{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T06:04:51Z","timestamp":1774937091037,"version":"3.50.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["20337"],"award-info":[{"award-number":["20337"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017089","name":"Board of Visitors","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["U54HD090257"],"award-info":[{"award-number":["U54HD090257"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007857","name":"Intellectual and Developmental Disabilities Research Center","doi-asserted-by":"publisher","award":["UL1TR001876"],"award-info":[{"award-number":["UL1TR001876"]}],"id":[{"id":"10.13039\/100007857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.isci.2020.101766","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T22:33:44Z","timestamp":1604442824000},"page":"101766","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Epidermal Growth Factor Receptor Inhibition Reverses Cellular and Transcriptomic Alterations Induced by Hypoxia in the Neonatal Piglet Brain"],"prefix":"10.1016","volume":"23","author":[{"given":"Panagiotis","family":"Kratimenos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-7405","authenticated-orcid":false,"given":"Evan Z.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8396-9022","authenticated-orcid":false,"given":"Ioannis","family":"Koutroulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Knoblach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Jablonska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-0213","authenticated-orcid":false,"given":"Shadi N.","family":"Malaeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surajit","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Isabel","family":"Almira-Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Delivoria-Papadopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2020.101766_bib3","first-page":"5280","article-title":"Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells","volume":"54","author":"Armstrong","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2020.101766_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00401-017-1718-6","article-title":"White matter injury in the preterm infant: pathology and mechanisms","volume":"134","author":"Back","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.isci.2020.101766_bib5","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1523\/JNEUROSCI.1039-08.2008","article-title":"Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol","volume":"28","author":"Bertran-Gonzalez","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2020.101766_bib6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.brainres.2006.04.119","article-title":"Hypoxic\/Ischemic models in newborn piglet: comparison of constant FiO2 versus variable FiO2 delivery","volume":"1100","author":"Bjorkman","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2020.101766_bib7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/00004647-199908000-00012","article-title":"Effects of the AMPA receptor antagonist NBQX on outcome of newborn pigs after asphyxic cardiac arrest","volume":"19","author":"Brambrink","year":"1999","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.isci.2020.101766_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000120571","article-title":"Quantitation of medullary astrogliosis in sudden infant death syndrome","volume":"17","author":"Bruce","year":"1991","journal-title":"Pediatr. Neurosurg."},{"key":"10.1016\/j.isci.2020.101766_bib9","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1038\/ncomms6811","article-title":"Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks","volume":"5","author":"Chakraborty","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2020.101766_bib10","doi-asserted-by":"crossref","first-page":"17184","DOI":"10.1073\/pnas.0508732102","article-title":"Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2020.101766_bib11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yexcr.2016.07.004","article-title":"NF-kappaB-dependent transcriptional upregulation of cyclin D1 exerts cytoprotection against hypoxic injury upon EGFR activation","volume":"347","author":"Chen","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2020.101766_bib12","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1128\/MCB.17.9.5328","article-title":"Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis","volume":"17","author":"Chin","year":"1997","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2020.101766_bib13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nn1258","article-title":"Neuregulin 1-erbB signaling and the molecular\/cellular basis of schizophrenia","volume":"7","author":"Corfas","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2020.101766_bib14","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1523\/JNEUROSCI.16-08-02649.1996","article-title":"In\u00a0vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain","volume":"16","author":"Craig","year":"1996","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2020.101766_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000327242","article-title":"Strain-specific differences in perinatal rodent oligodendrocyte lineage progression and its correlation with human","volume":"33","author":"Dean","year":"2011","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.isci.2020.101766_bib17","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1053\/j.semperi.2008.07.002","article-title":"Nuclear mechanisms of hypoxic cerebral injury in the newborn: the role of caspases","volume":"32","author":"Delivoria-Papadopoulos","year":"2008","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.isci.2020.101766_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.neulet.2011.01.017","article-title":"Brain tissue energy dependence of CaM kinase IV cascade activation during hypoxia in the cerebral cortex of newborn piglets","volume":"491","author":"Delivoria-Papadopoulos","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"Suppl 1","key":"10.1016\/j.isci.2020.101766_bib20","first-page":"24","article-title":"Effect of concurrent administration of apoptotic inhibitors and hypothermia on post hypoxic cerebral injury in the newborn","volume":"17","author":"Delivoria-Papadopoulou","year":"2014","journal-title":"Hell J. Nucl. Med."