{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:21:25Z","timestamp":1773667285408,"version":"3.50.1"},"reference-count":135,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270423"],"award-info":[{"award-number":["31270423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.isci.2022.105850","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T20:14:29Z","timestamp":1671826469000},"page":"105850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alternative telomere maintenance mechanism in Alligator sinensis provides insights into aging evolution"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-2611","authenticated-orcid":false,"given":"Yu-Zun","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-897X","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4744-8729","authenticated-orcid":false,"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-0804","authenticated-orcid":false,"given":"Jun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1810-3553","authenticated-orcid":false,"given":"Qiu-Hong","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7837-653X","authenticated-orcid":false,"given":"Jun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-2516","authenticated-orcid":false,"given":"Sheng-Guo","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.105850_bib1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ajpa.1330910217","article-title":"The evolutionary biology of aging","volume":"91","author":"Galloway","year":"1993","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.isci.2022.105850_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/jtbi.2001.2296","article-title":"Patterns of age-specific means and genetic variances of mortality rates predicted by the mutation-accumulation theory of ageing","volume":"210","author":"Charlesworth","year":"2001","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.isci.2022.105850_bib3","first-page":"1065","article-title":"Environment and longevity: Emergence without interaction, multiple steady states and stochastic clocks","volume":"4","author":"Mangel","year":"2002","journal-title":"Evol. Ecol. Res."},{"key":"10.1016\/j.isci.2022.105850_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.tpb.2003.07.005","article-title":"The shape of things to come: using models with physiological structure to predict mortality trajectories","volume":"65","author":"Mangel","year":"2004","journal-title":"Theor. Popul. Biol."},{"key":"10.1016\/j.isci.2022.105850_bib5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/270301a0","article-title":"Evolution of ageing","volume":"270","author":"Kirkwood","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105850_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1098\/rspb.1979.0083","article-title":"The evolution of ageing and longevity","volume":"205","author":"Kirkwood","year":"1979","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.isci.2022.105850_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1098\/rstb.1991.0028","article-title":"Evolution of senescence: late survival sacrificed for reproduction","volume":"332","author":"Kirkwood","year":"1991","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.isci.2022.105850_bib8","first-page":"587","article-title":"Evolution, stress, and longevity","volume":"197","author":"Kirkwood","year":"2000","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.isci.2022.105850_bib9","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.abg5332","article-title":"Origins and evolution of extreme life span in Pacific Ocean rockfishes","volume":"374","author":"Kolora","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105850_bib10","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105850_bib11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cell.2020.12.028","article-title":"Telomeres: history, health, and hallmarks of aging","volume":"184","author":"Chakravarti","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105850_bib12","doi-asserted-by":"crossref","first-page":"eaaz6876","DOI":"10.1126\/science.aaz6876","article-title":"Determinants of telomere length across human tissues","volume":"369","author":"Demanelis","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105850_bib13","series-title":"The Functional Nucleus","first-page":"127","author":"Chu","year":"2016"},{"key":"10.1016\/j.isci.2022.105850_bib14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/350569a0","article-title":"Structure and function of telomeres","volume":"350","author":"Blackburn","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105850_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/nrm2848","article-title":"Telomeres: protecting chromosomes against genome instability","volume":"11","author":"O'Sullivan","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2022.105850_bib16","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/mec.15331","article-title":"Telomere length is repeatable, shortens with age and reproductive success, and predicts remaining lifespan in a long-lived seabird","volume":"29","author":"Bichet","year":"2020","journal-title":"Mol. Ecol."},{"key":"10.1016\/j.isci.2022.105850_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0022-5193(73)90198-7","article-title":"A theory of marginotomy: the incomplete copying of template margin in enzymic synthesis of\u00a0polynucleotides and biological significance of the phenomenon","volume":"41","author":"Olovnikov","year":"1973","journal-title":"J.\u00a0Theor. Biol."