{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:06:04Z","timestamp":1790564764219,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00003\/3"],"award-info":[{"award-number":["MC_UU_00003\/3"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["HR0011"],"award-info":[{"award-number":["HR0011"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.isci.2022.104028","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T05:07:35Z","timestamp":1646370455000},"page":"104028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Embedding digital chronotherapy into bioelectronic medicines"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1969-3188","authenticated-orcid":false,"given":"John E.","family":"Fleming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaclav","family":"Kremen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ro'ee","family":"Gilron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayela","family":"Zamora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derk-Jan","family":"Dijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Worrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Denison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.104028_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.parkreldis.2011.09.001","article-title":"Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson\u2019s disease","volume":"18","author":"Amara","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.isci.2022.104028_bib2","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1001\/jama.2020.1224","article-title":"Choosing a Parkinson disease treatment","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2022.104028_bib3","doi-asserted-by":"crossref","first-page":"704170","DOI":"10.3389\/fneur.2021.704170","article-title":"Epilepsy personal assistant device\u2014a mobile platform for brain state, dense behavioral and physiology tracking and controlling adaptive stimulation","volume":"12","author":"Attia","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-017-02577-y","article-title":"Multi-day rhythms modulate seizure risk in epilepsy","volume":"9","author":"Baud","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.104028_bib5","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.3389\/fneur.2021.765203","article-title":"Basal ganglia local field potentials as a potential biomarker for sleep disturbance in Parkinson\u2019s disease","volume":"12","author":"Baumgartner","year":"2021","journal-title":"Front. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib6","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1212\/WNL.0000000000001280","article-title":"Long-term treatment with responsive brain stimulation in adults with refractory partial seizures","volume":"84","author":"Bergey","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2022.104028_bib7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.yebeh.2016.10.036","article-title":"Subjective seizure counts by epilepsy clinical drug trial participants are not reliable","volume":"67","author":"Blachut","year":"2017","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.isci.2022.104028_bib8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.seizure.2015.03.004","article-title":"Counting seizures: the primary outcome measure in epileptology from the patients\u2019 perspective","volume":"29","author":"Blachut","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.isci.2022.104028_bib9","doi-asserted-by":"crossref","first-page":"e13161","DOI":"10.1111\/apha.13161","article-title":"Emerging relevance of circadian rhythms in headaches and neuropathic pain","volume":"225","author":"Burish","year":"2019","journal-title":"Acta Physiol."},{"key":"10.1016\/j.isci.2022.104028_bib10","series-title":"Clinical pharmacology of sleep","first-page":"197","article-title":"Chronopharmacology and its implications to the pharmacology of sleep","author":"Cardinali","year":"2006"},{"key":"10.1016\/j.isci.2022.104028_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cmet.2019.06.019","article-title":"Medicine in the fourth dimension","volume":"30","author":"Cederroth","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2022.104028_bib12","first-page":"158","article-title":"New control strategies for neuroprosthetic systems","volume":"33","author":"Crago","year":"1996","journal-title":"J.\u00a0Rehabil. Res. Dev."},{"key":"10.1016\/j.isci.2022.104028_bib13","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1177\/0748730405277983","article-title":"Entrainment of the human circadian system by light","volume":"20","author":"Duffy","year":"2005","journal-title":"J.\u00a0Biol. Rhythm."