{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:34:04Z","timestamp":1790494444013,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.isci.2019.09.005","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T19:12:23Z","timestamp":1568056343000},"page":"25-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function"],"prefix":"10.1016","volume":"20","author":[{"given":"John","family":"Scott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Thakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaping","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Hejran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Yee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Klezovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeri","family":"Vasioukhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2019.09.005_bib1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature01486","article-title":"The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl","volume":"422","author":"Betschinger","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.isci.2019.09.005_bib2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1097-154","article-title":"Homologous recombination of a flanking repeat gene cluster is a mechanism for a common contiguous gene deletion syndrome","volume":"17","author":"Chen","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2019.09.005_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/(SICI)1098-2779(1996)2:3<122::AID-MRDD2>3.0.CO;2-U","article-title":"The smith-magenis syndrome [del(17)p11.2]: clinical review and molecular advances","volume":"2","author":"Chen","year":"1996","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.isci.2019.09.005_bib4","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.37881","article-title":"Par3 interacts with Prickle3 to generate apical PCP complexes in the vertebrate neural plate","volume":"7","author":"Chuykin","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.isci.2019.09.005_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1113\/jphysiol.1983.sp014478","article-title":"Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus","volume":"334","author":"Collingridge","year":"1983","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.isci.2019.09.005_bib6","first-page":"1","article-title":"The imaginary part of coherency in autism: differences in cortical functional connectivity in preschool children","volume":"8","author":"Dominguez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2019.09.005_bib7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1023\/A:1025800126086","article-title":"Brief report: cognitive and behavioral profiles in persons with smith-magenis syndrome","volume":"27","author":"Dykens","year":"1997","journal-title":"J.\u00a0Autism. Dev. Disord."},{"key":"10.1016\/j.isci.2019.09.005_bib8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2788.1998.4260481.x","article-title":"Distinctiveness and correlates of maladaptive behaviour in children and adolescents with Smith-Magenis syndrome","volume":"42","author":"Dykens","year":"1998","journal-title":"J.\u00a0Intellect. Disabil. Res."},{"key":"10.1016\/j.isci.2019.09.005_bib9","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1399-0004.2007.00815.x","article-title":"Gender, genotype, and phenotype differences in Smith\u2013Magenis syndrome: a meta-analysis of 105 cases","volume":"71","author":"Edelman","year":"2007","journal-title":"Clin. Genet."},{"key":"10.1016\/j.isci.2019.09.005_bib10","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.cub.2008.09.029","article-title":"Cdc42, Par6, and aPKC regulate Arp2\/3-mediated endocytosis to control local adherens junction stability","volume":"18","author":"Georgiou","year":"2008","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2019.09.005_bib11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/01.gim.0000228215.32110.89","article-title":"Genotype-phenotype correlation in Smith-Magenis syndrome: Evidence that multiple genes in 17p11.2 contribute to the clinical spectrum","volume":"8","author":"Girirajan","year":"2006","journal-title":"Genet. Med."},{"key":"10.1016\/j.isci.2019.09.005_bib12","first-page":"1","article-title":"The\u00a0open field test","volume":"42","author":"Gould","year":"2009"},{"key":"10.1016\/j.isci.2019.09.005_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1096-8628(19960329)62:3<247::AID-AJMG9>3.0.CO;2-Q","article-title":"Multi-disciplinary clinical study of smith-magenis syndrome (deletion 17p11.2)","volume":"62","author":"Greenberg","year":"1996","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.isci.2019.09.005_bib14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/WCO.0b013e3280895dba","article-title":"New developments in Smith-Magenis syndrome (del 17p11.2)","volume":"20","author":"Gropman","year":"2007","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.isci.2019.09.005_bib15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/dvg.20777","article-title":"Efficient inducible Pan-neuronal cre-mediated recombination in SLICK-H transgenic mice","volume":"49","author":"Heimer-McGinn","year":"2011","journal-title":"Genesis"},{"key":"10.1016\/j.isci.2019.09.005_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuron.2016.09.019","article-title":"Molecular and neural functions of rai1, the causal gene for smith-magenis syndrome","volume":"92","author":"Huang","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2019.09.005_bib17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.semcdb.2006.05.007","article-title":"Apical-basal polarity, Wnt signaling and vertebrate organogenesis","volume":"17","author":"Karner","year":"2006","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2019.09.005_bib18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.celrep.2013.10.003","article-title":"Local functional overconnectivity in posterior brain regions is associated with symptom severity in autism spectrum disorders","volume":"5","author":"Keown","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2019.09.005_bib19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1101\/gad.1178004","article-title":"Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice","volume":"18","author":"Klezovitch","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2019.09.005_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000134167","article-title":"The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2","volume":"72","author":"Koyama","year":"1996","journal-title":"Cytogenet. Cell Res."