{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:33:06Z","timestamp":1785270786546,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.isci.2022.104430","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T16:21:49Z","timestamp":1652890909000},"page":"104430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Alternative polarization of resident macrophages improves hyperglycemia-associated male infertility"],"prefix":"10.1016","volume":"25","author":[{"given":"Xiaobin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.104430_bib1","doi-asserted-by":"crossref","first-page":"E10418","DOI":"10.1073\/pnas.1713543114","article-title":"Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice","volume":"114","author":"Carrero","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2022.104430_bib2","doi-asserted-by":"crossref","first-page":"e20201839","DOI":"10.1084\/jem.20201839","article-title":"Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms","volume":"218","author":"Davis","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2022.104430_bib3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/dom.12168","article-title":"Macrophages and islet inflammation in type 2 diabetes","volume":"15","author":"Eguchi","year":"2013","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.isci.2022.104430_bib4","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1042\/BST0360340","article-title":"Macrophages, cytokines and beta-cell death in Type 2 diabetes","volume":"36","author":"Ehses","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.isci.2022.104430_bib5","doi-asserted-by":"crossref","first-page":"e04631","DOI":"10.7554\/eLife.04631","article-title":"Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and beta cells","volume":"3","author":"Fu","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.isci.2022.104430_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s13340-020-00482-2","article-title":"The role of adipose tissue M1\/M2 macrophages in type 2 diabetes mellitus","volume":"12","author":"Fujisaka","year":"2021","journal-title":"Diabetol. Int."},{"key":"10.1016\/j.isci.2022.104430_bib7","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1007\/s001250051038","article-title":"Beta-cell mass and proliferation following late fetal and early postnatal malnutrition in the rat","volume":"41","author":"Garofano","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2022.104430_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.immuni.2019.07.009","article-title":"Diabetes impedes the epigenetic switch of macrophages into repair mode","volume":"51","author":"Knipper","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2022.104430_bib9","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.4049\/jimmunol.168.7.3402","article-title":"Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter","volume":"168","author":"Lang","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2022.104430_bib10","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3389\/fimmu.2018.01175","article-title":"Transcriptional regulation of macrophages polarization by MicroRNAs","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.104430_bib11","first-page":"867023","article-title":"Altered polarization, morphology, and impaired innate immunity germane to resident peritoneal macrophages in mice with long-term type 2 diabetes","volume":"2012","author":"Liu","year":"2012","journal-title":"J.\u00a0Biomed. Biotechnol."},{"key":"10.1016\/j.isci.2022.104430_bib12","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3389\/fendo.2017.00307","article-title":"Cytokines in male fertility and reproductive pathologies: immunoregulation and beyond","volume":"8","author":"Loveland","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2022.104430_bib13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/humupd\/dmx033","article-title":"Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review","volume":"24","author":"Maresch","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.isci.2022.104430_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cca.2016.08.015","article-title":"Tissue resident macrophages: key players in the pathogenesis of type 2 diabetes and its complications","volume":"462","author":"Meshkani","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.isci.2022.104430_bib15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1615\/CritRevImmunol.v32.i6.10","article-title":"M1 and M2 macrophages: oracles of Health and disease","volume":"32","author":"Mills","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104430_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"Olefsky","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.isci.2022.104430_bib17","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0015-0282(16)49036-9","article-title":"Peritoneal macrophages and infertility: the association between cell number and pelvic pathology","volume":"44","author":"Olive","year":"1985","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2022.104430_bib18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2605.2008.00909.x","article-title":"Seminal macrophages in ejaculates from men with couple infertility","volume":"32","author":"Pelliccione","year":"2009","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.isci.2022.104430_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1530\/jrf.0.0820437","article-title":"Macrophages, lymphocytes and MHC II antigen in the ram and the rat testis","volume":"82","author":"Pollanen","year":"1988","journal-title":"J.\u00a0Reprod. Fertil."},{"key":"10.1016\/j.isci.2022.104430_bib20","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.isci.2022.104430_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/dmrr.2255","article-title":"Diagnosis and treatment of peripheral arterial disease in diabetic patients with a foot ulcer. A progress report of the International Working Group on the Diabetic Foot","volume":"28","author":"Schaper","year":"2012","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.isci.2022.104430_bib22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1189\/jlb.0911488","article-title":"Alveolar macrophages in diabetes: friends or foes?","volume":"91","author":"Sunahara","year":"2012","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.isci.2022.104430_bib23","doi-asserted-by":"crossref","first-page":"e0150792","DOI":"10.1371\/journal.pone.0150792","article-title":"Contrasting roles of islet resident immunoregulatory macrophages and dendritic cells in experimental autoimmune type 1 diabetes","volume":"11","author":"Thornley","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2022.104430_bib24","doi-asserted-by":"crossref","first-page":"17173","DOI":"10.1073\/pnas.262586099","article-title":"Reversible infertility in male mice after oral administration of alkylated imino sugars: a nonhormonal approach to male contraception","volume":"99","author":"van der Spoel","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2022.104430_bib25","article-title":"Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2022.104430_bib26","doi-asserted-by":"crossref","first-page":"e000921","DOI":"10.1136\/bmjdrc-2019-000921","article-title":"Placental growth factor in beta cells plays an essential role in gestational beta-cell growth","volume":"8","author":"Yang","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.isci.2022.104430_bib27","doi-asserted-by":"crossref","first-page":"104154","DOI":"10.1016\/j.cellimm.2020.104154","article-title":"Skin well-being in diabetes: role of macrophages","volume":"356","author":"Yaseen","year":"2020","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.isci.2022.104430_bib28","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1172\/JCI59901","article-title":"Estrogen promotes Leydig cell engulfment by macrophages in male infertility","volume":"124","author":"Yu","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.104430_bib29","doi-asserted-by":"crossref","first-page":"736153","DOI":"10.3389\/fimmu.2021.736153","article-title":"PlGF reduction compromises angiogenesis in diabetic foot disease through macrophages","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Immunol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222007015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222007015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T01:19:02Z","timestamp":1742519942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222007015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2589004222007015"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.104430","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternative polarization of resident macrophages improves hyperglycemia-associated male infertility","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.104430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"104430"}}