},{"key":"10.1016\/j.isci.2020.101766_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2020.06.078","article-title":"Plasma and CSF candidate biomarkers of neonatal encephalopathy severity and neurodevelopmental outcomes","author":"Dietrick","year":"2020","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.isci.2020.101766_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000243527","article-title":"Effect of graded hypoxia on brain cell membrane injury in newborn piglets","volume":"61","author":"Digiacomo","year":"1992","journal-title":"Biol. Neonate"},{"key":"10.1016\/j.isci.2020.101766_bib25","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000458438","article-title":"Dexmedetomidine combined with therapeutic hypothermia is associated with cardiovascular instability and neurotoxicity in a piglet model of perinatal asphyxia","volume":"39","author":"Ezzati","year":"2017","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.isci.2020.101766_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/1545968315586465","article-title":"Brain-derived neurotrophic factor (BDNF) in traumatic brain injury-related mortality: interrelationships between genetics and acute systemic and central nervous system BDNF profiles","volume":"30","author":"Failla","year":"2016","journal-title":"Neurorehabil. Neural. Repair"},{"key":"10.1016\/j.isci.2020.101766_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(99)00012-X","article-title":"Stereotaxic atlas of the pig brain","volume":"49","author":"Felix","year":"1999","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.isci.2020.101766_bib28","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMra041996","article-title":"Neonatal brain injury","volume":"351","author":"Ferriero","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2020.101766_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.vascn.2010.05.007","article-title":"The minipig as a platform for new technologies in toxicology","volume":"62","author":"Forster","year":"2010","journal-title":"J.\u00a0Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.isci.2020.101766_bib30","doi-asserted-by":"crossref","first-page":"13092","DOI":"10.1073\/pnas.0702387104","article-title":"Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer","volume":"104","author":"Franovic","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2020.101766_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1203\/00006450-199906000-00008","article-title":"Effects of hypoxia-ischemia and inhibition of nitric oxide synthase on cerebral energy metabolism in newborn piglets","volume":"45","author":"Groenendaal","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.isci.2020.101766_bib33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0169-328X(02)00285-1","article-title":"Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia","volume":"104","author":"Guerguerian","year":"2002","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.isci.2020.101766_bib34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1203\/00006450-199704000-00009","article-title":"Posthypoxic hypothermia in newborn piglets","volume":"41","author":"Haaland","year":"1997","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.isci.2020.101766_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0014-5793(01)02166-4","article-title":"Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling","volume":"491","author":"Hognason","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2020.101766_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jneumeth.2014.04.005","article-title":"Validation of a neuropathology score using quantitative methods to evaluate brain injury in a pig model of hypoxia ischaemia","volume":"230","author":"Hoque","year":"2014","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.isci.2020.101766_bib37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3171\/ped.2006.104.2.9","article-title":"A new model of focal cerebral ischemia in the miniature pig","volume":"104","author":"Imai","year":"2006","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.isci.2020.101766_bib38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/CIRCULATIONAHA.111.048215","article-title":"White matter protection in congenital heart surgery","volume":"125","author":"Ishibashi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2020.101766_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yexcr.2017.04.016","article-title":"EGFR-mediated apoptosis via STAT3","volume":"356","author":"Jackson","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2020.101766_bib40","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.3390\/ijms18112356","article-title":"Effect of intranasally delivered rh-VEGF165 on angiogenesis following cerebral hypoxia-ischemia in the cerebral cortex of newborn piglets","volume":"18","author":"Jain","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2020.101766_bib42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.1115462","article-title":"EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans","volume":"310","author":"Koprivica","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.isci.2020.101766_bib43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-3940(97)00937-3","article-title":"Brain