{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:25:58Z","timestamp":1778739958328,"version":"3.51.4"},"reference-count":82,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["ERCCoG-2017-773067"],"award-info":[{"award-number":["ERCCoG-2017-773067"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000738","name":"University of Leicester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.isci.2022.104746","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T02:51:07Z","timestamp":1658371867000},"page":"104746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Physiological changes throughout an insect ear due to age and noise - A longitudinal study"],"prefix":"10.1016","volume":"25","author":[{"given":"Alix","family":"Blockley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Ogle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlie","family":"Woodrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Montealegre-Z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7871-0091","authenticated-orcid":false,"given":"Ben","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.104746_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnins.2019.00077","article-title":"Age-related hearing loss is accelerated by repeated short-duration loud spound stimulation","volume":"13","author":"Alvarado","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib2","first-page":"1","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J.\u00a0Stat. Softw."},{"key":"10.1016\/j.isci.2022.104746_bib3","series-title":"Noise and Hearing Loss in: National Institutes of Health","author":"Bethesda","year":"1990"},{"key":"10.1016\/j.isci.2022.104746_bib4","first-page":"505","article-title":"Degeneration in the cochlea after noise damage: primary versus secondary events","volume":"21","author":"Bohne","year":"2000","journal-title":"Am. J. Otol."},{"key":"10.1016\/j.isci.2022.104746_bib5","doi-asserted-by":"crossref","first-page":"102486","DOI":"10.1016\/j.isci.2021.102486","article-title":"Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear","volume":"24","author":"Boyd-Gibbins","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.isci.2022.104746_bib78","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1085\/jgp.201511458","article-title":"The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells","volume":"146","author":"Beurg","year":"2015","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.isci.2022.104746_bib6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1177\/000348948509400116","article-title":"Age-related cochlear hair cell loss in the chinchilla","volume":"94","author":"Bhattacharyya","year":"1985","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib8","series-title":"Annals of Occupational Hygiene","article-title":"Hearing and noise in industry","author":"Burns","year":"1970"},{"key":"10.1016\/j.isci.2022.104746_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-5955(02)00802-X","article-title":"The relationship between noise-induced hearing loss and hair cell loss in rats","volume":"177","author":"Chen","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2022.104746_bib10","first-page":"81","article-title":"Effects of moderate noise exposure on hearing function in C57BL\/6J mice","volume":"9","author":"Chuang","year":"2014","journal-title":"J.\u00a0Otolaryngol."},{"key":"10.1016\/j.isci.2022.104746_bib11","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1121\/1.1903409","article-title":"Noise-induced haring loss in the chinchilla, as determined by a postive-reinforecement technqiue","volume":"56","author":"Clark","year":"1974","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.isci.2022.104746_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/00016487609120860","article-title":"Hair cell loss as a fucntion of age in the normal cochlea of the Guinea pig","volume":"82","author":"Coleman","year":"1976","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.isci.2022.104746_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1001\/archotol.77.4.53","article-title":"Age and sex diffeences in pure-tone thresholds. Survey and hearing levels from 18 to 65 years","volume":"77","author":"Corso","year":"1963","journal-title":"Arch. Otolaryngol."},{"key":"10.1016\/j.isci.2022.104746_bib14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/geronj\/31.1.58","article-title":"Auditory summation in resbyacusis and noise exposure","volume":"31","author":"Corso","year":"1976","journal-title":"J.\u00a0Gerontol."},{"key":"10.1016\/j.isci.2022.104746_bib15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/00206098009072664","article-title":"Age correction factor in noise-induced hearing loss: a quantitative model","volume":"19","author":"Corso","year":"1980","journal-title":"Audiology"},{"key":"10.1016\/j.isci.2022.104746_bib16","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/000348948609500513","article-title":"Comparative study of age-related cochlear hair cell loss","volume":"95","author":"Dayal","year":"1986","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/275213a0","article-title":"Adaptive value, entropy and survivorship curves","volume":"275","author":"Demetrius","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104746_bib18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1177\/000348947108000615","article-title":"Behavioural and ultrastructural correlates of acoustic trauma","volume":"80","author":"Dixon","year":"1971","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0378-5955(93)90125-K","article-title":"Neuronal degeneration of primary cochlear nad vestibular innervations after local injection of sisomicin in the Guinea pig","volume":"68","author":"Dupont","year":"1993","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2022.104746_bib20","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1121\/1.3466878","article-title":"Longitudinal changes in hearing sensitivity among men: the veterans affaris normative aging study","volume":"128","author":"Echt","year":"1998","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.isci.2022.104746_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/000348947408300109","article-title":"Senile changes in the middle ear joints","volume":"83","author":"Etholm","year":"1974","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib22","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.1523\/JNEUROSCI.5138-14.2015","article-title":"Aging after noise exposure: acceleration of cochlear synaptopathy in \u201crecovered\u201d ears","volume":"35","author":"Fernandez","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib23","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1523\/JNEUROSCI.2282-12.2013","article-title":"Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense","volume":"33","author":"Fetoni","year":"2013","journal-title":"J.