{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:57:36Z","timestamp":1791338256978,"version":"4.3.1"},"reference-count":116,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["101003361"],"award-info":[{"award-number":["101003361"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008967","name":"Bilim Akademisi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008967","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00dcB\u0130TAK","doi-asserted-by":"publisher","award":["118C391"],"award-info":[{"award-number":["118C391"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00dcB\u0130TAK","doi-asserted-by":"publisher","award":["120N019"],"award-info":[{"award-number":["120N019"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.isci.2022.104986","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T12:37:14Z","timestamp":1660826234000},"page":"104986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Disposable paper-based microfluidics for fertility testing"],"prefix":"10.1016","volume":"25","author":[{"given":"Misagh Rezapour","family":"Sarabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defne","family":"Yigci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Munzer","family":"Alseed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Begum Aydogan","family":"Mathyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Ata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Halicigil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savas","family":"Tasoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.104986_bib1","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.1021\/ac800604v","article-title":"Inkjet-printed microfluidic multianalyte chemical sensing paper","volume":"80","author":"Abe","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib2","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00216-010-4011-2","article-title":"Inkjet-printed paperfluidic immuno-chemical sensing device","volume":"398","author":"Abe","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2017.11.010","article-title":"Review on microfluidic paper-based analytical devices towards commercialisation","volume":"1001","author":"Akyazi","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.isci.2022.104986_bib4","doi-asserted-by":"crossref","first-page":"6351","DOI":"10.1021\/acs.analchem.7b01418","article-title":"Continuous-ink, multiplexed pen-plotter approach for low-cost, high-throughput fabrication of paper-based microfluidics","volume":"89","author":"Amin","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib5","doi-asserted-by":"crossref","first-page":"93922","DOI":"10.1039\/C6RA19483D","article-title":"Smart-phone attachable, flow-assisted magnetic focusing device","volume":"6","author":"Amin","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.isci.2022.104986_bib6","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.jnnfm.2010.06.013","article-title":"Creeping flow analysis of an integrated microfluidic device for rheometry","volume":"165","author":"Bandalusena","year":"2010","journal-title":"J.\u00a0Non-Newtonian Fluid Mech."},{"key":"10.1016\/j.isci.2022.104986_bib7","doi-asserted-by":"crossref","first-page":"2100200","DOI":"10.1002\/aisy.202100200","article-title":"Simultaneous morphology, motility, and fragmentation analysis of live individual sperm cells for male fertility evaluation","volume":"4","author":"Ben-Yehuda","year":"2021","journal-title":"Advanced Intelligent Systems"},{"key":"10.1016\/j.isci.2022.104986_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.11613\/BM.2011.010","article-title":"Comparison of methods: passing and bablok regression","volume":"21","author":"Bili\u0107-Zulle","year":"2011","journal-title":"Biochem. Med."},{"key":"10.1016\/j.isci.2022.104986_bib9","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1021\/ac702605a","article-title":"Low-cost printing of poly(dimethylsiloxane) barriers to define microchannels in paper","volume":"80","author":"Bruzewicz","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib10","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.fertnstert.2017.01.017","article-title":"Obesity and female infertility: potential mediators of obesity's impact","volume":"107","author":"Broughton","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.isci.2022.104986_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1472-6483(10)62187-6","article-title":"Definition and causes of infertility","volume":"2","author":"Brugo-Olmedo","year":"2001","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.isci.2022.104986_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1142\/S2339547817200011","article-title":"Modular pumps as programmable hydraulic batteries for microfluidic devices","volume":"05","author":"Cummins","year":"2017","journal-title":"Technology"},{"key":"10.1016\/j.isci.2022.104986_bib13","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1021\/ac901071p","article-title":"Understanding