{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:28:29Z","timestamp":1793104109792,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.isci.2022.104859","type":"journal-article","created":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T19:28:50Z","timestamp":1659814130000},"page":"104859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers"],"prefix":"10.1016","volume":"25","author":[{"given":"Yan-Ruide","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary Spencer","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaji","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.104859_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044219","article-title":"Xenogeneic graft-versus-host-disease in NOD-scid IL-2r\u03b3null mice display a T-effector memory phenotype","volume":"7","author":"Ali","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2022.104859_bib2","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1182\/blood-2004-08-3032","article-title":"Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ","volume":"105","author":"Anderson","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/35077251","article-title":"Haematopoietic cell transplantation as immunotherapy","volume":"411","author":"Appelbaum","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.104859_bib4","first-page":"53","article-title":"Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse","volume":"1","author":"Apperley","year":"1986","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.isci.2022.104859_bib5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s12272-019-01139-8","article-title":"Roles of NKT cells in cancer immunotherapy","volume":"42","author":"Bae","year":"2019","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.isci.2022.104859_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/bmt.2008.56","article-title":"Acute GvHD: pathogenesis and classification","volume":"41","author":"Ball","year":"2008","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.isci.2022.104859_bib7","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nri3369","article-title":"Invariant natural killer T\u00a0cells: an innate activation scheme linked to diverse effector functions","volume":"13","author":"Brennan","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1146\/annurev.immunol.22.012703.104608","article-title":"CD1: antigen presentation and T\u00a0cell function","volume":"22","author":"Brigl","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib10","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1182\/blood-2011-11-389304","article-title":"Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation","volume":"119","author":"Chaidos","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2006-12-022038","article-title":"The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia","volume":"110","author":"Chakraverty","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(09)01201-2","article-title":"Antigen presentation by CD1 lipids, T\u00a0cells, and NKT cells in microbial immunity","volume":"102","author":"Cohen","year":"2009","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib13","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1470735","article-title":"Human CD4- invariant NKT lymphocytes regulate graft versus host disease","volume":"7","author":"Coman","year":"2018","journal-title":"OncoImmunology"},{"key":"10.1016\/j.isci.2022.104859_bib14","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/j.celrep.2018.02.058","article-title":"Bimodal CD40\/fas-dependent crosstalk between iNKT cells and tumor-associated macrophages impairs prostate cancer progression","volume":"22","author":"Cortesi","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.104859_bib15","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-versus-host disease","volume":"373","author":"Ferrara","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2022.104859_bib16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fimmu.2013.00409","article-title":"NKT cells as an ideal anti-tumor immunotherapeutic","volume":"4","author":"Fujii","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib17","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/mt.2013.8","article-title":"Allelic exclusion and peripheral reconstitution by TCR transgenic T\u00a0cells arising from transduced human hematopoietic stem\/progenitor cells","volume":"21","author":"Giannoni","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.isci.2022.104859_bib18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nri2116","article-title":"Control points in NKT-cell development","volume":"7","author":"Godfrey","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib19","doi-asserted-by":"crossref","first-page":"605726","DOI":"10.3389\/fimmu.2021.605726","article-title":"GVHD prophylaxis 2020","volume":"12","author":"Gooptu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib20","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1182\/blood-2016-11-751065","article-title":"Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis","volume":"129","author":"Gorini","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1200\/JCO.2010.32.3865","article-title":"Update on therapy of chronic lymphocytic leukemia","volume":"29","author":"Gribben","year":"2011","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.isci.2022.104859_bib22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.bmt.1704582","article-title":"Recovery of V\u03b124+ NKT cells after hematopoietic stem cell transplantation","volume":"34","author":"Haraguchi","year":"2004","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.isci.2022.104859_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-immunol-102119-073227","article-title":"Current concepts and advances in graft-versus-host disease Immunology","volume":"39","author":"Hill","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1182\/blood.V75.3.555.555","article-title":"Graft-versus-leukemia reactions after bone marrow transplantation","volume":"75","author":"Horowitz","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib25","first-page":"2618","article-title":"Update of humanized animal disease models in studying Graft-versus-host disease","volume":"14","author":"Huang","year":"2018","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.isci.2022.104859_bib26","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1189\/jlb.1TA0214-121RR","article-title":"Technical advance: ascorbic acid induces development of double-positive T\u00a0cells from human hematopoietic stem cells in the absence of stromal cells","volume":"96","author":"Huijskens","year":"2014","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.isci.2022.104859_bib27","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41467-020-20658-3","article-title":"A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy","volume":"12","author":"Iriguchi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.104859_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/imm.12746","article-title":"Loss