{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:09:30Z","timestamp":1789002570341,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/STaR\/0029\/2017"],"award-info":[{"award-number":["NMRC\/STaR\/0029\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-CIRG18nov-0002"],"award-info":[{"award-number":["MOH-CIRG18nov-0002"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020025","name":"National Heart Centre Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018059","name":"Tanoto Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018059","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018247","name":"GOH Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018247","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.isci.2022.104806","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T12:50:58Z","timestamp":1658321458000},"page":"104806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["IL11 stimulates ERK\/P90RSK to inhibit LKB1\/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-7608","authenticated-orcid":false,"given":"Anissa A.","family":"Widjaja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivakumar","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Goh","family":"Wei Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamini G.","family":"Shekeran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Carling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wen","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.104806_bib1","doi-asserted-by":"crossref","first-page":"eabg6497","DOI":"10.1126\/sciadv.abg6497","article-title":"Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration","volume":"7","author":"Allanki","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2022.104806_bib2","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.01907","article-title":"The Snail genes as inducers of cell movement and survival: implications in development and cancer","volume":"132","author":"Barrallo-Gimeno","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.isci.2022.104806_bib3","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/ncb2117","article-title":"Primary cilia regulate mTORC1 activity and cell size through Lkb1","volume":"12","author":"Boehlke","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2022.104806_bib4","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1242\/dev.078543","article-title":"The regenerative capacity of the zebrafish heart is dependent on TGF\u03b2 signaling","volume":"139","author":"Chablais","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.isci.2022.104806_bib5","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-med-041818-011649","article-title":"Hiding in plain sight: interleukin-11 emerges as a master regulator of fibrosis, tissue integrity, and stromal inflammation","volume":"71","author":"Cook","year":"2020","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.isci.2022.104806_bib53","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1472-6750-12-8","article-title":"A designer hyper interleukin 11 (H11) is a biologically active cytokine","volume":"12","author":"Dams-Kozlowska","year":"2012","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.isci.2022.104806_bib6","doi-asserted-by":"crossref","first-page":"15106","DOI":"10.1073\/pnas.1900475116","article-title":"Deep evolutionary origin of limb and fin regeneration","volume":"116","author":"Darnet","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.104806_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1074\/jbc.M806153200","article-title":"Characterization of an alternative splice variant of LKB1","volume":"284","author":"Denison","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2022.104806_bib8","doi-asserted-by":"crossref","first-page":"e68843","DOI":"10.7554\/eLife.68843","article-title":"The pro-regenerative effects of HyperIL6\u00a0in drug induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling","volume":"10","author":"Dong","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.isci.2022.104806_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41467-020-20303-z","article-title":"Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH","volume":"12","author":"Dong","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.104806_bib10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bbrc.2008.01.099","article-title":"Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts","volume":"368","author":"Du","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2022.104806_bib11","first-page":"2021","article-title":"Interleukin-11 drives human and mouse alcohol-related liver disease","author":"Effenberger","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.isci.2022.104806_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1196371","article-title":"Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy","volume":"331","author":"Egan","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.104806_bib13","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1158\/1078-0432.CCR-13-2492","article-title":"Molecular pathways: IL11 as a tumor-promoting cytokine-translational implications for cancers","volume":"20","author":"Ernst","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.isci.2022.104806_bib14","doi-asserted-by":"crossref","first-page":"E2700","DOI":"10.3390\/ijms20112700","article-title":"ERK pathway in activated, myofibroblast-like, hepatic stellate cells: a critical signaling crossroad sustaining liver fibrosis","volume":"20","author":"Foglia","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2022.104806_bib15","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1128\/MCB.01218-10","article-title":"Hepatocyte-derived Snail1 propagates liver fibrosis progression","volume":"31","author":"Grant Rowe","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2022.104806_bib16","doi-asserted-by":"crossref","first-page":"22162","DOI":"10.1016\/S0021-9258(17)31770-2","article-title":"Critical phosphorylation sites for acetyl-CoA carboxylase activity","volume":"269","author":"Ha","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2022.104806_bib17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1681\/ASN.2014121181","article-title":"Deletion of Lkb1 in renal tubular epithelial cells leads to CKD by altering metabolism","volume":"27","author":"Han","year":"2016","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2022.104806_bib18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1741-7007-11-36","article-title":"LKB1 and AMPK and the cancer-metabolism link - ten years after","volume":"11","author":"Hardie","year":"2013","journal-title":"BMC Biol."},{"key":"10.1016\/j.isci.2022.104806_bib19","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/s41556-019-0346-x","article-title":"Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments","volume":"21","author":"Janiszewska","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2022.104806_bib20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.mce.2013.05.021","article-title":"Hepatic ERK activity plays a role in energy metabolism","volume":"375","author":"Jiao","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.isci.2022.104806_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/BJ20131673","article-title":"A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and other AMPK activators","volume":"460","author":"Lai","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.isci.2022.104806_bib22","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1172\/JCI29044","article-title":"AMP-activated protein kinase signaling in metabolic