{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:34:12Z","timestamp":1790620452927,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005897","name":"SFD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ARF20170938613"],"award-info":[{"award-number":["ARF20170938613"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["EQU202003010517"],"award-info":[{"award-number":["EQU202003010517"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SAICTPAC\/0019\/2015 - LISBOA-01-0145-FEDER-016405"],"award-info":[{"award-number":["SAICTPAC\/0019\/2015 - LISBOA-01-0145-FEDER-016405"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/MED-FAR\/29097\/2017 - LISBOA-01-0145-FEDER-029097"],"award-info":[{"award-number":["PTDC\/MED-FAR\/29097\/2017 - LISBOA-01-0145-FEDER-029097"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008966","name":"Soci\u00e9t\u00e9 Francophone du Diab\u00e8te","doi-asserted-by":"publisher","award":["SFD \\u2013 R19114DD"],"award-info":[{"award-number":["SFD \\u2013 R19114DD"]}],"id":[{"id":"10.13039\/501100008966","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","award":["ANR-21-CE18-0002-01"],"award-info":[{"award-number":["ANR-21-CE18-0002-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.isci.2022.105166","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T12:34:43Z","timestamp":1663590883000},"page":"105166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes"],"prefix":"10.1016","volume":"25","author":[{"given":"Julie","family":"Magusto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Beaup\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta B.","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Auclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Delaunay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Antoine","family":"Soret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Courtois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tounsia","family":"A\u00eft-Slimane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Housset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"J\u00e9ru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"F\u00e8ve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Ratziu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia M.P.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Gautheron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.105166_bib1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/CS20140732","article-title":"Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis","volume":"129","author":"Afonso","year":"2015","journal-title":"Clin. Sci."},{"key":"10.1016\/j.isci.2022.105166_bib2","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1136\/gutjnl-2020-321767","article-title":"RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease","volume":"70","author":"Afonso","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.isci.2022.105166_bib3","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2022.105166_bib4","doi-asserted-by":"crossref","first-page":"dmm042663","DOI":"10.1242\/dmm.042663","article-title":"Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis","volume":"13","author":"Aoudjehane","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.isci.2022.105166_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1292\/jvms.13-0359","article-title":"Induction of beige-like adipocytes in 3T3-L1 cells","volume":"76","author":"Asano","year":"2014","journal-title":"J.\u00a0Vet. Med. Sci."},{"key":"10.1016\/j.isci.2022.105166_bib6","doi-asserted-by":"crossref","first-page":"E5931","DOI":"10.3390\/ijms21165931","article-title":"Necroptosis in hepatosteatotic ischaemia-reperfusion injury","volume":"21","author":"Baidya","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2022.105166_bib7","doi-asserted-by":"crossref","first-page":"E212","DOI":"10.3390\/jcm10020212","article-title":"Inhibition of MLKL attenuates necroptotic cell death in a murine cell model of ischaemia injury","volume":"10","author":"Baidya","year":"2021","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.isci.2022.105166_bib8","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1242\/dev.067710","article-title":"Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis","volume":"138","author":"Birsoy","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.isci.2022.105166_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bone.2011.08.010","article-title":"Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a beta-catenin-dependent mechanism","volume":"50","author":"Cawthorn","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.isci.2022.105166_bib10","doi-asserted-by":"crossref","first-page":"6067349","DOI":"10.1155\/2016\/6067349","article-title":"Mitochondria in white, brown, and beige adipocytes","volume":"2016","author":"Cedikova","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.isci.2022.105166_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.tem.2008.09.002","article-title":"Adipogenesis and WNT signalling","volume":"20","author":"Christodoulides","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.isci.2022.105166_bib12","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00125-006-0144-4","article-title":"WNT10B mutations in human obesity","volume":"49","author":"Christodoulides","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2022.105166_bib13","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/oby.2011.212","article-title":"Regulation of Wnt\/beta-catenin signaling by CCAAT\/enhancer binding protein beta during adipogenesis","volume":"20","author":"Chung","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.isci.2022.105166_bib14","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","article-title":"Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans","volume":"46","author":"Cinti","year":"2005","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.isci.2022.105166_bib15","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41419-020-2483-3","article-title":"A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression","volume":"11","author":"Dai","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2022.105166_bib16","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/bib\/bbs046","article-title":"A comprehensive evaluation of normalization methods for illumina high-throughput RNA sequencing data analysis","volume":"14","author":"Dillies","year":"2013","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.isci.2022.105166_bib17","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1001\/archinte.161.13.1581","article-title":"Impact of overweight on the risk of developing common chronic diseases during\u00a0a\u00a010-year period","volume":"161","author":"Field","year":"2001","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.isci.2022.105166_bib18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2020.04.001","article-title":"Lytic cell death in metabolic liver disease","volume":"73","author":"Gautheron","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.isci.2022.105166_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12916-022-02296-2","article-title":"Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes","volume":"20","author":"Gautheron","year":"2022","journal-title":"BMC Med."},{"key":"10.1016\/j.isci.2022.105166_bib20","doi-asserted-by":"crossref","first-page":"e68445","DOI":"10.7554\/eLife.68445","article-title":"EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence","volume":"10","author":"Gautheron","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.isci.2022.105166_bib21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jcmgh.2015.02.001","article-title":"Necroptosis in nonalcoholic steatohepatitis","volume":"1","author":"Gautheron","year":"2015","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2022.105166_bib22","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.15252\/emmm.201403856","article-title":"A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis","volume":"6","author":"Gautheron","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.isci.2022.105166_bib23","doi-asserted-by":"crossref","first-page":"11869","DOI":"10.1038\/ncomms11869","article-title":"The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance","volume":"7","author":"Gautheron","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105166_bib24","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0092-8674(74)90116-0","article-title":"An established pre-adipose cell line and its differentiation in culture","volume":"3","author":"Green","year":"1974","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105166_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105166_bib26","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2022.105166_bib27","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2022.105166_bib28","doi-asserted-by":"crossref","first-page":"5879090","DOI":"10.1155\/2017\/5879090","article-title":"Interactions between PPAR gamma and the canonical Wnt\/beta-catenin pathway in type 2 diabetes and colon cancer","volume":"2017","author":"Lecarpentier","year":"2017","journal-title":"PPAR Res."