{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:46:40Z","timestamp":1790999200340,"version":"4.1.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31730034"],"award-info":[{"award-number":["31730034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501105"],"award-info":[{"award-number":["81501105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81861138013"],"award-info":[{"award-number":["81861138013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009399","name":"Peking University Third Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFE0126500"],"award-info":[{"award-number":["2017YFE0126500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.isci.2022.104609","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:43:02Z","timestamp":1655332982000},"page":"104609","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress"],"prefix":"10.1016","volume":"25","author":[{"given":"Yanhui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangjin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5418-9759","authenticated-orcid":false,"given":"Bai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.104609_bib1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1751-7893.2007.00043.x","article-title":"The promise of early intervention","volume":"1","author":"Addington","year":"2007","journal-title":"Early Interv Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/schbul\/sbr133","article-title":"Is the acute NMDA receptor hypofunction a valid model of schizophrenia?","volume":"38","author":"Adell","year":"2012","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.isci.2022.104609_bib3","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jnr.21139","article-title":"Mouse and rat BDNF gene structure and expression revisited","volume":"85","author":"Aid","year":"2007","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.isci.2022.104609_bib4","doi-asserted-by":"crossref","first-page":"16813","DOI":"10.1073\/pnas.1014168108","article-title":"Spatial segregation of BDNF transcripts enables BDNF to differentially shape distinct dendritic compartments","volume":"108","author":"Baj","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A."},{"key":"10.1016\/j.isci.2022.104609_bib5","doi-asserted-by":"crossref","first-page":"9O","DOI":"10.1677\/joe.0.0660093","article-title":"Effects of acute and chronic stress on plasma corticosterone levels in the pregnant and non-pregnant mouse","volume":"66","author":"Barlow","year":"1975","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.isci.2022.104609_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroscience.2013.01.074","article-title":"Stress effects on BDNF expression: effects of age, sex, and form of stress","volume":"239","author":"Bath","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2022.104609_bib7","doi-asserted-by":"crossref","first-page":"9.55.1","DOI":"10.1002\/cpns.15","article-title":"The neonatal ventral hippocampal lesion (NVHL) rodent model of schizophrenia","volume":"77","author":"Brady","year":"2016","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.metabol.2017.11.019","article-title":"Developmental origins of adult health and disease: the metabolic role of BDNF from early life to adulthood","volume":"81","author":"Briana","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2022.104609_bib9","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1176\/appi.ajp.159.7.1080","article-title":"Obstetric complications and schizophrenia: historical and meta-analytic review","volume":"159","author":"Cannon","year":"2002","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib10","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/mp.2015.219","article-title":"KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia","volume":"21","author":"Carr","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fnbeh.2013.00113","article-title":"DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders","volume":"7","author":"Cash-Padgett","year":"2013","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrn1078","article-title":"Neurotrophins and their receptors: a convergence point for many signalling pathways","volume":"4","author":"Chao","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neubiorev.2016.03.017","article-title":"A review of vulnerability and risks for schizophrenia: beyond the two hit hypothesis","volume":"65","author":"Davis","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.isci.2022.104609_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/YPG.0000000000000237","article-title":"Brain-derived neurotrophic factor and schizophrenia","volume":"29","author":"Di Carlo","year":"2019","journal-title":"Psychiatr. Genet."},{"key":"10.1016\/j.isci.2022.104609_bib15","doi-asserted-by":"crossref","first-page":"104208","DOI":"10.1016\/j.nbd.2018.06.020","article-title":"Alterations in cortical interneurons and cognitive function in schizophrenia","volume":"131","author":"Dienel","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2022.104609_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ng1296","article-title":"Convergent evidence for impaired AKT1-GSK3\u03b2 signaling in schizophrenia","volume":"36","author":"Emamian","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2022.104609_bib17","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/381706a0","article-title":"Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus","volume":"381","author":"Figurov","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104609_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11920-017-0807-5","article-title":"Genetics of schizophrenia: ready to translate?","volume":"19","author":"Foley","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.isci.2022.104609_bib19","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1056\/NEJMra035458","article-title":"Schizophrenia","volume":"349","author":"Freedman","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2022.104609_bib20","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/mp.2010.88","article-title":"Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis","volume":"16","author":"Green","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib21","doi-asserted-by":"crossref","first-page":"12764","DOI":"10.1523\/JNEUROSCI.3566-09.2009","article-title":"New insights in the biology of BDNF synthesis and release: implications in CNS function","volume":"29","author":"Greenberg","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib22","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.schres.2010.07.013","article-title":"Relationships between perceptions of the family environment and of negative life events in recent-onset schizophrenia