wax printing: a simple micropatterning process for paper-based microfluidics","volume":"81","author":"Carrilho","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1021\/ac503968p","article-title":"Recent developments in paper-based microfluidic devices","volume":"87","author":"Cate","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib15","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1021\/ac020579e","article-title":"Passively driven integrated microfluidic system for separation of motile sperm","volume":"75","author":"Cho","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib16","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1039\/c2lc21204h","article-title":"Commercialization of microfluidic point-of-care diagnostic devices","volume":"12","author":"Chin","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib17","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1039\/c0lc00512f","article-title":"Laser-treated hydrophobic paper: an inexpensive microfluidic platform","volume":"11","author":"Chitnis","year":"2011","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.chempr.2017.01.009","article-title":"Small but perfectly formed? Successes, challenges, and opportunities for microfluidics in the chemical and biological sciences","volume":"2","author":"Chiu","year":"2017","journal-title":"Chem"},{"key":"10.1016\/j.isci.2022.104986_bib19","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/humrep\/dep413","article-title":"SpermCheck Fertility, an immunodiagnostic home test that detects normozoospermia and severe oligozoospermia","volume":"25","author":"Coppola","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2022.104986_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/1471-0528.15526","article-title":"In\u00a0vitro fertilisation\/intracytoplasmic sperm injection beyond 2020","volume":"126","author":"Crawford","year":"2019","journal-title":"BJOG"},{"key":"10.1016\/j.isci.2022.104986_bib21","doi-asserted-by":"crossref","first-page":"011502","DOI":"10.1063\/5.0042816","article-title":"Increasing the packing density of assays in paper-based microfluidic devices","volume":"15","author":"Dabbagh","year":"2021","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.isci.2022.104986_bib22","doi-asserted-by":"crossref","first-page":"061506","DOI":"10.1063\/5.0025462","article-title":"Machine learning-enabled multiplexed microfluidic sensors","volume":"14","author":"Dabbagh","year":"2020","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.isci.2022.104986_bib23","doi-asserted-by":"crossref","first-page":"102012","DOI":"10.1016\/j.isci.2020.102012","article-title":"3D-printed microneedles in biomedical applications","volume":"24","author":"Dabbagh","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.isci.2022.104986_bib24","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1039\/b912547g","article-title":"Inertial microfluidics","volume":"9","author":"Di Carlo","year":"2009","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib25","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1364\/BOE.5.000690","article-title":"4D tracking of clinical seminal samples for quantitative characterization of motility parameters","volume":"5","author":"Di Caprio","year":"2014","journal-title":"Biomedical Optics Express"},{"key":"10.1016\/j.isci.2022.104986_bib26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/jbio.201400093","article-title":"Holographic imaging of unlabelled sperm cells for semen analysis: a review","volume":"8","author":"Di Caprio","year":"2015","journal-title":"J.\u00a0Biophotonics"},{"key":"10.1016\/j.isci.2022.104986_bib27","doi-asserted-by":"crossref","first-page":"e0212562","DOI":"10.1371\/journal.pone.0212562","article-title":"Automated smartphone-based system for measuring sperm viability, DNA fragmentation, and hyaluronic binding assay score","volume":"14","author":"Dimitriadis","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2022.104986_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1039\/C0AN00406E","article-title":"A low-cost, simple, and rapid fabrication method for paper-based microfluidics using wax screen-printing","volume":"136","author":"Dungchai","year":"2011","journal-title":"Analyst"},{"key":"10.1016\/j.isci.2022.104986_bib29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/nbt.1490","article-title":"Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis","volume":"26","author":"Einav","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2022.104986_bib30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ymeth.2017.09.009","article-title":"Individual sperm selection by microfluidics integrated with interferometric phase microscopy","volume":"136","author":"Eravuchira","year":"2018","journal-title":"Methods"},{"key":"10.1016\/j.isci.2022.104986_bib31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/am800043z","article-title":"Multiplex lateral-flow test strips fabricated by two-dimensional