{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:21:42Z","timestamp":1788168102371,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T00:00:00Z","timestamp":1686528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["IFI16\/00016"],"award-info":[{"award-number":["IFI16\/00016"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["MV19\/00023"],"award-info":[{"award-number":["MV19\/00023"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016391","name":"Societat Catalana de Digestologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K12HL141952"],"award-info":[{"award-number":["K12HL141952"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50AA024333"],"award-info":[{"award-number":["P50AA024333"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K99\/R00AA028048"],"award-info":[{"award-number":["K99\/R00AA028048"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA023722"],"award-info":[{"award-number":["R01AA023722"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA027456"],"award-info":[{"award-number":["R01AA027456"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA028763"],"award-info":[{"award-number":["R01AA028763"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01DK113196"],"award-info":[{"award-number":["R01DK113196"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01GM119174"],"award-info":[{"award-number":["R01GM119174"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21AR071046"],"award-info":[{"award-number":["R21AR071046"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R56HL141744"],"award-info":[{"award-number":["R56HL141744"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA021890"],"award-info":[{"award-number":["U01AA021890"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA026264"],"award-info":[{"award-number":["U01AA026264"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01AA026976"],"award-info":[{"award-number":["U01AA026976"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01DK061732"],"award-info":[{"award-number":["U01DK061732"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01DK062470"],"award-info":[{"award-number":["U01DK062470"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.isci.2023.107133","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:04:25Z","timestamp":1686873865000},"page":"107133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Altered anti-viral immune responses in monocytes in overweight heavy drinkers"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-3912","authenticated-orcid":false,"given":"Adam","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00ed","family":"Ortega-Ribera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan R.","family":"McMullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Bellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyinoluwa","family":"Taiwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vai","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Streem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaividhya","family":"Dasarathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Dasarathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidula","family":"Vachharajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.107133_bib1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.pnpbp.2015.09.001","article-title":"Opposing effects of alcohol on the\u00a0immune system","volume":"65","author":"Barr","year":"2016","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.isci.2023.107133_bib2","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.3390\/nu13103317","article-title":"Alcohol use and the risk of communicable diseases","volume":"13","author":"Morojele","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2023.107133_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/01.CCM.0000254340.91644.B2","article-title":"Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients","volume":"35","author":"O'Brien","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.isci.2023.107133_bib4","doi-asserted-by":"crossref","first-page":"e13496","DOI":"10.1111\/obr.13496","article-title":"COVID-19, obesity, and immune response 2 years after the pandemic: A timeline of scientific advances","volume":"23","author":"Belchior-Bezerra","year":"2022","journal-title":"Obes. Rev."},{"key":"10.1016\/j.isci.2023.107133_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.15585\/mmwr.mm7010e4","article-title":"Body mass index and risk for COVID-19-related hospitalization, intensive care unit admission, invasive mechanical ventilation, and death - United States, March-December 2020","volume":"70","author":"Kompaniyets","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.isci.2023.107133_bib6","doi-asserted-by":"crossref","first-page":"e33022","DOI":"10.2196\/33022","article-title":"Investigating unhealthy alcohol use as an independent risk factor for increased COVID-19 disease severity: observational cross-sectional study","volume":"7","author":"Bhalla","year":"2021","journal-title":"JMIR Public Health Surveill."},{"key":"10.1016\/j.isci.2023.107133_bib7","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.3390\/nu13051592","article-title":"Alcohol consumption is associated with poor prognosis in obese patients with COVID-19: a mendelian randomization study using UK biobank","volume":"13","author":"Fan","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2023.107133_bib8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.immuni.2019.03.025","article-title":"Shared and distinct functions of type I and type III interferons","volume":"50","author":"Lazear","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2023.107133_bib9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.coviro.2011.10.008","article-title":"Interferon-stimulated genes and their antiviral effector functions","volume":"1","author":"Schoggins","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.isci.2023.107133_bib10","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1146\/annurev-virology-092818-015756","article-title":"Interferon-stimulated genes: what do they all