{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:51:19Z","timestamp":1790783479467,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T00:00:00Z","timestamp":1668124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY029268-01"],"award-info":[{"award-number":["R01 EY029268-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY003790"],"award-info":[{"award-number":["P30EY003790"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007229","name":"Harvard University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007229","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL 1TR002541"],"award-info":[{"award-number":["UL 1TR002541"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.isci.2022.105568","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T18:10:42Z","timestamp":1668363042000},"page":"105568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes"],"prefix":"10.1016","volume":"25","author":[{"given":"Arpan G.","family":"Mazumder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie M.","family":"Jul\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-3290","authenticated-orcid":false,"given":"Daniel","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.105568_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.isci.2022.105568_bib2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/brainsci10030168","article-title":"No longer underappreciated: the emerging concept of astrocyte heterogeneity in neuroscience","volume":"10","author":"Pestana","year":"2020","journal-title":"Brain Sci."},{"key":"10.1016\/j.isci.2022.105568_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-neuro-070918-050443","article-title":"The emerging nature of astrocyte diversity","volume":"42","author":"Khakh","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib4","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1007\/s11064-020-02959-7","article-title":"Astrocyte diversity: current insights and future directions","volume":"45","author":"Westergard","year":"2020","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.isci.2022.105568_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","article-title":"Neural circuit-specialized astrocytes: transcriptomic, proteomic, morphological, and functional evidence","volume":"95","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2022.105568_bib6","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1038\/s41467-018-03940-3","article-title":"Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers","volume":"9","author":"Lanjakornsiripan","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105568_bib7","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.cell.2009.11.011","article-title":"Application of a translational profiling approach for the comparative analysis of CNS cell types","volume":"139","author":"Doyle","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105568_bib8","doi-asserted-by":"crossref","first-page":"8706","DOI":"10.1523\/JNEUROSCI.3956-16.2017","article-title":"Molecular and functional properties of regional astrocytes in the adult brain","volume":"37","author":"Morel","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41593-020-0602-1","article-title":"Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in\u00a0situ transcriptomic map","volume":"23","author":"Bayraktar","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib10","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/s41593-019-0366-7","article-title":"Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin","volume":"22","author":"Miller","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/glia.23545","article-title":"Intracortical astrocyte subpopulations defined by astrocyte reporter Mice in the adult brain","volume":"67","author":"Morel","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.isci.2022.105568_bib12","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nn.4493","article-title":"Identification of diverse astrocyte populations and their malignant analogs","volume":"20","author":"John Lin","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib13","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s41467-019-14198-8","article-title":"Identification of region-specific astrocyte subtypes at single cell resolution","volume":"11","author":"Batiuk","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105568_bib14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular architecture of the mouse nervous system","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105568_bib15","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2018.07.028","article-title":"Molecular diversity and specializations among the cells of the adult mouse brain","volume":"174","author":"Saunders","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105568_bib16","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib17","doi-asserted-by":"crossref","first-page":"E302","DOI":"10.1073\/pnas.1716032115","article-title":"Cell-specific and region-specific transcriptomics in the multiple sclerosis model: focus on astrocytes","volume":"115","author":"Itoh","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105568_bib18","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.neuron.2009.02.010","article-title":"Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1","volume":"61","author":"Yang","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2022.105568_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-3-319-55769-4_6","article-title":"EAAT2 and the molecular signature of amyotrophic lateral sclerosis","volume":"16","author":"Rosenblum","year":"2017","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.isci.2022.105568_bib20","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/j.1471-4159.2006.04131.x","article-title":"Progressive loss of a glial potassium channel (KCNJ10) in the spinal cord of the SOD1 (G93A) transgenic mouse model of amyotrophic lateral sclerosis","volume":"99","author":"Kaiser","year":"2006","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.isci.2022.105568_bib21","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nn.3691","article-title":"Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington\u2019s disease model mice","volume":"17","author":"Tong","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib22","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1002\/glia.20845","article-title":"Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation","volume":"57","author":"Yeh","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.isci.2022.105568_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.22058","article-title":"The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse","volume":"516","author":"Sun","year":"2009","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.isci.2022.105568_bib24","doi-asserted-by":"crossref","first-page":"e67094","DOI":"10.1371\/journal.pone.0067094","article-title":"The