{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:30:54Z","timestamp":1793377854784,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["084804\/2\/08\/Z"],"award-info":[{"award-number":["084804\/2\/08\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010872","name":"King's College Hospital NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/K016164\/1"],"award-info":[{"award-number":["BB\/K016164\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009360","name":"King\u2019s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004941","name":"Guy's and St Thomas' NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.isci.2022.105911","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T20:22:34Z","timestamp":1672345354000},"page":"105911","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism"],"prefix":"10.1016","volume":"26","author":[{"given":"Hong Wa","family":"Yung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Glover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Burrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poh-Choo","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Duhig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matts","family":"Olovsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C.","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart M.","family":"Haslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham J.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Stephen","family":"Charnock-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2022.105911_bib1","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.placenta.2011.11.013","article-title":"Review: the placenta and developmental programming: balancing fetal nutrient demands with maternal resource allocation","volume":"33","author":"Burton","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.isci.2022.105911_bib2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1095\/biolreprod.114.121798","article-title":"The role of placental nutrient sensing in maternal-fetal resource allocation","volume":"91","author":"D\u00edaz","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.isci.2022.105911_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fphar.2014.00065","article-title":"Physiologic and pharmacokinetic changes in pregnancy","volume":"5","author":"Costantine","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2022.105911_bib4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1086\/418300","article-title":"Genetic conflicts in human pregnancy","volume":"68","author":"Haig","year":"1993","journal-title":"Q.\u00a0Rev. Biol."},{"key":"10.1016\/j.isci.2022.105911_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/10641950601146574","article-title":"Risk factors for cardiovascular disease in women with a history of pregnancy complicated by preeclampsia or intrauterine growth restriction","volume":"26","author":"Manten","year":"2007","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.isci.2022.105911_bib6","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jacc.2014.02.529","article-title":"Pre-eclampsia and future cardiovascular risk among women: a review","volume":"63","author":"Ahmed","year":"2014","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2022.105911_bib7","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1161\/CIRCULATIONAHA.111.034884","article-title":"Birth characteristics and subsequent risks of maternal cardiovascular disease: effects of gestational age and fetal growth","volume":"124","author":"Bonamy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2022.105911_bib8","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/HYPERTENSIONAHA.110.150078","article-title":"Preeclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort","volume":"56","author":"Mongraw-Chaffin","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.isci.2022.105911_bib9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MED.0b013e32834c800d","article-title":"Placental hormones and the control of maternal metabolism and fetal growth","volume":"18","author":"Newbern","year":"2011","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.isci.2022.105911_bib10","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.placenta.2012.11.024","article-title":"Review: adiponectin--the missing link between maternal adiposity, placental transport and fetal growth?","volume":"34","author":"Aye","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.isci.2022.105911_bib11","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1038\/emm.2015.122","article-title":"Regulation of glucose metabolism from a liver-centric perspective","volume":"48","author":"Han","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.isci.2022.105911_bib12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1478-3231.2009.02183.x","article-title":"Gene profiling of maternal hepatic adaptations to pregnancy","volume":"30","author":"Bustamante","year":"2010","journal-title":"Liver Int."},{"key":"10.1016\/j.isci.2022.105911_bib13","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0002-9378(12)80011-1","article-title":"Longitudinal changes in basal hepatic glucose production and suppression during insulin infusion in normal pregnant women","volume":"167","author":"Catalano","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.isci.2022.105911_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0008-6363(00)00087-0","article-title":"Vascular function in preeclampsia","volume":"47","author":"VanWijk","year":"2000","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2022.105911_bib15","doi-asserted-by":"crossref","first-page":"327.e1","DOI":"10.1016\/j.ajog.2011.02.024","article-title":"Maternal insulin resistance and preeclampsia","volume":"204","author":"Hauth","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.isci.2022.105911_bib16","doi-asserted-by":"crossref","first-page":"1218S","DOI":"10.1093\/ajcn\/71.5.1218s","article-title":"Physiology of pregnancy and nutrient metabolism","volume":"71","author":"King","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2022.105911_bib17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","article-title":"Glycosylation in health and disease","volume":"15","author":"Reily","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.isci.2022.105911_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0968-0004(85)90112-4","article-title":"Sialic acids and their role as biological masks","volume":"10","author":"Schauer","year":"1985","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2022.105911_bib19","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.009100","article-title":"N-glycans modulate the function of human corticosteroid-binding globulin","volume":"10","author":"Sumer-Bayraktar","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.isci.2022.105911_bib20","doi-asserted-by":"crossref","first-page":"15153","DOI":"10.1016\/S0021-9258(18)66845-0","article-title":"Immunochemical evidence for a role of complex carbohydrate chains in thyroglobulin