patients","volume":"127","author":"Gretchen-Doorly","year":"2011","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.isci.2022.104609_bib23","doi-asserted-by":"crossref","first-page":"104590","DOI":"10.1016\/j.nbd.2019.104590","article-title":"TrkB agonistic antibodies superior to BDNF: utility in treating motoneuron degeneration","volume":"132","author":"Guo","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2022.104609_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.nbd.2019.04.009","article-title":"Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury","volume":"127","author":"Han","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2022.104609_bib25","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1176\/appi.ajp.163.3.534","article-title":"BDNF Val66Met polymorphism and GAD67 mRNA expression in the prefrontal cortex of subjects with schizophrenia","volume":"163","author":"Hashimoto","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib26","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/15622975.2018.1462532","article-title":"Plasma and serum brain-derived neurotrophic factor (BDNF) levels and their association with neurocognition in at-risk mental state, first episode psychosis and chronic schizophrenia patients","volume":"20","author":"Heitz","year":"2019","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib27","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuron.2008.09.024","article-title":"A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition","volume":"60","author":"Hong","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2022.104609_bib28","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.euroneuro.2014.05.011","article-title":"Effects of prenatal hypoxia on schizophrenia-related phenotypes in heterozygous reeler mice: a gene\u00d7environment interaction study","volume":"24","author":"Howell","year":"2014","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.isci.2022.104609_bib29","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5694\/j.1326-5377.1998.tb126782.x","article-title":"MJA practice essentials. Managing schizophrenia in the community","volume":"168","author":"Hustig","year":"1998","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.isci.2022.104609_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.nbd.2010.04.017","article-title":"An inverse relationship between cortisol and BDNF levels in schizophrenia: data from human postmortem and animal studies","volume":"39","author":"Issa","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2022.104609_bib31","first-page":"S160","article-title":"Balancing therapeutic safety and efficacy to improve clinical and economic outcomes in schizophrenia: a clinical overview","volume":"20","author":"Javitt","year":"2014","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.isci.2022.104609_bib32","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nn.2505","article-title":"Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons","volume":"13","author":"Ji","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib33","doi-asserted-by":"crossref","first-page":"19593","DOI":"10.1073\/pnas.0904289106","article-title":"Role of dysbindin in dopamine receptor trafficking and cortical GABA function","volume":"106","author":"Ji","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2022.104609_bib34","doi-asserted-by":"crossref","first-page":"12131","DOI":"10.1073\/pnas.1105296108","article-title":"A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in\u00a0vivo","volume":"108","author":"Jiao","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2022.104609_bib35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jneumeth.2014.02.001","article-title":"Burrowing and nest building behavior as indicators of well-being in mice","volume":"234","author":"Jirkof","year":"2014","journal-title":"J.\u00a0Neurosci. Meth."},{"key":"10.1016\/j.isci.2022.104609_bib36","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1476-5381.2011.01386.x","article-title":"Animal models of schizophrenia","volume":"164","author":"Jones","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2022.104609_bib37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/1469-8986.2004.00166.x","article-title":"Menstrual cycle phase effects on prepulse inhibition of acoustic startle","volume":"41","author":"Jovanovic","year":"2004","journal-title":"Psychophysiology"},{"key":"10.1016\/j.isci.2022.104609_bib38","doi-asserted-by":"crossref","first-page":"15067","DOI":"10.1038\/nrdp.2015.67","article-title":"Schizophrenia","volume":"1","author":"Kahn","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.isci.2022.104609_bib39","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuint.2008.11.005","article-title":"Maternal supply of BDNF to mouse fetal brain through the placenta","volume":"54","author":"Kodomari","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.isci.2022.104609_bib40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.104609_bib41","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/npp.2009.195","article-title":"Evidence for a role of progesterone in menstrual cycle-related variability in prepulse inhibition in healthy young women","volume":"35","author":"Kumari","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2022.104609_bib42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0893-133X(00)00137-8","article-title":"To model a psychiatric disorder in animals: schizophrenia as a reality test","volume":"23","author":"Lipska","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2022.104609_bib43","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/363350a0","article-title":"Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF","volume":"363","author":"Lohof","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104609_bib44","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nn1971","article-title":"New insights into BDNF function in depression and anxiety","volume":"10","author":"Martinowich","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib45","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1038\/npp.2015.349","article-title":"Functional role of BDNF production from unique promoters in aggression and serotonin signaling","volume":"41","author":"Maynard","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2022.104609_bib46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/oxfordjournals.schbul.a006887","article-title":"Neural development, cell-cell signaling, and the \"two-hit\" hypothesis of schizophrenia","volume":"27","author":"Maynard","year":"2001","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.isci.2022.104609_bib47","doi-asserted-by":"crossref","first-page":"E1168","DOI":"10.1152\/ajpendo.00205.2018","article-title":"Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice","volume":"315","author":"McAllan","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2022.104609_bib48","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/07853890310010005","article-title":"The neurodevelopmental hypothesis of schizophrenia: a review of recent developments","volume":"35","author":"McGrath","year":"2003","journal-title":"Ann. Med."