},{"key":"10.1016\/j.isci.2022.104028_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0002-9149(88)91314-8","article-title":"The activitrax rate responsive pacemaker system","volume":"61","author":"den Dulk","year":"1988","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.isci.2022.104028_bib15","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1528-1167.2010.02536.x","article-title":"Electrical stimulation of\u00a0the\u00a0anterior nucleus of thalamus for treatment\u00a0of refractory epilepsy","volume":"51","author":"Fisher","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2022.104028_bib16","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/epi.13740","article-title":"Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy","volume":"58","author":"Geller","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2022.104028_bib17","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hup.964","article-title":"Circadian rhythm disturbances in depression","volume":"23","author":"Germain","year":"2008","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.isci.2022.104028_bib18","first-page":"1307","article-title":"Sleep-aware adaptive deep brain stimulation control: chronic use at home with dual independent linear discriminate detectors","volume":"0","author":"Gilron","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2022.104028_bib19","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1177\/193229681300700605","article-title":"Periodic-zone model predictive control for diurnal closed-loop operation of an artificial pancreas","volume":"7","author":"Gondhalekar","year":"2013","journal-title":"J.\u00a0Diabetes Sci. Technol."},{"key":"10.1016\/j.isci.2022.104028_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1006606","article-title":"Bayesian adaptive dual control of deep brain stimulation in a computational model of Parkinson\u2019s disease","volume":"14","author":"Grado","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.isci.2022.104028_bib21","doi-asserted-by":"crossref","first-page":"fcaa008","DOI":"10.1093\/braincomms\/fcaa008","article-title":"Circadian and multiday seizure periodicities, and seizure clusters in canine epilepsy","volume":"2","author":"Gregg","year":"2020","journal-title":"Brain Commun."},{"key":"10.1016\/j.isci.2022.104028_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-03555-7","article-title":"Thalamic deep brain stimulation modulates\u00a0cycles of seizure risk in epilepsy","volume":"11","author":"Gregg","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.104028_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/biology8010013","article-title":"The mammalian circadian timing system and the suprachiasmatic nucleus as its pacemaker","volume":"8","author":"Hastings","year":"2019","journal-title":"Biology"},{"key":"10.1016\/j.isci.2022.104028_bib24","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/mds.10639","article-title":"Improvement of sleep quality in patients with advanced Parkinson\u2019s disease treated with deep brain stimulation of the subthalamic nucleus","volume":"19","author":"Hjort","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.isci.2022.104028_bib25","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1001\/archneur.64.11.1595","article-title":"Epilepsy: accuracy of patient seizure counts","volume":"64","author":"Hoppe","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1096\/fasebj.2.2.3277888","article-title":"Control strategies in physiological systems","volume":"2","author":"Houk","year":"1988","journal-title":"FASEB J."},{"key":"10.1016\/j.isci.2022.104028_bib27","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/epi.13116","article-title":"The evolution of epilepsy surgery between 1991 and 2011 in nine major epilepsy centers across the United States, Germany, and Australia","volume":"56","author":"Jehi","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2022.104028_bib28","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S1474-4422(18)30274-6","article-title":"Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study","volume":"17","author":"Karoly","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41582-021-00464-1","article-title":"Cycles in epilepsy","volume":"17","author":"Karoly","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib30","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S1474-4422(18)30335-1","article-title":"Circadian rhythm and epilepsy","volume":"17","author":"Khan","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib31","doi-asserted-by":"crossref","first-page":"23965","DOI":"10.1109\/ACCESS.2020.2968440","article-title":"Physiological closed-loop control (PCLC) systems: review of a modern frontier in automation","volume":"8","author":"Khodaei","year":"2020","journal-title":"IEEE Access"},{"key":"10.1016\/j.isci.2022.104028_bib32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1210\/er.2018-00049","article-title":"Coupling the circadian clock to homeostasis: the role of period in timing physiology","volume":"40","author":"Kim","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.isci.2022.104028_bib33","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neulet.2010.10.030","article-title":"Feed-forward changes in carotid blood flow velocity during active standing","volume":"487","author":"Kitaoka","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2022.104028_bib34","doi-asserted-by":"crossref","first-page":"2500112","DOI":"10.1109\/JTEHM.2018.2869398","article-title":"Integrating brain implants with local and distributed computing devices: a next generation epilepsy management system","volume":"6","author":"Kremen","year":"2018","journal-title":"IEEE J. Transl. Eng. Health Med."