antigenicity","volume":"261","author":"Fenouillet","year":"1986","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2022.105911_bib21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm1259","article-title":"Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis","volume":"11","author":"Scheuner","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2022.105911_bib22","doi-asserted-by":"crossref","first-page":"E10089","DOI":"10.1073\/pnas.1805425115","article-title":"XBP1s activation can globally remodel N-glycan structure distribution patterns","volume":"115","author":"Wong","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105911_bib23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction","volume":"173","author":"Yung","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2022.105911_bib24","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1007\/s00125-016-4040-2","article-title":"Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants","volume":"59","author":"Yung","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2022.105911_bib25","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/19420862.2015.1134410","article-title":"Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies","volume":"8","author":"Houston","year":"2016","journal-title":"mAbs"},{"key":"10.1016\/j.isci.2022.105911_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/path.4394","article-title":"Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early- and late-onset pre-eclampsia","volume":"234","author":"Yung","year":"2014","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.isci.2022.105911_bib27","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/glycob\/cwl034","article-title":"Site-specific glycan analysis of human chorionic gonadotropin beta-subunit from malignancies and pregnancy by liquid chromatography--electrospray mass spectrometry","volume":"16","author":"Valmu","year":"2006","journal-title":"Glycobiology"},{"key":"10.1016\/j.isci.2022.105911_bib28","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1093\/oxfordjournals.humrep.a019303","article-title":"Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy","volume":"11","author":"Clark","year":"1996","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.isci.2022.105911_bib29","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1097-2765(01)00265-9","article-title":"Translational control is required for the unfolded protein response and in\u00a0vivo glucose homeostasis","volume":"7","author":"Scheuner","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2022.105911_bib30","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/path.4068","article-title":"Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction","volume":"228","author":"Yung","year":"2012","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.isci.2022.105911_bib31","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0300-9084(01)01301-3","article-title":"The human sialyltransferase family","volume":"83","author":"Harduin-Lepers","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.isci.2022.105911_bib32","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ygeno.2005.07.008","article-title":"Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family","volume":"86","author":"Zebhauser","year":"2005","journal-title":"Genomics"},{"key":"10.1016\/j.isci.2022.105911_bib33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ydbio.2011.07.036","article-title":"Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta","volume":"358","author":"Hu","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2022.105911_bib34","doi-asserted-by":"crossref","first-page":"R213","DOI":"10.1530\/REP-20-0007","article-title":"Placental glycogen stores and fetal growth: insights from genetic mouse models","volume":"159","author":"Tunster","year":"2020","journal-title":"Reproduction"},{"key":"10.1016\/j.isci.2022.105911_bib35","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Perk is essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2022.105911_bib36","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.3389\/fimmu.2019.02951","article-title":"Crosstalk between hypoxia and ER stress response: a key regulator of macrophage polarization","volume":"10","author":"D\u00edaz-Bulnes","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2022.105911_bib37","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1113\/JP271073","article-title":"Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy","volume":"594","author":"Matheson","year":"2016","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.isci.2022.105911_bib38","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1096\/fj.11-190082","article-title":"Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude","volume":"26","author":"Yung","year":"2012","journal-title":"FASEb. J."},{"key":"10.1016\/j.isci.2022.105911_bib39","doi-asserted-by":"crossref","first-page":"1256S","DOI":"10.1093\/ajcn\/71.5.1256s","article-title":"Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus","volume":"71","author":"Butte","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2022.105911_bib40","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s001250050861","article-title":"Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes","volume":"41","author":"Peak","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2022.105911_bib41","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1101\/gad.2039011","article-title":"De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state","volume":"25","author":"Pawlak","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2022.105911_bib42","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1172\/JCI107794","article-title":"Measurement of pregnancy-associated plasma proteins during human gestation","volume":"54","author":"Lin","year":"1974","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2022.105911_bib43","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/REP-21-0390","article-title":"Pregnancy-specific glycoproteins: evolution, expression, functions and disease associations","volume":"163","author":"Moore","year":"2022","journal-title":"Reproduction"},{"key":"10.1016\/j.isci.2022.105911_bib44","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1038\/s41467-021-22695-y","article-title":"The RNA landscape of the human placenta in health and disease","volume":"12","author":"Gong","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2022.105911_bib45","doi-asserted-by":"crossref","first-page":"12157","DOI":"10.1074\/jbc.M113.544973","article-title":"Modulation of mannose and asialoglycoprotein receptor expression determines glycoprotein hormone half-life at critical points in the reproductive cycle","volume":"289","author":"Mi","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2022.105911_bib46","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jsgi.2004.03.003","article-title":"Placental oxidative stress: from miscarriage to preeclampsia","volume":"11","author":"Burton","year":"2004","journal-title":"J.\u00a0Soc. Gynecol. Investig."