},{"key":"10.1016\/j.isci.2022.104609_bib49","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1017\/S0033291714001378","article-title":"The onset and offset of psychosis--and what happens in between--a commentary on 'Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 Study' by Morgan et\u00a0al. (2014)","volume":"44","author":"McGrath","year":"2014","journal-title":"Psychol. Med."},{"key":"10.1016\/j.isci.2022.104609_bib50","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1176\/ajp.138.4.478","article-title":"Animal models of schizophrenia","volume":"138","author":"McKinney","year":"1981","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pneurobio.2009.10.018","article-title":"Epidemiology-driven neurodevelopmental animal models of schizophrenia","volume":"90","author":"Meyer","year":"2010","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.isci.2022.104609_bib52","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1001\/archpsyc.64.8.978-a","article-title":"CUtLASS confirms CATIE","volume":"64","author":"Mintz","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib53","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/sj.mp.4000865","article-title":"Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia","volume":"6","author":"Molteni","year":"2001","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0920-9964(02)00349-3","article-title":"Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis","volume":"62","author":"Nanko","year":"2003","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.isci.2022.104609_bib55","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/sj.mp.4001575","article-title":"BDNF gene is a risk factor for schizophrenia in a Scottish population","volume":"10","author":"Neves-Pereira","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/mp.2010.106","article-title":"Dysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine\/D2 pathways","volume":"17","author":"Papaleo","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib57","doi-asserted-by":"crossref","first-page":"4859","DOI":"10.1523\/JNEUROSCI.4632-15.2016","article-title":"Behavioral, neurophysiological, and synaptic impairment in a transgenic Neuregulin1 (NRG1-IV) murine schizophrenia model","volume":"36","author":"Papaleo","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib58","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.mcn.2004.11.010","article-title":"Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in\u00a0vivo","volume":"28","author":"Pattabiraman","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib59","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neulet.2011.01.039","article-title":"Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: a positive correlation","volume":"491","author":"Pedrini","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.isci.2022.104609_bib60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.placenta.2016.11.010","article-title":"Maternal obesity alters brain derived neurotrophic factor (BDNF) signaling in the placenta in a sexually dimorphic manner","volume":"49","author":"Prince","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.isci.2022.104609_bib61","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ygeno.2007.05.004","article-title":"Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters","volume":"90","author":"Pruunsild","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/j.isci.2022.104609_bib62","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nbd.2015.03.011","article-title":"Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder","volume":"77","author":"Reinhart","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.isci.2022.104609_bib63","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1139\/jpn.0334","article-title":"Understanding antipsychotic \"atypicality\": a clinical and pharmacological moving target","volume":"28","author":"Remington","year":"2003","journal-title":"J.\u00a0Psychiatry Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib64","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41380-019-0530-1","article-title":"KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits","volume":"25","author":"Ren","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib65","doi-asserted-by":"crossref","first-page":"15103","DOI":"10.1073\/pnas.1222872110","article-title":"Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance","volume":"110","author":"Sakata","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2022.104609_bib66","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1073\/pnas.0811431106","article-title":"Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex","volume":"106","author":"Sakata","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.isci.2022.104609_bib67","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104609_bib68","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/npp.2014.95","article-title":"Neurodevelopment, GABA system dysfunction, and schizophrenia","volume":"40","author":"Schmidt","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.isci.2022.104609_bib69","first-page":"e52434","article-title":"Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice","author":"Seibenhener","year":"2015","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.isci.2022.104609_bib70","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ajmg.b.30275","article-title":"The involvement of ErbB4 with schizophrenia: association and expression studies","volume":"141B","author":"Silberberg","year":"2006","journal-title":"Am. J. Med. Genet. B. Neuropsychiatr. Genet."},{"key":"10.1016\/j.isci.2022.104609_bib71","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/mp.2017.144","article-title":"BDNF at the synapse: why location matters","volume":"22","author":"Song","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib72","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/jama.294.5.557","article-title":"Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961","volume":"294","author":"St Clair","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2022.104609_bib73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1017\/S1092852918001013","article-title":"Beyond the dopamine hypothesis of schizophrenia to three neural networks of psychosis: dopamine, serotonin, and glutamate","volume":"23","author":"Stahl","year":"2018","journal-title":"CNS Spectr."