time course of gene expression during reactive gliosis in the optic nerve","volume":"8","author":"Qu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2022.105568_bib25","doi-asserted-by":"crossref","first-page":"19287","DOI":"10.1073\/pnas.2001858117","article-title":"The optic nerve lamina region is a neural progenitor cell niche","volume":"117","author":"Bernstein","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105568_bib26","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1073\/pnas.1013965108","article-title":"Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma","volume":"108","author":"Nguyen","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105568_bib27","first-page":"1702","article-title":"Microvasculature of the rat optic nerve head","volume":"40","author":"Morrison","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2022.105568_bib28","first-page":"2206","article-title":"Morphology of the murine optic nerve","volume":"43","author":"May","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2022.105568_bib29","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105568_bib30","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1002\/cpns.77","article-title":"RiboTag: ribosomal tagging strategy to analyze cell-type-specific mRNA expression in\u00a0vivo","volume":"88","author":"Sanz","year":"2019","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib31","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/s41590-018-0110-6","article-title":"Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies","volume":"19","author":"Haimon","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2022.105568_bib32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1167\/iovs.18-25700","article-title":"Early optic nerve head glial proliferation and jak-stat pathway activation in chronic experimental glaucoma","volume":"60","author":"Lozano","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2022.105568_bib33","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/s41593-018-0216-z","article-title":"Variation among intact tissue samples reveals the core transcriptional features of human CNS cell classes","volume":"21","author":"Kelley","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib34","first-page":"749","article-title":"Astrocytes in the optic nerve head express putative mechanosensitive channels","volume":"21","author":"Choi","year":"2015","journal-title":"Mol. Vis."},{"key":"10.1016\/j.isci.2022.105568_bib35","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3389\/fimmu.2019.01007","article-title":"The challenges and promise of complement therapeutics for ocular diseases","volume":"10","author":"Park","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.105568_bib36","doi-asserted-by":"crossref","first-page":"100998","DOI":"10.1016\/j.preteyeres.2021.100998","article-title":"Molecular regulation of neuroinflammation in glaucoma: current knowledge and the ongoing search for new treatment targets","volume":"87","author":"Tezel","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.isci.2022.105568_bib37","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1523\/JNEUROSCI.2534-16.2017","article-title":"Astrocytic orosomucoid-2 modulates microglial activation and neuroinflammation","volume":"37","author":"Jo","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib38","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1073858418783959","article-title":"Microglia-astrocyte crosstalk: an intimate molecular conversation","volume":"25","author":"Jha","year":"2019","journal-title":"Neuroscientist"},{"key":"10.1016\/j.isci.2022.105568_bib39","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.isci.2022.105568_bib40","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1007\/s11064-014-1481-1","article-title":"Glutathione-dependent detoxification processes in astrocytes","volume":"40","author":"Dringen","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.isci.2022.105568_bib41","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1007\/s00429-017-1380-8","article-title":"Store-operated calcium entry is essential for glial calcium signalling in CNS white matter","volume":"222","author":"Papanikolaou","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.isci.2022.105568_bib42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.exer.2017.02.014","article-title":"Neuroinflammation in glaucoma: a new opportunity","volume":"157","author":"Williams","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2022.105568_bib43","doi-asserted-by":"crossref","first-page":"a017269","DOI":"10.1101\/cshperspect.a017269","article-title":"The complex role of neuroinflammation in glaucoma","volume":"4","author":"Soto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.isci.2022.105568_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.neuro.051508.135728","article-title":"Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy","volume":"35","author":"Nickells","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib45","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105568_bib46","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib47","doi-asserted-by":"crossref","first-page":"170534","DOI":"10.1016\/j.peptides.2021.170534","article-title":"Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: a twenty-five year expedition","volume":"140","author":"Singh","year":"2021","journal-title":"Peptides"},{"key":"10.1016\/j.isci.2022.105568_bib48","doi-asserted-by":"crossref","first-page":"14489","DOI":"10.1073\/pnas.0602932103","article-title":"Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection","volume":"103","author":"Xu","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105568_bib49","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1523\/JNEUROSCI.0907-11.2011","article-title":"Retinal ganglion cells with distinct directional preferences differ in molecular identity, structure, and central projections","volume":"31","author":"Kay","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib50","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cell.2018.06.035","article-title":"A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality","volume":"174","author":"Daigle","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105568_bib51","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.celrep.2017.01.075","article-title":"Diverse central projection patterns of retinal ganglion cells","volume":"18","author":"Martersteck","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.105568_bib52","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41593-022-01068-8","article-title":"Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin","volume":"25","author":"Tsai","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib53","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1167\/iovs.06-1282","article-title":"Global