},{"key":"10.1016\/j.isci.2022.105850_bib18","doi-asserted-by":"crossref","first-page":"101115","DOI":"10.1016\/j.arr.2020.101115","article-title":"Telomere transcription in ageing","volume":"62","author":"Aguado","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.isci.2022.105850_bib19","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1111\/febs.12326","article-title":"Telomere shortening in human diseases","volume":"280","author":"Kong","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.isci.2022.105850_bib20","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.celrep.2012.08.023","article-title":"The rate of increase of short telomeres predicts longevity in mammals","volume":"2","author":"Vera","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2022.105850_bib21","doi-asserted-by":"crossref","first-page":"15122","DOI":"10.1073\/pnas.1902452116","article-title":"Telomere shortening rate predicts species life span","volume":"116","author":"Whittemore","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105850_bib22","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1073\/pnas.0609367104","article-title":"High-throughput telomere length quantification by FISH and its application to human population studies","volume":"104","author":"Canela","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105850_bib23","first-page":"1563","article-title":"Telomerase: structure, functions, and activity regulation","volume":"75","author":"Zvereva","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2022.105850_bib24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41576-019-0099-1","article-title":"Telomeres and telomerase: three decades of progress","volume":"20","author":"Shay","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.isci.2022.105850_bib25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0092-8674(04)00038-8","article-title":"Beginning to understand the end of the chromosome","volume":"116","author":"Cech","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105850_bib26","series-title":"Encyclopedia of Cancer","first-page":"437","author":"Tomita","year":"2019"},{"key":"10.1016\/j.isci.2022.105850_bib27","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/sj.emboj.7600598","article-title":"Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging","volume":"24","author":"Blasco","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2022.105850_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/9781118268667.ch10","article-title":"Cellular senescence, telomerase, and cancer in human cells","author":"Smiraldo","year":"2012","journal-title":"Telomerases"},{"key":"10.1016\/j.isci.2022.105850_bib29","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/BF03324363","article-title":"Telomerase expression in human cells and tissues","volume":"7","author":"Chiu","year":"1995","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.isci.2022.105850_bib30","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/(SICI)1520-6408(1996)18:2<173::AID-DVG10>3.0.CO;2-3","article-title":"Telomerase activity in human germline and embryonic tissues and cells","volume":"18","author":"Wright","year":"1996","journal-title":"Dev. Genet."},{"key":"10.1016\/j.isci.2022.105850_bib31","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1103>3.0.CO;2-V","article-title":"Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development","volume":"91","author":"Ulaner","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.isci.2022.105850_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41559-018-0733-x","article-title":"Giant tortoise genomes provide insights into longevity and age-related disease","volume":"3","author":"Quesada","year":"2019","journal-title":"Nat. Ecol Evol."},{"key":"10.1016\/j.isci.2022.105850_bib33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12983-014-0054-0","article-title":"Reproductive cessation and post-reproductive lifespan in Asian elephants and pre-industrial humans","volume":"11","author":"Lahdenper\u00e4","year":"2014","journal-title":"Front. Zool."},{"key":"10.1016\/j.isci.2022.105850_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1098\/rsbl.2008.0006","article-title":"Mortality rate acceleration and post-reproductive lifespan in matrilineal whale species","volume":"4","author":"Foote","year":"2008","journal-title":"Biol. Lett."},{"key":"10.1016\/j.isci.2022.105850_bib35","first-page":"1235","article-title":"The Loci of repeated evolution: a catalog of genetic hotspots of phenotypic variation","volume":"67","author":"Martin","year":"2013","journal-title":"Evolution"},{"key":"10.1016\/j.isci.2022.105850_bib36","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nrg3483","article-title":"The genetic causes of convergent evolution","volume":"14","author":"Stern","year":"2013","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.isci.2022.105850_bib37","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0531-5565(03)00106-2","article-title":"Testing hypotheses of aging in long-lived painted turtles (Chrysemys picta)","volume":"38","author":"Congdon","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.isci.2022.105850_bib38","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1111\/j.1420-9101.2009.01783.x","article-title":"A database of vertebrate longevity records and their relation to other life-history traits","volume":"22","author":"de Magalh\u00e3es","year":"2009","journal-title":"J.\u00a0Evol. Biol."},{"key":"10.1016\/j.isci.2022.105850_bib39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature12789","article-title":"Diversity of ageing across the tree of life","volume":"505","author":"Jones","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105850_bib40","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1126\/science.abm0151","article-title":"Diverse aging rates in ectothermic tetrapods provide insights for the evolution of aging and longevity","volume":"376","author":"Reinke","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105850_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0016756800046434","article-title":"Protosuchus, Proterochampsa, and the origin of phytosaurs and crocodiles","volume":"105","author":"Walker","year":"1968","journal-title":"Geol. Mag."},{"key":"10.1016\/j.isci.2022.105850_bib42","first-page":"781","article-title":"The Prosauropod Dinosaur Ammosaurus, the Crocodile Protosuchus, and their bearing on the age of the Navajo Sandstone of Northeastern Arizona","volume":"45","author":"Galton","year":"1971","journal-title":"J.\u00a0Paleontol."