derived neurotrophic factor is increased in cerebrospinal fluid of children suffering from asphyxia","volume":"240","author":"Korhonen","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2020.101766_bib44","first-page":"1395","article-title":"Multi-targeted molecular therapeutic approach in aggressive neuroblastoma: the effect of Focal Adhesion Kinase-Src-Paxillin system","volume":"18","author":"Kratimenos","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.isci.2020.101766_bib45","doi-asserted-by":"crossref","first-page":"16664","DOI":"10.1038\/s41598-017-16983-1","article-title":"Effect of Src kinase inhibition on cytochrome c, smac\/DIABLO and apoptosis inducing factor (AIF) following cerebral hypoxia-ischemia in newborn piglets","volume":"7","author":"Kratimenos","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2020.101766_bib46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000480067","article-title":"Effect of concurrent Src kinase inhibition with short-duration hypothermia on Ca2+\/calmodulin kinase IV activity and neuropathology after hypoxia-ischemia in the newborn swine brain","volume":"113","author":"Kratimenos","year":"2017","journal-title":"Neonatology"},{"key":"10.1016\/j.isci.2020.101766_bib47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/08880018.2017.1360969","article-title":"FAK-Src-paxillin system expression and disease outcome in human neuroblastoma","volume":"34","author":"Kratimenos","year":"2017","journal-title":"Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.isci.2020.101766_bib48","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.1523\/JNEUROSCI.17-15-05820.1997","article-title":"Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain","volume":"17","author":"Kuhn","year":"1997","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2020.101766_bib49","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.earlhumdev.2010.05.010","article-title":"Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy","volume":"86","author":"Kurinczuk","year":"2010","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.isci.2020.101766_bib51","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0140-6736(05)71048-5","article-title":"4 million neonatal deaths: when? Where? Why?","volume":"365","author":"Lawn","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2020.101766_bib53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12013-012-9478-3","article-title":"Dynamic changes of cerebral-specific proteins in full-term newborns with hypoxic\u2013ischemic encephalopathy","volume":"66","author":"Liu","year":"2013","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.isci.2020.101766_bib56","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/(SICI)1096-9861(19970113)377:2<262::AID-CNE8>3.0.CO;2-1","article-title":"Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia","volume":"377","author":"Martin","year":"1997","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.isci.2020.101766_bib57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ana.410420310","article-title":"Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum","volume":"42","author":"Martin","year":"1997","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.isci.2020.101766_bib58","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neulet.2007.11.043","article-title":"Effect of hypoxia on protein tyrosine phosphatase activity and expression of protein tyrosine phosphatases PTP-1B, PTP-SH1 and PTP-SH2 in the cerebral cortex of Guinea pig fetus","volume":"432","author":"Maulik","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2020.101766_bib59","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bbr.2018.06.023","article-title":"Increased expression of BDNF mRNA in the frontal cortex of autistic patients","volume":"359","author":"Maussion","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.isci.2020.101766_bib60","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-3940(94)90574-6","article-title":"Increased apoptosis in the cingulate sulcus of newborn piglets following transient hypoxia-ischaemia is related to the degree of high energy phosphate depletion during the insult","volume":"181","author":"Mehmet","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2020.101766_bib61","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/sj.cdd.4400353","article-title":"Relation of impaired energy metabolism to apoptosis and necrosis following transient cerebral hypoxia-ischaemia","volume":"5","author":"Mehmet","year":"1998","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2020.101766_bib62","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neulet.2009.05.041","article-title":"NO-mediated activation of Src kinase during hypoxia in the cerebral cortex of newborn piglets","volume":"460","author":"Mishra","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2020.101766_bib63","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s11064-010-0208-1","article-title":"Hypoxia-induced activation of epidermal growth factor receptor (EGFR) kinase in the cerebral cortex of newborn piglets: the role of nitric oxide","volume":"35","author":"Mishra","year":"2010","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.isci.2020.101766_bib64","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fnmol.2017.00044","article-title":"Cerebrospinal fluid cortisol mediates brain-derived neurotrophic factor relationships to mortality after severe TBI: a prospective cohort study","volume":"10","author":"Munoz","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.isci.2020.101766_bib66","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1651-2227.1989.tb11276.x","article-title":"Cerebral blood flow during experimental hypoxaemia and ischaemia in the newborn piglet","volume":"360","author":"Odden","year":"1989","journal-title":"Acta Paediatr. Scand. Suppl."