},{"key":"10.1016\/j.isci.2022.104028_bib35","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00001756-199504190-00022","article-title":"Intracranial temperature across 24-hour sleep-wake cycles in humans","volume":"6","author":"Landolt","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.isci.2022.104028_bib36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1474-4422(18)30461-7","article-title":"Association between circadian rhythms and neurodegenerative diseases","volume":"18","author":"Leng","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib37","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/jnnp-2015-310972","article-title":"Bilateral adaptive deep brain stimulation is effective in Parkinson\u2019s disease","volume":"87","author":"Little","year":"2016","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.isci.2022.104028_bib38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.hrthm.2016.11.016","article-title":"Rate adaptive pacing in an intracardiac pacemaker","volume":"14","author":"Lloyd","year":"2017","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.isci.2022.104028_bib39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41583-018-0088-y","article-title":"Rhythms of life: circadian disruption and brain disorders across the lifespan","volume":"20","author":"Logan","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2022.104028_bib40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1109\/TNSRE.2019.2952637","article-title":"Application of reinforcement learning to deep brain stimulation in a computational model of Parkinson\u2019s disease","volume":"28","author":"Lu","year":"2020","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"10.1016\/j.isci.2022.104028_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11828","article-title":"Circadian regulation of human cortical excitability","volume":"7","author":"Ly","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.104028_bib42","doi-asserted-by":"crossref","first-page":"e12673","DOI":"10.1111\/jsr.12673","article-title":"An overview of sleep and circadian dysfunction in Parkinson\u2019s disease","volume":"27","author":"Mantovani","year":"2018","journal-title":"J.\u00a0Sleep Res."},{"key":"10.1016\/j.isci.2022.104028_bib43","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7600\/jpfsm.1.573","article-title":"Central command: feedforward control of the sympathoadrenal system during exercise","volume":"1","author":"Matsukawa","year":"2012","journal-title":"J.\u00a0Phys. Fit. Sports Med."},{"key":"10.1016\/j.isci.2022.104028_bib44","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/mds.870120405","article-title":"Sleep benefit in Parkinson\u2019s disease","volume":"12","author":"Merello","year":"1997","journal-title":"Mov. Disord."},{"key":"10.1016\/j.isci.2022.104028_bib45","article-title":"Electrical brain stimulation and continuous behavioral state tracking in ambulatory humans","author":"Mivalt","year":"2021","journal-title":"medRxiv"},{"key":"10.1016\/j.isci.2022.104028_bib46","doi-asserted-by":"crossref","first-page":"17359","DOI":"10.1073\/pnas.2001560117","article-title":"Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia","volume":"117","author":"Mizrahi-Kliger","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.isci.2022.104028_bib47","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.pnpbp.2010.07.028","article-title":"Circadian rhythms and treatment implications in depression","volume":"35","author":"Monteleone","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104028_bib48","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s13311-021-01021-w","article-title":"Sleep and epilepsy: a focused review of pathophysiology, clinical syndromes, Co-morbidities, and therapy","volume":"18","author":"Moore","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.isci.2022.104028_bib49","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1212\/WNL.0b013e3182302056","article-title":"Responsive cortical stimulation for the treatment of medically intractable partial epilepsy","volume":"77","author":"Morrell","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2022.104028_bib50","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.aad2993","article-title":"Local modulation of human brain responses by circadian rhythmicity and sleep debt","volume":"353","author":"Muto","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.104028_bib51","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1177\/0333102419851815","article-title":"The biological clock in cluster headache: a review and hypothesis","volume":"39","author":"Naber","year":"2019","journal-title":"Cephalalgia"},{"key":"10.1016\/j.isci.2022.104028_bib52","doi-asserted-by":"crossref","first-page":"e1244","DOI":"10.1212\/WNL.0000000000010154","article-title":"Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy","volume":"95","author":"Nair","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2022.104028_bib53","doi-asserted-by":"crossref","first-page":"401","DOI":"10.5664\/JCSM.1204","article-title":"Obstructive sleep apnea and respiratory complications associated with vagus nerve stimulators","volume":"7","author":"Parhizgar","year":"2011","journal-title":"J.\u00a0Clin. Sleep Med."