},{"key":"10.1016\/j.isci.2022.105850_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1096-3642.2007.00283.x","article-title":"Growth and textural ageing in long bones of the American alligator Alligator mississippiensis (Crocodylia: Alligatoridae)","volume":"150","author":"Tumarkin-Deratzian","year":"2007","journal-title":"Zool. J. Linn. Soc."},{"key":"10.1016\/j.isci.2022.105850_bib44","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/1365-2656.12723","article-title":"Life histories and conservation of long-lived reptiles, an illustration with the American crocodile (Crocodylus acutus)","volume":"86","author":"Briggs-Gonzalez","year":"2017","journal-title":"J.\u00a0Anim. Ecol."},{"key":"10.1016\/j.isci.2022.105850_bib45","doi-asserted-by":"crossref","first-page":"722205","DOI":"10.3389\/fcell.2021.722205","article-title":"The Paradoxical Role of Cellular Senescence in Cancer","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2022.105850_bib46","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/biology9120485","article-title":"The senescence-associated secretory phenotype (SASP) in the challenging future of cancer therapy and age-related diseases","volume":"9","author":"Cuollo","year":"2020","journal-title":"Biology"},{"key":"10.1016\/j.isci.2022.105850_bib47","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00280-017-3410-x","article-title":"Animals living in polluted environments are a potential source of anti-tumor molecule(s)","volume":"80","author":"Jeyamogan","year":"2017","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.isci.2022.105850_bib48","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nature01495","article-title":"Genetics and the making of Homo sapiens","volume":"422","author":"Carroll","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105850_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00265-018-2477-7","article-title":"Demographic measures of an individual's \"pace of life\": fecundity rate, lifespan, generation time, or a composite variable?","volume":"72","author":"Araya-Ajoy","year":"2018","journal-title":"Behav. Ecol. Sociobiol."},{"key":"10.1016\/j.isci.2022.105850_bib50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature03666","article-title":"Generation time and temporal scaling of bird population dynamics","volume":"436","author":"S\u00e6ther","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105850_bib51","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1365-2656.2010.01669.x","article-title":"Parent age, lifespan and offspring survival: structured variation in life history in a wild population","volume":"79","author":"Reid","year":"2010","journal-title":"J.\u00a0Anim. Ecol."},{"key":"10.1016\/j.isci.2022.105850_bib52","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cell.2019.06.004","article-title":"Relaxed selection limits lifespan by increasing mutation load","volume":"178","author":"Cui","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105850_bib53","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0168-9525(01)02523-9","article-title":"Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity","volume":"17","author":"Hekimi","year":"2001","journal-title":"Trends Genet."},{"key":"10.1016\/j.isci.2022.105850_bib54","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1474-9726.2008.00442.x","article-title":"The Human Ageing Genomic Resources: online databases and tools for biogerontologists","volume":"8","author":"de Magalh\u00e3es","year":"2009","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2022.105850_bib55","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1038\/sj.onc.1210880","article-title":"ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks","volume":"26","author":"Lavin","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2022.105850_bib56","doi-asserted-by":"crossref","first-page":"31542","DOI":"10.1074\/jbc.M111.258152","article-title":"ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control","volume":"286","author":"Gatei","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2022.105850_bib57","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/ncb3209","article-title":"Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation","volume":"17","author":"Jiang","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2022.105850_bib58","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0092-8674(02)00671-2","article-title":"Hairpin opening and overhang processing by an Artemis\/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination","volume":"108","author":"Ma","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105850_bib59","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.18632\/oncotarget.3137","article-title":"TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1","volume":"6","author":"Zou","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.isci.2022.105850_bib60","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.cell.2014.10.059","article-title":"Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1","volume":"159","author":"Freund","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.isci.2022.105850_bib61","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1093\/nar\/gkg509","article-title":"SIFT: predicting amino acid changes that affect protein function","volume":"31","author":"Ng","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib62","doi-asserted-by":"crossref","first-page":"W452","DOI":"10.1093\/nar\/gks539","article-title":"SIFT web server: predicting effects of amino acid substitutions on proteins","volume":"40","author":"Sim","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib63","first-page":"D190","article-title":"The universal protein resource (UniProt)","volume":"36","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib64","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ncb1170","article-title":"A new effector pathway links ATM kinase with the DNA damage response","volume":"6","author":"Demonacos","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2022.105850_bib65","first-page":"24","article-title":"ATM