do?","volume":"6","author":"Schoggins","year":"2019","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.isci.2023.107133_bib11","doi-asserted-by":"crossref","first-page":"e23820","DOI":"10.4161\/jkst.23820","article-title":"The regulation of inflammation by interferons and their STATs","volume":"2","author":"Rauch","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1016\/j.isci.2023.107133_bib12","doi-asserted-by":"crossref","first-page":"6705","DOI":"10.4049\/jimmunol.178.11.6705","article-title":"Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production","volume":"178","author":"Chang","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib13","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1038\/s41467-019-11147-3","article-title":"IFN-gamma selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation","volume":"10","author":"Kang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2023.107133_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajem.2021.09.040","article-title":"Bacterial infections and death among patients with Covid-19 versus non Covid-19 patients with pneumonia","volume":"51","author":"Scott","year":"2022","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.isci.2023.107133_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhin.2021.04.001","article-title":"Fungal and bacterial coinfections increase mortality of severely ill COVID-19 patients","volume":"113","author":"Silva","year":"2021","journal-title":"J.\u00a0Hosp. Infect."},{"key":"10.1016\/j.isci.2023.107133_bib16","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.107133_bib17","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.abm8108","article-title":"The immunology and immunopathology of COVID-19","volume":"375","author":"Merad","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.107133_bib18","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1126\/science.abc6027","article-title":"Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients","volume":"369","author":"Hadjadj","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.107133_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41586-020-2588-y","article-title":"Longitudinal analyses reveal immunological misfiring in severe COVID-19","volume":"584","author":"Lucas","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.107133_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41590-020-00840-x","article-title":"Untuned antiviral immunity in COVID-19 revealed by temporal type I\/III interferon patterns and flu comparison","volume":"22","author":"Galani","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib21","doi-asserted-by":"crossref","first-page":"eabd1554","DOI":"10.1126\/sciimmunol.abd1554","article-title":"Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19","volume":"5","author":"Lee","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib22","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1016\/j.cell.2021.08.016","article-title":"The interferon landscape along the respiratory tract impacts the severity of COVID-19","volume":"184","author":"Sposito","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.107133_bib23","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1002\/jmv.27172","article-title":"Immunostimulation with interferon-gamma in protracted SARS-CoV-2 pneumonia","volume":"93","author":"Lukaszewicz","year":"2021","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.isci.2023.107133_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41420-020-00376-x","article-title":"A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients","volume":"6","author":"Sadanandam","year":"2020","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.isci.2023.107133_bib25","doi-asserted-by":"crossref","first-page":"585647","DOI":"10.3389\/fimmu.2020.585647","article-title":"Lower circulating interferon-gamma is a risk factor for lung fibrosis in COVID-19 patients","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib26","doi-asserted-by":"crossref","first-page":"103642","DOI":"10.1016\/j.ebiom.2021.103642","article-title":"Off balance: interferons in COVID-19 lung infections","volume":"73","author":"Akamatsu","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.isci.2023.107133_bib27","doi-asserted-by":"crossref","first-page":"198171","DOI":"10.1016\/j.virusres.2020.198171","article-title":"IFN-gamma is an independent risk factor associated with mortality in patients with moderate and severe COVID-19 infection","volume":"289","author":"Gadotti","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.isci.2023.107133_bib28","doi-asserted-by":"crossref","first-page":"100287","DOI":"10.1016\/j.xcrm.2021.100287","article-title":"Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions","volume":"2","author":"Filbin","year":"2021","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.isci.2023.107133_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3389\/fimmu.2020.00397","article-title":"TREML4 promotes inflammatory programs in human and murine macrophages and alters atherosclerosis lesion composition in the apolipoprotein E deficient mouse","volume":"11","author":"Gonzalez-Cotto","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib30","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep.31759","article-title":"Gene deconvolution reveals aberrant liver regeneration and immune cell infiltration in alcohol-associated Hepatitis","volume":"74","author":"Kim","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2023.107133_bib31","doi-asserted-by":"crossref","first-page":"e20210582","DOI":"10.1084\/jem.20210582","article-title":"Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19","volume":"218","author":"Wilk","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2023.107133_bib32","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1038\/s41366-020-00677-2","article-title":"Obesity is a potential risk factor contributing to clinical manifestations of COVID-19","volume":"44","author":"Kang","year":"2020","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.isci.2023.107133_bib33","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1467-789X.2011.00864.x","article-title":"Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: a systematic review and meta-analysis","volume":"12","author":"Fezeu","year":"2011","journal-title":"Obes. Rev."