{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:59:17Z","timestamp":1791845957214,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J02052"],"award-info":[{"award-number":["2021J02052"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["K99HL164888"],"award-info":[{"award-number":["K99HL164888"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R35HL135775"],"award-info":[{"award-number":["R35HL135775"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["T32HL007917"],"award-info":[{"award-number":["T32HL007917"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["U01HL143365"],"award-info":[{"award-number":["U01HL143365"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003769","name":"Foundation for Women&apos;s Wellness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015132","name":"Foundation for Women\u2019s Wellness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007161","name":"Boston University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.isci.2023.107602","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T17:26:01Z","timestamp":1691688361000},"page":"107602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication"],"prefix":"10.1016","volume":"26","author":[{"given":"Lin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Scartelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanzhang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Merrill-Skoloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsan","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Flaumenhaft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.107602_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","article-title":"Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.107602_bib2","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa2118542","article-title":"Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19","volume":"386","author":"Hammond","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2023.107602_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMoa2204919","article-title":"Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge","volume":"387","author":"Arbel","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2023.107602_bib4","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1038\/s41467-020-19662-4","article-title":"Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2023.107602_bib5","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2147\/DDDT.S359009","article-title":"Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory Compounds","volume":"16","author":"Zhu","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.isci.2023.107602_bib6","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","article-title":"An oral SARS-CoV-2 M(pro) inhibitor clinical candidate for the treatment of COVID-19","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.107602_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00697-22","article-title":"A Randomized Phase 2\/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part","volume":"66","author":"Mukae","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.isci.2023.107602_bib8","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/cid\/ciac933","article-title":"Efficacy and safety of ensitrelvir in patients with mild-to-moderate COVID-19: the phase 2b part of a randomized, placebo-controlled, phase 2\/3 study","volume":"76","author":"Mukae","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2023.107602_bib9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1001\/jamainternmed.2022.6834","article-title":"Safely Prescribing Nirmatrelvir and Ritonavir-Avoiding Drug-Drug Interactions","volume":"183","author":"Culas","year":"2023","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.isci.2023.107602_bib10","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1056\/NEJMc2205944","article-title":"Nirmatrelvir-Ritonavir and Viral Load Rebound in Covid-19","volume":"387","author":"Anderson","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2023.107602_bib11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1056\/NEJMc2206449","article-title":"Rebound of SARS-CoV-2 Infection after Nirmatrelvir-Ritonavir Treatment","volume":"387","author":"Charness","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2023.107602_bib12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.3947\/ic.2022.0123","article-title":"Nirmatrelvir\/Ritonavir Prescription Rate and Outcomes in Coronavirus Disease 2019: A Single Center Study","volume":"54","author":"Park","year":"2022","journal-title":"Infect. Chemother."},{"key":"10.1016\/j.isci.2023.107602_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq7360","article-title":"SARS-CoV-2 3CL(pro) mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376","volume":"15","author":"Heilmann","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2023.107602_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26175377","article-title":"Plant Flavonoids: Chemical Characteristics and Biological Activity","volume":"26","author":"Dias","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.isci.2023.107602_bib15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tplants.2005.03.002","article-title":"Flavonoids: a colorful model for the regulation and evolution of biochemical pathways","volume":"10","author":"Koes","year":"2005","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.isci.2023.107602_bib16","article-title":"Flavonoids: Classification, Biosynthesis and Chemical Ecology","volume":"Ch. 1","author":"Erica","year":"2017"},{"key":"10.1016\/j.isci.2023.107602_bib17","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10529-011-0845-8","article-title":"Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris","volume":"34","author":"Nguyen","year":"2012","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.isci.2023.107602_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11101-021-09759-z","article-title":"Flavonoids are promising safe therapy against COVID-19","volume":"21","author":"Alzaabi","year":"2022","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.isci.2023.107602_bib19","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1111\/cbdd.13604","article-title":"Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors","volume":"94","author":"Jo","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.isci.2023.107602_bib20","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: an overview","volume":"5","author":"Panche","year":"2016","journal-title":"J.\u00a0Nutr. Sci."},{"key":"10.1016\/j.isci.2023.107602_bib21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","article-title":"Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.107602_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94951-6","article-title":"Comprehensive virtual screening of 4.8\u00a0k flavonoids reveals novel insights into allosteric inhibition of SARS-CoV-2 M(PRO)","volume":"11","author":"Jim\u00e9nez-Avalos","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2023.107602_bib23","article-title":"Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors","author":"Fink","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2023.107602_bib24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.tips.2014.12.001","article-title":"Beware of docking","volume":"36","author":"Chen","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.isci.2023.107602_bib25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/14756366.2019.1690480","article-title":"Inhibition of SARS-CoV 3CL protease by flavonoids","volume":"35","author":"Jo","year":"2020","journal-title":"J.