{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:43:35Z","timestamp":1788817415660,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.isci.2020.101728","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T19:20:23Z","timestamp":1603567223000},"page":"101728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics"],"prefix":"10.1016","volume":"23","author":[{"given":"Rengasamy","family":"Palanivel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinesh","family":"Vinayachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Biswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Deiuliis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongsoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-5952","authenticated-orcid":false,"given":"Roopesh Singh","family":"Gangwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-5580","authenticated-orcid":false,"given":"Jared C.","family":"Durieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Ann","family":"Ebreo Cara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lopa","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-7436","authenticated-orcid":false,"given":"Graham","family":"Bevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi A.","family":"Fayad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Tawakol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh K.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Rajagopalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2020.101728_bib1","doi-asserted-by":"crossref","first-page":"e1001840","DOI":"10.1371\/journal.pbio.1001840","article-title":"Machine learning helps identify CHRONO as a circadian clock component","volume":"12","author":"Anafi","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.isci.2020.101728_bib2","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2020.101728_bib3","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1074\/jbc.M113.534651","article-title":"Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression","volume":"289","author":"Annayev","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2020.101728_bib4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cmet.2011.01.006","article-title":"Crosstalk between components of circadian and metabolic cycles in mammals","volume":"13","author":"Asher","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2020.101728_bib5","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/07420528.2014.986682","article-title":"Dim light at night increases body mass of female mice","volume":"32","author":"Aubrecht","year":"2015","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.isci.2020.101728_bib6","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.aah4965","article-title":"Circadian time signatures of fitness and disease","volume":"354","author":"Bass","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.isci.2020.101728_bib7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-physiol-021115-105102","article-title":"Endocrine effects of circadian disruption","volume":"78","author":"Bedrosian","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.isci.2020.101728_bib8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4161\/epi.27584","article-title":"Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis","volume":"9","author":"Bind","year":"2014","journal-title":"Epigenetics"},{"key":"10.1016\/j.isci.2020.101728_bib9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1126\/science.1141194","article-title":"SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins","volume":"316","author":"Busino","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.isci.2020.101728_bib10","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.envint.2016.06.026","article-title":"DNA hypomethylation and its mediation in the effects of fine particulate air pollution on cardiovascular biomarkers: a randomized crossover trial","volume":"94","author":"Chen","year":"2016","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2020.101728_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11048","article-title":"Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta","volume":"485","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.isci.2020.101728_bib12","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nmeth.4396","article-title":"An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues","volume":"14","author":"Corces","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2020.101728_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41569-019-0167-4","article-title":"Circadian rhythms and the molecular clock in cardiovascular biology and disease","volume":"16","author":"Crnko","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.isci.2020.101728_bib14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.cmet.2018.09.015","article-title":"AMPK regulates the epigenome through phosphorylation of TET2","volume":"28","author":"Fiedler","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2020.101728_bib15","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1017\/S0029665116000288","article-title":"Circadian regulation of lipid metabolism","volume":"75","author":"Gooley","year":"2016","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.isci.2020.101728_bib16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/07853890.2016.1276301","article-title":"CHRONO integrates behavioral stress and epigenetic control of metabolism","volume":"49","author":"Hatanaka","year":"2017","journal-title":"Ann. Med."},{"key":"10.1016\/j.isci.2020.101728_bib17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1248\/bpb.30.621","article-title":"Characterization of the molecular clock in mouse peritoneal macrophages","volume":"30","author":"Hayashi","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.isci.2020.101728_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10528-019-09938-w","article-title":"Disruption of the molecular circadian clock and cancer: an epigenetic link","volume":"58","author":"Hernandez-Rosas","year":"2020","journal-title":"Biochem. Genet."