shaping","volume":"1","author":"Fenton","year":"2008","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.isci.2022.104986_bib32","first-page":"194","article-title":"Biomedical infertility care in sub-Saharan Africa: a social science-- review of current practices, experiences and view points","volume":"2","author":"Gerrits","year":"2010","journal-title":"Facts Views Vis. Obgyn"},{"key":"10.1016\/j.isci.2022.104986_bib33","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1038\/s41598-017-02931-6","article-title":"High-throughput rapid-prototyping of low-cost paper-based microfluidics","volume":"7","author":"Ghaderinezhad","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.104986_bib34","doi-asserted-by":"crossref","first-page":"13620","DOI":"10.1038\/s41598-020-70456-6","article-title":"Sensing of electrolytes in urine using a miniaturized paper-based device","volume":"10","author":"Ghaderinezhad","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.104986_bib35","doi-asserted-by":"crossref","first-page":"141","DOI":"10.11613\/BM.2015.015","article-title":"Understanding bland altman analysis","volume":"25","author":"Giavarina","year":"2015","journal-title":"Biochem. Med."},{"key":"10.1016\/j.isci.2022.104986_bib36","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1021\/acs.chemrev.7b00024","article-title":"Turning the page: advancing paper-based microfluidics for broad diagnostic application","volume":"117","author":"Gong","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.isci.2022.104986_bib37","doi-asserted-by":"crossref","first-page":"13913","DOI":"10.1021\/jacs.5b08523","article-title":"Direct DNA analysis with paper-based ion concentration polarization","volume":"137","author":"Gong","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.isci.2022.104986_bib38","series-title":"Biosynthesis and Biodegradation of Cellulose","author":"Haigler","year":"1990"},{"key":"10.1016\/j.isci.2022.104986_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0967199419000595","article-title":"Sperm DNA fragmentation: causes and identification","volume":"28","author":"Hamilton","year":"2020","journal-title":"Zygote"},{"key":"10.1016\/j.isci.2022.104986_bib40","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1021\/ac702390u","article-title":"Analytical technique for label-free multi-protein detection based on Western blot and surface-enhanced Raman scattering","volume":"80","author":"Han","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib41","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.snb.2017.01.088","article-title":"\u201cDrop-slip\u201d bulk sample flow on fully inkjet-printed microfluidic paper-based analytical device","volume":"244","author":"Henares","year":"2017","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.isci.2022.104986_bib42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s40828-021-00139-w","article-title":"Functional paper-based materials for diagnostics","volume":"7","author":"Hillscher","year":"2021","journal-title":"Chemtexts"},{"key":"10.1016\/j.isci.2022.104986_bib44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.elecom.2012.03.041","article-title":"Application of conducting paper for selective detection of troponin","volume":"20","author":"Jagadeesan","year":"2012","journal-title":"Electrochem. Commun."},{"key":"10.1016\/j.isci.2022.104986_bib45","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1039\/C9LC01027K","article-title":"Wide-field, high-resolution lensless on-chip microscopy via near-field blind ptychographic modulation","volume":"20","author":"Jiang","year":"2020","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib46","doi-asserted-by":"crossref","first-page":"eaai7863","DOI":"10.1126\/scitranslmed.aai7863","article-title":"An automated smartphone-based diagnostic assay for point-of-care semen analysis","volume":"9","author":"Kanakasabapathy","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2022.104986_bib47","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1039\/C8AY02641F","article-title":"A hydrogel sensor-based microfluidic platform for the quantitative and multiplexed detection of fertility markers for point-of-care immunoassays","volume":"11","author":"Kalme","year":"2019","journal-title":"Anal. Methods"},{"key":"10.1016\/j.isci.2022.104986_bib48","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3390\/chemosensors9060126","article-title":"Recent microfluidic innovations for sperm sorting","volume":"9","author":"Khodamoradi","year":"2021","journal-title":"Chemosensors"},{"key":"10.1016\/j.isci.2022.104986_bib49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/2211068211426695","article-title":"Lens-free imaging for biological applications","volume":"17","author":"Kim","year":"2012","journal-title":"J.\u00a0Lab. Autom."