},{"key":"10.1016\/j.isci.2022.105166_bib29","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1111\/ajt.12448","article-title":"Necroptosis in immunity and ischemia-reperfusion injury","volume":"13","author":"Linkermann","year":"2013","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.isci.2022.105166_bib30","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S2213-8587(14)70224-4","article-title":"Leptin: 20 years later","volume":"2","author":"MacReady","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.isci.2022.105166_bib31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jhep.2019.11.008","article-title":"Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease","volume":"72","author":"Majdi","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.isci.2022.105166_bib32","doi-asserted-by":"crossref","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.isci.2022.105166_bib33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105166_bib34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cmet.2012.01.019","article-title":"PPARgamma agonists induce\u00a0a white-to-brown fat conversion through\u00a0stabilization of PRDM16 protein","volume":"15","author":"Ohno","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2022.105166_bib35","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12536","article-title":"RIPK3 in cell death and inflammation: the good, the bad, and the ugly","volume":"277","author":"Orozco","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.isci.2022.105166_bib36","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ceb.2007.09.014","article-title":"Wnt\/beta-catenin signaling in adipogenesis and metabolism","volume":"19","author":"Prestwich","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.isci.2022.105166_bib37","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1161\/ATVBAHA.119.313640","article-title":"Loss of MLKL (mixed lineage kinase domain-like protein) decreases necrotic Core but increases macrophage lipid accumulation in atherosclerosis","volume":"40","author":"Rasheed","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2022.105166_bib38","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/cdd.2015.70","article-title":"Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis","volume":"23","author":"Rodriguez","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2022.105166_bib39","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrm2066","article-title":"Adipocyte differentiation from the inside out","volume":"7","author":"Rosen","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2022.105166_bib40","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of adipogenesis by Wnt signaling","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105166_bib41","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/hep.28676","article-title":"Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury","volume":"64","author":"Roychowdhury","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2022.105166_bib42","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1111\/jgh.14740","article-title":"Decrease in fat de novo synthesis and chemokine ligand expression in non-alcoholic fatty liver disease caused by inhibition of mixed lineage kinase domain-like pseudokinase","volume":"34","author":"Saeed","year":"2019","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2022.105166_bib43","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1172\/JCI45887","article-title":"Adipose tissue remodeling and obesity","volume":"121","author":"Sun","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.105166_bib44","doi-asserted-by":"crossref","first-page":"564339","DOI":"10.3389\/fmolb.2020.564339","article-title":"A transcriptomic analysis reveals novel patterns of gene expression during 3T3-L1 adipocyte differentiation","volume":"7","author":"Sun","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.isci.2022.105166_bib45","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105166_bib46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmet.2006.04.002","article-title":"Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation","volume":"3","author":"Uldry","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2022.105166_bib47","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"Regulated necrosis: the expanding network of non-apoptotic cell death pathways","volume":"15","author":"Vanden Berghe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2022.105166_bib48","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11010-014-2067-6","article-title":"Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression","volume":"393","author":"Wang","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2022.105166_bib49","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2011.11.030","article-title":"The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105166_bib50","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1158\/2326-6066.CIR-19-0261","article-title":"RIPK3 orchestrates fatty acid metabolism in tumor-associated macrophages and hepatocarcinogenesis","volume":"8","author":"Wu","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.isci.2022.105166_bib51","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jhep.2020.03.023","article-title":"MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis","volume":"73","author":"Wu","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.isci.2022.105166_bib52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.molmet.2019.02.003","article-title":"The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation","volume":"23","author":"Xu","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.isci.2022.105166_bib53","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20212808","article-title":"Inhibition of RIP3 increased ADSC viability under OGD and modified the competency of adipogenesis, angiogenesis, and inflammation regulation","volume":"42","author":"Yang","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.isci.2022.105166_bib54","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41556-017-0022-y","article-title":"RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis","volume":"20","author":"Yang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2022.105166_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/cdd.2015.92","article-title":"Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it","volume":"23","author":"Yoon","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.isci.2022.105166_bib56","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105166_bib57","doi-asserted-by":"crossref","first-page":"e2905","DOI":"10.1038\/cddis.2017.286","article-title":"Necroptosis in neurodegenerative diseases: a potential therapeutic target","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2022.105166_bib58","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nm.4017","article-title":"CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis","volume":"22","author":"Zhang","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2022.105166_bib59","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1210\/me.2011-1287","article-title":"Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis","volume":"26","author":"Zhang","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.isci.2022.105166_bib60","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fphar.2018.00721","article-title":"The role of necroptosis in cardiovascular disease","volume":"9","author":"Zhe-Wei","year":"2018","journal-title":"Front. Pharmacol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222014389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222014389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:57:33Z","timestamp":1778900253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222014389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S2589004222014389"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.105166","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.105166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"105166"}}