{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:22:50Z","timestamp":1790738570049,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.isci.2022.105090","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T05:33:18Z","timestamp":1662528798000},"page":"105090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Visualizing lymphocytic choriomeningitis virus infection in cells and living mice"],"prefix":"10.1016","volume":"25","author":[{"given":"Yuxi","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijuan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7233-0354","authenticated-orcid":false,"given":"Runming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gengfu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-2571","authenticated-orcid":false,"given":"Leike","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.105090_bib1","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1128\/JVI.00276-09","article-title":"Efficient reverse genetics generation of infectious Junin viruses differing in glycoprotein processing","volume":"83","author":"Albarino","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib2","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1128\/JVI.02556-10","article-title":"Efficient rescue of recombinant Lassa virus reveals the influence of S segment noncoding regions on virus replication and virulence","volume":"85","author":"Albarino","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib3","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03679","article-title":"Favipiravir elicits antiviral mutagenesis during virus replication in\u00a0vivo","volume":"3","author":"Arias","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.isci.2022.105090_bib4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-017-0637-x","article-title":"Molecular pathogenesis of viral hemorrhagic fever","volume":"39","author":"Basler","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.isci.2022.105090_bib5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1128\/JVI.73.1.251-259.1999","article-title":"Generation of bovine respiratory syncytial virus (Brsv) from Cdna: Brsv Ns2 is not essential for virus replication in tissue culture, and the human rsv leader region Acts as A functional Brsv genome promoter","volume":"73","author":"Buchholz","year":"1999","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01759-16","article-title":"Imaging with bioluminescent enterovirus 71 Allows for real-time visualization of tissue tropism and viral spread","volume":"91","author":"Caine","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib8","first-page":"41","article-title":"Illuminating epigenetics and inheritance in the immune system with bioluminescence","author":"Dimond","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2022.105090_bib9","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1128\/JVI.02102-10","article-title":"Rescue from cloned Cdnas and in\u00a0vivo characterization of recombinant pathogenic romero and live-attenuated Candid #1 strains of Junin virus, the Causative agent of Argentine hemorrhagic fever disease","volume":"85","author":"Emonet","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib10","first-page":"239","article-title":"Junin virus vaccines","volume":"263","author":"Enria","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.isci.2022.105090_bib11","first-page":"253","article-title":"Arenaviruses","volume":"315","author":"Gonzalez","year":"2007","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.isci.2022.105090_bib12","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1021\/cb3002478","article-title":"Engineered luciferase reporter from A deep sea shrimp utilizing A novel imidazopyrazinone substrate","volume":"7","author":"Hall","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.isci.2022.105090_bib13","article-title":"Inhibition of arenaviruses by Combinations of orally available approved drugs","volume":"65","author":"Herring","year":"2021","journal-title":"Antimicrobial Agents And Chemotherapy"},{"key":"10.1016\/j.isci.2022.105090_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/226325a0","article-title":"Defective viral particles and viral disease processes","volume":"226","author":"Huang","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105090_bib15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1128\/JVI.02110-13","article-title":"Sodium Hydrogen exchangers Contribute to arenavirus cell entry","volume":"88","author":"Iwasaki","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-10-3413","article-title":"An animal model of hemophagocytic lymphohistiocytosis (Hlh): Cd8+ T\u00a0cells and interferon Gamma are essential for the disorder","volume":"104","author":"Jordan","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.105090_bib17","doi-asserted-by":"crossref","first-page":"7578","DOI":"10.1128\/JVI.03117-13","article-title":"Irf7-Dependent type I interferon production induces Lethal immune-Mediated disease in Stat1 Knockout mice infected with lymphocytic choriomeningitis virus","volume":"88","author":"Li","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2017.07.101","article-title":"An lasv gpc pseudotyped virus based reporter system enables evaluation of vaccines in mice under non-bsl-4 conditions","author":"Li","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/j.isci.2022.105090_bib19","doi-asserted-by":"crossref","first-page":"912","DOI":"10.7150\/thno.16615","article-title":"Visualization of A neurotropic flavivirus infection in mouse reveals unique Viscerotropism Controlled by host type I interferon signaling","volume":"7","author":"Li","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.isci.2022.105090_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41392-021-00541-3","article-title":"Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct Target Ther."},{"key":"10.1016\/j.isci.2022.105090_bib21","article-title":"Systematic Comparison of 2a peptides for cloning Multi-genes in A polycistronic Vector","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2022.105090_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.antiviral.2008.01.158","article-title":"Applications of bioluminescence imaging to antiviral research and therapy: multiple luciferase enzymes and Quantitation","volume":"78","author":"Luker","year":"2008","journal-title":"Antivir. Res."},{"key":"10.1016\/j.isci.2022.105090_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1086\/514211","article-title":"Protective efficacy of A live attenuated vaccine against Argentine hemorrhagic fever. Ahf study group","volume":"177","author":"Maiztegui","year":"1998","journal-title":"The Journal Of Infectious Diseases"},{"key":"10.1016\/j.isci.2022.105090_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.conb.2020.01.017","article-title":"Functions of Acetylcholine-producing Lymphocytes in immunobiology","volume":"62","author":"Malin","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.isci.2022.105090_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01587-15","article-title":"Identification and mechanism of action of A novel small Molecule inhibitor of arenavirus Multiplication","author":"Ngo","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002804","article-title":"Evaluation of antiviral efficacy of ribavirin, Arbidol, and T-705 (favipiravir) in A mouse model for Crimean-Congo hemorrhagic fever","volume":"8","author":"Oestereich","year":"2014","journal-title":"Plos. Negl. Trop Dis."