},{"key":"10.1016\/j.isci.2022.104986_bib50","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00542-019-04527-8","article-title":"New disposable microfluidic chip without evaporation effect for semen analysis in clinics and homes","volume":"26","author":"Kim","year":"2020","journal-title":"Microsyst. Technol."},{"key":"10.1016\/j.isci.2022.104986_bib51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tibtech.2015.01.005","article-title":"Microfluidics for sperm research","volume":"33","author":"Knowlton","year":"2015","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.isci.2022.104986_bib52","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1039\/C4LC00920G","article-title":"Self-powered imbibing microfluidic pump by liquid encapsulation","volume":"14","author":"Kokalj","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib53","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0974-1208.170370","article-title":"Trends of male factor infertility, an important cause of infertility: a review of literature","volume":"8","author":"Kumar","year":"2015","journal-title":"J.\u00a0Hum. Reprod. Sci."},{"key":"10.1016\/j.isci.2022.104986_bib54","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1021\/ac302861v","article-title":"Vapor phase deposition of functional polymers onto paper-based microfluidic devices for advanced unit operations","volume":"84","author":"Kwong","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib55","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/s41598-017-01343-w","article-title":"A chemically patterned microfluidic paper-based analytical device (C-microPAD) for point-of-care diagnostics","volume":"7","author":"Lam","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.104986_bib56","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1139\/m87-017","article-title":"Enzyme-linked immunosorbent assay on nitrocellulose membranes (dot-ELISA) in the serodiagnosis of plant pathogenic bacteria","volume":"33","author":"Lazarovits","year":"1987","journal-title":"Can. J. Microbiol."},{"key":"10.1016\/j.isci.2022.104986_bib57","doi-asserted-by":"crossref","first-page":"051501","DOI":"10.1063\/1.4996768","article-title":"Paper-based assays for urine analysis","volume":"11","author":"Lepowsky","year":"2017","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.isci.2022.104986_bib58","doi-asserted-by":"crossref","first-page":"104061","DOI":"10.1016\/j.compbiomed.2020.104061","article-title":"Quantification of human sperm concentration using machine learning-based spectrophotometry","volume":"127","author":"Lesani","year":"2020","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.isci.2022.104986_bib59","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/jbm.b.35007","article-title":"Lower reactive oxygen species production and faster swimming speed of human sperm cells on nanodiamond spin-coated glass substrates","volume":"110","author":"Lesani","year":"2022","journal-title":"J.\u00a0Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.isci.2022.104986_bib60","doi-asserted-by":"crossref","first-page":"11301","DOI":"10.1063\/1.3687398","article-title":"A perspective on paper-based microfluidics: current status and future trends","volume":"6","author":"Li","year":"2012","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.isci.2022.104986_bib61","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10815-006-9022-8","article-title":"The effects of sperm quality on embryo development after intracytoplasmic sperm injection","volume":"23","author":"Loutradi","year":"2006","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"key":"10.1016\/j.isci.2022.104986_bib62","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10404-015-1614-0","article-title":"Deformation of a single mouse oocyte in a constricted microfluidic channel","volume":"19","author":"Luo","year":"2015","journal-title":"Microfluid. Nanofluidics"},{"key":"10.1016\/j.isci.2022.104986_bib63","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1021\/ac9020193","article-title":"Fabrication and characterization of paper-based microfluidics prepared in nitrocellulose membrane by wax printing","volume":"82","author":"Lu","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib64","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/elps.200800563","article-title":"Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay","volume":"30","author":"Lu","year":"2009","journal-title":"Electrophoresis"},{"key":"10.1016\/j.isci.2022.104986_bib65","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.colsurfb.2009.12.023","article-title":"Fabrication of paper-based microfluidic sensors by printing","volume":"76","author":"Li","year":"2010","journal-title":"Colloids and surfaces Biointerfaces"},{"key":"10.1016\/j.isci.2022.104986_bib66","doi-asserted-by":"crossref","first-page":"9131","DOI":"10.1021\/ac801729t","article-title":"Paper-based microfluidic devices by plasma treatment","volume":"80","author":"Li","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2009.05.006","article-title":"Gold nanoparticles based dipstick immunoassay for