{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:02:19Z","timestamp":1783832539426,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870641"],"award-info":[{"award-number":["81870641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070939"],"award-info":[{"award-number":["82070939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ23H120005"],"award-info":[{"award-number":["LQ23H120005"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.isci.2023.106921","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T03:23:33Z","timestamp":1684466613000},"page":"106921","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lens regeneration in situ using hESCs-derived cells \u2014similar to natural lens"],"prefix":"10.1016","volume":"26","author":[{"given":"Xinyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanle","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjie","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peike","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuli","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6764-7365","authenticated-orcid":false,"given":"Ke","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.106921_bib1","unstructured":"SeeInternational. Cataracts. https:\/\/www.seeintl.org\/cataracts\/."},{"key":"10.1016\/j.isci.2023.106921_bib2","unstructured":"NEI. Cataract data and statistics. https:\/\/www.nei.nih.gov\/learn-about-eye-health\/resources-for-health-educators\/eye-health-data-and-statistics\/cataract-data-and-statistics."},{"key":"10.1016\/j.isci.2023.106921_bib3","doi-asserted-by":"crossref","first-page":"100008","DOI":"10.1016\/j.aopr.2021.100008","article-title":"Cataract: advances in surgery and whether surgery remains the only treatment in future","volume":"1","author":"Chen","year":"2021","journal-title":"Advances in Ophthalmology Practice and Research"},{"key":"10.1016\/j.isci.2023.106921_bib4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1387\/ijdb.180084nv","article-title":"Lens regeneration: a historical perspective","volume":"62","author":"Vergara","year":"2018","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.isci.2023.106921_bib5","doi-asserted-by":"crossref","first-page":"4911","DOI":"10.1007\/s11033-021-06489-5","article-title":"Lens regeneration: scientific discoveries and clinical possibilities","volume":"48","author":"Gu","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.isci.2023.106921_bib6","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/molbev\/msy045","article-title":"Diverse evolutionary origins and mechanisms of lens regeneration","volume":"35","author":"Henry","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.isci.2023.106921_bib7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.survophthal.2005.11.005","article-title":"Lens regeneration in mammals: a review","volume":"51","author":"Gwon","year":"2006","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.isci.2023.106921_bib8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature17181","article-title":"Lens regeneration using endogenous stem cells with gain of visual function","volume":"531","author":"Lin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106921_bib9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1634\/stemcells.2008-0884","article-title":"BAC transgenesis in human embryonic stem cells as a novel tool to define the human neural lineage","volume":"27","author":"Placantonakis","year":"2009","journal-title":"Stem Cell."},{"key":"10.1016\/j.isci.2023.106921_bib10","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.21037\/atm-2019-rcs-03","article-title":"Lens regeneration in humans: using regenerative potential for tissue repairing","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.isci.2023.106921_bib11","doi-asserted-by":"crossref","first-page":"108808","DOI":"10.1016\/j.exer.2021.108808","article-title":"The importance of the epithelial fibre cell interface to lens regeneration in an in\u00a0vivo rat model and in a human bag-in-the-lens (BiL) sample","volume":"213","author":"Wu","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2023.106921_bib12","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.1038\/nature26149","article-title":"Lens regeneration in children","volume":"556","author":"Vavvas","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.106921_bib13","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1167\/iovs.02-1168","article-title":"Induction of the differentiation of lentoids from primate embryonic stem cells","volume":"44","author":"Ooto","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2023.106921_bib14","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1096\/fj.10-157255","article-title":"Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions","volume":"24","author":"Yang","year":"2010","journal-title":"Faseb. J."