},{"key":"10.1016\/j.isci.2022.105911_bib47","doi-asserted-by":"crossref","first-page":"18109","DOI":"10.1073\/pnas.1907548116","article-title":"Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia","volume":"116","author":"Yung","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105911_bib48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/glycob\/cwm017","article-title":"Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys","volume":"17","author":"Jones","year":"2007","journal-title":"Glycobiology"},{"key":"10.1016\/j.isci.2022.105911_bib49","series-title":"Essentials of Glycobiology","first-page":"99","article-title":"N-Glycans","author":"Stanley","year":"2015"},{"key":"10.1016\/j.isci.2022.105911_bib50","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.acthis.2010.12.001","article-title":"Distribution of sugar residues in human placentas from pregnancies complicated by hypertensive disorders","volume":"113","author":"Marini","year":"2011","journal-title":"Acta Histochem."},{"key":"10.1016\/j.isci.2022.105911_bib51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.placenta.2016.05.002","article-title":"Differences of glycocalyx composition in the structural elements of placenta in preeclampsia","volume":"43","author":"Sukhikh","year":"2016","journal-title":"Placenta"},{"key":"10.1016\/j.isci.2022.105911_bib52","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1111\/febs.14759","article-title":"Mammalian sugar-binding receptors: known functions and unexplored roles","volume":"286","author":"Taylor","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.isci.2022.105911_bib53","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1073\/pnas.75.3.1399","article-title":"Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages","volume":"75","author":"Stahl","year":"1978","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105911_bib54","doi-asserted-by":"crossref","first-page":"E1491","DOI":"10.1210\/jc.2015-3204","article-title":"Epigenetic alterations in human liver from subjects with type 2 diabetes in parallel with reduced folate levels","volume":"100","author":"Nilsson","year":"2015","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2022.105911_bib55","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1113\/JP281994","article-title":"Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss","volume":"599","author":"Capatina","year":"2021","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.isci.2022.105911_bib56","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12884-020-03481-y","volume":"21","author":"Hague","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.isci.2022.105911_bib57","doi-asserted-by":"crossref","first-page":"597.e1","DOI":"10.1016\/j.ajog.2009.06.024","article-title":"Evidence of increased oxidative stress and a change in the plasminogen activator inhibitor (PAI)-1 to PAI-2 ratio in early-onset but not late-onset preeclampsia","volume":"201","author":"Wikstr\u00f6m","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.isci.2022.105911_bib58","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.kint.2015.10.012","article-title":"Diagnostic and predictive biomarkers for pre-eclampsia in patients with established hypertension and chronic kidney disease","volume":"89","author":"Bramham","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.isci.2022.105911_bib59","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/bioinformatics\/btr645","article-title":"MSnbase-an R\/Bioconductor package for isobaric tagged mass spectrometry data visualization, processing and quantitation","volume":"28","author":"Gatto","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2022.105911_bib60","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1021\/pr7008252","article-title":"GlycoWorkbench: a tool for the computer-assisted annotation of mass spectra of glycans","volume":"7","author":"Ceroni","year":"2008","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.isci.2022.105911_bib61","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41587-020-0439-x","article-title":"The nf-core framework for community-curated bioinformatics pipelines","volume":"38","author":"Ewels","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2022.105911_bib62","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2022.105911_bib63","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.24956.2","article-title":"gprofiler2 -- an R package for gene list functional enrichment analysis and namespace conversion toolset g:Profiler","volume":"9","author":"Kolberg","year":"2020","journal-title":"F1000Research"},{"key":"10.1016\/j.isci.2022.105911_bib64","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2022.105911_bib65","doi-asserted-by":"crossref","DOI":"10.1081\/PRG-100104165","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.isci.2022.105911_bib66","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/MCB.22.11.3864-3874.2002","article-title":"The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2022.105911_bib67","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ydbio.2007.01.009","article-title":"Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta","volume":"304","author":"Simmons","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2022.105911_bib68","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/cvr\/cvq346","article-title":"Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling","volume":"89","author":"Cindrova-Davies","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2022.105911_bib69","doi-asserted-by":"crossref","first-page":"22.2.1","DOI":"10.1002\/0471140864.ps2202s75","article-title":"Protein profiling using two-dimensional difference gel electrophoresis (2-D DIGE)","volume":"75","author":"Feret","year":"2014","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.isci.2022.105911_bib70","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","article-title":"MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes","volume":"86","author":"McAlister","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.isci.2022.105911_bib71","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0076-6879(06)15005-3","article-title":"Glycomic profiling of cells and tissues by mass spectrometry: fingerprinting and sequencing methodologies","volume":"415","author":"Jang-Lee","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.isci.2022.105911_bib72","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nbt.3820","article-title":"Nextflow enables reproducible computational workflows","volume":"35","author":"Di Tommaso","year":"2017","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2022.105911_bib73","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2022.105911_bib74","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ajpath.2018.10.015","article-title":"Role of endoplasmic reticulum stress in proinflammatory cytokine-mediated inhibition of trophoblast invasion in placenta-related complications of pregnancy","volume":"189","author":"Lee","year":"2019","journal-title":"Am. J. Pathol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222021848?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004222021848?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:13:54Z","timestamp":1762881234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004222021848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":74,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2589004222021848"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2022.105911","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2022.105911","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"105911"}}