},{"key":"10.1016\/j.isci.2020.101766_bib67","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1017\/S1092852914000108","article-title":"Aggression, DRD1 polymorphism, and lesion location in penetrating traumatic brain injury","volume":"19","author":"Pardini","year":"2014","journal-title":"CNS Spectr."},{"key":"10.1016\/j.isci.2020.101766_bib69","doi-asserted-by":"crossref","first-page":"e62342","DOI":"10.1371\/journal.pone.0062342","article-title":"EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS","volume":"8","author":"Le Pichon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2020.101766_bib70","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.bcp.2005.12.009","article-title":"Epidermal growth factor receptor inhibitor (PD168393) potentiates cytotoxic effects of paclitaxel against androgen-independent prostate cancer cells","volume":"71","author":"Pu","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2020.101766_bib71","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2020.101766_bib72","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature12880","article-title":"Intranasal epidermal growth factor treatment rescues neonatal brain injury","volume":"506","author":"Scafidi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2020.101766_bib74","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuroscience.2011.10.004","article-title":"Expression and function of dopamine receptors in the developing medial frontal cortex and striatum of the rat","volume":"199","author":"Sillivan","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2020.101766_bib75","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0968-0004(99)01383-3","article-title":"The Ca-calmodulin-dependent protein kinase cascade","volume":"24","author":"Soderling","year":"1999","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2020.101766_bib76","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neuroscience.2015.07.021","article-title":"EGFR signaling upregulates surface expression of the GluN2B-containing NMDA receptor and contributes to long-term potentiation in the hippocampus","volume":"304","author":"Tang","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2020.101766_bib77","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1203\/00006450-199611000-00014","article-title":"A piglet survival model of posthypoxic encephalopathy","volume":"40","author":"Thoresen","year":"1996","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.isci.2020.101766_bib78","doi-asserted-by":"crossref","first-page":"e0155230","DOI":"10.1371\/journal.pone.0155230","article-title":"EGFR activation leads to cell death independent of PI3K\/AKT\/mTOR in an AD293 cell line","volume":"11","author":"Treda","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2020.101766_bib79","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.neulet.2008.05.095","article-title":"Mechanism of Ca2+-influx and Ca2+\/calmodulin-dependent protein kinase IV activity during in utero hypoxia in cerebral cortical neuronal nuclei of the Guinea pig fetus at term","volume":"440","author":"Vibert","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2020.101766_bib80","doi-asserted-by":"crossref","first-page":"a008987","DOI":"10.1101\/cshperspect.a008987","article-title":"Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling","volume":"5","author":"Wagner","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.isci.2020.101766_bib83","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.5213\/inj.1938190.095","article-title":"Neuregulin-1 protects neuronal cells against damage due to CoCl2-induced hypoxia by suppressing hypoxia-inducible factor-1alpha and P53 in SH-SY5Y cells","volume":"23","author":"Yoo","year":"2019","journal-title":"Int. Neurourol J."},{"key":"10.1016\/j.isci.2020.101766_bib84","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1002\/hbm.23181","article-title":"Effect of rs1063843 in the CAMKK2 gene on the dorsolateral prefrontal cortex","volume":"37","author":"Yu","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.isci.2020.101766_bib85","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1365-2990.1997.tb01181.x","article-title":"Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischaemia","volume":"23","author":"Yue","year":"1997","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.isci.2020.101766_bib86","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10048-016-0500-6","article-title":"DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury","volume":"18","author":"Yue","year":"2017","journal-title":"Neurogenetics"},{"key":"10.1016\/j.isci.2020.101766_bib87","doi-asserted-by":"crossref","first-page":"10726","DOI":"10.1073\/pnas.1320290111","article-title":"The transcription factor Fezf2 directs the differentiation of neural stem cells in the subventricular zone toward a cortical phenotype","volume":"111","author":"Zuccotti","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004220309639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004220309639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:20:25Z","timestamp":1762878025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004220309639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S2589004220309639"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2020.101766","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidermal Growth Factor Receptor Inhibition Reverses Cellular and Transcriptomic Alterations Induced by Hypoxia in the Neonatal Piglet Brain","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2020.101766","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"101766"}}