\u00a0Neurosci."},{"issue":"6","key":"10.1016\/j.isci.2022.104746_bib81","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1152\/jn.00119.2021","article-title":"Gene transcription changes in a locust model of noise-induced deafness","volume":"125","author":"French","year":"2021","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.isci.2022.104746_bib25","first-page":"228","article-title":"The neurometabolic cascase of concussion","volume":"36","author":"Giza","year":"2001","journal-title":"J.\u00a0Athl. Train."},{"key":"10.1016\/j.isci.2022.104746_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/2041-210X.12504","article-title":"simr: an R package for power analysis of generalisd linear mixed models by simulation","volume":"7","author":"Green","year":"2016","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.isci.2022.104746_bib77","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00606437","article-title":"The physiology of locust auditory receptors. I. Discrete depolarisations of receptor cells.","volume":"152","author":"Hill","year":"1983","journal-title":"J. Comp. Physiol. A"},{"key":"10.1016\/j.isci.2022.104746_bib27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00003446-199602000-00002","article-title":"Aging effects in multifrequency tympanometry","volume":"17","author":"Holte","year":"1996","journal-title":"Ear Hear."},{"key":"10.1016\/j.isci.2022.104746_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.heares.2011.03.009","article-title":"A behavioural meausre of the cochlear changes underlying temporary threshold shifts","volume":"277","author":"Howgate","year":"2011","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2022.104746_bib29","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/(SICI)1097-010X(19990215)283:3<270::AID-JEZ5>3.0.CO;2-C","article-title":"Tympanal receptor cells of Schistocerca gregaria: correlation of soma positions and dendrite attachment sites, central projections and physiologies","volume":"283","author":"Jacobs","year":"1999","journal-title":"J.\u00a0Exp. Zool."},{"key":"10.1016\/j.isci.2022.104746_bib30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1113\/JP280256","article-title":"Biophysical nad morphological changes in inner hair cells and their efferent innervation in the aging mouse cochlea","volume":"599","author":"Jeng","year":"2020","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.isci.2022.104746_bib31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/000348947208100203","article-title":"Sensory and neural degeneration with aging, as seen in icrodissections of the human inner ear","volume":"81","author":"Johnson","year":"1972","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-64498-z","article-title":"Homeostatic maintenance and age-related functional decline in the Drosophila ear","volume":"10","author":"Keder","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.isci.2022.104746_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0378-5955(82)90017-X","article-title":"Hair cell counts in an age-graded series of rat cochleas","volume":"8","author":"Keithley","year":"1982","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2022.104746_bib33","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1523\/JNEUROSCI.4985-05.2006","article-title":"Acceleration of age-related hearing loss by early noise exposure: evidence of a misspend youth","volume":"26","author":"Kujawa","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib34","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","article-title":"Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss","volume":"29","author":"Kujawa","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.heares.2015.02.009","article-title":"Synaptopathy in the noise-exposed and aging cochlea: primary neural degeneration in acquired sensorineural hearing loss","volume":"330","author":"Kujawa","year":"2015","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2022.104746_bib36","first-page":"1","article-title":"Package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J.\u00a0Stat. Softw."},{"key":"10.1016\/j.isci.2022.104746_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0378-5955(93)90060-E","article-title":"Auditory degenreation after acoustic trauma in two genotypes of mice","volume":"68","author":"Li","year":"1993","journal-title":"Hear. Res."},{"key":"10.1016\/j.isci.2022.104746_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000276611","article-title":"Age-related degeneration of the organ of corti in two genotypes of mice","volume":"56","author":"Li","year":"1994","journal-title":"ORL. J. Otorhinolaryngol. Relat. Spec."