{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:19:36Z","timestamp":1774055976363,"version":"3.50.1"},"reference-count":72,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.isci.2023.106294","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T22:22:25Z","timestamp":1678400545000},"page":"106294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation"],"prefix":"10.1016","volume":"26","author":[{"given":"Sumita","family":"Mishra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desirae","family":"McKoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Farinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Page","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Ranek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Zachara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-2299","authenticated-orcid":false,"given":"David A.","family":"Kass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.106294_bib1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-3-642-54215-2_7","article-title":"TRPC6: physiological function and pathophysiological relevance","volume":"222","author":"Dietrich","year":"2014","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.isci.2023.106294_bib2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/ng1592","article-title":"TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function","volume":"37","author":"Reiser","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2023.106294_bib3","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1073\/pnas.1308963111","article-title":"Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy","volume":"111","author":"Seo","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.106294_bib4","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1038\/sj.emboj.7601417","article-title":"TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy","volume":"25","author":"Onohara","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2023.106294_bib5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1161\/CIRCRESAHA.114.302614","article-title":"Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation","volume":"114","author":"Seo","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2023.106294_bib6","doi-asserted-by":"crossref","first-page":"e158906","DOI":"10.1172\/jci.insight.158906","article-title":"Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy","volume":"7","author":"Lin","year":"2022","journal-title":"JCI insight"},{"key":"10.1016\/j.isci.2023.106294_bib7","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.devcel.2012.08.017","article-title":"A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in\u00a0vivo","volume":"23","author":"Davis","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2023.106294_bib8","doi-asserted-by":"crossref","first-page":"19093","DOI":"10.1073\/pnas.0606728103","article-title":"Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange","volume":"103","author":"Weissmann","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.106294_bib9","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1084\/jem.20111355","article-title":"TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation","volume":"209","author":"Tauseef","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2023.106294_bib10","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1113\/JP280950","article-title":"Vascular calcium signalling and ageing","volume":"599","author":"Harraz","year":"2021","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.isci.2023.106294_bib11","first-page":"4159","article-title":"Mechanosensitive ATP release from hemichannels and Ca(2)(+) influx through TRPC6 accelerate wound closure in keratinocytes","volume":"127","author":"Takada","year":"2014","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.isci.2023.106294_bib12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jneuroim.2018.10.010","article-title":"The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function","volume":"325","author":"Ramirez","year":"2018","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.isci.2023.106294_bib13","doi-asserted-by":"crossref","first-page":"10156","DOI":"10.1073\/pnas.1815354116","article-title":"In\u00a0vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease","volume":"116","author":"Lin","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.106294_bib14","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1172\/JCI27702","article-title":"TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling","volume":"116","author":"Kuwahara","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2023.106294_bib15","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1172\/JCI76767","article-title":"Gq signaling causes glomerular injury by activating TRPC6","volume":"125","author":"Wang","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2023.106294_bib16","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1106215","article-title":"A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis","volume":"308","author":"Winn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.106294_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/cells9010044","article-title":"TRPC channels in proteinuric kidney diseases","volume":"9","author":"Hall","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.isci.2023.106294_bib18","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1093\/ndt\/gfp229","article-title":"TRPC6 mutational analysis in a large cohort of patients with focal segmental glomerulosclerosis","volume":"24","author":"Sant\u00edn","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.isci.2023.106294_bib19","doi-asserted-by":"crossref","first-page":"10381","DOI":"10.1074\/jbc.RA118.003183","article-title":"Cryo-EM structure of the cytoplasmic domain of murine transient receptor potential cation channel subfamily C member 6 (TRPC6)","volume":"293","author":"Azumaya","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106294_bib20","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41422-018-0038-2","article-title":"Structure of the receptor-activated human TRPC6 and TRPC3 ion channels","volume":"28","author":"Tang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.isci.2023.106294_bib21","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2021.12.023","article-title":"Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites","volume":"110","author":"Guo","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2023.106294_bib22","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1091\/mbc.e10-12-0929","article-title":"Tyrosine phosphorylation-dependent activation of TRPC6 regulated by PLC-gamma1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis","volume":"22","author":"Kanda","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.isci.2023.106294_bib23","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1096\/fj.201700309R","article-title":"Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression","volume":"32","author":"Hagmann","year":"2018","journal-title":"Faseb