the rapid detection of dichlorodiphenyltrichloroethane: an organochlorine pesticide","volume":"25","author":"Lisa","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.isci.2022.104986_bib68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-90855-7","article-title":"Development of hydrophobic paper substrates using silane and sol\u2013gel based processes and deriving the best coating technique using machine learning strategies","volume":"11","author":"Manoharan","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.104986_bib69","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/ange.200603817","article-title":"Patterned paper as a platform for inexpensive, low-volume, portable bioassays","volume":"46","author":"Martinez","year":"2007","journal-title":"Angewandte. Chemie."},{"key":"10.1016\/j.isci.2022.104986_bib70","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1039\/b811135a","article-title":"FLASH: a rapid method for prototyping paper-based microfluidic devices","volume":"8","author":"Martinez","year":"2008","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib71","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.19082\/1597","article-title":"Trends in global assisted reproductive technologies research: a scientometrics study","volume":"7","author":"Maryam Okhovati","year":"2015","journal-title":"Electron. Physician"},{"key":"10.1016\/j.isci.2022.104986_bib72","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10404-014-1378-y","article-title":"Paper-based diagnostic devices for evaluating the quality of human sperm","volume":"16","author":"Matsuura","year":"2014","journal-title":"Microfluid. Nanofluidics"},{"key":"10.1016\/j.isci.2022.104986_bib73","first-page":"2223","article-title":"A novel microfluidic device for male subfertility screening","volume":"175","author":"Mccormack","year":"2006","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.isci.2022.104986_bib74","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1021\/ac60033a032","article-title":"Automatic paper chromatography","volume":"21","author":"M\u00fcller","year":"1949","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib75","doi-asserted-by":"crossref","first-page":"129681","DOI":"10.1016\/j.snb.2021.129681","article-title":"Paper-based microfluidics: simplified fabrication and assay methods","volume":"336","author":"Nishat","year":"2021","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.isci.2022.104986_bib76","doi-asserted-by":"crossref","first-page":"6260","DOI":"10.1039\/C6AY01506A","article-title":"Paper-based sperm DNA integrity analysis","volume":"8","author":"Nosrati","year":"2016","journal-title":"Anal. Methods"},{"key":"10.1016\/j.isci.2022.104986_bib77","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrurol.2017.175","article-title":"Microfluidics for sperm analysis and selection","volume":"14","author":"Nosrati","year":"2017","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.isci.2022.104986_bib78","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1373\/clinchem.2015.250282","article-title":"Paper-based quantification of male fertility potential","volume":"62","author":"Nosrati","year":"2016","journal-title":"Clin. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib79","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1021\/ac100431y","article-title":"Metering the capillary-driven flow of fluids in paper-based microfluidic devices","volume":"82","author":"Noh","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib80","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1039\/c004821f","article-title":"Microfluidics without pumps: reinventing the T-sensor and H-filter in paper networks","volume":"10","author":"Osborn","year":"2010","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib81","doi-asserted-by":"crossref","first-page":"10246","DOI":"10.1021\/ac1027066","article-title":"Flexographically printed fluidic structures in paper","volume":"82","author":"Olkkonen","year":"2010","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib82","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/humupd\/dmv024","article-title":"Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing","volume":"21","author":"Otten","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.isci.2022.104986_bib83","first-page":"e197","article-title":"3D bioprinted organ-on-chips","volume":"2022","author":"Rahmani Dabbagh","year":"2022","journal-title":"Aggregate"},{"key":"10.1016\/j.isci.2022.104986_bib84","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/bios12070491","article-title":"Machine learning-enabled prediction of 3D-printed microneedle features","volume":"12","author":"Rezapour Sarabi","year":"2022","journal-title":"Biosensors"},{"key":"10.1016\/j.isci.2022.104986_bib85","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1039\/D0LC01155J","article-title":"Biomedical optical fibers","volume":"21","author":"Rezapour