},{"key":"10.1016\/j.isci.2019.09.005_bib21","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/ajmg.c.30275","article-title":"Autism spectrum features in Smith-Magenis syndrome","volume":"154","author":"Laje","year":"2010","journal-title":"Am. J. Med. Genet. C\u00a0Semin. Med. Genet."},{"key":"10.1016\/j.isci.2019.09.005_bib22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nrm1332","article-title":"Parsing the polarity code","volume":"5","author":"Macara","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2019.09.005_bib23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10803-006-0093-2","article-title":"Adaptive and maladaptive behavior in children with smith-magenis syndrome","volume":"36","author":"Martin","year":"2006","journal-title":"J.\u00a0Autism. Dev. Disord."},{"key":"10.1016\/j.isci.2019.09.005_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.pa.29.040189.002053","article-title":"The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system","volume":"29","author":"Monaghan","year":"1989","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.isci.2019.09.005_bib25","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature09965","article-title":"Shank3 mutant mice display autistic like behaviours and striatal dysfunction","volume":"472","author":"Pe\u00e7a","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.isci.2019.09.005_bib26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/01.GIM.0000095625.14160.AB","article-title":"Variability in clinical phenotype despite commonchromosomal deletion in Smith-Magenis syndrome[del(17)(p11.2p11.2)]","volume":"5","author":"Potocki","year":"2003","journal-title":"Genet. Med."},{"key":"10.1016\/j.isci.2019.09.005_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/(SICI)1096-8628(19980328)81:2<179::AID-AJMG10>3.0.CO;2-E","article-title":"Behavioral phenotype of Smith-Magenis syndrome (del 17p11.2)","volume":"81","author":"Smith","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.isci.2019.09.005_bib28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ajmg.1320240303","article-title":"Interstitial deletion of (17)(p11.2p11.2) in nine patients","volume":"24","author":"Smith","year":"1986","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.isci.2019.09.005_bib29","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.celrep.2013.10.001","article-title":"Brain hyperconnectivity in children with autism and its links to social deficits","volume":"5","author":"Supekar","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2019.09.005_bib30","doi-asserted-by":"crossref","first-page":"E610","DOI":"10.1073\/pnas.1612062114","article-title":"Evidence for opposing roles of Celsr3 and Vangl2 in glutamatergic synapse formation","volume":"114","author":"Thakar","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2019.09.005_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S1096-7192(03)00048-9","article-title":"Refinement of the Smith\u2013Magenis syndrome critical region to 950 kb and assessment of 17p11.2 deletions. Are all deletions created equally?","volume":"79","author":"Vlangos","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.isci.2019.09.005_bib32","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.neuroscience.2007.07.065","article-title":"Changes in hippocampal synapses and learning-memory abilities in age-increasing rats and effects of tetrahydroxystilbene glucoside in aged rats","volume":"149","author":"Wang","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2019.09.005_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pa.21.040181.001121","article-title":"Excitatory amino acid transmitters","volume":"21","author":"Watkins","year":"1981","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.isci.2019.09.005_bib34","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1242\/jcs.02938","article-title":"Lgl mediates apical domain disassembly by suppressing the\u00a0PAR-3-aPKC-PAR-6 complex to orient apical\u00a0membrane polarity","volume":"119","author":"Yamanaka","year":"2006","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.isci.2019.09.005_bib35","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0960-9822(03)00244-6","article-title":"Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity","volume":"13","author":"Yamanaka","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2019.09.005_bib36","article-title":"Automated three-chambered social approach\u00a0task for mice","volume":"8","author":"Yang","year":"2011","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.isci.2019.09.005_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.devcel.2004.10.020","article-title":"Fragile X protein functions with lgl and the par complex in flies and mice","volume":"8","author":"Zarnescu","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2019.09.005_bib38","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn.2016.18","article-title":"Mechanistic basis of MAGUK-organized complexes in synaptic development and signaling","volume":"17","author":"Zhu","year":"2016","journal-title":"Nat. Rev. Neurosci."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004219303426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004219303426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:02:39Z","timestamp":1762876959000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004219303426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":38,"alternative-id":["S2589004219303426"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2019.09.005","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2019.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}