of natural killer T\u00a0cells promotes pancreatic cancer in LSL-Kras(G12D\/+) mice","volume":"152","author":"Janakiram","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.isci.2022.104859_bib29","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1172\/JCI133909","article-title":"Donor monocyte-derived macrophages promote human acute graft-versus-host disease","volume":"130","author":"Jardine","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.104859_bib30","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3389\/fimmu.2018.01519","article-title":"CD1d-Invariant natural killer T\u00a0cell-based cancer immunotherapy: \u03b1-galactosylceramide and beyond","volume":"9","author":"King","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2249.2009.03933.x","article-title":"Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex","volume":"157","author":"King","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib32","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1182\/blood-2009-03-211441","article-title":"TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors","volume":"114","author":"Kohrt","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fimmu.2018.00367","article-title":"The role of natural killer T\u00a0cells in cancer-A phenotypical and functional approach","volume":"9","author":"Krijgsman","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib34","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1146\/annurev.immunol.23.021704.115742","article-title":"Toward an understanding of NKT cell biology: progress and paradoxes","volume":"23","author":"Kronenberg","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib35","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.3389\/fimmu.2017.01858","article-title":"Natural killer T\u00a0cells: an ecological evolutionary developmental biology perspective","volume":"8","author":"Kumar","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib36","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1083-8791(03)00108-3","article-title":"Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versus-host disease: the role of CD1-reactive natural killer T\u00a0cells","volume":"9","author":"Lan","year":"2003","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.isci.2022.104859_bib37","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.4049\/jimmunol.167.4.2087","article-title":"Predominance of NK1.1\u00a0+ TCR\u03b1\u03b2\u00a0+ or DX5\u00a0+ TCR\u03b1\u03b2\u00a0+ T\u00a0cells in mice conditioned with fractionated lymphoid irradiation protects against graft-versus-host disease: \u201cnatural suppressor\u201d cells","volume":"167","author":"Lan","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib38","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1182\/blood-2005-11-4388","article-title":"Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus\/liver and CD34+ cell transplantation","volume":"108","author":"Lan","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib39","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1084\/jem.180.3.1097","article-title":"An invariant T\u00a0cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T\u00a0cells in mice and humans","volume":"180","author":"Lantz","year":"1994","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2022.104859_bib40","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.3390\/cancers14112749","article-title":"Targeting immunosuppressive tumor-associated macrophages using innate T\u00a0cells for enhanced antitumor reactivity","volume":"14","author":"Li","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.isci.2022.104859_bib41","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13287-022-02787-2","article-title":"Development of off - the - shelf hematopoietic stem cell - engineered invariant natural killer T\u00a0cells for COVID - 19 therapeutic intervention","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.isci.2022.104859_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123497","article-title":"Development of stem cell-derived immune cells for off-the-shelf cancer immunotherapies","volume":"10","author":"Li","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.isci.2022.104859_bib43","doi-asserted-by":"crossref","first-page":"100449","DOI":"10.1016\/j.xcrm.2021.100449","article-title":"Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy","volume":"2","author":"Li","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.isci.2022.104859_bib44","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa050642","article-title":"Protective conditioning for acute graft-versus-host disease","volume":"353","author":"Lowsky","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2022.104859_bib45","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s41375-020-0804-2","article-title":"Treatment and unmet needs in steroid-refractory acute graft-versus-host disease","volume":"34","author":"Malard","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2022.104859_bib46","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3389\/fimmu.2017.00900","article-title":"Invariant natural killer T\u00a0cells as suppressors of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation","volume":"8","author":"Mavers","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib47","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.stem.2018.12.011","article-title":"Organoid-induced differentiation of conventional T\u00a0cells from human pluripotent stem cells","volume":"24","author":"Montel-Hagen","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2022.104859_bib48","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1158\/1078-0432.CCR-06-2602","article-title":"The graft content of donor T\u00a0cells expressing gamma delta TCR+ and CD4+foxp3+ predicts the risk of acute graft versus host disease after transplantation of allogeneic peripheral blood stem cells from unrelated donors","volume":"13","author":"Pabst","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.isci.2022.104859_bib49","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1038\/s41409-020-0826-4","article-title":"The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy 2018: CAR-T\u2019s come into focus","volume":"55","author":"Passweg","year":"2020","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.isci.2022.104859_bib50","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.4049\/jimmunol.178.10.6242","article-title":"Host NKT cells can prevent graft-versus-host disease and permit graft antitumor activity after bone marrow transplantation","volume":"178","author":"Pillai","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib51","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1182\/blood.2019001696","article-title":"Pathogenic Bhlhe40+ GM-CSF+ CD4+ T\u00a0cells promote indirect alloantigen presentation in the GI tract during GVHD","volume":"135","author":"Piper","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib52","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.det.2019.05.014","article-title":"Review