},{"key":"10.1016\/j.isci.2022.105090_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3369","article-title":"Visualizing influenza virus infection in living mice","volume":"4","author":"Pan","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105090_bib28","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1128\/JVI.02925-13","article-title":"Rescue of A recombinant Machupo virus from cloned Cdnas and in\u00a0vivo characterization in interferon (Alphabeta\/Gamma) receptor double Knockout mice","volume":"88","author":"Patterson","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib29","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1128\/JVI.79.7.4519-4526.2005","article-title":"Dual role of the lymphocytic choriomeningitis virus intergenic region in transcription termination and virus propagation","volume":"79","author":"Pinschewer","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib30","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1517\/17460441.2012.687719","article-title":"Drug discovery technologies and strategies for Machupo virus and other new World arenaviruses","volume":"7","author":"Radoshitzky","year":"2012","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.isci.2022.105090_bib31","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1007\/s00705-015-2418-y","article-title":"Past, present, and future of arenavirus taxonomy","volume":"160","author":"Radoshitzky","year":"2015","journal-title":"Arch. Virol."},{"key":"10.1016\/j.isci.2022.105090_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms6104","article-title":"Visualizing the replication of respiratory syncytial virus in cells and in living mice","volume":"5","author":"Rameix-Welti","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105090_bib33","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.3201\/eid2409.180233","article-title":"Use of favipiravir to treat Lassa virus infection in Macaques","volume":"24","author":"Rosenke","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.isci.2022.105090_bib34","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/pbc.23226","article-title":"Rapamycin does not control hemophagocytic lymphohistiocytosis in Lcmv-infected perforin-deficient mice","volume":"57","author":"Rothman","year":"2011","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.isci.2022.105090_bib35","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00449-21","article-title":"Cg dinucleotide removal in bioluminescent and fluorescent reporters improves Hiv-1 replication and reporter gene expression for dual imaging in Humanized mice","volume":"95","author":"Roy","year":"2021","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.antiviral.2018.12.008","article-title":"Metal Chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain","volume":"162","author":"Saez-Ayala","year":"2018","journal-title":"Antiviral Res."},{"key":"10.1016\/j.isci.2022.105090_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00061-15","article-title":"Efficacy of T-705 (favipiravir) in the treatment of infections with Lethal severe fever with thrombocytopenia syndrome virus","volume":"1","author":"Tani","year":"2016","journal-title":"mSphere"},{"key":"10.1016\/j.isci.2022.105090_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2021.08.015","article-title":"Live imaging of sars-Cov-2 infection in mice reveals that neutralizing Antibodies require fc function for Optimal efficacy","volume":"54","author":"Ullah","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2022.105090_bib39","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.antiviral.2013.05.012","article-title":"Inhibition of Multiplication of the prototypic arenavirus Lcmv by Valproic Acid","volume":"99","author":"Vazquez-Calvo","year":"2013","journal-title":"Antiviral Res"},{"key":"10.1016\/j.isci.2022.105090_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008161","article-title":"Longitudinal bioluminescent imaging of Hiv-1 infection during Antiretroviral therapy and treatment interruption in Humanized mice","volume":"15","author":"Ventura","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2022.105090_bib41","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1021\/acsinfecdis.0c00486","article-title":"High-throughput screening of an fda-approved drug library identifies inhibitors against arenaviruses and sars-Cov-2","volume":"7","author":"Wan","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.isci.2022.105090_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1423-0127-21-31","article-title":"Animal models of enterovirus 71 infection: Applications and Limitations","volume":"21","author":"Wang","year":"2014","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.isci.2022.105090_bib44","doi-asserted-by":"crossref","first-page":"6430","DOI":"10.7150\/thno.43177","article-title":"In\u00a0vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and Vertical propagation during pregnancy","volume":"10","author":"Wang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.isci.2022.105090_bib45","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1182\/blood-2017-12-820852","article-title":"Interleukin-18 diagnostically distinguishes and pathogenically promotes human and Murine Macrophage Activation syndrome","volume":"131","author":"Weiss","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.isci.2022.105090_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.antiviral.2016.10.007","article-title":"Lassa and ebola virus inhibitors identified using Minigenome and recombinant virus reporter systems","volume":"136","author":"Welch","year":"2016","journal-title":"Antiviral Res."},{"key":"10.1016\/j.isci.2022.105090_bib47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2011.07.015","article-title":"Lymphocytic choriomeningitis virus (Lcmv) infection of Macaques: amodel for Lassa fever","volume":"92","author":"Zapata","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.isci.2022.105090_bib48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A simple statistical parameter for use in evaluation and Validation of high throughput screening assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J.\u00a0Biomol. Screen"},{"key":"10.1016\/j.isci.2022.105090_bib49","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01443-19","article-title":"Comprehensive interactome analysis reveals that Stt3b is required for N-Glycosylation of Lassa virus glycoprotein","volume":"93","author":"Zhu","year":"2019","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2022.105090_bib51","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.tim.2020.02.006","article-title":"Defective interfering particles of negative-strand rna viruses","volume":"28","author":"Ziegler","year":"2020","journal-title":"Trends Microbiol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222013621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222013621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T06:16:33Z","timestamp":1724739393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222013621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S2589004222013621"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.105090","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Visualizing lymphocytic choriomeningitis virus infection in cells and living mice","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.105090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"105090"}}