{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:26:40Z","timestamp":1790666800175,"version":"4.1.0"},"reference-count":106,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009531","name":"Istituto Italiano di Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.isci.2021.103702","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T03:36:29Z","timestamp":1640662589000},"page":"103702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-7368","authenticated-orcid":false,"given":"Assunta Maria","family":"Casale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3456-6574","authenticated-orcid":false,"given":"Francesco","family":"Liguori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-4931","authenticated-orcid":false,"given":"Federico","family":"Ansaloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5862-1390","authenticated-orcid":false,"given":"Ugo","family":"Cappucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-5358","authenticated-orcid":false,"given":"Sara","family":"Finaurini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Spirito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Persichetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-9713","authenticated-orcid":false,"given":"Remo","family":"Sanges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gustincich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3656-5068","authenticated-orcid":false,"given":"Lucia","family":"Piacentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2021.103702_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nrm.2017.119","article-title":"Ten principles of heterochromatin formation and function","volume":"19","author":"Allshire","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.103702_bib2","series-title":"FASTQC. A Quality Control Tool for High Throughput Sequence Data","author":"Andrews","year":"2010"},{"key":"10.1016\/j.isci.2021.103702_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0896-6273(95)90059-4","article-title":"Flybrain, an on-line atlas and database of the Drosophila nervous system","volume":"15","author":"Armstrong","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2021.103702_bib4","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1523\/JNEUROSCI.4844-08.2008","article-title":"Organization and postembryonic development of glial cells in the adult central brain of Drosophila","volume":"28","author":"Awasaki","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2021.103702_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.5808\/GI.2014.12.3.98","article-title":"The impact of transposable elements in genome evolution and genetic instability and their implications in various diseases","volume":"12","author":"Ayarpadikannan","year":"2014","journal-title":"Genomics Inform."},{"key":"10.1016\/j.isci.2021.103702_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13100-015-0041-9","article-title":"Repbase update, a database of repetitive elements in eukaryotic genomes","volume":"6","author":"Bao","year":"2015","journal-title":"Mob. DNA"},{"key":"10.1016\/j.isci.2021.103702_bib7","series-title":"Neuroepigenomics in Aging and Disease","first-page":"277","article-title":"Epigenetics of Huntington\u2019s disease","author":"Bassi","year":"2017"},{"key":"10.1016\/j.isci.2021.103702_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1101\/gr.5558208","article-title":"Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health","volume":"18","author":"Belancio","year":"2008","journal-title":"Genome Res."},{"key":"10.1016\/j.isci.2021.103702_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2867-6-13","article-title":"Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells","volume":"6","author":"Belgnaoui","year":"2006","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.isci.2021.103702_bib10","doi-asserted-by":"crossref","first-page":"e97374","DOI":"10.15252\/embj.201797374","article-title":"Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression","volume":"37","author":"Blaudin de Th\u00e9","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2021.103702_bib11","doi-asserted-by":"crossref","first-page":"180074","DOI":"10.1098\/rsob.180074","article-title":"Retrotransposon-induced mosaicism in the neural genome","volume":"8","author":"Bodea","year":"2018","journal-title":"Open Biol."},{"key":"10.1016\/j.isci.2021.103702_bib12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/hmg\/ddm315","article-title":"Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases","volume":"17","author":"Branco","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.isci.2021.103702_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/10253890.2018.1485647","article-title":"Stress-induced strain and brain region-specific activation of LINE-1 transposons in adult mice","volume":"21","author":"Cappucci","year":"2018","journal-title":"Stress"},{"key":"10.1016\/j.isci.2021.103702_bib15","doi-asserted-by":"crossref","first-page":"17943","DOI":"10.1073\/pnas.1903936116","article-title":"The Hsp70 chaperone is a major player in stress-induced transposable element activation","volume":"116","author":"Cappucci","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2021.103702_bib16","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1038\/s41598-019-40152-1","article-title":"Heterochromatin protein 1 (HP1) is intrinsically required for post-transcriptional regulation of Drosophila Germline Stem Cell (GSC) maintenance","volume":"9","author":"Casale","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2021.103702_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00412-021-00760-1","article-title":"Unravelling HP1 functions: post-transcriptional regulation of stem cell