gene product phosphorylates I kappa B-alpha","volume":"57","author":"Jung","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2022.105850_bib66","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/ncb1337","article-title":"ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks","volume":"8","author":"Jazayeri","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2022.105850_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-230X(08)60095-0","article-title":"p53 and ATM: cell cycle, cell death, and cancer","volume":"71","author":"Morgan","year":"1997","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.isci.2022.105850_bib68","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/bjc.2015.60","article-title":"ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels","volume":"112","author":"Rondeau","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.isci.2022.105850_bib69","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.tree.2010.10.008","article-title":"Pleiotropy, apparent stabilizing selection and uncovering fitness optima","volume":"26","author":"McGuigan","year":"2011","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.isci.2022.105850_bib70","doi-asserted-by":"crossref","first-page":"10809","DOI":"10.1093\/nar\/gks862","article-title":"The roles of WRN and BLM RecQ helicases in the alternative lengthening of telomeres","volume":"40","author":"Mendez Bermudez","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib71","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrg2763","article-title":"Alternative lengthening of telomeres: models, mechanisms and implications","volume":"11","author":"Cesare","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.isci.2022.105850_bib72","doi-asserted-by":"crossref","first-page":"14928","DOI":"10.1038\/ncomms14928","article-title":"Structural and functional analysis of the human POT1-TPP1 telomeric complex","volume":"8","author":"Rice","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105850_bib73","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.csbj.2022.01.005","article-title":"POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance","volume":"20","author":"Aramburu","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.isci.2022.105850_bib74","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.trecan.2015.07.007","article-title":"ALTernative telomere maintenance and cancer","volume":"1","author":"Dilley","year":"2015","journal-title":"Trends Cancer"},{"key":"10.1016\/j.isci.2022.105850_bib75","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12885-019-5424-8","article-title":"Alternative lengthening of telomeres (ALT) influences survival in soft tissue sarcomas: a systematic review with meta-analysis","volume":"19","author":"Lawlor","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.isci.2022.105850_bib76","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.tree.2005.11.007","article-title":"Do telomere dynamics link lifestyle and lifespan?","volume":"21","author":"Monaghan","year":"2006","journal-title":"Trends Ecol. Evol."},{"key":"10.1016\/j.isci.2022.105850_bib77","doi-asserted-by":"crossref","first-page":"20170463","DOI":"10.1098\/rsbl.2017.0463","article-title":"Does oxidative stress shorten telomeres in\u00a0vivo? A review","volume":"13","author":"Reichert","year":"2017","journal-title":"Biol. Lett."},{"key":"10.1016\/j.isci.2022.105850_bib78","doi-asserted-by":"crossref","first-page":"20140991","DOI":"10.1098\/rsbl.2014.0991","article-title":"Socioecological variables predict telomere length in wild spotted hyenas","volume":"11","author":"Lewin","year":"2015","journal-title":"Biol. Lett."},{"key":"10.1016\/j.isci.2022.105850_bib79","first-page":"20133287","article-title":"Nestling telomere shortening, but not telomere length, reflects developmental stress and predicts survival in wild birds","volume":"281","author":"Boonekamp","year":"2014","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.isci.2022.105850_bib80","first-page":"20141610","article-title":"An experimental demonstration that early-life competitive disadvantage accelerates telomere loss","volume":"282","author":"Nettle","year":"2015","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.isci.2022.105850_bib81","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1073\/pnas.1113306109","article-title":"Telomere length in early life predicts lifespan","volume":"109","author":"Heidinger","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105850_bib82","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cub.2004.06.063","article-title":"Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance","volume":"14","author":"Bi","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2022.105850_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gde.2020.01.002","article-title":"Telomere maintenance mechanisms in cancer: telomerase, ALT or lack thereof","volume":"60","author":"Claude","year":"2020","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.isci.2022.105850_bib84","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13073-016-0324-x","article-title":"Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies","volume":"8","author":"Jafri","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.isci.2022.105850_bib85","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1158\/1541-7786.MCR-05-0147","article-title":"Telomerase and cancer","volume":"3","author":"Blackburn","year":"2005","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.isci.2022.105850_bib86","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1093\/nar\/gkv160","article-title":"Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation","volume":"43","author":"Bakr","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0304-3835(02)00702-4","article-title":"Alternative lengthening of telomeres, telomerase, and cancer","volume":"194","author":"Reddel","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.isci.2022.105850_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2021.726714","article-title":"Aging: what we can learn from elephants","volume":"2","author":"Chusyd","year":"2021","journal-title":"Front. Aging"},{"key":"10.1016\/j.isci.2022.105850_bib89","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1093\/gerona\/gls086","article-title":"GH and IGF1: roles in energy metabolism of long-living GH mutant mice","volume":"67","author":"Brown-Borg","year":"2012","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.isci.2022.105850_bib90","first-page":"393","article-title":"The role of ATM and ATR in DNA damage-induced cell cycle control","volume":"5","author":"Goodarzi","year":"2003","journal-title":"Prog. Cell Cycle Res."