{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:27:49Z","timestamp":1783024069109,"version":"3.54.6"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-040"],"award-info":[{"award-number":["2021-I2M-1-040"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070169"],"award-info":[{"award-number":["82070169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270153"],"award-info":[{"award-number":["82270153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2020YFE0203000"],"award-info":[{"award-number":["2020YFE0203000"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.isci.2023.106817","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T17:49:25Z","timestamp":1683308965000},"page":"106817","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["R274X-mutated Phf6 increased the self-renewal and skewed T\u00a0cell differentiation of hematopoietic stem cells"],"prefix":"10.1016","volume":"26","author":[{"given":"Yanjie","family":"Lan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengxiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaibing","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanzhu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yigeng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.106817_bib1","doi-asserted-by":"crossref","first-page":"11443","DOI":"10.1128\/JVI.79.17.11443-11456.2005","article-title":"Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene","volume":"79","author":"Landais","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2023.106817_bib2","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1074\/jbc.M113.535351","article-title":"Structural and functional insights into the human B\u00f6rjeson-Forssman-Lehmann syndrome-associated protein PHF6","volume":"289","author":"Liu","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106817_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0968-0004(00)88957-4","article-title":"The PHD finger: implications for chromatin-mediated transcriptional regulation","volume":"20","author":"Aasland","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2023.106817_bib4","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1074\/jbc.M112.414839","article-title":"PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis","volume":"288","author":"Wang","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106817_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.599472","article-title":"PHF6 expression levels impact human hematopoietic stem cell differentiation","volume":"8","author":"Loontiens","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2023.106817_bib6","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1182\/bloodadvances.2019000391","article-title":"Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentials","volume":"3","author":"Hsu","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.isci.2023.106817_bib7","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1182\/blood-2018-07-860726","article-title":"PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia","volume":"133","author":"McRae","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.isci.2023.106817_bib8","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1182\/blood.2019000468","article-title":"The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells","volume":"133","author":"Miyagi","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.isci.2023.106817_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1158\/2159-8290.CD-18-1005","article-title":"Phf6 loss enhances HSC self-renewal driving tumor initiation and leukemia stem cell activity in T-ALL","volume":"9","author":"Wendorff","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.isci.2023.106817_bib10","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1038\/s41375-020-0938-2","article-title":"A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models","volume":"34","author":"Loontiens","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2023.106817_bib11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1101\/gad.254151.114","article-title":"A genome-scale in\u00a0vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth","volume":"29","author":"Meacham","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2023.106817_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ng.542","article-title":"PHF6 mutations in T-cell acute lymphoblastic leukemia","volume":"42","author":"Van Vlierberghe","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2023.106817_bib13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/leu.2010.247","article-title":"PHF6 mutations in adult acute myeloid leukemia","volume":"25","author":"Van Vlierberghe","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2023.106817_bib14","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1038\/leu.2016.212","article-title":"Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms","volume":"30","author":"Mori","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2023.106817_bib15","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1074\/jbc.M113.535351","article-title":"Structural and functional insights into the human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6","volume":"289","author":"Liu","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.106817_bib16","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.3324\/haematol.2011.043083","article-title":"Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia","volume":"96","author":"Wang","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.isci.2023.106817_bib17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/gcc.22039","article-title":"The molecular profile of adult T-cell acute lymphoblastic leukemia:\u00a0mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL","volume":"52","author":"Grossmann","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.isci.2023.106817_bib18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00277-012-1664-2","article-title":"Gene mutation profiles and prognostic implications in Korean patients with T-lymphoblastic leukemia","volume":"92","author":"Huh","year":"2013","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.isci.2023.106817_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3892\/ol.2016.4581","article-title":"Co-existence of PHF6 and NOTCH1 mutations in adult T-cell acute lymphoblastic leukemia","volume":"12","author":"Li","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.isci.2023.106817_bib32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3390\/genes6020325","article-title":"PHF6 Degrees of separation: the Multifaceted roles of a chromatin Adaptor protein","volume":"6","author":"Todd","year":"2015","journal-title":"Genes"},{"key":"10.1016\/j.isci.2023.106817_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1097-0320(19970101)27:1<71::AID-CYTO9>3.0.CO;2-O","article-title":"Flow cytometric analysis of activation markers on stimulated T\u00a0cells and their correlation with cell proliferation","volume":"27","author":"Caruso","year":"1997","journal-title":"Cytometry"},{"key":"10.1016\/j.isci.2023.106817_bib21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41375-021-01392-1","article-title":"PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression","volume":"36","author":"Yuan","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2023.106817_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106817_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature01587","article-title":"Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells","volume":"423","author":"Park","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106817_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043300","article-title":"Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation","volume":"7","author":"Dumon","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.106817_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cells9091991","article-title":"Investigating the role of Methylation in silencing of VDR gene expression in normal cells during hematopoiesis and in their leukemic counterparts","volume":"9","author":"Nowak","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.isci.2023.106817_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc4822","article-title":"Functional reconstruction of human AML\u00a0reveals stem cell origin and vulnerability of\u00a0treatment-resistant MLL-rearranged leukemia","volume":"13","author":"Zeisig","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2023.106817_bib27","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1038\/sj.leu.2404401","article-title":"Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells","volume":"20","author":"Gal","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2023.106817_bib28","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"Mullighan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106817_bib29","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1101\/gad.295857.117","article-title":"PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes","volume":"31","author":"Soto-Feliciano","year":"2017","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2023.106817_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-genet-111212-133424","article-title":"Organizing principles of mammalian nonsense-mediated mRNA decay","volume":"47","author":"Popp","year":"2013","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.isci.2023.106817_bib31","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/hmg\/ddab081","article-title":"Transgenic mice with an R342X mutation in\u00a0Phf6 display clinical features of B\u00f6rjeson-Forssman-Lehmann Syndrome\u00a0(BFLS)","volume":"30","author":"Ahmed","year":"2021","journal-title":"Hum. Mol. Genet."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223008945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223008945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:00:00Z","timestamp":1783022400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223008945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2589004223008945"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.106817","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"R274X-mutated Phf6 increased the self-renewal and skewed T\u00a0cell differentiation of hematopoietic stem cells","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.106817","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"106817"}}