fate","volume":"130","author":"Casale","year":"2021","journal-title":"Chromosoma"},{"key":"10.1016\/j.isci.2021.103702_bib18","doi-asserted-by":"crossref","first-page":"D762","DOI":"10.1093\/nar\/gkx1020","article-title":"The UCSC genome browser database: 2018 update","volume":"46","author":"Casper","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2021.103702_bib19","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1093\/hmg\/11.23.2895","article-title":"Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila","volume":"11","author":"Chan","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib20","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1016\/j.cub.2019.07.071","article-title":"The gypsy endogenous retrovirus drives non-cell-autonomous propagation in a Drosophila TDP-43 model of neurodegeneration","volume":"29","author":"Chang","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2021.103702_bib21","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1177\/0960327118818248","article-title":"Toxicity and genotoxicity induced by abacavir antiretroviral medication alone or in combination with zidovudine and\/or lamivudine in Drosophila melanogaster","volume":"38","author":"Chen-Chen","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.isci.2021.103702_bib22","doi-asserted-by":"crossref","first-page":"20382","DOI":"10.1073\/pnas.1100273108","article-title":"Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells","volume":"108","author":"Coufal","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2021.103702_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0784-9","article-title":"L1 drives IFN in senescent cells and promotes age-associated inflammation","volume":"566","author":"De Cecco","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.isci.2021.103702_bib24","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/hmg\/ddu446","article-title":"The Drosophila Huntington\u2019s disease gene ortholog dhtt influences chromatin regulation during development","volume":"24","author":"Dietz","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0896-6273(95)90346-1","article-title":"Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons","volume":"14","author":"DiFiglia","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2021.103702_bib26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ana.22149","article-title":"Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis","volume":"69","author":"Douville","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.isci.2021.103702_bib27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1126\/science.7618107","article-title":"Inactivation of the mouse Huntington\u2019s disease gene homolog Hdh","volume":"269","author":"Duyao","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.isci.2021.103702_bib28","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1101\/gad.323004","article-title":"Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila","volume":"18","author":"Ebert","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2021.103702_bib29","doi-asserted-by":"crossref","first-page":"9923","DOI":"10.1073\/pnas.87.24.9923","article-title":"Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster","volume":"87","author":"Eissenberg","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2021.103702_bib30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/genetics\/131.2.345","article-title":"The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation","volume":"131","author":"Eissenberg","year":"1992","journal-title":"Genetics"},{"key":"10.1016\/j.isci.2021.103702_bib31","doi-asserted-by":"crossref","first-page":"a017780","DOI":"10.1101\/cshperspect.a017780","article-title":"Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila","volume":"5","author":"Elgin","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.isci.2021.103702_bib32","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1242\/dev.119.3.855","article-title":"Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein","volume":"119","author":"Ellis","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.isci.2021.103702_bib33","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/nn.4388","article-title":"L1-associated genomic regions are deleted in somatic cells of the healthy human brain","volume":"19","author":"Erwin","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2021.103702_bib34","doi-asserted-by":"crossref","first-page":"e12966","DOI":"10.7554\/eLife.12966","article-title":"Resolving rates of mutation in the brain using single-neuron genomics","volume":"5","author":"Evrony","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.isci.2021.103702_bib35","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1126\/science.338.6108.758","article-title":"Transposable elements, epigenetics, and genome evolution","volume":"338","author":"Fedoroff","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.isci.2021.103702_bib36","series-title":"Huntington\u2019s Disease: A Disorder of Families, the Johns Hopkins Series in Contemporary Medicine and Public Health","author":"Folstein","year":"1989"},{"key":"10.1016\/j.isci.2021.103702_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nn.3639","article-title":"Tau promotes neurodegeneration through global chromatin relaxation","volume":"17","author":"Frost","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2021.103702_bib38","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022751118","article-title":"Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration","volume":"118","author":"Fukuda","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"11","key":"10.1016\/j.isci.2021.103702_bib39","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1101\/gr.218032.116","article-title":"The Mobile Element Locator Tool (MELT): population-scale mobile element discovery and biology","volume":"27","author":"Gardner","year":"2017","journal-title":"Genome Res"},{"key":"10.1016\/j.isci.2021.103702_bib40","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jmb.2006.01.089","article-title":"The human LINE-1 retrotransposon creates DNA double-strand breaks","volume":"357","author":"Gasior","year":"2006","journal-title":"J.