},{"key":"10.1016\/j.isci.2022.104746_bib39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/00016487909137156","article-title":"Hair cell condition and auditory nerve response in normal and noise-damaged cochleas","volume":"88","author":"Liberman","year":"1978","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.isci.2022.104746_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3109\/00206097109072569","article-title":"Noise-induced hearing loss and prebyacusis","volume":"10","author":"Macrae","year":"1971","journal-title":"Audiology"},{"key":"10.1016\/j.isci.2022.104746_bib41","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2003.10.031","article-title":"Tome course of efferent fibre and spiral ganglion cell degeneration following complete hair cell loss in the chincilla","volume":"997","author":"McFadden","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2022.104746_bib42","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/220585a0","article-title":"Frequency discrimination in the locust ear by means of four groups of receptor cells","volume":"220","author":"Michelsen","year":"1968","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104746_bib43","first-page":"117","article-title":"Interaction of noise-induced hearing loss and prebyacusis","volume":"48","author":"Mills","year":"1998","journal-title":"Scand. Audiol. Suppl."},{"issue":"13","key":"10.1016\/j.isci.2022.104746_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109758","article-title":"A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma","volume":"36","author":"Milon","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.104746_bib44","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00359-007-0239-5","article-title":"The generation of DPOAEs in the locust ear is contingent upon the sensory neurons","volume":"193","author":"M\u00f6ckel","year":"2007","journal-title":"J.\u00a0Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol."},{"key":"10.1016\/j.isci.2022.104746_bib45","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/05384916909079071","article-title":"Acoustic trauma and presbyacusis","volume":"8","author":"Mollica","year":"1969","journal-title":"Int. Audiol."},{"key":"10.1016\/j.isci.2022.104746_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00456301","article-title":"Hearing loss and cochlear pathology in the monkey (Macaca) following exposure to high levels of noise","volume":"220","author":"Moody","year":"1978","journal-title":"Arch. Otorhinolaryngol."},{"key":"10.1016\/j.isci.2022.104746_bib83","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF00456301","article-title":"Hearing loss and cochlear pathology in the monkey (Macaca) following exposure to high levels of noise","volume":"220","author":"Moody","year":"1978","journal-title":"Arch. Oto. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib47","first-page":"504","article-title":"Bridging the gap between mammla and insect ears \u2013 a comparative and evolutionary view of sound-reception","volume":"9","author":"Nowotny","year":"2021","journal-title":"Front. Ecol. Evol."},{"key":"10.1016\/j.isci.2022.104746_bib48","doi-asserted-by":"crossref","first-page":"e42714","DOI":"10.4025\/actasciagron.v41i1.42714","article-title":"Insecticide resistance and control failure likelihood among populations of the boll weevil (Anthonomus grandis) from Mata Gtosso (Brazil)","volume":"41","author":"Oliveira-Marra","year":"2019","journal-title":"Acta Sci. Agron."},{"issue":"3","key":"10.1016\/j.isci.2022.104746_bib79","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.neuron.2013.06.019","article-title":"TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear","volume":"79","author":"Pan","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2022.104746_bib49","series-title":"Hearing Loss Due to Exposure to Steady-State Broadband Noise, Report No. 35 and Supplement to Report No. 35","author":"Passchier-Vermeer","year":"1968"},{"issue":"Supplement to Report No. 35","key":"10.1016\/j.isci.2022.104746_bib80","article-title":"earing loss due to exposure to steady-state broadband noise","volume":"Report No. 35","author":"Passchier-Vermeer","year":"1968","journal-title":"Institute for Public Health Engineering, The Netherlands"},{"key":"10.1016\/j.isci.2022.104746_bib50","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1121\/1.1903482","article-title":"Hearing loss due to exposure to steady-state broadband noise","volume":"56","author":"Passchier-Vermeer","year":"1974","journal-title":"J.\u00a0Acoust. Soc. Am."},{"key":"10.1016\/j.isci.2022.104746_bib51","series-title":"Report B367","article-title":"Hearing levels of non-noise exposed subjects and of suubjects exposed to constant noise during working hours","author":"Passchier-Vermeer","year":"1977"},{"key":"10.1016\/j.isci.2022.104746_bib52","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1073\/pnas.1116981109","article-title":"Mechanisms contributing to central excitability changes during hearing loss","volume":"109","author":"Pilati","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.104746_bib53","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/00016487309125498","article-title":"The relationship between permamnent threshold shift and the loss of hair cells in monkeys exposed to impulse noise","volume":"312","author":"Pinheiro","year":"1973","journal-title":"Acta Otolaryngol. Suppl."},{"key":"10.1016\/j.isci.2022.104746_bib54","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/019459988910000105","article-title":"Is there a conductive type of presbyacussis?","volume":"100","author":"Ramadan","year":"1989","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2022.104746_bib55","doi-asserted-by":"crossref","first-page":"e0146021","DOI":"10.1371\/journal.pone.0146021","article-title":"Dose-response analysis using R","volume":"10","author":"Ritz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2022.104746_bib86","article-title":"Analysis of Dose-Response Curves","author":"Ritz","year":"2016","journal-title":"RStudio"},{"key":"10.1016\/j.isci.2022.104746_bib56","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/s41598-018-19803-2","article-title":"Early bone aging in human auditory ossicles is accompanied by excessive hypermineralization, osteocytle death and micropetrosis","volume":"8","author":"Rolvien","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.104746_bib57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00663438","article-title":"Die Informationsverarbeitung tympanler Rezeptorelemente von Locusta migratoria (Arcrididae, Orthoptera)","volume":"109","author":"R\u00f6mer","year":"1976","journal-title":"J.