{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:20:28Z","timestamp":1794363628136,"version":"4.9.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H05041"],"award-info":[{"award-number":["18H05041"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP 18K15068"],"award-info":[{"award-number":["JP 18K15068"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K07388"],"award-info":[{"award-number":["19K07388"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.isci.2021.102836","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T11:05:21Z","timestamp":1627556721000},"page":"102836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance"],"prefix":"10.1016","volume":"24","author":[{"given":"Jun","family":"Takai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaho","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Douglas","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Moriguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2021.102836_bib1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijmm.2005.12.015","article-title":"Infectious diseases \u2013 a global challenge","volume":"296","author":"Becker","year":"2006","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.isci.2021.102836_bib2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1084\/jem.20101459","article-title":"The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency","volume":"208","author":"Bigley","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2021.102836_bib3","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1182\/bloodadvances.2020002953","article-title":"Human GATA2 mutations and hematologic disease: how many paths to pathogenesis?","volume":"4","author":"Bresnick","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.isci.2021.102836_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00225","article-title":"Revisiting mouse peritoneal macrophages: heterogeneity, development, and function","volume":"6","author":"Cassado","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s40496-014-0016-9","article-title":"Cytokine networks regulating inflammation and immune defense in the oral cavity","volume":"1","author":"Cavalla","year":"2014","journal-title":"Curr. Oral Health Rep."},{"key":"10.1016\/j.isci.2021.102836_bib6","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1210\/me.2005-0378","article-title":"Pituitary-specific Gata2 knockout: effects on gonadotrope and thyrotrope function","volume":"20","author":"Charles","year":"2006","journal-title":"Mol. Endocrinol. (Baltimore, Md.)"},{"key":"10.1016\/j.isci.2021.102836_bib7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"10.1016\/j.isci.2021.102836_bib8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/bjh.13317","article-title":"Haematopoietic and immune defects associated with GATA2 mutation","volume":"169","author":"Collin","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.isci.2021.102836_bib9","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1182\/blood-2011-06-360313","article-title":"Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency","volume":"118","author":"Dickinson","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib10","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3324\/haematol.2017.181909","article-title":"Natural history of GATA2 deficiency in a survey of 79 French and Belgian patients","volume":"103","author":"Donadieu","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.isci.2021.102836_bib11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2009.11.001","article-title":"Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy","volume":"36","author":"Fujiwara","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2021.102836_bib12","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1038\/s41598-017-04121-w","article-title":"Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in\u00a0vivo","volume":"7","author":"Genster","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2021.102836_bib13","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/ng.913","article-title":"Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia","volume":"43","author":"Hahn","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2021.102836_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1046\/j.1365-2443.1998.00166.x","article-title":"Differential roles of GATA-1 and GATA-2 in growth and differentiation of mast cells","volume":"3","author":"Harigae","year":"1998","journal-title":"Genes Cells"},{"key":"10.1016\/j.isci.2021.102836_bib15","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1128\/MCB.00506-15","article-title":"Whole-body in\u00a0vivo monitoring of inflammatory diseases exploiting human interleukin 6-luciferase transgenic mice","volume":"35","author":"Hayashi","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.102836_bib16","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.bbmt.2020.02.015","article-title":"Comparison of outcomes of myeloablative allogeneic stem cell transplantation for pediatric patients with bone marrow failure, myelodysplastic syndrome and acute myeloid leukemia with and without germline GATA2 mutations","volume":"26","author":"Hofmann","year":"2020","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.isci.2021.102836_bib17","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1182\/blood-2012-08-452763","article-title":"GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome","volume":"121","author":"Hsu","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib18","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1182\/blood-2011-05-356352","article-title":"Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome","volume":"118","author":"Hsu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib19","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1128\/CMR.00119-16","article-title":"Impact of childhood malnutrition on host defense and infection","volume":"30","author":"Ibrahim","year":"2017","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.isci.2021.102836_bib20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","article-title":"Differential roles of interleukin-17a and -17F in host defense against mucoepithelial bacterial infection and allergic responses","volume":"30","author":"Ishigame","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2021.102836_bib21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFN\u03b3: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib22","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.immuni.2011.02.012","article-title":"Functional specialization of interleukin-17 family