{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:22:47Z","timestamp":1793125367468,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"MASSACHUSETTS GENERAL HOSPITAL","doi-asserted-by":"publisher","award":["237254"],"award-info":[{"award-number":["237254"]}],"id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.isci.2023.107202","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T05:51:56Z","timestamp":1687672316000},"page":"107202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-5937","authenticated-orcid":false,"given":"Ander","family":"Dorken-Gallastegi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guansheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Naar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Van Cott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Rosovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gregory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Tompkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Karniadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haytham MA.","family":"Kaafarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Velmahos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarone","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit H.","family":"Frydman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.107202_bib1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri3345","article-title":"Thrombosis as an intravascular effector of innate immunity","volume":"13","author":"Engelmann","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2023.107202_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.smim.2016.10.010","article-title":"Blood coagulation in immunothrombosis\u2014At the frontline of intravascular immunity","volume":"28","author":"Gaertner","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.isci.2023.107202_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13054-015-0735-x","article-title":"Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock","volume":"19","author":"Gando","year":"2015","journal-title":"Crit. Care"},{"key":"10.1016\/j.isci.2023.107202_bib4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000453002","article-title":"Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation","volume":"93","author":"Frantzeskaki","year":"2017","journal-title":"Respiration"},{"key":"10.1016\/j.isci.2023.107202_bib5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/nri2532","article-title":"Intravascular immunity: The host-pathogen encounter in blood vessels","volume":"9","author":"Hickey","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2023.107202_bib6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41577-021-00536-9","article-title":"Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19","volume":"21","author":"Bonaventura","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2023.107202_bib7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/MOH.0000000000000666","article-title":"Mechanisms of immunothrombosis in COVID-19","volume":"28","author":"Portier","year":"2021","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.isci.2023.107202_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.it.2007.02.006","article-title":"Complement and coagulation: strangers or partners in crime?","volume":"28","author":"Markiewski","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.isci.2023.107202_bib9","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3389\/fimmu.2020.01131","article-title":"Lessons Learned to Date on COVID-19 Hyperinflammatory Syndrome: Considerations for Interventions to Mitigate SARS-CoV-2 Viral Infection and Detrimental Hyperinflammation","volume":"11","author":"Cardone","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2023.107202_bib10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/rth2.12496","article-title":"Risk of thrombotic complications in influenza versus COVID-19 hospitalized patients","volume":"5","author":"Stals","year":"2021","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"10.1016\/j.isci.2023.107202_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.thromres.2020.08.020","article-title":"Venous thromboembolism in patients with COVID-19: Systematic review and meta-analysis","volume":"196","author":"Porfidia","year":"2020","journal-title":"Thromb. Res."},{"key":"10.1016\/j.isci.2023.107202_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJMoa2103417","article-title":"Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19","volume":"385","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2023.107202_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMoa2105911","article-title":"Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19","volume":"385","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2023.107202_bib14","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(21)01203-4","article-title":"Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial","volume":"397","author":"Lopes","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2023.107202_bib15","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1001\/jama.2021.4152","volume":"325","author":"Sadeghipour","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2023.107202_bib16","article-title":"Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation","volume":"2","author":"Fraser","year":"2020","journal-title":"Crit. Care Explor."},{"key":"10.1016\/j.isci.2023.107202_bib17","doi-asserted-by":"crossref","first-page":"e575","DOI":"10.1016\/S2352-3026(20)30216-7","article-title":"Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study","volume":"7","author":"Goshua","year":"2020","journal-title":"Lancet. Haematol."