regulation","volume":"116","author":"Long","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.104806_bib23","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2022.104806_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature13556","article-title":"Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity","volume":"514","author":"Marusyk","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104806_bib25","doi-asserted-by":"crossref","first-page":"718942","DOI":"10.3389\/fendo.2021.718942","article-title":"A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan","volume":"12","author":"Mohammed","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2022.104806_bib26","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/s41467-021-22450-3","article-title":"Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer","volume":"12","author":"Nishina","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.104806_bib27","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1172\/JCI93597","article-title":"Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK\/STAT3 pathway","volume":"128","author":"Ollila","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.104806_bib28","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s41591-018-0087-6","article-title":"Metformin reverses established lung fibrosis in a bleomycin model","volume":"24","author":"Rangarajan","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2022.104806_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jim.2006.07.009","article-title":"Development of an in\u00a0vitro potency assay for therapeutic TGFbeta antagonists: the A549 cell bioassay","volume":"316","author":"Rapoza","year":"2006","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.isci.2022.104806_bib30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/bj3620481","article-title":"Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1\/STK11, the protein kinase mutated in Peutz\u2013Jeghers cancer syndrome","volume":"362","author":"Sapkota","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.isci.2022.104806_bib31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature24676","article-title":"IL-11 is a crucial determinant of cardiovascular fibrosis","volume":"552","author":"Schafer","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104806_bib32","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.jhep.2016.02.004","article-title":"IL-6 pathway in the liver: from physiopathology to therapy","volume":"64","author":"Schmidt-Arras","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.isci.2022.104806_bib52","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods."},{"key":"10.1016\/j.isci.2022.104806_bib33","doi-asserted-by":"crossref","first-page":"11175","DOI":"10.1073\/pnas.1016122108","article-title":"Glycogen synthase kinase 3\u03b2-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration","volume":"108","author":"Sekiya","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.104806_bib34","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2022.104806_bib35","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1126\/science.1120781","article-title":"The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin","volume":"310","author":"Shaw","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.104806_bib36","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1016\/j.celrep.2019.05.077","article-title":"Modeling of fibrotic lung disease using 3D organoids derived from human pluripotent stem cells","volume":"27","author":"Strikoudis","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.104806_bib37","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41586-019-1897-5","article-title":"TGF-\u03b2 orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1","volume":"577","author":"Su","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104806_bib38","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.ajpath.2015.04.014","article-title":"Activation of AMP-activated protein\u00a0kinase prevents TGF-\u03b21-induced epithelial-mesenchymal transition and myofibroblast activation","volume":"185","author":"Thakur","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2022.104806_bib39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3390\/cancers14020429","article-title":"STAT3 signaling in breast cancer: multicellular actions and therapeutic potential","volume":"14","author":"To","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.isci.2022.104806_bib40","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41467-017-00594-5","article-title":"interleukin-11 induces and maintains progenitors of different cell lineages during Xenopus tadpole tail regeneration","volume":"8","author":"Tsujioka","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.104806_bib41","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1242\/jcs.032706","article-title":"Lkb1 is required for TGFbeta-mediated myofibroblast\u00a0differentiation","volume":"121","author":"Vaahtomeri","year":"2008","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.isci.2022.104806_bib42","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.1002\/cpz1.251","article-title":"Critical conditions for studying interleukin-11 signaling in\u00a0vitro and avoiding experimental artefacts","volume":"1","author":"Viswanathan","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.isci.2022.104806_bib43","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1742-4658.2005.04544.x","article-title":"Cloning and expression of the first nonmammalian interleukin-11 gene in rainbow trout Oncorhynchus mykiss","volume":"272","author":"Wang","year":"2005","journal-title":"FEBS J."},{"key":"10.1016\/j.isci.2022.104806_bib44","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1681\/ASN.2021040577","article-title":"A neutralizing IL-11 antibody improves renal function and increases lifespan in a mouse model of alport syndrome","volume":"33","author":"Widjaja","year":"2022","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2022.104806_bib45","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1053\/j.gastro.2019.05.002","article-title":"Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of non-alcoholic steatohepatitis","volume":"157","author":"Widjaja","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2022.104806_bib46","doi-asserted-by":"crossref","first-page":"eaba8146","DOI":"10.1126\/scitranslmed.aba8146","article-title":"Redefining IL11 as a regeneration-limiting hepatotoxin and\u00a0therapeutic target in acetaminophen-induced liver injury","volume":"13","author":"Widjaja","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2022.104806_bib47","doi-asserted-by":"crossref","first-page":"740650","DOI":"10.3389\/fmolb.2021.740650","article-title":"Molecular dissection of pro-fibrotic IL11 signaling in cardiac and pulmonary fibroblasts","volume":"8","author":"Widjaja","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.isci.2022.104806_bib48","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1016\/j.celrep.2017.03.011","article-title":"Liver-specific activation of AMPK prevents steatosis on a high-fructose diet","volume":"18","author":"Woods","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.104806_bib49","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.1178377","article-title":"Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation","volume":"326","author":"Zeqiraj","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.104806_bib50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.molcel.2008.12.026","article-title":"Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation","volume":"33","author":"Zheng","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2022.104806_bib51","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1677\/JOE-09-0181","article-title":"Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats","volume":"203","author":"Zheng","year":"2009","journal-title":"J.\u00a0Endocrinol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222010781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222010781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:56:54Z","timestamp":1778900214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222010781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":53,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2589004222010781"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.104806","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL11 stimulates ERK\/P90RSK to inhibit LKB1\/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.104806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"104806"}}