j"},{"key":"10.1016\/j.isci.2023.106294_bib24","doi-asserted-by":"crossref","first-page":"18887","DOI":"10.1074\/jbc.M311274200","article-title":"Regulation of TRPC6 channel activity by tyrosine phosphorylation","volume":"279","author":"Hisatsune","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106294_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/cells9010135","article-title":"Post-translational modification and natural mutation of TRPC channels","volume":"9","author":"Liu","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.isci.2023.106294_bib26","doi-asserted-by":"crossref","first-page":"C541","DOI":"10.1152\/ajpcell.00028.2017","article-title":"Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization","volume":"313","author":"Chaudhuri","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.isci.2023.106294_bib27","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1159\/000257517","article-title":"NADPH oxidase-derived ROS contributes to upregulation of TRPC6 expression in puromycin aminonucleoside-induced podocyte injury","volume":"24","author":"Wang","year":"2009","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.isci.2023.106294_bib28","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.1074\/jbc.RA119.008299","article-title":"Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6","volume":"294","author":"Talbot","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106294_bib29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.106294_bib30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.yjmcc.2009.11.015","article-title":"Cyclic GMP\/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition","volume":"48","author":"Koitabashi","year":"2010","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2023.106294_bib31","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/CIRCRESAHA.109.208314","article-title":"Inhibition of TRPC6 channel activity contributes to the antihypertrophic effects of natriuretic peptides-guanylyl cyclase-A signaling in the heart","volume":"106","author":"Kinoshita","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2023.106294_bib32","first-page":"2421","article-title":"Participation of the AngII\/TRPC6\/NFAT axis in the pathogenesis of podocyte injury in rats with type 2 diabetes","volume":"19","author":"Ma","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.isci.2023.106294_bib33","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1681\/ASN.2009121253","article-title":"Activation of NFAT signaling in podocytes causes glomerulosclerosis","volume":"21","author":"Wang","year":"2010","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2023.106294_bib34","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1681\/ASN.2018030280","article-title":"A NOX4\/TRPC6 pathway in podocyte calcium regulation and renal damage in diabetic kidney disease","volume":"29","author":"Ilatovskaya","year":"2018","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2023.106294_bib35","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2337\/db09-1100","article-title":"High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes","volume":"59","author":"Wuensch","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2023.106294_bib36","first-page":"14063","article-title":"FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression","volume":"8","author":"Ma","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.isci.2023.106294_bib37","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/ATVBAHA.108.162222","article-title":"High glucose enhances transient receptor potential channel canonical type 6-dependent calcium influx in human platelets via phosphatidylinositol 3-kinase-dependent pathway","volume":"28","author":"Liu","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2023.106294_bib38","doi-asserted-by":"crossref","first-page":"R689","DOI":"10.1152\/ajpregu.00548.2011","article-title":"Excess protein O-GlcNAcylation and the progression of diabetic cardiomyopathy","volume":"303","author":"Fricovsky","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.isci.2023.106294_bib39","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fendo.2018.00642","article-title":"Chronic O-GlcNAcylation and diabetic cardiomyopathy: the bitterness of glucose","volume":"9","author":"Ducheix","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2023.106294_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1586\/14789450.2013.820536","article-title":"Protein O-GlcNAcylation in diabetes and diabetic complications","volume":"10","author":"Ma","year":"2013","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.isci.2023.106294_bib41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1152\/physrev.00043.2019","article-title":"Role of O-linked N-acetylglucosamine protein modification in cellular (Patho)Physiology","volume":"101","author":"Chatham","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2023.106294_bib42","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature05815","article-title":"Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteins","volume":"446","author":"Hart","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106294_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coph.2020.08.005","article-title":"Role of O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins in diabetic cardiovascular complications","volume":"57","author":"Chatham","year":"2021","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.isci.2023.106294_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev-nutr-071812-161240","article-title":"O-GlcNAc cycling: a link between metabolism and chronic disease","volume":"33","author":"Bond","year":"2013","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.isci.2023.106294_bib45","doi-asserted-by":"crossref","first-page":"15822","DOI":"10.1021\/acs.chemrev.1c01006","article-title":"Demystifying the O-GlcNAc code: a systems view","volume":"122","author":"Ma","year":"2022","journal-title":"Chem. Rev."