{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:24:23Z","timestamp":1786991063962,"version":"build-2736575974"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["CA162445"],"award-info":[{"award-number":["CA162445"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["CA170906"],"award-info":[{"award-number":["CA170906"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["CA160433"],"award-info":[{"award-number":["CA160433"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["CA150334"],"award-info":[{"award-number":["CA150334"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019481","name":"Southwestern Medical Foundation","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100019481","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA129906"],"award-info":[{"award-number":["CA129906"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA138671"],"award-info":[{"award-number":["CA138671"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA172741"],"award-info":[{"award-number":["CA172741"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA127672"],"award-info":[{"award-number":["CA127672"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020464","name":"Stupid Strong Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.isci.2023.106913","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T12:48:46Z","timestamp":1684500526000},"page":"106913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases"],"prefix":"10.1016","volume":"26","author":[{"given":"Shuangtao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa Pool","family":"Pizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Shanbhag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Futreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Badgwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Calin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Vykoukal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Yih","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir M.","family":"Hanash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaffer A.","family":"Ajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.106913_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.isci.2023.106913_bib2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.36","article-title":"Gastric adenocarcinoma","volume":"3","author":"Ajani","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.isci.2023.106913_bib3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(10)61121-X","article-title":"Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial","volume":"376","author":"Bang","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2023.106913_bib4","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/14737140.2019.1671189","article-title":"The use of intraperitoneal chemotherapy for gastric malignancies","volume":"19","author":"Macr\u00ec","year":"2019","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.isci.2023.106913_bib5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nature13480","article-title":"Comprehensive molecular characterization of gastric adenocarcinoma","volume":"513","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106913_bib6","first-page":"3519","article-title":"Reverse phase protein arrays in signaling pathways: a data integration perspective","volume":"9","author":"Creighton","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.isci.2023.106913_bib7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/gutjnl-2018-318070","article-title":"Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.isci.2023.106913_bib8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41591-020-1125-8","article-title":"Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma","volume":"27","author":"Wang","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2023.106913_bib9","doi-asserted-by":"crossref","first-page":"9446","DOI":"10.1073\/pnas.0911863107","article-title":"Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth","volume":"107","author":"Murray","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.106913_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000330095","article-title":"S100A8 and S100A9: new insights into their roles in malignancy","volume":"4","author":"Srikrishna","year":"2012","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.isci.2023.106913_bib11","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.106913_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature13438","article-title":"Proteogenomic characterization of human colon and rectal cancer","volume":"513","author":"Zhang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106913_bib13","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cell.2016.05.069","article-title":"Integrated proteogenomic characterization of human high-grade serous ovarian cancer","volume":"166","author":"Zhang","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.106913_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature18003","article-title":"Proteogenomics connects somatic mutations to signalling in breast cancer","volume":"534","author":"Mertins","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106913_bib15","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41568-021-00366-w","article-title":"Cancer stem cell-immune cell crosstalk in tumour progression","volume":"21","author":"Bayik","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2023.106913_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2018.11.017","article-title":"Targeting cancer stemness in the clinic: from hype to hope","volume":"24","author":"Saygin","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2023.106913_bib17","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798311","article-title":"Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis","volume":"37","author":"Willet","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2023.106913_bib18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.devcel.2020.07.005","article-title":"A dedicated evolutionarily conserved molecular network licenses differentiated cells to return to the cell cycle","volume":"55","author":"Miao","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2023.106913_bib19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/15548627.2020.1857080","article-title":"Autophagy repurposes cells during paligenosis","volume":"17","author":"Miao","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.isci.2023.106913_bib20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1053\/j.gastro.2020.09.016","article-title":"DDIT4 licenses only healthy cells to proliferate during injury-induced metaplasia","volume":"160","author":"Miao","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2023.106913_bib21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nature13255","article-title":"mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)","volume":"510","author":"Rodgers","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106913_bib22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/s41577-021-00541-y","article-title":"Metabolic barriers to cancer immunotherapy","volume":"21","author":"DePeaux","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2023.106913_bib23","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2018.03.023","article-title":"The immune landscape of cancer","volume":"48","author":"Thorsson","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2023.106913_bib24","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.trecan.2020.12.014","article-title":"The role of the microenvironment and immune system in regulating stem cell fate in cancer","volume":"7","author":"Ferguson","year":"2021","journal-title":"Trends Cancer"},{"key":"10.1016\/j.isci.2023.106913_bib25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.stem.2018.12.009","article-title":"Cancer stem cells: the architects of the tumor ecosystem","volume":"24","author":"Prager","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2023.106913_bib26","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1038\/s12276-022-00905-x","article-title":"Effect of chromatin modifiers on the plasticity and immunogenicity of small-cell lung cancer","volume":"54","author":"Kirk","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.isci.2023.106913_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.61","article-title":"Ovarian cancer","volume":"2","author":"Matulonis","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.isci.2023.106913_bib28","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s41591-020-0926-0","article-title":"A single-cell landscape of high-grade serous ovarian cancer","volume":"26","author":"Izar","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2023.106913_bib29","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41467-018-03121-2","article-title":"A proteomic landscape of diffuse-type gastric cancer","volume":"9","author":"Ge","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2023.106913_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1074\/mcp.M200008-MCP200","article-title":"Discordant protein and mRNA expression in lung adenocarcinomas","volume":"1","author":"Chen","year":"2002","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.isci.2023.106913_bib31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/dna.2018.4377","article-title":"Novel-miR-4885 promotes migration and invasion of esophageal cancer cells through targeting CTNNA2","volume":"38","author":"Song","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.isci.2023.106913_bib32","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/ncomms3531","article-title":"Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas","volume":"4","author":"Fanjul-Fern\u00e1ndez","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2023.106913_bib33","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1038\/onc.2012.434","article-title":"Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms","volume":"32","author":"Deng","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2023.106913_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.692117","article-title":"LTF regulates the immune microenvironment of prostate cancer through JAK\/STAT3 pathway","volume":"11","author":"Zhao","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2023.106913_bib35","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1046\/j.1523-1747.2003.12318.x","article-title":"cTAGE: a cutaneous T\u00a0cell lymphoma associated antigen family with tumor-specific splicing","volume":"121","author":"Usener","year":"2003","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.isci.2023.106913_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.996026","article-title":"Blocking LAIR1 signaling in immune cells inhibits tumor development","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.106913_bib37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbrc.2022.09.019","article-title":"A perspective on LILRBs and LAIR1 as immune checkpoint targets for cancer treatment","volume":"633","author":"Zhang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2023.106913_bib38","article-title":"Differential expression of HAVCR2 gene in pan-cancer: a potential biomarker for survival and immunotherapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2023.106913_bib39","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.isci.2023.106913_bib40","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.106913_bib41","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223009902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223009902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:50:33Z","timestamp":1783021833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223009902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2589004223009902"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.106913","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.106913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"106913"}}