Sarabi","year":"2021","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib86","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3390\/mi13071099","article-title":"3D-Printed microneedles for point-of-care biosensing applications","volume":"13","author":"Rezapour Sarabi","year":"2022","journal-title":"Micromachines"},{"key":"10.1016\/j.isci.2022.104986_bib87","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1039\/C2LC21065G","article-title":"Uniform mixing in paper-based microfluidic systems using surface acoustic waves","volume":"12","author":"Rezk","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib88","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.3390\/app11125329","article-title":"Finger-actuated microneedle array for sampling body fluids","volume":"11","author":"Sarabi","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.isci.2022.104986_bib89","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2217\/3dp-2021-0010","article-title":"3D printing of microneedle arrays: challenges towards clinical translation","volume":"5","author":"Sarabi","year":"2021","journal-title":"J.\u00a03D Printing Med."},{"key":"10.1016\/j.isci.2022.104986_bib90","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.tibtech.2022.03.010","article-title":"Magnetic levitation for space exploration","volume":"40","author":"Sarabi","year":"2022","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.isci.2022.104986_bib91","doi-asserted-by":"crossref","first-page":"18327","DOI":"10.1038\/s41598-021-97602-y","article-title":"Rheotaxis-based sperm separation using a biomimicry microfluidic device","volume":"11","author":"Sarbandi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.104986_bib92","doi-asserted-by":"crossref","first-page":"E420","DOI":"10.3390\/mi9090420","article-title":"Rapid fabrication of epidermal paper-based electronic devices using razor printing","volume":"9","author":"Sadri","year":"2018","journal-title":"Micromachines"},{"key":"10.1016\/j.isci.2022.104986_bib93","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/ac202837s","article-title":"Fully enclosed microfluidic paper-based analytical devices","volume":"84","author":"Schilling","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.104986_bib94","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/cyto.b.21388","article-title":"Translating microfluidics: cell separation technologies and their barriers to commercialization","volume":"92","author":"Shields","year":"2017","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.isci.2022.104986_bib95","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1016\/j.talanta.2011.08.024","article-title":"Novel, simple and low-cost alternative method for fabrication of paper-based microfluidics by wax dipping","volume":"85","author":"Songjaroen","year":"2011","journal-title":"Talanta"},{"key":"10.1016\/j.isci.2022.104986_bib96","doi-asserted-by":"crossref","first-page":"27560","DOI":"10.1039\/D0RA04566G","article-title":"Droplet microfluidics: fundamentals and its advanced applications","volume":"10","author":"Sohrabi","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.isci.2022.104986_bib97","doi-asserted-by":"crossref","first-page":"067003","DOI":"10.1088\/0960-1317\/23\/6\/067003","article-title":"CO2 laser cutting and ablative etching for the fabrication of paper-based devices - IOPscience","volume":"23","author":"Spicar-Mihalic","year":"2013","journal-title":"J.\u00a0Micromech. Microeng."},{"key":"10.1016\/j.isci.2022.104986_bib98","doi-asserted-by":"crossref","first-page":"16018","DOI":"10.1073\/pnas.1212506109","article-title":"High-throughput lensfree 3D tracking of human sperms reveals rare statistics of helical trajectories","volume":"109","author":"Su","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.104986_bib117","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.18632\/aging.102497","article-title":"Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990\u20132017: results from a global burden of disease study, 2017","author":"Sun","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.isci.2022.104986_bib99","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aca.2018.07.053","article-title":"Multiplex quantification of metals in airborne particulate matter via smartphone and paper-based microfluidics","volume":"1044","author":"Sun","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.isci.2022.104986_bib100","doi-asserted-by":"crossref","first-page":"e20031","DOI":"10.2196\/20031","article-title":"Web- and artificial intelligence-based image recognition for sperm motility analysis: verification study","volume":"8","author":"Tsai","year":"2020","journal-title":"JMIR Med. Inform."