.11.005_bib0105","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.3390\/ani13172699","article-title":"Sedline miscalculation of depth of anaesthesia variables in two pigs due to electrocardiographic signal contamination","volume":"13","author":"Mirra","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.isatra.2025.11.005_bib0110","article-title":"Pharmacokinetic models for target controlled infusion of propofol: comparing Marsh and Schnider","volume":"26","author":"Weber","year":"2016","journal-title":"Rev Med Minas Gerais"},{"issue":"1","key":"10.1016\/j.isatra.2025.11.005_bib0115","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/bja\/aep143","article-title":"Pharmacokinetic models for propofol- defining and illuminating the Devil in the detail","volume":"103","author":"Absalom","year":"2009","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.isatra.2025.11.005_bib0120","series-title":"Road map for sliding mode control design","author":"Utkin","year":"2020"},{"key":"10.1016\/j.isatra.2025.11.005_bib0125","series-title":"Applied nonlinear control","author":"Slotine","year":"1991"},{"key":"10.1016\/j.isatra.2025.11.005_bib0130","series-title":"Sliding mode control in engineering","author":"Perruquetti","year":"2002"},{"issue":"1","key":"10.1016\/j.isatra.2025.11.005_bib0135","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19160-7","article-title":"The misuse of colour in science communication","volume":"11","author":"Crameri","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.isatra.2025.11.005_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.automatica.2020.108921","article-title":"Conditioned super-twisting algorithm for systems with saturated control action","volume":"116","author":"Seeber","year":"2020","journal-title":"Automatica"}],"container-title":["ISA Transactions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019057825006238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019057825006238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:51:29Z","timestamp":1777409489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0019057825006238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"alternative-id":["S0019057825006238"],"URL":"https:\/\/doi.org\/10.1016\/j.isatra.2025.11.005","relation":{},"ISSN":["0019-0578"],"issn-type":[{"value":"0019-0578","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced chattering target-tracking sliding mode control for intraprocedural propofol control","name":"articletitle","label":"Article Title"},{"value":"ISA Transactions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isatra.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society of Automation. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}