},{"key":"10.1016\/j.isci.2022.104028_bib54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.appet.2007.10.006","article-title":"Anticipatory physiological regulation in feeding biology: cephalic phase responses","volume":"50","author":"Power","year":"2008","journal-title":"Appetite"},{"key":"10.1016\/j.isci.2022.104028_bib55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1479-8425.2012.00541.x","article-title":"What is chronotype?","volume":"10","author":"Roenneberg","year":"2012","journal-title":"Sleep Biol. Rhythm"},{"key":"10.1016\/j.isci.2022.104028_bib56","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1126\/science.aax7621","article-title":"Dosing time matters","volume":"365","author":"Ruben","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.104028_bib57","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/epi4.12382","article-title":"Sleep disruption is not observed with brain-responsive neurostimulation for epilepsy","volume":"5","author":"Ruoff","year":"2020","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.isci.2022.104028_bib58","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0006-8993(89)91163-3","article-title":"Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract","volume":"493","author":"Rusak","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2022.104028_bib59","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1111\/epi.16895","article-title":"The SANT\u00c9 study at 10 years of follow-up: effectiveness, safety, and sudden unexpected death in epilepsy","volume":"62","author":"Salanova","year":"2021","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2022.104028_bib60","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1212\/WNL.0000000000001334","article-title":"Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy","volume":"84","author":"Salanova","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.isci.2022.104028_bib61","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1126\/science.7063851","article-title":"Suprachiasmatic stimulation phase shifts rodent circadian rhythms","volume":"215","author":"Schal","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.104028_bib62","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1093\/brain\/123.11.2297","article-title":"Dyskinesias and motor fluctuations in Parkinson\u2019s diseaseA community-based study","volume":"123","author":"Schrag","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.isci.2022.104028_bib63","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3389\/fneur.2018.00697","article-title":"Deep brain stimulation and sleep-wake disturbances in Parkinson disease: a review","volume":"0","author":"Sharma","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib64","article-title":"Distributed brain Co-processor for neurophysiologic tracking and adaptive stimulation: application to drug resistant epilepsy","author":"Sladky","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2022.104028_bib65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coph.2020.10.014","article-title":"Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes","volume":"57","author":"Smolensky","year":"2021","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2022.104028_bib66","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.addr.2007.07.001","article-title":"Chronobiology, drug delivery, and chronotherapeutics","volume":"59","author":"Smolensky","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.isci.2022.104028_bib67","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.smrv.2014.06.005","article-title":"Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions","volume":"21","author":"Smolensky","year":"2015","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.isci.2022.104028_bib68","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1109\/TBCAS.2018.2880148","article-title":"A chronically implantable neural coprocessor for investigating the treatment of neurological disorders","volume":"12","author":"Stanslaski","year":"2018","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"10.1016\/j.isci.2022.104028_bib69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13311-021-01031-8","article-title":"Circadian rhythm sleep\u2013wake disorders: a contemporary review of neurobiology, treatment, and dysregulation in neurodegenerative disease","volume":"18","author":"Steele","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.isci.2022.104028_bib70","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1586\/17434440.2014.947274","article-title":"The RNS System: responsive cortical stimulation for the treatment of refractory partial epilepsy","volume":"11","author":"Sun","year":"2014","journal-title":"Expert Rev. Med. devices"},{"key":"10.1016\/j.isci.2022.104028_bib71","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1113\/jphysiol.2011.208199","article-title":"Feedback and feedforward sympathetic haemodynamic control: chicken or egg?","volume":"589","author":"Tan","year":"2011","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.isci.2022.104028_bib72","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1093\/brain\/awh449","article-title":"Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis","volume":"128","author":"T\u00e9llez-Zenteno","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.isci.2022.104028_bib73","first-page":"3433","article-title":"DyNeuMo mk-2: an investigational circadian-locked neuromodulator with responsive stimulation for applied chronobiology","volume":"2020","author":"Toth","year":"2020","journal-title":"IEEE Trans. Syst. Man, Cybernetics: Syst."