changes in optic nerve head gene expression after exposure to elevated intraocular pressure in a rat glaucoma model","volume":"48","author":"Johnson","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2022.105568_bib54","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1167\/iovs.10-5317","article-title":"Cell proliferation and interleukin-6-type cytokine signaling are implicated by gene expression responses in early optic nerve head injury in rat glaucoma","volume":"52","author":"Johnson","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2022.105568_bib55","doi-asserted-by":"crossref","first-page":"5539","DOI":"10.1167\/iovs.07-0542","article-title":"Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms","volume":"48","author":"Yang","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2022.105568_bib56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/glia.10051","article-title":"Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray","volume":"38","author":"Hernandez","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.isci.2022.105568_bib57","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fncel.2017.00227","article-title":"The P2X7 receptor primes IL-1\u03b2 and the NLRP3 inflammasome in astrocytes exposed to mechanical strain","volume":"11","author":"Albalawi","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib58","doi-asserted-by":"crossref","first-page":"C111","DOI":"10.1152\/ajpcell.00539.2008","article-title":"Elevated hydrostatic pressure activates sodium\/hydrogen exchanger-1 in rat optic nerve head astrocytes","volume":"297","author":"Mandal","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.isci.2022.105568_bib59","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13041-020-00603-7","article-title":"Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA\/2\u00a0J mice","volume":"13","author":"Tribble","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.isci.2022.105568_bib60","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13024-018-0303-3","article-title":"Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA\/2J glaucoma","volume":"14","author":"Williams","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.isci.2022.105568_bib61","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI44646","article-title":"Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma","volume":"121","author":"Howell","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.105568_bib62","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0166-2236(96)10045-X","article-title":"Glial-neuronal interactions in non-synaptic areas of the brain: studies in the optic nerve","volume":"19","author":"Ransom","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib63","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1523\/JNEUROSCI.3430-11.2012","article-title":"The energetics of CNS white matter","volume":"32","author":"Harris","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib64","first-page":"431","article-title":"Features of the cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: an anatomic study","volume":"11","author":"Moody","year":"1990","journal-title":"AJNR. Am. J. Neuroradiol."},{"key":"10.1016\/j.isci.2022.105568_bib65","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1523\/JNEUROSCI.20-18-06804.2000","article-title":"Astrocytic glycogen influences axon function and survival during glucose deprivation in central white matter","volume":"20","author":"Wender","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib66","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000017324","article-title":"Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle","volume":"20","author":"Pellerin","year":"1998","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.isci.2022.105568_bib67","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0006-8993(93)91429-V","article-title":"Glycogen in astrocytes: possible function as lactate supply for neighboring cells","volume":"623","author":"Dringen","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.isci.2022.105568_bib68","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/jnr.20573","article-title":"Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity","volume":"81","author":"Tekk\u00f6k","year":"2005","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.isci.2022.105568_bib69","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1113\/jphysiol.2003.042416","article-title":"Glycogen regulation and functional role in mouse white matter","volume":"549","author":"Brown","year":"2003","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.isci.2022.105568_bib70","doi-asserted-by":"crossref","first-page":"18810","DOI":"10.1073\/pnas.2009425117","article-title":"Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress","volume":"117","author":"Cooper","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105568_bib71","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1126\/science.1164022","article-title":"Astroglial metabolic networks sustain hippocampal synaptic transmission","volume":"322","author":"Rouach","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105568_bib72","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.celrep.2018.02.022","article-title":"Oligodendrocytes in the mouse corpus callosum maintain axonal function by delivery of glucose","volume":"22","author":"Meyer","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.105568_bib73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-3-030-27480-1_7","article-title":"Metabolism of glycogen in brain white matter","volume":"23","author":"Brown","year":"2019","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.isci.2022.105568_bib74","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1083\/jcb.201803152","article-title":"Fueling thought: management of glycolysis and oxidative phosphorylation in neuronal metabolism","volume":"217","author":"Yellen","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.isci.2022.105568_bib75","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2016.06.027","article-title":"Adaptive regulation of the brain\u2019s antioxidant defences by neurons and astrocytes","volume":"100","author":"Baxter","year":"2016","journal-title":"Free Radic. Biol. Med."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222018405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222018405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:58:07Z","timestamp":1778900287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222018405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":75,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S2589004222018405"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.105568","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.105568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}],"article-number":"105568"}}