of graft-versus-host disease","volume":"37","author":"Ramachandran","year":"2019","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.isci.2022.104859_bib53","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/leu.2016.281","article-title":"Pre-transplant donor CD4 - invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease","volume":"31","author":"Rubio","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2022.104859_bib54","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1182\/blood-2012-01-404673","article-title":"Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival","volume":"120","author":"Rubio","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib55","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1182\/blood-2014-11-612762","article-title":"Third-party CD4+ invariant natural killer T\u00a0cells protect from murine GVHD lethality","volume":"125","author":"Schneidawind","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib56","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1182\/blood-2014-05-576017","article-title":"CD4+ invariant natural killer T\u00a0cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T\u00a0cells","volume":"124","author":"Schneidawind","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib57","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1242\/dmm.006668","article-title":"Mouse models of graft-versus-host disease: advances and limitations","volume":"4","author":"Schroeder","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.isci.2022.104859_bib58","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nmeth.4237","article-title":"Generation of mature T\u00a0cells from human hematopoietic stem and progenitor cells in artificial thymic organoids","volume":"14","author":"Seet","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2022.104859_bib59","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1182\/blood-2008-10-161638","article-title":"The role of B cells in the pathogenesis of graft-versus-host disease","volume":"114","author":"Shimabukuro-Vornhagen","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.104859_bib60","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nri2000","article-title":"Graft-versus-host disease","volume":"7","author":"Shlomchik","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib61","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nmeth.4258","article-title":"Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1","volume":"14","author":"Shukla","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2022.104859_bib62","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri2017","article-title":"Humanized mice in translational biomedical research","volume":"7","author":"Shultz","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib63","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1073\/pnas.1424877112","article-title":"Genetic engineering of hematopoietic stem cells to generate invariant natural killer T\u00a0cells","volume":"112","author":"Smith","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.104859_bib64","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1172\/JCI37869","article-title":"Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages","volume":"119","author":"Song","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.104859_bib65","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.immunol.21.120601.141057","article-title":"The regulatory role of Valpha14 NKT cells in innate and acquired immune response","volume":"21","author":"Taniguchi","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib66","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nbt.2678","article-title":"Generation of tumor-targeted human T lymphocytes from induced pluripotent stem cells for cancer therapy","volume":"31","author":"Themeli","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2022.104859_bib67","doi-asserted-by":"crossref","first-page":"eaat8410","DOI":"10.1126\/scitranslmed.aat8410","article-title":"Graft-versus-host disease, but not graft-versus-leukemia immunity, is mediated by GM-CSF-licensed myeloid cells","volume":"10","author":"Tugues","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2022.104859_bib68","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00441-010-1023-3","article-title":"Invariant natural killer T\u00a0cells: bridging innate and adaptive immunity","volume":"343","author":"Van Kaer","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.isci.2022.104859_bib69","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/01.tp.0000260140.04815.77","article-title":"Regulatory T-cells in the graft and the risk of acute graft-versus-host disease after allogeneic stem cell transplantation","volume":"83","author":"Wolf","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.isci.2022.104859_bib70","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4049\/jimmunol.1300657","article-title":"Thymic damage, impaired negative selection, and development of chronic graft-versus-host disease caused by donor CD4+ and CD8+ T\u00a0cells","volume":"191","author":"Wu","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2022.104859_bib71","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.bmt.1704165","article-title":"Influence of transplanted dose of CD56+ cells on development of graft-versus-host disease in patients receiving G-CSF-mobilized peripheral blood progenitor cells from HLA-identical sibling donors","volume":"32","author":"Yamasaki","year":"2003","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.isci.2022.104859_bib72","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1084\/jem.189.7.1073","article-title":"Bone marrow NK1.1(-) and NK1.1(+) T\u00a0cells reciprocally regulate acute graft versus host disease","volume":"189","author":"Zeng","year":"1999","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2022.104859_bib73","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-0716-1775-5_4","article-title":"Methods for studying mouse and human invariant natural killer T\u00a0cells","volume":"2388","author":"Zhou","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2022.104859_bib74","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.stem.2019.08.004","article-title":"Development of hematopoietic stem cell-engineered invariant natural killer T\u00a0cell therapy for cancer","volume":"25","author":"Zhu","year":"2019","journal-title":"Cell Stem Cell"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222011312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222011312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:01:09Z","timestamp":1762880469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222011312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2589004222011312"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.104859","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.104859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"104859"}}