},{"key":"10.1016\/j.isci.2023.106921_bib15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1167\/iovs.16-20504","article-title":"Generation of functional lentoid bodies from human induced pluripotent stem cells derived from urinary cells","volume":"58","author":"Fu","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2023.106921_bib16","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/jcmm.12099","article-title":"Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt\/beta-catenin signalling and apoptosis regulation in breast cancer cells","volume":"17","author":"Xiang","year":"2013","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.isci.2023.106921_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1534-5807(02)00176-4","article-title":"Planar signaling and morphogenesis in Drosophila","volume":"2","author":"Adler","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2023.106921_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0092-8674(00)81226-X","article-title":"Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling","volume":"94","author":"Boutros","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.106921_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/embo-reports\/kvf008","article-title":"JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates","volume":"3","author":"Yamanaka","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.isci.2023.106921_bib20","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.genet.42.110807.091432","article-title":"Planar cell polarity signaling: from fly development to human disease","volume":"42","author":"Simons","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.isci.2023.106921_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-12-386035-4.00002-1","article-title":"New insights into the mechanism of Wnt signaling pathway activation","volume":"291","author":"Kikuchi","year":"2011","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2023.106921_bib22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exer.2016.04.009","article-title":"Intrinsic and extrinsic regulatory mechanisms are required to form and maintain a lens of the correct size and shape","volume":"156","author":"McAvoy","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2023.106921_bib23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4161\/org.7.3.18421","article-title":"Planar cell polarity in the mammalian eye lens","volume":"7","author":"Sugiyama","year":"2011","journal-title":"Organogenesis"},{"key":"10.1016\/j.isci.2023.106921_bib24","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1167\/iovs.12-11357","article-title":"Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation","volume":"54","author":"Dawes","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2023.106921_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ydbio.2013.10.030","article-title":"Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism","volume":"385","author":"Dawes","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2023.106921_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ydbio.2009.11.033","article-title":"Secreted frizzled-related protein disrupts PCP in eye lens fiber cells that have polarised primary cilia","volume":"338","author":"Sugiyama","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2023.106921_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.01.020","article-title":"Growth factor regulation of lens development","volume":"280","author":"Lovicu","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2023.106921_bib28","first-page":"75","article-title":"Cell signaling pathways in vertebrate lens regeneration","volume":"367","author":"Henry","year":"2013","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.isci.2023.106921_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jss.2015.11.045","article-title":"Efficacy of gelatin gel sheets in sustaining the release of basic fibroblast growth factor for murine skin defects","volume":"201","author":"Sakamoto","year":"2016","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.isci.2023.106921_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1242\/dev.107.2.221","article-title":"Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration","volume":"107","author":"McAvoy","year":"1989","journal-title":"Development"},{"key":"10.1016\/j.isci.2023.106921_bib31","series-title":"Mesenchymal Stromal Cells","first-page":"1","article-title":"MSCs translational process","author":"Viswanathan","year":"2017"},{"key":"10.1016\/j.isci.2023.106921_bib32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.fct.2006.08.011","article-title":"Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation","volume":"45","author":"Schauss","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.isci.2023.106921_bib33","series-title":"Reproductive and Developmental Toxicology","first-page":"385","article-title":"Selected herbal supplements and nutraceuticals","author":"Bagchi","year":"2011"},{"key":"10.1016\/j.isci.2023.106921_bib34","first-page":"5","article-title":"Final report of\u00a0the\u00a0safety assessment of\u00a0hyaluronic\u00a0acid,\u00a0potassium hyaluronate,\u00a0and\u00a0sodium\u00a0hyaluronate","volume":"28","author":"Becker","year":"2009","journal-title":"Int.\u00a0J.\u00a0Toxicol."},{"key":"10.1016\/j.isci.2023.106921_bib35","series-title":"Recent Advances in Ophthalmology","first-page":"31","article-title":"The use of viscous and viscoelastic substances in ophthalmology","author":"Eisner","year":"1985"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223009987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223009987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:07:00Z","timestamp":1783022820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223009987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2589004223009987"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.106921","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lens regeneration in situ using hESCs-derived cells \u2014similar to natural lens","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.106921","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"106921"}}