},{"key":"10.1016\/j.isci.2022.105850_bib91","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.18632\/aging.102863","article-title":"ATM is a key driver of NF-\u03baB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging","volume":"12","author":"Zhao","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.isci.2022.105850_bib92","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1534\/genetics.114.165720","article-title":"Pleiotropic mutations are subject to strong stabilizing selection","volume":"197","author":"McGuigan","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.isci.2022.105850_bib93","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/genetics\/122.2.459","article-title":"Pleiotropic stabilizing selection limits the number of polymorphic loci to at most the number of characters","volume":"122","author":"Hastings","year":"1989","journal-title":"Genetics"},{"key":"10.1016\/j.isci.2022.105850_bib94","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence","volume":"426","author":"d'Adda di Fagagna","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105850_bib95","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(04)00256-4","article-title":"Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)","volume":"14","author":"Herbig","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2022.105850_bib96","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ncb2466","article-title":"Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation","volume":"14","author":"Fumagalli","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2022.105850_bib97","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ncomms1708","article-title":"Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence","volume":"3","author":"Hewitt","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105850_bib98","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.molcel.2007.03.023","article-title":"A RAP1\/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends","volume":"26","author":"Bae","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2022.105850_bib99","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41580-020-00314-w","article-title":"Cellular senescence in ageing: from mechanisms to therapeutic opportunities","volume":"22","author":"Di Micco","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.isci.2022.105850_bib100","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","article-title":"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication","volume":"444","author":"Di Micco","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.isci.2022.105850_bib101","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.4161\/cc.6.15.4516","article-title":"The DNA damage signaling pathway connects oncogenic stress to cellular senescence","volume":"6","author":"Mallette","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.isci.2022.105850_bib102","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1196\/annals.1297.047","article-title":"Mechanism of telomere shortening by oxidative stress","volume":"1019","author":"Kawanishi","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2022.105850_bib103","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","author":"von Zglinicki","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2022.105850_bib104","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1073\/pnas.71.6.2169","article-title":"Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species","volume":"71","author":"Hart","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105850_bib105","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0047-6374(84)90068-X","article-title":"Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span","volume":"24","author":"Hall","year":"1984","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.isci.2022.105850_bib106","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/geronj\/34.6.808","article-title":"DNA Repair in a Short-and a Long-lived Rodent Species1","volume":"34","author":"Hart","year":"1979","journal-title":"J.\u00a0Gerontol."},{"key":"10.1016\/j.isci.2022.105850_bib107","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1080\/15476286.2020.1792116","article-title":"Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance","volume":"17","author":"Jiang","year":"2020","journal-title":"RNA Biol."},{"key":"10.1016\/j.isci.2022.105850_bib108","first-page":"100108","article-title":"Comparative analyses of aging-related genes in long-lived mammals provide insights into natural longevity","volume":"2","author":"Yu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.isci.2022.105850_bib109","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1474-9726.2006.00262.x","article-title":"Telomerase activity coevolves with body mass not lifespan","volume":"6","author":"Seluanov","year":"2007","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2022.105850_bib110","doi-asserted-by":"crossref","first-page":"104726","DOI":"10.1016\/j.phrs.2020.104726","article-title":"Telomerase: key regulator of inflammation and cancer","volume":"155","author":"Wu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.isci.2022.105850_bib111","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1158\/2159-8290.CD-16-0062","article-title":"Role of telomeres and telomerase in aging and