{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:27:02Z","timestamp":1781058422109,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21022037"],"award-info":[{"award-number":["21022037"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["23406009"],"award-info":[{"award-number":["23406009"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["26305013"],"award-info":[{"award-number":["26305013"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.isci.2020.101544","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T11:44:52Z","timestamp":1599565492000},"page":"101544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice"],"prefix":"10.1016","volume":"23","author":[{"given":"Risa","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeko","family":"Moriyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmina","family":"Deloer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masachika","family":"Senba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihoko","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-3038","authenticated-orcid":false,"given":"Shigeo","family":"Koyasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyo","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinjiro","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2020.101544_bib1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/s41590-019-0423-0","article-title":"c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies","volume":"20","author":"Bernink","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2020.101544_bib2","doi-asserted-by":"crossref","first-page":"e1004607","DOI":"10.1371\/journal.ppat.1004607","article-title":"IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T\u00a0cells","volume":"11","author":"Besnard","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2020.101544_bib3","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1086\/314781","article-title":"Serum from Entamoeba histolytica-infected gerbils selectively suppresses T\u00a0cell proliferation by inhibiting interleukin-2 production","volume":"179","author":"Campbell","year":"1999","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.isci.2020.101544_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-3024.2009.01120.x","article-title":"Gonadectomy inhibits development of experimental amoebic liver abscess in hamsters through downregulation of the inflammatory immune response","volume":"31","author":"Cervantes-Rebolledo","year":"2009","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.isci.2020.101544_bib5","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1084\/jem.176.6.1605","article-title":"A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica","volume":"176","author":"Cieslak","year":"1992","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2020.101544_bib6","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1128\/iai.57.6.1750-1756.1989","article-title":"Cytokine activation of murine macrophages for in\u00a0vitro killing of Entamoeba histolytica trophozoites","volume":"57","author":"Denis","year":"1989","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2020.101544_bib7","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jlb.46.3.270","article-title":"Human neutrophils activated by interferon-gamma and tumour necrosis factor-alpha kill Entamoeba histolytica trophozoites in\u00a0vitro","volume":"46","author":"Denis","year":"1989","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.isci.2020.101544_bib8","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1645\/GE-1223.1","article-title":"IL-6 KO mice develop experimental amoebic liver infection with eosinophilia","volume":"93","author":"Estrada-Villasenor","year":"2007","journal-title":"J.\u00a0Parasitol."},{"key":"10.1016\/j.isci.2020.101544_bib9","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1126\/science.aac9593","article-title":"Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs","volume":"350","author":"Gasteiger","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.isci.2020.101544_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0171-2985(11)80498-5","article-title":"In\u00a0vitro effect of recombinant interferon gamma in combination with LPS on amoebicidal activity of murine Kupffer cells","volume":"188","author":"Ghadirian","year":"1993","journal-title":"Immunobiology"},{"key":"10.1016\/j.isci.2020.101544_bib11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.aohep.2018.12.001","article-title":"Group 2 innate lymphoid cells exhibit progressively higher levels of activation during worsening of liver fibrosis","volume":"18","author":"Gonzalez-Polo","year":"2019","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.isci.2020.101544_bib12","doi-asserted-by":"crossref","first-page":"e0006216","DOI":"10.1371\/journal.pntd.0006216","article-title":"Characteristics of inflammatory reactions during development of liver abscess in hamsters inoculated with Entamoeba nuttalli","volume":"12","author":"Guan","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.isci.2020.101544_bib13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2011.12.020","article-title":"Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation","volume":"36","author":"Halim","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2020.101544_bib14","series-title":"Amebiasis. Feigin and Cherrys's Textbook of Pediatric Infectious Diseases","author":"Hamano","year":"2013"},{"key":"10.1016\/j.isci.2020.101544_bib15","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1056\/NEJMra022710","article-title":"Amebiasis","volume":"348","author":"Haque","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2020.101544_bib16","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/eji.201848006","article-title":"Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells","volume":"49","author":"Hochdorfer","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2020.101544_bib17","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.4049\/jimmunol.169.8.4496","article-title":"The mouse model of amebic colitis reveals mouse strain susceptibility to infection and exacerbation of disease by CD4+ T\u00a0cells","volume":"169","author":"Houpt","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2020.101544_bib18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2020.101544_bib19","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1073\/pnas.1115884109","article-title":"IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G","volume":"109","author":"Lefrancais","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2020.101544_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1128\/IAI.74.1.118-124.2006","article-title":"Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease","volume":"74","author":"Lotter","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2020.101544_bib21","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/mi.2016.20","article-title":"IL-27 suppresses type 2 immune responses in\u00a0vivo via direct effects on group 2 innate lymphoid cells","volume":"9","author":"Mchedlidze","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.isci.2020.101544_bib22","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ni.3309","article-title":"Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses","volume":"17","author":"Moro","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2020.101544_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.isci.2020.101544_bib24","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2014.04.013","article-title":"Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation","volume":"40","author":"Motomura","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2020.101544_bib25","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2020.101544_bib26","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.isci.2020.101544_bib27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nature12526","article-title":"Type 2 innate lymphoid cells control eosinophil homeostasis","volume":"502","author":"Nussbaum","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.isci.2020.101544_bib28","doi-asserted-by":"crossref","first-page":"e1006345","DOI":"10.1371\/journal.ppat.1006345","article-title":"IL-33\/ST2 pathway drives regulatory T\u00a0cell dependent suppression of liver damage upon cytomegalovirus infection","volume":"13","author":"Popovic","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2020.101544_bib29","series-title":"Abscess, Amebic Liver","author":"Prakash","year":"2017"},{"key":"10.1016\/j.isci.2020.101544_bib30","series-title":"Amebiasis","first-page":"594","article-title":"Human infection by Entamoeba histolytica","author":"Ravdin","year":"1988"},{"key":"10.1016\/j.isci.2020.101544_bib31","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1128\/IAI.74.3.1471-1479.2006","article-title":"Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity","volume":"74","author":"Reiman","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2020.101544_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4269\/ajtmh.1987.37.72","article-title":"The role of gamma interferon in the generation of human macrophages cytotoxic for Entamoeba histolytica trophozoites","volume":"37","author":"Salata","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.isci.2020.101544_bib33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/IAI.68.1.400-402.2000","article-title":"Innate immunity to amebic liver abscess is dependent on gamma interferon and nitric oxide in a murine model of disease","volume":"68","author":"Seydel","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2020.101544_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00011-018-1197-9","article-title":"CD8(+) T\u00a0cell\/IL-33\/ILC2 axis exacerbates the liver injury in Con A-induced hepatitis in T\u00a0cell-transferred Rag2-deficient mice","volume":"68","author":"Zhang","year":"2019","journal-title":"Inflamm. Res."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004220307367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004220307367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:18:43Z","timestamp":1762877923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004220307367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S2589004220307367"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2020.101544","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2020.101544","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"101544"}}