\u00a0Mol. Biol."},{"issue":"2","key":"10.1016\/j.isci.2021.103702_bib41","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cub.2005.12.011","article-title":"The class I PITP giotto is required for Drosophila cytokinesis","volume":"16","author":"Giansanti","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2021.103702_bib42","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ni.2542","article-title":"RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila","volume":"14","author":"Goic","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2021.103702_bib43","article-title":"Molecular mechanisms of dietary restriction promoting health and longevity","author":"Green","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2021.103702_bib44","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/em.20389","article-title":"Comparative analysis of genetic toxicity of AZT and ddI antiretrovirals in somatic cells of Drosophila melanogaster","volume":"49","author":"Guimar\u00e3es","year":"2008","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.isci.2021.103702_bib45","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1016\/j.celrep.2018.05.004","article-title":"Tau activates transposable elements in Alzheimer\u2019s disease","volume":"23","author":"Guo","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2021.103702_bib46","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/mds.26001","article-title":"Genetic modifiers of Huntington\u2019s disease","volume":"29","author":"Gusella","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.isci.2021.103702_bib47","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1534\/g3.116.027060","article-title":"Quantitative assessment of eye phenotypes for functional genetic studies using Drosophila melanogaster","volume":"6","author":"Iyer","year":"2016","journal-title":"G3"},{"key":"10.1016\/j.isci.2021.103702_bib48","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/ng.3945","article-title":"LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo","volume":"49","author":"Jachowicz","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/cr.2018.8","article-title":"Whole-genome sequencing reveals principles of brain retrotransposition in neurodevelopmental disorders","volume":"28","author":"Jacob-Hirsch","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.isci.2021.103702_bib50","first-page":"3862","article-title":"Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene","volume":"6","author":"James","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.isci.2021.103702_bib51","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.cub.2013.06.021","article-title":"Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling","volume":"23","author":"Jin","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2021.103702_bib52","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature09830","article-title":"DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration","volume":"471","author":"Kaneko","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.isci.2021.103702_bib53","doi-asserted-by":"crossref","first-page":"18760","DOI":"10.1073\/pnas.1106676108","article-title":"Separation of stem cell maintenance and transposon silencing functions of Piwi protein","volume":"108","author":"Klenov","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2021.103702_bib54","doi-asserted-by":"crossref","first-page":"e1006635","DOI":"10.1371\/journal.pgen.1006635","article-title":"Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS","volume":"13","author":"Krug","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.isci.2021.103702_bib55","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2021.103702_bib56","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2019.06.036","article-title":"CAG repeat not polyglutamine length determines timing of Huntington\u2019s disease onset","volume":"178","author":"Lee","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.isci.2021.103702_bib57","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2021.103702_bib58","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2021.103702_bib59","doi-asserted-by":"crossref","first-page":"e44099","DOI":"10.1371\/journal.pone.0044099","article-title":"Transposable elements in TDP-43-mediated neurodegenerative disorders","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2021.103702_bib60","doi-asserted-by":"crossref","first-page":"307ra153","DOI":"10.1126\/scitranslmed.aac8201","article-title":"Human endogenous retrovirus-K contributes to motor neuron disease","volume":"7","author":"Li","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2021.103702_bib61","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.celrep.2019.04.003","article-title":"Loss of nuclear TDP-43 is associated with decondensation of LINE retrotransposons","volume":"27","author":"Liu","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2021.103702_bib62","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.aay6018","article-title":"N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription","volume":"367","author":"Liu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2021.103702_bib63","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.isci.2021.103702_bib64","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1101\/gr.095406.109","article-title":"Population