},{"key":"10.1016\/j.isci.2023.106294_bib46","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/glycob\/cwab003","article-title":"O-GlcNAcAtlas: a database of experimentally identified O-GlcNAc sites and proteins","volume":"31","author":"Ma","year":"2021","journal-title":"Glycobiology"},{"key":"10.1016\/j.isci.2023.106294_bib47","doi-asserted-by":"crossref","first-page":"e18121","DOI":"10.1371\/journal.pone.0018121","article-title":"The serine 814 of TRPC6 is phosphorylated under unstimulated conditions","volume":"6","author":"Bousquet","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.106294_bib48","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ceca.2019.03.005","article-title":"The structure of TRPC ion channels","volume":"80","author":"Li","year":"2019","journal-title":"Cell Calcium"},{"key":"10.1016\/j.isci.2023.106294_bib49","doi-asserted-by":"crossref","first-page":"e53311","DOI":"10.7554\/eLife.53311","article-title":"Structural basis for pharmacological modulation of the TRPC6 channel","volume":"9","author":"Bai","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.isci.2023.106294_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/344036a0","article-title":"Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins","volume":"344","author":"Lux","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106294_bib51","doi-asserted-by":"crossref","first-page":"15168","DOI":"10.1021\/bi062188q","article-title":"Ankyrin repeat: a unique motif mediating protein-protein interactions","volume":"45","author":"Li","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2023.106294_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/prot.340170405","article-title":"Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?","volume":"17","author":"Bork","year":"1993","journal-title":"Proteins"},{"key":"10.1016\/j.isci.2023.106294_bib53","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1110\/ps.03554604","article-title":"The ankyrin repeat as molecular architecture for protein recognition","volume":"13","author":"Mosavi","year":"2004","journal-title":"Protein Sci."},{"key":"10.1016\/j.isci.2023.106294_bib54","doi-asserted-by":"crossref","first-page":"34456","DOI":"10.1074\/jbc.M404778200","article-title":"Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat","volume":"279","author":"Erler","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106294_bib55","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0006-291X(03)00175-X","article-title":"O-GlcNAc: a regulatory post-translational modification","volume":"302","author":"Wells","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2023.106294_bib56","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.yjmcc.2011.08.009","article-title":"Protein O-linked beta-N-acetylglucosamine: a novel effector of cardiomyocyte metabolism and function","volume":"52","author":"Darley-Usmar","year":"2012","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2023.106294_bib57","series-title":"Essentials of Glycobiology","first-page":"239","article-title":"The O-GlcNAc modification","author":"Zachara","year":"2015"},{"key":"10.1016\/j.isci.2023.106294_bib58","doi-asserted-by":"crossref","first-page":"9316","DOI":"10.1074\/jbc.272.14.9316","article-title":"O-Linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats","volume":"272","author":"Lubas","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106294_bib59","doi-asserted-by":"crossref","first-page":"H142","DOI":"10.1152\/ajpheart.00438.2013","article-title":"Cardiomyocyte Ogt is essential for postnatal viability","volume":"306","author":"Watson","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2023.106294_bib60","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2016778118","article-title":"Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase","volume":"118","author":"Levine","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.106294_bib61","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1091\/mbc.e09-11-0941","article-title":"O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins","volume":"21","author":"Zeidan","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.isci.2023.106294_bib62","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nchembio.1774","article-title":"O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains","volume":"11","author":"Zhu","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2023.106294_bib63","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jmcb\/mjv033","article-title":"Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter","volume":"8","author":"Zhu","year":"2016","journal-title":"J.\u00a0Mol. Cell Biol."},{"key":"10.1016\/j.isci.2023.106294_bib64","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/glycob\/cwq071","article-title":"Inhibition of phospholamban phosphorylation by O-GlcNAcylation: implications for diabetic cardiomyopathy","volume":"20","author":"Yokoe","year":"2010","journal-title":"Glycobiology"},{"key":"10.1016\/j.isci.2023.106294_bib65","doi-asserted-by":"crossref","first-page":"39094","DOI":"10.1074\/jbc.M112.383778","article-title":"Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes","volume":"287","author":"Zhu-Mauldin","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106294_bib66","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106294_bib67","doi-asserted-by":"crossref","first-page":"24.10.1","DOI":"10.1002\/cpps.24","article-title":"Analysis of protein O-GlcNAcylation by mass spectrometry","volume":"87","author":"Ma","year":"2017","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.isci.2023.106294_bib68","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1158\/2326-6066.CIR-18-0266","article-title":"A mechanism of resistance to antibody-targeted immune attack","volume":"7","author":"Aldeghaither","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.isci.2023.106294_bib73","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2007.01.021","article-title":"Integration of phosphoinositide- and calmodulin-mediated regulation of TRPC6","volume":"25","author":"Kwon","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2023.106294_bib70","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2174\/157436210790226492","article-title":"Protein O-GlcNAcylation: A critical regulator of the cellular response to stress","volume":"5","author":"Chatham","year":"2010","journal-title":"Curr. Signal. Transduct. Ther."},{"key":"10.1016\/j.isci.2023.106294_bib71","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.taap.2014.05.004","article-title":"A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes","volume":"279","author":"Galvis-Pareja","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.isci.2023.106294_bib72","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148798","article-title":"Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice","volume":"131","author":"Mishra","year":"2021","journal-title":"J. Clin. Invest."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223003711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223003711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:30:19Z","timestamp":1740180619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223003711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2589004223003711"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.106294","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.106294","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"106294"}}