members","volume":"34","author":"Iwakura","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2021.102836_bib23","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1172\/JCI61623","article-title":"Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity","volume":"122","author":"Johnson","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2021.102836_bib24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ajpath.2015.06.024","article-title":"The role of mast cells in bacterial infection","volume":"186","author":"Johnzon","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2021.102836_bib25","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3389\/fimmu.2020.01065","article-title":"Primary immunodeficiencies with defects in innate immunity: focus on orofacial manifestations","volume":"11","author":"Jung","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib26","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1038\/emboj.2011.173","article-title":"Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression","volume":"30","author":"Kanki","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2021.102836_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(14)60890-4","article-title":"Challenges of infectious diseases in the USA","volume":"384","author":"Khabbaz","year":"2014","journal-title":"The Lancet"},{"key":"10.1016\/j.isci.2021.102836_bib28","doi-asserted-by":"crossref","first-page":"10263","DOI":"10.1128\/MCB.24.23.10263-10276.2004","article-title":"Multiple, distant Gata2 enhancers specify temporally and tissue-specific patterning in the developing urogenital system","volume":"24","author":"Khandekar","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.102836_bib29","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/s41590-018-0178-z","article-title":"Disruption of an antimycobacterial circuit between dendritic and helper T\u00a0cells in human SPPL2a deficiency","volume":"19","author":"Kong","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/08830185.2010.529976","article-title":"Pathogen recognition by the innate immune system","volume":"30","author":"Kumar","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41467-020-20766-0","article-title":"GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2021.102836_bib32","article-title":"The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE\/mast cell-mediated anaphylaxis","author":"Li","year":"2017","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib33","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.4049\/jimmunol.1500018","article-title":"The STAT5-GATA2 pathway is critical in basophil and mast cell differentiation and maintenance","volume":"194","author":"Li","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib34","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1172\/JCI61619","article-title":"Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning","volume":"122","author":"Lim","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2021.102836_bib35","doi-asserted-by":"crossref","first-page":"13641","DOI":"10.1073\/pnas.1108440108","article-title":"Genetic framework for GATA factor function in vascular biology","volume":"108","author":"Linnemann","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2021.102836_bib36","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1182\/blood-2011-12-397083","article-title":"High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia","volume":"120","author":"Luesink","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2021.102836_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1756-8722-6-61","article-title":"An evolving new paradigm: endothelial cells--conditional innate immune cells","volume":"6","author":"Mai","year":"2013","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.isci.2021.102836_bib39","doi-asserted-by":"crossref","first-page":"eaau6759","DOI":"10.1126\/sciimmunol.aau6759","article-title":"Human IFN-\u03b3 immunity to mycobacteria is governed by both IL-12 and IL-23","volume":"3","author":"Mart\u00ednez-Barricarte","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib40","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/cc11442","article-title":"Depletion of neutrophil extracellular traps in\u00a0vivo results in hypersusceptibility to polymicrobial sepsis in mice","volume":"16","author":"Meng","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.isci.2021.102836_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12185-014-1568-0","article-title":"A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation","volume":"100","author":"Moriguchi","year":"2014","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.isci.2021.102836_bib42","first-page":"69","article-title":"Statistics corner: a guide to appropriate use of correlation coefficient in medical research","volume":"24","author":"Mukaka","year":"2012","journal-title":"Malawi Med. J."},{"key":"10.1016\/j.isci.2021.102836_bib43","series-title":"Immune Response Activation and Immunomodulation","first-page":"9","article-title":"Cytokine profiling plays a crucial role in activating immune system to clear infectious pathogens","author":"Mu\u00f1oz-Carrillo","year":"2018"},{"key":"10.1016\/j.isci.2021.102836_bib44","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1182\/blood-2014-11-612465","article-title":"GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow","volume":"125","author":"Ohmori","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib45","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1128\/MCB.00718-12","article-title":"Regulation of GATA factor expression is distinct between erythroid and mast cell lineages","volume":"32","author":"Ohmori","year":"2012","journal-title":"Mol. Cell Biol"},{"key":"10.1016\/j.isci.2021.102836_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00314-19","article-title":"GATA2 and PU.1 collaborate to activate the expression of the mouse <em>Ms4a2<\/em> gene, encoding Fc\u03b5RI\u03b2, through distinct mechanisms","volume":"39","author":"Ohmori","year":"2019","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.102836_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184603","article-title":"Mouse tryptase gene expression is coordinately regulated by GATA1 and GATA2 in bone marrow-derived mast cells","volume":"20","author":"Ohneda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2021.102836_bib48","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1182\/blood-2016-02-698118","article-title":"GATA2 regulates dendritic cell