dynamics of PIWI-interacting RNAs (piRNAs) and their targets in Drosophila","volume":"20","author":"Lu","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.isci.2021.103702_bib65","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/j.1460-2075.1996.tb00474.x","article-title":"Developmental timing and tissue specificity of heterochromatin-mediated silencing","volume":"15","author":"Lu","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2021.103702_bib66","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.4161\/cc.28401","article-title":"Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events","volume":"13","author":"McCloy","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.isci.2021.103702_bib67","doi-asserted-by":"crossref","first-page":"eaal1641","DOI":"10.1126\/science.aal1641","article-title":"Intersection of diverse neuronal genomes and neuropsychiatric disease: the Brain Somatic Mosaicism Network","volume":"356","author":"McConnell","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.isci.2021.103702_bib68","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature09544","article-title":"L1 retrotransposition in neurons is modulated by MeCP2","volume":"468","author":"Muotri","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.isci.2021.103702_bib69","doi-asserted-by":"crossref","first-page":"109694","DOI":"10.1016\/j.celrep.2021.109694","article-title":"The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress","volume":"36","author":"Napoletano","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2021.103702_bib70","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0092-8674(95)90542-1","article-title":"Targeted disruption of the Huntington\u2019s disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes","volume":"81","author":"Nasir","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.isci.2021.103702_bib71","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41576-018-0073-3","article-title":"PIWI-interacting RNAs: small RNAs with big functions","volume":"20","author":"Ozata","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib72","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.molcel.2013.03.002","article-title":"The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus","volume":"50","author":"Padeken","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2021.103702_bib73","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1101\/gad.388706","article-title":"Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins","volume":"20","author":"Papp","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2021.103702_bib74","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2018.05.043","article-title":"A LINE1-nucleolin partnership regulates early development and ESC identity","volume":"174","author":"Percharde","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2021.103702_bib75","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.94.14.7583","article-title":"Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis","volume":"94","author":"Perron","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2021.103702_bib76","doi-asserted-by":"crossref","DOI":"10.4161\/fly.4.4.13261","article-title":"Positive regulation of euchromatic gene expression by HP1","author":"Piacentini","year":"2010","journal-title":"Fly (Austin)"},{"key":"10.1016\/j.isci.2021.103702_bib77","series-title":"Drosophila Protocols","first-page":"1","article-title":"Preparation and analysis of drosophila mitotic chromosomes","author":"Pimpinelli","year":"2000"},{"key":"10.1016\/j.isci.2021.103702_bib78","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1261\/rna.034405.112","article-title":"Shutdown is a component of the Drosophila piRNA biogenesis machinery","volume":"18","author":"Preall","year":"2012","journal-title":"RNA"},{"key":"10.1016\/j.isci.2021.103702_bib79","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1093\/hmg\/ddx233","article-title":"Repetitive element transcripts are elevated in the brain of C9orf72 ALS\/FTLD patients","volume":"26","author":"Prudencio","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib80","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2021.103702_bib81","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nmeth.3250","article-title":"Improved and expanded Q-system reagents for genetic manipulations","volume":"12","author":"Riabinina","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2021.103702_bib82","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0012-1606(88)90139-X","article-title":"The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages","volume":"126","author":"Robinow","year":"1988","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2021.103702_bib83","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41588-019-0562-0","article-title":"Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition","volume":"52","author":"Rodriguez-Martin","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib84","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12915-020-00816-1","article-title":"TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity","volume":"18","author":"Romano","year":"2020","journal-title":"BMC Biol."