\u00a0Comp. Physiol."},{"key":"10.1016\/j.isci.2022.104746_bib85","article-title":"RStudio: Integrated Development Environment for R","author":"RStudio Team","year":"2021","journal-title":"RStudio Team"},{"key":"10.1016\/j.isci.2022.104746_bib58","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1001\/archotol.1991.01870180063013","article-title":"Age realted morphologic changes in the human tympanic membrane","volume":"117","author":"Ruah","year":"1991","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.isci.2022.104746_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)04090-8","article-title":"Upregulated iNOS and oxidative damage to the cochlear stria vascularis due to noise stress","volume":"967","author":"Shi","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2022.104746_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/00034894931020S101","article-title":"Cochlear pathology in presbycusis","volume":"102","author":"Schuknecht","year":"1993","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib61","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1288\/00005537-197410000-00012","article-title":"Atrophy of the stria vascularis, a common cause for hearing loss","volume":"84","author":"Schuknecht","year":"1974","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2022.104746_bib62","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1523\/JNEUROSCI.3977-13.2014","article-title":"Auditory nerve perinodal dysmyelination in noise-induced hearing loss","volume":"34","author":"Tagoe","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1044\/jshr.2201.29","article-title":"Acoustic admittance and the aging ear","volume":"22","author":"Thompson","year":"1979","journal-title":"J.\u00a0Speech Hear. Res."},{"key":"10.1016\/j.isci.2022.104746_bib64","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/000348948509400117","article-title":"Changing relationships between structure and function in the cochlea during recovery from intense sound exposure","volume":"94","author":"Thorne","year":"1985","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.isci.2022.104746_bib65","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10162-016-0596-2","article-title":"Longitudinal changes in audiometirc phenotypes of age-related hearing loss","volume":"18","author":"Vaden","year":"2017","journal-title":"J.\u00a0Assoc. Res. Otolaryngol."},{"key":"10.1016\/j.isci.2022.104746_bib66","first-page":"4033","article-title":"Plasmodium infection decreases fecundity and increases survival of mosquitoes","volume":"279","author":"V\u00e9zilier","year":"2012","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.isci.2022.104746_bib67","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3950\/jibiinkoka.97.898","article-title":"The effect of aging on middle ear dynamic characteristics","volume":"97","author":"Wada","year":"1994","journal-title":"Nihon Jibiinkoka Gakkai Kaiho"},{"key":"10.1016\/j.isci.2022.104746_bib68","doi-asserted-by":"crossref","first-page":"14487","DOI":"10.1038\/ncomms14487","article-title":"Transient auditory neve demylination as a new mechannism for hidden hearing loss","volume":"8","author":"Wan","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.104746_bib69","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0960-9822(02)01144-2","article-title":"Drosophila atonal fully rescues the phenotype of Math1 null mice: new functions evolve in new cellular contexts","volume":"12","author":"Wang","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2022.104746_bib70","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1523\/JNEUROSCI.2310-17.2018","article-title":"The role of the mechanotransduction ion channel candidate nanchung-inactive in auditory transduction in an insect ear","volume":"38","author":"Warren","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib71","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1523\/JNEUROSCI.2279-19.2019","article-title":"Physioloigcal basis of noise-induced hearing loss in a tympanal ear","volume":"40","author":"Warren","year":"2020","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib73","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neuroscience.2018.07.053","article-title":"Primary neural degeneration in the human cochlea: evidence for hidden hearing loss in the aging ear","volume":"407","author":"Wu","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2022.104746_bib74","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1523\/JNEUROSCI.0937-20.2020","article-title":"Age-related hearing loss is dominated by damage to inner ear sensory cells, bot the cellular battery that powers them","volume":"40","author":"Wu","year":"2020","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.104746_bib75","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fncel.2015.00276","article-title":"Afe-related hearing impariment and the triad of acquired hearing loss","volume":"9","author":"Yang","year":"2015","journal-title":"Front. Cell. Neurosci."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222010185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222010185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:01:52Z","timestamp":1762880512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222010185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":82,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2589004222010185"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.104746","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiological changes throughout an insect ear due to age and noise - A longitudinal study","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.104746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2022","name":"copyright","label":"Copyright"}],"article-number":"104746"}}