},{"key":"10.1016\/j.isci.2022.104028_bib74","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/mds.22351","article-title":"Beta activity in the subthalamic nucleus during sleep in patients with Parkinson\u2019s disease","volume":"24","author":"Urrestarazu","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.isci.2022.104028_bib75","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.brs.2019.02.020","article-title":"Dual threshold neural closed loop deep brain stimulation in Parkinson disease patients","volume":"12","author":"Velisar","year":"2019","journal-title":"Brain Stimulation"},{"key":"10.1016\/j.isci.2022.104028_bib76","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nrneurol.2014.206","article-title":"\u2019The clocks that time us\u2019\u2014circadian rhythms in neurodegenerative disorders","volume":"10","author":"Videnovic","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib77","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1111\/epi.13045","article-title":"Deep brain stimulation of anterior nucleus thalami disrupts sleep in epilepsy patients","volume":"56","author":"Voges","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2022.104028_bib78","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41586-018-0649-2","article-title":"Targeted neurotechnology restores walking in humans with spinal cord injury","volume":"563","author":"Wagner","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104028_bib79","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1468-1331.2010.03213.x","article-title":"Effect of controlled-release\u00a0levodopa on the microstructure of sleep in Parkinson\u2019s disease","volume":"18","author":"Wailke","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib80","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/practneurol-2012-000463","article-title":"When the going gets tough: how to select patients with Parkinson\u2019s disease for advanced therapies","volume":"13","author":"Worth","year":"2013","journal-title":"Pract. Neurol."},{"key":"10.1016\/j.isci.2022.104028_bib81","first-page":"312","article-title":"A review of control strategies in closed-loop neuroprosthetic systems","volume":"0","author":"Wright","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2022.104028_bib82","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1192\/bjp.bp.111.096321","article-title":"Sleep and circadian rhythm disruption in schizophrenia","volume":"200","author":"Wulff","year":"2012","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.isci.2022.104028_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41531-020-0117-1","article-title":"Current and projected future economic burden of Parkinson\u2019s disease in the US","volume":"6","author":"Yang","year":"2020","journal-title":"npj Parkinsons Dis."},{"key":"10.1016\/j.isci.2022.104028_bib84","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1111\/j.1528-1167.2009.02159.x","article-title":"Economic impact of epilepsy in the United States","volume":"50","author":"Yoon","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.isci.2022.104028_bib85","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/mds.28562","article-title":"The neurophysiology of sleep in Parkinson\u2019s disease","volume":"36","author":"Zahed","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.isci.2022.104028_bib86","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/WNF.0000000000000341","article-title":"Chronotherapeutics: recognizing the importance of timing factors in the treatment of disease and sleep disorders","volume":"42","author":"Zaki","year":"2019","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.isci.2022.104028_bib87","first-page":"1196","article-title":"Case report: embedding \u201cdigital chronotherapy\u201d into medical devices\u2014a canine validation for controlling status epilepticus through multi-scale rhythmic brain stimulation","volume":"0","author":"Zamora","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2022.104028_bib88","article-title":"DyNeuMo mk-1: a fully-implantable, motion-adaptive neurostimulator with configurable response algorithms","author":"Zamora","year":"2020","journal-title":"bioRxiv"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422200298X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422200298X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:51:46Z","timestamp":1778899906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422200298X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":88,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S258900422200298X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.104028","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Embedding digital chronotherapy into bioelectronic medicines","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.104028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"104028"}}