{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:23:06Z","timestamp":1790886186708,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.isci.2023.106430","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T03:33:11Z","timestamp":1678937591000},"page":"106430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neutrophils modulate natural killer-mediated osteoclastogenesis during Aggregatibacter actinomycetemcomitans (JP2 clone) infection"],"prefix":"10.1016","volume":"26","author":[{"given":"Bshara","family":"Halloun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koren","family":"Hashai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noy","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Musai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3211-1330","authenticated-orcid":false,"given":"David","family":"Polak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.106430_bib1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-0757.2010.00340.x","article-title":"Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis","volume":"53","author":"Stabholz","year":"2010","journal-title":"Periodontol2000"},{"key":"10.1016\/j.isci.2023.106430_bib2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/00016357.2011.642002","article-title":"The highly leukotoxic JP2 clone of Aggregatibacter actinomycetemcomitans in localized and generalized forms of aggressive periodontitis","volume":"70","author":"Ennibi","year":"2012","journal-title":"Acta Odontol. Scand."},{"key":"10.1016\/j.isci.2023.106430_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fcell.2018.00109","article-title":"Autophagy in neutrophils: from granulopoiesis to neutrophil extracellular traps","volume":"6","author":"Skendros","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2023.106430_bib4","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202154446","article-title":"NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis","volume":"23","author":"Kaufmann","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.isci.2023.106430_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1749-6632.2012.06607.x","article-title":"Current insights into neutrophil homeostasis","volume":"1266","author":"Bugl","year":"2012","journal-title":"Ann. Ny. Acad. Sci."},{"key":"10.1016\/j.isci.2023.106430_bib6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1136\/thoraxjnl-2017-210010","article-title":"Neutrophils drive alveolar macrophage IL-1beta release during respiratory viral infection","volume":"73","author":"Peir\u00f3","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.isci.2023.106430_bib7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.106430_bib8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41419-018-0710-y","article-title":"Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-kappaB activation","volume":"9","author":"Marwick","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2023.106430_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aao4747","article-title":"Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma","volume":"3","author":"Krishnamoorthy","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2023.106430_bib10","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.jaci.2018.01.003","article-title":"Human TH17 cell development requires processing of dendritic cell-derived CXCL8 by neutrophil elastase","volume":"141","author":"Souwer","year":"2018","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.isci.2023.106430_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20130062","article-title":"Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity","volume":"212","author":"Weber","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2023.106430_bib12","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/s41590-019-0496-9","article-title":"Locally instructed CXCR4(hi) neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps","volume":"20","author":"Radermecker","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2023.106430_bib13","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20150577","article-title":"BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis","volume":"213","author":"Parsa","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2023.106430_bib14","first-page":"2887","article-title":"APRIL secreted by neutrophils binds to heparan\u00a0sulfate proteoglycans to create plasma cell niches in human mucosa","volume":"118","author":"Huard","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2023.106430_bib15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-051X.2010.01693.x","article-title":"Proteome analysis of proteins related to aggressive periodontitis combined with neutrophil chemotaxis dysfunction","volume":"38","author":"Mizuno","year":"2011","journal-title":"J.\u00a0Clin. Periodontol."},{"key":"10.1016\/j.isci.2023.106430_bib16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/prd.12092","article-title":"The role of natural killer cells in periodontitis","volume":"69","author":"Wilensky","year":"2015","journal-title":"Periodontol2000"},{"key":"10.1016\/j.isci.2023.106430_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.1198687","article-title":"Innate or adaptive immunity? The example of natural killer cells","volume":"331","author":"Vivier","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.106430_bib18","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2023.106430_bib19","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1128\/IAI.00895-12","article-title":"Role of the NK cell-activating receptor CRACC in periodontitis","volume":"81","author":"Kr\u00e4mer","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2023.106430_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.847372","article-title":"CD18 mediates neutrophil imperviousness to the aggregatibacter actinomycetemcomitans JP2 clone in molar-incisor pattern periodontitis","volume":"13","author":"Hashai","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.106430_bib21","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.4049\/jimmunol.1500709","article-title":"TLR-stimulated neutrophils instruct NK cells to trigger dendritic cell maturation and promote adaptive T\u00a0cell responses","volume":"195","author":"Riise","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2023.106430_bib22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/mmy\/myv030","article-title":"Polymorphonuclear neutrophils and granulocytic myeloid-derived suppressor cells inhibit natural killer cell activity toward Aspergillus fumigatus","volume":"53","author":"Mueller-Leisse","year":"2015","journal-title":"Med. Mycol."},{"key":"10.1016\/j.isci.2023.106430_bib23","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1073\/pnas.1000546107","article-title":"Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis","volume":"107","author":"S\u00f6derstr\u00f6m","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.106430_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11926-017-0635-y","article-title":"The multifunctional\u00a0role of the chemokine system in arthritogenic processes","volume":"19","author":"Bernardini","year":"2017","journal-title":"Curr. Rheumatol. Rep."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223005072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223005072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:37:36Z","timestamp":1762882656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223005072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2589004223005072"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.106430","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophils modulate natural killer-mediated osteoclastogenesis during Aggregatibacter actinomycetemcomitans (JP2 clone) infection","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.106430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"106430"}}