},{"key":"10.1016\/j.isci.2021.103702_bib85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neuron.2007.11.025","article-title":"Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length Huntingtin accumulating in the cytoplasm","volume":"57","author":"Romero","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2021.103702_bib86","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington\u2019s disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2021.103702_bib87","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","author":"Rozen","year":"1999"},{"key":"10.1016\/j.isci.2021.103702_bib88","doi-asserted-by":"crossref","first-page":"dev156844","DOI":"10.1242\/dev.156844","article-title":"Chromosomal instability during neurogenesis in Huntington\u2019s disease","volume":"145","author":"Ruzo","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.isci.2021.103702_bib89","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/emboj\/21.5.1121","article-title":"Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing","volume":"21","author":"Schotta","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2021.103702_bib106","doi-asserted-by":"crossref","DOI":"10.1007\/PL00008659","article-title":"Controlled expression of tagged proteins in Drosophila using a new modular P-element vector system","author":"Schotta","year":"2000","journal-title":"Mol Gen Genet MGG"},{"key":"10.1016\/j.isci.2021.103702_bib90","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/hmg\/ddp524","article-title":"Huntingtin facilitates polycomb repressive complex 2","volume":"19","author":"Seong","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2021.103702_bib91","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1101\/gad.8.17.2046","article-title":"An env-like protein encoded by a Drosophila retroelement: evidence that gypsy is an infectious retrovirus","volume":"8","author":"Song","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2021.103702_bib92","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1093\/nar\/gku1394","article-title":"Genome-wide analyses of LINE\u2013LINE-mediated nonallelic homologous recombination","volume":"43","author":"Startek","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2021.103702_bib93","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/s41593-018-0194-1","article-title":"Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies","volume":"21","author":"Sun","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2021.103702_bib94","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13100-019-0176-1","article-title":"Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease","volume":"10","author":"Tam","year":"2019","journal-title":"Mob. DNA"},{"key":"10.1016\/j.isci.2021.103702_bib95","doi-asserted-by":"crossref","first-page":"e4262","DOI":"10.1371\/journal.pone.0004262","article-title":"Glial cell lineage expression of mutant ataxin-1 and Huntingtin induces developmental and late-onset neuronal pathologies in Drosophila models","volume":"4","author":"Tamura","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2021.103702_bib96","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.isci.2021.103702_bib97","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.stem.2017.07.009","article-title":"Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation","volume":"21","author":"Thomas","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2021.103702_bib98","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2015.03.026","article-title":"Ubiquitous L1 mosaicism in hippocampal neurons","volume":"161","author":"Upton","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.isci.2021.103702_bib99","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.celrep.2012.12.014","article-title":"TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila","volume":"3","author":"Vanden Broeck","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2021.103702_bib100","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.isci.2021.103702_bib101","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0092-8674(00)81159-9","article-title":"Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila","volume":"93","author":"Wakimoto","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.isci.2021.103702_bib102","doi-asserted-by":"crossref","first-page":"21164","DOI":"10.1073\/pnas.1107892109","article-title":"Drosophila piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2021.103702_bib103","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.cell.2018.06.040","article-title":"Hijacking oogenesis enables massive propagation of LINE and retroviral transposons","volume":"174","author":"Wang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2021.103702_bib104","doi-asserted-by":"crossref","first-page":"11277","DOI":"10.1073\/pnas.1604621113","article-title":"Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila","volume":"113","author":"Wood","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2021.103702_bib105","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1038\/nprot.2006.336","article-title":"A protocol for dissecting Drosophila melanogaster brains for live imaging or immunostaining","volume":"1","author":"Wu","year":"2006","journal-title":"Nat. Protoc."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004221016722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004221016722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T19:35:17Z","timestamp":1762630517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004221016722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":106,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2589004221016722"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2021.103702","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transposable element activation promotes neurodegeneration in a Drosophila model of Huntington's disease","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2021.103702","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"103702"}}