\u00a0Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.isci.2023.107602_bib26","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3389\/fpls.2019.00943","article-title":"The Origin and Evolution of Plant Flavonoid Metabolism","volume":"10","author":"Yonekura-Sakakibara","year":"2019","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.isci.2023.107602_bib27","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.molp.2019.06.001","article-title":"The Structure and Function of Major Plant Metabolite Modifications","volume":"12","author":"Wang","year":"2019","journal-title":"Mol. Plant"},{"key":"10.1016\/j.isci.2023.107602_bib28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.isci.2023.107602_bib29","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1021\/acsptsci.0c00216","article-title":"Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in\u00a0Vitro Repurposing Screen","volume":"4","author":"Kuzikov","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.isci.2023.107602_bib30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbrc.2022.04.086","article-title":"Crystal structure of SARS-CoV 3C-like protease with baicalein","volume":"611","author":"Feng","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2023.107602_bib31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/14756366.2021.1873977","article-title":"Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in\u00a0vitro","volume":"36","author":"Liu","year":"2021","journal-title":"J.\u00a0Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.isci.2023.107602_bib32","doi-asserted-by":"crossref","first-page":"44542","DOI":"10.1021\/acsomega.2c05766","article-title":"Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules","volume":"7","author":"Guerra","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.isci.2023.107602_bib33","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41401-020-0483-6","article-title":"Anti-SARS-CoV-2 activities in\u00a0vitro of Shuanghuanglian preparations and bioactive ingredients","volume":"41","author":"Su","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.isci.2023.107602_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12906-019-2632-3","article-title":"Characterization of the anti-Staphylococcus aureus fraction from Penthorum chinense Pursh stems","volume":"19","author":"Ding","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.isci.2023.107602_bib35","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.3390\/molecules190811045","article-title":"Polyphenols with anti-proliferative activities from Penthorum chinense Pursh","volume":"19","author":"Huang","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.isci.2023.107602_bib36","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1039\/c3fo60245a","article-title":"Hepatoprotective function of Penthorum chinense Pursh","volume":"4","author":"Zhang","year":"2013","journal-title":"Food Funct."},{"key":"10.1016\/j.isci.2023.107602_bib37","article-title":"A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota","volume":"2019","author":"Wang","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.isci.2023.107602_bib38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/17425255.2017.1251903","article-title":"Pharmacokinetic properties and drug interactions of apigenin, a natural flavone","volume":"13","author":"Tang","year":"2017","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.isci.2023.107602_bib39","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s40495-017-0113-2","article-title":"Plant flavone apigenin: An emerging anticancer agent","volume":"3","author":"Shankar","year":"2017","journal-title":"Curr. Pharmacol. Rep."},{"key":"10.1016\/j.isci.2023.107602_bib40","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3390\/v14071458","article-title":"Commercially Available Flavonols Are Better SARS-CoV-2 Inhibitors than Isoflavone and Flavones","volume":"14","author":"Chaves","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.isci.2023.107602_bib41","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41392-020-00353-x","article-title":"Baicalein inhibits SARS-CoV-2\/VSV replication with interfering mitochondrial oxidative phosphorylation in a mPTP dependent manner","volume":"5","author":"Huang","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2023.107602_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114302","article-title":"The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in\u00a0vivo and in\u00a0vitro","volume":"183","author":"Song","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2023.107602_bib43","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1080\/07391102.2021.1944909","article-title":"In silico screening of phytopolyphenolics for the identification of bioactive compounds as novel protease inhibitors effective against SARS-CoV-2","volume":"40","author":"Rudrapal","year":"2022","journal-title":"J.\u00a0Biomol. Struct. Dyn."},{"key":"10.1016\/j.isci.2023.107602_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104464","article-title":"The interaction of the bioflavonoids with five SARS-CoV-2 proteins targets: An in\u00a0silico study","volume":"134","author":"Mishra","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.isci.2023.107602_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2021.103473","article-title":"In silico screening, SAR and kinetic studies of naturally occurring flavonoids against SARS CoV-2 main protease","volume":"15","author":"Imran","year":"2022","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.isci.2023.107602_bib46","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.3390\/molecules26216559","article-title":"Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2","volume":"26","author":"Al-Karmalawy","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.isci.2023.107602_bib47","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00862-21","article-title":"SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway","volume":"95","author":"Chen","year":"2021","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2023.107602_bib48","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2023.107602_bib49","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/1756-0500-7-233","article-title":"A robust scoring system to evaluate sepsis severity in an animal model","volume":"7","author":"Shrum","year":"2014","journal-title":"BMC Res. Notes"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223016796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223016796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T22:17:50Z","timestamp":1738880270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223016796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2589004223016796"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.107602","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.107602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"107602"}}