},{"key":"10.1016\/j.isci.2023.107202_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10456-020-09753-7","article-title":"Microvascular dysfunction in COVID-19: the MYSTIC study","volume":"24","author":"Rovas","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.isci.2023.107202_bib19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/cells10010186","article-title":"ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients","volume":"10","author":"Vassiliou","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.isci.2023.107202_bib20","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1161\/ATVBAHA.120.315175","article-title":"Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia","volume":"40","author":"Taus","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2023.107202_bib21","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1182\/blood.2020007214","article-title":"Platelet gene expression and function in patients with COVID-19","volume":"136","author":"Manne","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.isci.2023.107202_bib22","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood.2020007252","article-title":"Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19","volume":"136","author":"Hottz","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.isci.2023.107202_bib23","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1055\/a-1347-5555","article-title":"Platelets are Hyperactivated but Show Reduced Glycoprotein VI Reactivity in COVID-19 Patients","volume":"121","author":"L\u00e9opold","year":"2021","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.isci.2023.107202_bib24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-021-03234-7","article-title":"Global absence and targeting of protective immune states in severe COVID-19","volume":"591","author":"Combes","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.107202_bib25","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/bjh.17666","article-title":"Immunothrombosis: a COVID-19 concerto","volume":"194","author":"Goshua","year":"2021","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.isci.2023.107202_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009892","article-title":"Multiphysics and multiscale modeling of microthrombosis in COVID-19","volume":"18","author":"Li","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.isci.2023.107202_bib27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1080\/09537104.2018.1430358","article-title":"Measuring and interpreting platelet-leukocyte aggregates","volume":"29","author":"Finsterbusch","year":"2018","journal-title":"Platelets"},{"key":"10.1016\/j.isci.2023.107202_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/MEG.0b013e3282f246c2","article-title":"Platelet-leucocyte aggregates form in the mesenteric vasculature in patients with ulcerative colitis","volume":"20","author":"Irving","year":"2008","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2023.107202_bib29","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1681\/ASN.V8121838","article-title":"A role for P-selectin in neutrophil and platelet infiltration in immune complex glomerulonephritis","volume":"8","author":"Zachem","year":"1997","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2023.107202_bib30","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1017\/S1431927614013518","article-title":"Erythrocyte\u2013Platelet Interaction in Uncomplicated Pregnancy","volume":"20","author":"Swanepoel","year":"2014","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.isci.2023.107202_bib31","first-page":"507","article-title":"Platelet activation and platelet-erythrocyte aggregates in patients with sickle cell anemia","volume":"129","author":"Wun","year":"1997","journal-title":"J.\u00a0Lab. Clin. Med."},{"key":"10.1016\/j.isci.2023.107202_bib32","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1182\/blood.V99.11.3978","article-title":"Platelet-erythrocyte interactions enhance \u03b1IIb\u03b23 integrin receptor activation and P-selectin expression during platelet recruitment: down-regulation by aspirin ex\u00a0vivo","volume":"99","author":"Vall\u00e9s","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.isci.2023.107202_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081002","article-title":"Platelets and Erythrocyte-Bound Platelets Bind Infectious HIV-1 in Plasma of Chronically Infected Patients","volume":"8","author":"Beck","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.107202_bib34","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3389\/fphys.2019.00945","article-title":"Red Blood Cells: Chasing Interactions","volume":"10","author":"Pretini","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2023.107202_bib35","doi-asserted-by":"crossref","first-page":"15932","DOI":"10.1038\/s41598-019-52041-8","article-title":"Neutrophils promote venular thrombosis by shaping the rheological environment for platelet aggregation","volume":"9","author":"Puhr-Westerheide","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2023.107202_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100434","article-title":"Megakaryocytes and platelet-fibrin thrombi characterize multi-organ thrombosis at autopsy in COVID-19: A case series","volume":"24","author":"Rapkiewicz","year":"2020","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.isci.2023.107202_bib37","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.4049\/jimmunol.1201719","article-title":"Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity","volume":"189","author":"Kaplan","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2023.107202_bib38","doi-asserted-by":"crossref","first-page":"086","DOI":"10.1055\/s-0038-1677040","article-title":"Neutrophil Extracellular Traps in Arterial and Venous Thrombosis","volume":"45","author":"Laridan","year":"2019","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.isci.2023.107202_bib39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1529\/biophysj.104.051029","article-title":"A 3-D Computational Model Predicts that Cell Deformation Affects Selectin-Mediated Leukocyte Rolling","volume":"88","author":"Jadhav","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2023.107202_bib40","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0006-3495(94)80529-6","article-title":"Role