cancer","volume":"6","author":"Shay","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.isci.2022.105850_bib112","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.exger.2007.03.004","article-title":"Telomerase activity is maintained throughout the lifespan of long-lived birds","volume":"42","author":"Haussmann","year":"2007","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.isci.2022.105850_bib113","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nm0395-249","article-title":"Correlating telomerase activity levels with human neuroblastoma outcomes","volume":"1","author":"Hiyama","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2022.105850_bib114","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/S0959-8049(97)00226-8","article-title":"Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behaviour?","volume":"33","author":"Hiyama","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.isci.2022.105850_bib115","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.279.5349.349","article-title":"Extension of life-span by introduction of telomerase into normal human cells","volume":"279","author":"Bodnar","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105850_bib116","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0959-8049(97)00062-2","article-title":"A survey of telomerase activity in human cancer","volume":"33A","author":"Shay","year":"1997","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.isci.2022.105850_bib117","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomerase activity with immortal cells and cancer","volume":"266","author":"Kim","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.isci.2022.105850_bib118","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1093\/nar\/gkn1027","article-title":"Telomere length measurement by a novel monochrome multiplex quantitative PCR method","volume":"37","author":"Cawthon","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib119","doi-asserted-by":"crossref","DOI":"10.1111\/1755-0998.13152","article-title":"Standard guidelines for the publication of telomere qPCR results in evolutionary ecology","volume":"20","author":"Morinha","year":"2020","journal-title":"Mol. Ecol. Resour"},{"key":"10.1016\/j.isci.2022.105850_bib120","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/gkp045","article-title":"Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data","volume":"37","author":"Ruijter","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib121","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT\u2013PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib122","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2022.105850_bib123","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.isci.2022.105850_bib124","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.isci.2022.105850_bib125","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2022.105850_bib126","doi-asserted-by":"crossref","first-page":"eaao0926","DOI":"10.1126\/sciadv.aao0926","article-title":"Growing old, yet staying young: The role of telomeres in bats\u2019 exceptional longevity","volume":"4","author":"Foley","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2022.105850_bib127","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/1471-2148-13-251","article-title":"Molecular adaptation of telomere associated genes in mammals","volume":"13","author":"Morgan","year":"2013","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.isci.2022.105850_bib128","series-title":"Multiple Sequence Alignment Methods","first-page":"155","author":"L\u00f6ytynoja","year":"2014"},{"key":"10.1016\/j.isci.2022.105850_bib129","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/oxfordjournals.molbev.a026334","article-title":"Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis","volume":"17","author":"Castresana","year":"2000","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.isci.2022.105850_bib130","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies","volume":"30","author":"Stamatakis","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2022.105850_bib131","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/molbev\/msm088","article-title":"PAML 4: phylogenetic analysis by maximum likelihood","volume":"24","author":"Yang","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.isci.2022.105850_bib132","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/molbev\/msr311","article-title":"An improved likelihood ratio test for detecting site-specific functional divergence among clades of protein-coding genes","volume":"29","author":"Weadick","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.isci.2022.105850_bib133","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/molbev\/msz257","article-title":"RASP 4: ancestral state reconstruction tool for multiple genes and characters","volume":"37","author":"Yu","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.isci.2022.105850_bib134","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"Biasini","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2022.105850_bib135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13321-018-0259-x","article-title":"Key features and updates for Origin 2018","volume":"10","author":"Moberly","year":"2018","journal-title":"J.\u00a0Cheminform."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422202123X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422202123X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:03:50Z","timestamp":1762880630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422202123X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":135,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S258900422202123X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.105850","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternative telomere maintenance mechanism in Alligator sinensis provides insights into aging evolution","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.105850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"105850"}}