differentiation","volume":"128","author":"Onodera","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ng.923","article-title":"Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)","volume":"43","author":"Ostergaard","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2021.102836_bib50","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.bbmt.2018.01.030","article-title":"Allogeneic hematopoietic stem cell transplantation for GATA2 deficiency using a busulfan-based regimen","volume":"24","author":"Parta","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.isci.2021.102836_bib51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2021.102836_bib52","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.exphem.2016.05.010","article-title":"GATA-related hematologic disorders","volume":"44","author":"Shimizu","year":"2016","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.isci.2021.102836_bib53","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/iub.2188","article-title":"Quantitative and qualitative impairments in GATA2 and myeloid neoplasms","volume":"72","author":"Shimizu","year":"2020","journal-title":"IUBMB Life"},{"key":"10.1016\/j.isci.2021.102836_bib54","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood-2013-07-515528","article-title":"GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity","volume":"123","author":"Spinner","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib55","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/gtc.12086","article-title":"GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation","volume":"18","author":"Suzuki","year":"2013","journal-title":"Genes Cells"},{"key":"10.1016\/j.isci.2021.102836_bib56","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1073\/pnas.0508928103","article-title":"Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche","volume":"103","author":"Suzuki","year":"2006","journal-title":"Proc. Natl. Acad. Sci. United States America"},{"key":"10.1016\/j.isci.2021.102836_bib57","doi-asserted-by":"crossref","first-page":"15603","DOI":"10.1038\/s41598-019-51716-6","article-title":"Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G+ myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice","volume":"9","author":"Takai","year":"2019","journal-title":"Scientific Rep."},{"key":"10.1016\/j.isci.2021.102836_bib58","doi-asserted-by":"crossref","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"10.1016\/j.isci.2021.102836_bib59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10875-019-00737-x","article-title":"Human inborn errors of immunity: 2019 update on the classification from the international union of immunological societies expert committee","volume":"40","author":"Tangye","year":"2020","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.isci.2021.102836_bib60","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nm.3895","article-title":"IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases","volume":"21","author":"Teng","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2021.102836_bib61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/371221a0","article-title":"An early haematopoietic defect in mice lacking the transcription factor GATA-2","volume":"371","author":"Tsai","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.isci.2021.102836_bib62","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1182\/blood.V89.10.3636","article-title":"Transcription factor GATA-2 is required for proliferation\/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation","volume":"89","author":"Tsai","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib63","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/339446a0","article-title":"Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells","volume":"339","author":"Tsai","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.isci.2021.102836_bib64","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1182\/blood-2009-03-208629","article-title":"Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia","volume":"115","author":"Vinh","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.isci.2021.102836_bib65","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/gtc.12795","article-title":"GATA2 functions in adrenal chromaffin cells","volume":"25","author":"Watanabe-Asaka","year":"2020","journal-title":"Genes Cells"},{"key":"10.1016\/j.isci.2021.102836_bib66","first-page":"4854","article-title":"A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells","volume":"10","author":"Wilson","year":"1990","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.102836_bib67","doi-asserted-by":"crossref","first-page":"e72404","DOI":"10.1371\/journal.pone.0072404","article-title":"GATA-2 transduces LPS-induced il-1\u03b2 gene expression in macrophages via a toll-like receptor 4\/MD88\/MAPK-dependent mechanism","volume":"8","author":"Wu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2021.102836_bib68","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1101\/gad.4.10.1650","article-title":"Activity and tissue-specific expression of the transcription factor NF-E1 multigene family","volume":"4","author":"Yamamoto","year":"1990","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2021.102836_bib69","doi-asserted-by":"crossref","first-page":"e00211","DOI":"10.1128\/MCB.00211-17","article-title":"Reducing inflammatory cytokine production from renal collecting duct cells by inhibiting GATA2 ameliorates acute kidney injury","volume":"37","author":"Yu","year":"2017","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.102836_bib70","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1128\/MCB.01659-13","article-title":"GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts","volume":"34","author":"Yu","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.102836_bib71","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1182\/blood.V81.12.3234.3234","article-title":"Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription","volume":"81","author":"Zon","year":"1993","journal-title":"Blood"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422100804X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422100804X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:29:52Z","timestamp":1762878592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422100804X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S258900422100804X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2021.102836","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gata2 heterozygous mutant mice exhibit reduced inflammatory responses and impaired bacterial clearance","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2021.102836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"102836"}}