},{"key":"10.1016\/j.isci.2023.107133_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/irv.12618","article-title":"Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses","volume":"13","author":"Moser","year":"2019","journal-title":"Influenza Other Respir. Viruses"},{"key":"10.1016\/j.isci.2023.107133_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.nut.2012.04.019","article-title":"Decreased interferon-alpha and interferon-beta production in obesity and expression of suppressor of cytokine signaling","volume":"29","author":"Teran-Cabanillas","year":"2013","journal-title":"Nutrition"},{"key":"10.1016\/j.isci.2023.107133_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3390\/vaccines9020102","article-title":"Immune response to SARS-CoV-2 infection in obesity and T2D: literature review","volume":"9","author":"Perez-Galarza","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.isci.2023.107133_bib37","doi-asserted-by":"crossref","first-page":"e0251768","DOI":"10.1371\/journal.pone.0251768","article-title":"The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients","volume":"16","author":"Besutti","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.107133_bib38","doi-asserted-by":"crossref","first-page":"e23923","DOI":"10.1002\/jcla.23923","article-title":"Risk factors for prolonged virus shedding of respiratory tract and fecal in adults with severe acute respiratory syndrome coronavirus-2 infection","volume":"35","author":"Zhang","year":"2021","journal-title":"J.\u00a0Clin. Lab. Anal."},{"key":"10.1016\/j.isci.2023.107133_bib39","doi-asserted-by":"crossref","first-page":"760288","DOI":"10.3389\/fimmu.2021.760288","article-title":"Obesity correlates with pronounced aberrant innate immune responses in hospitalized aged COVID-19 patients","volume":"12","author":"Zulu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib40","doi-asserted-by":"crossref","first-page":"e543","DOI":"10.1016\/S2666-5247(21)00237-8","article-title":"The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries","volume":"3","author":"Hoenigl","year":"2022","journal-title":"Lancet. Microbe"},{"key":"10.1016\/j.isci.2023.107133_bib41","doi-asserted-by":"crossref","first-page":"185","DOI":"10.35946\/arcr.v37.2.04","article-title":"Impact of alcohol abuse on the adaptive immune system","volume":"37","author":"Pasala","year":"2015","journal-title":"Alcohol Res."},{"key":"10.1016\/j.isci.2023.107133_bib42","doi-asserted-by":"crossref","first-page":"e0239246","DOI":"10.1371\/journal.pone.0239246","article-title":"Alcohol dependence promotes systemic IFN-gamma and IL-17 responses in mice","volume":"15","author":"Frank","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.107133_bib43","doi-asserted-by":"crossref","first-page":"724015","DOI":"10.3389\/fimmu.2021.724015","article-title":"Transcriptional, epigenetic, and functional reprogramming of monocytes from non-human primates following chronic alcohol drinking","volume":"12","author":"Lewis","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib44","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fmed.2020.00532","article-title":"Clinical characteristics and risk factors for disease severity and death in patients with Coronavirus disease 2019 in Wuhan, China","volume":"7","author":"Zou","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.isci.2023.107133_bib45","doi-asserted-by":"crossref","first-page":"e1008570","DOI":"10.1371\/journal.ppat.1008570","article-title":"Biological sex impacts COVID-19 outcomes","volume":"16","author":"Klein","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2023.107133_bib46","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41577-020-0348-8","article-title":"Considering how biological sex impacts immune responses and COVID-19 outcomes","volume":"20","author":"Scully","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib47","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.3389\/fimmu.2019.01295","article-title":"miRNAs involved in M1\/M2 hyperpolarization are clustered and coordinately expressed in alcoholic Hepatitis","volume":"10","author":"Kim","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.107133_bib48","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/hep4.1563","article-title":"Functionally diverse inflammatory responses in peripheral and liver monocytes in alcohol-associated Hepatitis","volume":"4","author":"Kim","year":"2020","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.isci.2023.107133_bib49","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13059-018-1603-1","article-title":"Cell hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics","volume":"19","author":"Stoeckius","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2023.107133_bib50","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.107133_bib51","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2023.107133_bib52","article-title":"Systematic comparative analysis of single cell RNA-sequencing methods","author":"Ding","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2023.107133_bib53","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.1038\/s41467-021-25960-2","article-title":"Confronting false discoveries in single-cell differential expression","volume":"12","author":"Squair","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2023.107133_bib54","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223012105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223012105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:55:16Z","timestamp":1788166516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223012105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2589004223012105"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.107133","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered anti-viral immune responses in monocytes in overweight heavy drinkers","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.107133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"107133"}}