},{"key":"10.1016\/j.isci.2022.104609_bib74","first-page":"140","article-title":"Schizophrenia after prenatal exposure to the Dutch hunger winter of 1944-1945","volume":"9","author":"Susser","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib75","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jpsychires.2011.12.005","article-title":"Hippocampal volume and the AKT signaling system in first-episode schizophrenia","volume":"46","author":"Szamosi","year":"2012","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.isci.2022.104609_bib76","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0920-9964(02)00505-4","article-title":"The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia","volume":"65","author":"Szekeres","year":"2003","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.isci.2022.104609_bib77","first-page":"51785","article-title":"Behavioral and locomotor measurements using an open field activity monitoring system for skeletal muscle diseases","author":"Tatem","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.isci.2022.104609_bib78","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1503\/jpn.100048","article-title":"Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders","volume":"36","author":"Ray","year":"2011","journal-title":"J.\u00a0Psychiatry Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib79","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10519-006-9120-5","article-title":"Animal models relevant to schizophrenia and autism: validity and limitations","volume":"37","author":"Tordjman","year":"2007","journal-title":"Behav. Genet."},{"key":"10.1016\/j.isci.2022.104609_bib80","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizophrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104609_bib81","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.biopsych.2006.03.030","article-title":"Altered prefrontal cortical metabolic response to mesocortical activation in adult animals with a neonatal ventral hippocampal lesion","volume":"60","author":"Tseng","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib82","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/s41591-018-0021-y","article-title":"Convergence of placenta biology and genetic risk for schizophrenia","volume":"24","author":"Ursini","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2022.104609_bib83","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nature09563","article-title":"The environment and schizophrenia","volume":"468","author":"van Os","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104609_bib84","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/sj.mp.4001678","article-title":"Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia","volume":"10","author":"Weickert","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib85","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.euroneuro.2013.11.008","article-title":"Social interaction and social withdrawal in rodents as readouts for investigating the negative symptoms of schizophrenia","volume":"24","author":"Wilson","year":"2014","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.isci.2022.104609_bib86","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/schbul\/sbr070","article-title":"Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia","volume":"39","author":"Wong","year":"2013","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.isci.2022.104609_bib87","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuroscience.2012.10.024","article-title":"Sex differences and the role of estrogen in animal models of schizophrenia: interaction with BDNF","volume":"239","author":"Wu","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2022.104609_bib88","doi-asserted-by":"crossref","first-page":"6888","DOI":"10.1523\/JNEUROSCI.20-18-06888.2000","article-title":"The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB","volume":"20","author":"Xu","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib89","doi-asserted-by":"crossref","first-page":"108412","DOI":"10.1016\/j.neuropharm.2020.108412","article-title":"mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress","volume":"184","author":"Xu","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.isci.2022.104609_bib90","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3390\/ijms18081689","article-title":"New targets for schizophrenia treatment beyond the dopamine hypothesis","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2022.104609_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12991-015-0084-9","article-title":"Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia","volume":"15","author":"Yoshimura","year":"2016","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.isci.2022.104609_bib92","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.molmet.2019.11.013","article-title":"A subpopulation of Bdnf-e1\u2013expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control","volume":"31","author":"You","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2022.104609_bib93","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jad.2009.10.017","article-title":"Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia","volume":"124","author":"Yuan","year":"2010","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.isci.2022.104609_bib94","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1523\/JNEUROSCI.2180-18.2019","article-title":"Chronic suppression of glucagon-like peptide-1 receptor (GLP1R) mRNA translation in the rat bed nucleus of the stria terminalis reduces anxiety-like behavior and stress-induced hypophagia, but prolongs stress-induced elevation of plasma corticosterone","volume":"39","author":"Zheng","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104609_bib95","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/YPG.0b013e32801119da","article-title":"Brain-derived neurotrophic factor gene polymorphisms and schizophrenia: a meta-analysis","volume":"17","author":"Zintzaras","year":"2007","journal-title":"Psychiatr. Genet."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222008811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222008811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T16:51:34Z","timestamp":1762879894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222008811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":95,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S2589004222008811"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.104609","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.104609","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"104609"}}