of the membrane cortex in neutrophil deformation in small pipets","volume":"67","author":"Zhelev","year":"1994","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2023.107202_bib41","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1164\/rccm.201712-2530OC","article-title":"Early Intravascular Events Are Associated with Development of Acute Respiratory Distress Syndrome. A Substudy of the LIPS-A Clinical Trial","volume":"197","author":"Abdulnour","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.isci.2023.107202_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam5861","article-title":"Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia","volume":"9","author":"Yuan","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2023.107202_bib43","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/0886022X.2021.1948864","article-title":"Platelet-leukocyte aggregates - a predictor for acute kidney injury after cardiac surgery","volume":"43","author":"Yang","year":"2021","journal-title":"Ren. Fail."},{"key":"10.1016\/j.isci.2023.107202_bib44","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/ajh.20655","article-title":"Increased circulating platelet\u2013neutrophil, platelet\u2013monocyte complexes, and platelet activation in patients with ulcerative colitis: A comparative study","volume":"81","author":"Pamuk","year":"2006","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.isci.2023.107202_bib45","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/CIRCULATIONAHA.122.060785","article-title":"Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales","volume":"146","author":"Knight","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2023.107202_bib46","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.cma.2010.02.001","article-title":"Systematic coarse-graining of spectrin-level red blood cell models","volume":"199","author":"Fedosov","year":"2010","journal-title":"Comput. Methods Appl. Mech. Eng."},{"key":"10.1016\/j.isci.2023.107202_bib47","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1039\/C6SM00154H","article-title":"Sub-cellular modeling of platelet transport in blood flow through microchannels with constriction","volume":"12","author":"Yazdani","year":"2016","journal-title":"Soft Matter"},{"key":"10.1016\/j.isci.2023.107202_bib48","doi-asserted-by":"crossref","first-page":"11326","DOI":"10.1073\/pnas.1221297110","article-title":"Probing vasoocclusion phenomena in sickle cell anemia via mesoscopic simulations","volume":"110","author":"Lei","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.107202_bib49","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.bpj.2018.08.031","article-title":"Quantifying Platelet Margination in Diabetic Blood Flow","volume":"115","author":"Chang","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2023.107202_bib50","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1182\/blood.V56.5.866.866","article-title":"Morphometry of Human Leukocytes","volume":"56","author":"Schmid-Sch\u00f6nbein","year":"1980","journal-title":"Blood"},{"key":"10.1016\/j.isci.2023.107202_bib51","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1152\/jappl.1990.69.5.1767","article-title":"Retention of leukocytes in capillaries: role of cell size and deformability","volume":"69","author":"Downey","year":"1990","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.isci.2023.107202_bib52","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.bpj.2020.07.026","article-title":"Quantifying Fibrinogen-Dependent Aggregation of Red Blood Cells in Type 2 Diabetes Mellitus","volume":"119","author":"Deng","year":"2020","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2023.107202_bib53","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1159\/000369460","article-title":"Metabolic Control of Microvascular Networks: Oxygen Sensing and Beyond","volume":"51","author":"Reglin","year":"2014","journal-title":"J.\u00a0Vasc. Res."},{"key":"10.1016\/j.isci.2023.107202_bib54","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.bpj.2017.10.020","article-title":"Direct Numerical Simulation of Cellular-Scale Blood Flow in 3D Microvascular Networks","volume":"113","author":"Balogh","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2023.107202_bib55","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1085\/jgp.78.4.431","article-title":"On connecting large vessels to small. The meaning of Murray\u2019s law","volume":"78","author":"Sherman","year":"1981","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.isci.2023.107202_bib56","first-page":"H349","article-title":"Structural adaptation and stability of microvascular networks: theory and simulations","volume":"275","author":"Pries","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.isci.2023.107202_bib57","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/01.RES.43.5.738","article-title":"The Distribution of Blood Rheological Parameters in the Microvasculature of Cat Mesentery","volume":"43","author":"Lipowsky","year":"1978","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2023.107202_bib58","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/1536867X0600600302","article-title":"Confidence Intervals for Rank Statistics: Somers\u2019 D and Extensions","volume":"6","author":"Newson","year":"2006","journal-title":"STATA J."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223012798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223012798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:47:41Z","timestamp":1788166061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223012798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2589004223012798"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.107202","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating cellular clusters are associated with thrombotic complications and clinical outcomes in COVID-19","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.107202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"107202"}}