{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:41:03Z","timestamp":1793932863901,"version":"4.8.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019BH018"],"award-info":[{"award-number":["ZR2019BH018"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ts201712089"],"award-info":[{"award-number":["ts201712089"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770818"],"award-info":[{"award-number":["81770818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800727"],"award-info":[{"award-number":["81800727"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.isci.2022.105145","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:33:10Z","timestamp":1663288390000},"page":"105145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["cGAS-STING activation contributes to podocyte injury in diabetic kidney disease"],"prefix":"10.1016","volume":"25","author":[{"given":"Nan","family":"Zang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguo","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-8062","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.105145_bib1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.2337\/dbi18-0052","article-title":"The cGAS-cGAMP-STING pathway: a molecular link between immunity and metabolism","volume":"68","author":"Bai","year":"2019","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2022.105145_bib2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2022.105145_bib3","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cmet.2019.08.003","article-title":"Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis","volume":"30","author":"Chung","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2022.105145_bib4","first-page":"2615286","article-title":"Research progress on mechanism of podocyte depletion in diabetic nephropathy","volume":"2017","author":"Dai","year":"2017","journal-title":"J.\u00a0Diabetes Res."},{"key":"10.1016\/j.isci.2022.105145_bib5","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1016\/j.celrep.2017.11.061","article-title":"Trafficking-mediated STING degradation requires sorting to acidified endolysosomes and can Be targeted to enhance anti-tumor response","volume":"21","author":"Gonugunta","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.105145_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1146\/annurev-physiol-020911-153238","article-title":"Cell biology and pathology of podocytes","volume":"74","author":"Greka","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.isci.2022.105145_bib7","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41467-017-00573-w","article-title":"Signalling strength determines proapoptotic functions of STING","volume":"8","author":"Gulen","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105145_bib8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature23470","article-title":"Mitotic progression following DNA damage enables pattern recognition within micronuclei","volume":"548","author":"Harding","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105145_bib9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-1-59745-521-3_23","article-title":"Establishment of human cell lines lacking mitochondrial DNA","volume":"554","author":"Hashiguchi","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2022.105145_bib10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11892-018-0984-6","article-title":"Role of the immune system in diabetic kidney disease","volume":"18","author":"Hickey","year":"2018","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.isci.2022.105145_bib11","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbrc.2020.03.034","article-title":"Remdesivir attenuates high fat diet (HFD)-induced NAFLD by regulating hepatocyte dyslipidemia and inflammation via the suppression of STING","volume":"526","author":"Li","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2022.105145_bib12","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1053\/j.gastro.2018.09.010","article-title":"Expression of STING is increased in liver tissues from patients with NAFLD and promotes macrophage-mediated hepatic inflammation and fibrosis in mice","volume":"155","author":"Luo","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2022.105145_bib13","article-title":"Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes","author":"Ma","year":"2022","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.isci.2022.105145_bib14","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.105145_bib15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.it.2017.03.004","article-title":"Evolutionary origins of cGAS-STING signaling","volume":"38","author":"Margolis","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2022.105145_bib16","doi-asserted-by":"crossref","first-page":"eaao6047","DOI":"10.1126\/science.aao6047","article-title":"BAK\/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis","volume":"359","author":"McArthur","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105145_bib17","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1007\/s00125-007-0821-y","article-title":"Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease","volume":"50","author":"Menini","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2022.105145_bib18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000324942","article-title":"Pathology of human diabetic nephropathy","volume":"170","author":"Najafian","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.isci.2022.105145_bib19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrneph.2011.51","article-title":"Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy","volume":"7","author":"Navarro-Gonzalez","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.isci.2022.105145_bib20","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.immuni.2013.05.004","article-title":"Immune sensing of DNA","volume":"38","author":"Paludan","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2022.105145_bib21","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00020.2002","article-title":"Cell biology of the glomerular podocyte","volume":"83","author":"Pavenstadt","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2022.105145_bib22","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1056\/NEJMoa021835","article-title":"Regression of microalbuminuria in type 1 diabetes","volume":"348","author":"Perkins","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2022.105145_bib23","doi-asserted-by":"crossref","first-page":"16544","DOI":"10.1073\/pnas.1308331110","article-title":"STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease","volume":"110","author":"Petrasek","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105145_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.metabol.2017.09.010","article-title":"Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease","volume":"81","author":"Qiao","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2022.105145_bib25","doi-asserted-by":"crossref","first-page":"715903","DOI":"10.3389\/fcvm.2021.715903","article-title":"The innate immune cGAS-STING-pathway in cardiovascular diseases - a mini review","volume":"8","author":"Rech","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.isci.2022.105145_bib26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1096\/fj.201700206R","article-title":"Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons","volume":"32","author":"Rumora","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.isci.2022.105145_bib27","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2022.105145_bib28","doi-asserted-by":"crossref","first-page":"F821","DOI":"10.1152\/ajprenal.00196.2010","article-title":"Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids","volume":"299","author":"Sieber","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.isci.2022.105145_bib29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ajpath.2013.05.023","article-title":"Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2","volume":"183","author":"Sieber","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2022.105145_bib30","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1159\/000518132","article-title":"The updates of podocyte lipid metabolism in proteinuric kidney disease","volume":"7","author":"Sun","year":"2021","journal-title":"Kidney Dis."},{"key":"10.1016\/j.isci.2022.105145_bib31","doi-asserted-by":"crossref","first-page":"ra20","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.isci.2022.105145_bib32","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1021\/acsmedchemlett.9b00027","article-title":"Discovery of GSK8612, a highly selective and potent TBK1 inhibitor","volume":"10","author":"Thomson","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.isci.2022.105145_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2174\/157339913804143207","article-title":"Current update in the management of diabetic nephropathy","volume":"9","author":"Van Buren","year":"2013","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.isci.2022.105145_bib34","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41374-019-0342-6","article-title":"STING expression in monocyte-derived macrophages is associated with the progression of liver inflammation and fibrosis in patients with nonalcoholic fatty liver disease","volume":"100","author":"Wang","year":"2020","journal-title":"Lab. Invest."},{"key":"10.1016\/j.isci.2022.105145_bib35","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA stress primes the antiviral innate immune response","volume":"520","author":"West","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105145_bib36","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.cell.2014.11.036","article-title":"Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production","volume":"159","author":"White","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105145_bib37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1172\/JCI121842","article-title":"STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis","volume":"129","author":"Yu","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.105145_bib38","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41586-019-1000-2","article-title":"Structural basis of STING binding with and phosphorylation by TBK1","volume":"567","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105145_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.celrep.2014.01.003","article-title":"The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop","volume":"6","author":"Zhang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.105145_bib40","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2018.01.007","article-title":"TBK1 at the crossroads of inflammation and energy homeostasis in adipose tissue","volume":"172","author":"Zhao","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105145_bib41","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/01.ASN.0000093460.24823.5B","article-title":"Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator","volume":"15","author":"Ziyadeh","year":"2004","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2022.105145_bib42","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1073\/pnas.120055097","article-title":"Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db\/db diabetic mice","volume":"97","author":"Ziyadeh","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222014171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222014171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T02:19:55Z","timestamp":1724725195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222014171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S2589004222014171"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.105145","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"cGAS-STING activation contributes to podocyte injury in diabetic kidney disease","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.105145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"105145"}}