},{"key":"10.1016\/j.isci.2022.104986_bib101","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41585-021-00558-x","article-title":"Toilet-based continuous health monitoring using urine","volume":"19","author":"Tasoglu","year":"2022","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.isci.2022.104986_bib102","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1109\/JPROC.2014.2384836","article-title":"Advances in nanotechnology and microfluidics for human papillomavirus diagnostics","volume":"103","author":"Tasoglu","year":"2015","journal-title":"Proc. IEEE"},{"key":"10.1016\/j.isci.2022.104986_bib103","doi-asserted-by":"crossref","first-page":"e10176","DOI":"10.1002\/btm2.10176","article-title":"Point-of-care semen analysis of patients with infertility via smartphone and colorimetric paper-based diagnostic device","volume":"6","author":"Tsao","year":"2020","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.isci.2022.104986_bib104","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3390\/mi12020182","article-title":"Hemp-based microfluidics","volume":"12","author":"Temirel","year":"2021","journal-title":"Micromachines"},{"key":"10.1016\/j.isci.2022.104986_bib105","doi-asserted-by":"crossref","first-page":"107548","DOI":"10.1016\/j.microc.2022.107548","article-title":"Recent advances in the fabrication strategies of paper-based microfluidic devices for rapid detection of bacteria and viruses","volume":"180","author":"Trinh","year":"2022","journal-title":"Microchem. J."},{"key":"10.1016\/j.isci.2022.104986_bib106","series-title":"Oxford Research Encyclopedia of Global Public Health","article-title":"Biological and social aspects of human infertility: a global perspective","author":"Thoma","year":"2021"},{"key":"10.1016\/j.isci.2022.104986_bib107","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s42791-019-0011-3","article-title":"Microfluidic technology for in\u00a0vitro fertilization (IVF)","volume":"1","author":"Thapa","year":"2019","journal-title":"JMST Adv."},{"key":"10.1016\/j.isci.2022.104986_bib108","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tibtech.2014.04.010","article-title":"Commercialization of microfluidic devices","volume":"32","author":"Volpatti","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.isci.2022.104986_bib109","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1039\/C3LC51313K","article-title":"Hydrophobic sol-gel channel patterning strategies for paper-based microfluidics","volume":"14","author":"Wang","year":"2014","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib110","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/acssensors.1c02703","article-title":"Single-impact electrochemistry in paper-based microfluidics","volume":"7","author":"Wei\u00df","year":"2022","journal-title":"ACS Sens."},{"key":"10.1016\/j.isci.2022.104986_bib111","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.clinbiochem.2018.03.012","article-title":"Fertility and infertility: definition and epidemiology","volume":"62","author":"Vander Borght","year":"2018","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.isci.2022.104986_bib112","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1530\/REP-17-0600","article-title":"Maternal inheritance of mitochondria: implications for male fertility?","volume":"155","author":"Vaught","year":"2018","journal-title":"Reproduction"},{"key":"10.1016\/j.isci.2022.104986_bib113","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1039\/C7LC00780A","article-title":"Inkjet-printed barcodes for a rapid and multiplexed paper-based assay compatible with mobile devices","volume":"17","author":"Yang","year":"2017","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib114","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1039\/c3lc50169h","article-title":"Paper-based microfluidic point-of-care diagnostic devices","volume":"13","author":"Yetisen","year":"2013","journal-title":"Lab Chip"},{"key":"10.1016\/j.isci.2022.104986_bib115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41585-021-00465-1","article-title":"Machine learning for sperm selection","volume":"18","author":"You","year":"2021","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.isci.2022.104986_bib116","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s10404-019-2208-z","article-title":"Parametric analysis of wax printing technique for fabricating microfluidic paper-based analytic devices (\u03bcPAD) for milk adulteration analysis","volume":"23","author":"Younas","year":"2019","journal-title":"Microfluid. Nanofluidics"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222012585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222012585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:55:11Z","timestamp":1778900111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222012585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":116,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2589004222012585"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.104986","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disposable paper-based microfluidics for fertility testing","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.104986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"104986"}}