},{"key":"10.1016\/j.isci.2020.101728_bib19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.1226339","article-title":"Transcriptional architecture and chromatin landscape of the core circadian clock in mammals","volume":"338","author":"Koike","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.isci.2020.101728_bib20","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cmet.2017.03.019","article-title":"Clock regulation of metabolites reveals coupling between transcription and metabolism","volume":"25","author":"Krishnaiah","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2020.101728_bib21","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/s41467-019-09671-3","article-title":"Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight","volume":"10","author":"Kupers","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2020.101728_bib22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(17)32345-0","article-title":"The Lancet Commission on pollution and health","volume":"391","author":"Landrigan","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2020.101728_bib23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.envint.2018.07.041","article-title":"Short-term exposure to fine particulate air pollution and genome-wide DNA methylation: a randomized, double-blind, crossover trial","volume":"120","author":"Li","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.isci.2020.101728_bib24","doi-asserted-by":"crossref","first-page":"114179","DOI":"10.1016\/j.envpol.2020.114179","article-title":"Ambient fine particulate matter disrupts hepatic circadian oscillation and lipid metabolism in a mouse model","volume":"262","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.isci.2020.101728_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12940-015-0052-5","article-title":"Characterization of genome-wide H3K27ac profiles reveals a distinct PM2.5-associated histone modification signature","volume":"14","author":"Liu","year":"2015","journal-title":"Environ. Health"},{"key":"10.1016\/j.isci.2020.101728_bib26","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1038\/s41467-019-10487-4","article-title":"An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2020.101728_bib27","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1038\/s41467-019-12103-x","article-title":"Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation","volume":"10","author":"Lombardi","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2020.101728_bib28","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2337\/db18-1193","article-title":"A peripheral blood DNA methylation signature of hepatic fat reveals a potential causal pathway for Nonalcoholic fatty liver disease","volume":"68","author":"Ma","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2020.101728_bib29","first-page":"557","article-title":"Environmental stressors and cardio-metabolic disease: part II-mechanistic insights","volume":"38","author":"Munzel","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2020.101728_bib30","first-page":"550","article-title":"Environmental stressors and cardio-metabolic disease: part I-epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies","volume":"38","author":"Munzel","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2020.101728_bib31","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0029665118000198","article-title":"Dark matters: effects of light at night on metabolism","volume":"77","author":"Nelson","year":"2018","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/j.isci.2020.101728_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fendo.2017.00136","article-title":"Desynchronization of circadian clocks in cancer: a metabolic and epigenetic connection","volume":"8","author":"Padmanabhan","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.isci.2020.101728_bib33","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","article-title":"Molecular architecture of the mammalian circadian clock","volume":"24","author":"Partch","year":"2014","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.isci.2020.101728_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnut.2020.00039","article-title":"Feeding rhythms and the circadian regulation of metabolism","volume":"7","author":"Pickel","year":"2020","journal-title":"Front. Nutr."},{"key":"10.1016\/j.isci.2020.101728_bib35","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2018.07.099","article-title":"Air pollution and cardiovascular disease: JACC state-of-the-art review","volume":"72","author":"Rajagopalan","year":"2018","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2020.101728_bib36","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1172\/JCI137315","article-title":"Metabolic effects of air pollution exposure and reversibility","volume":"130","author":"Rajagopalan","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2020.101728_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13148-019-0713-2","article-title":"Air pollution and DNA methylation: effects of exposure in humans","volume":"11","author":"Rider","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.isci.2020.101728_bib38","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.physbeh.2017.08.029","article-title":"Light at night as an environmental endocrine disruptor","volume":"190","author":"Russart","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.isci.2020.101728_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1101\/gad.324046.119","article-title":"Help from my friends-cooperation of BMAL1 with noncircadian transcription factors","volume":"33","author":"Shostak","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2020.101728_bib40","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.cell.2007.04.030","article-title":"Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression","volume":"129","author":"Siepka","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.isci.2020.101728_bib41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41574-018-0122-1","article-title":"Circadian clocks and insulin resistance","volume":"15","author":"Stenvers","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.isci.2020.101728_bib45","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/CIRCULATIONAHA.108.799015","article-title":"Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity","volume":"119","author":"Sun","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2020.101728_bib42","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature11232","article-title":"The accessible chromatin landscape of the human genome","volume":"489","author":"Thurman","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.isci.2020.101728_bib43","doi-asserted-by":"crossref","first-page":"126392","DOI":"10.1016\/j.chemosphere.2020.126392","article-title":"Ambient fine particulate matter exposure perturbed circadian rhythm and oscillations of lipid metabolism in adipose tissues","volume":"251","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.isci.2020.101728_bib44","doi-asserted-by":"crossref","first-page":"e0118101","DOI":"10.1371\/journal.pone.0118101","article-title":"Daily variation in global and local DNA methylation in mouse livers","volume":"10","author":"Xia","year":"2015","journal-title":"PLoS One"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004220309251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004220309251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:21:53Z","timestamp":1762878113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004220309251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S2589004220309251"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2020.101728","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2020.101728","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"101728"}}