{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:10:08Z","timestamp":1790291408925,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960175"],"award-info":[{"award-number":["81960175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171057"],"award-info":[{"award-number":["82171057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360207"],"award-info":[{"award-number":["82360207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202206080005"],"award-info":[{"award-number":["202206080005"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010891","name":"Guizhou Provincial Health Commission","doi-asserted-by":"publisher","award":["gzwjkj2017-1- 042"],"award-info":[{"award-number":["gzwjkj2017-1- 042"]}],"id":[{"id":"10.13039\/501100010891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017957","name":"Health Commission of Guizhou Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.isci.2023.108024","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T12:53:49Z","timestamp":1695387229000},"page":"108024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cell atlas of trabecular meshwork in glaucomatous non-human primates and DEGs related to tissue contract based on single-cell transcriptomics"],"prefix":"10.1016","volume":"26","author":[{"given":"Xu","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caibin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenru","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehong","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.108024_bib1","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.isci.2023.108024_bib2","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.isci.2023.108024_bib3","first-page":"429","article-title":"The relationship between control of intraocular pressure and visual field deterioration","volume":"130","year":"2000","journal-title":"AGIS Invest."},{"key":"10.1016\/j.isci.2023.108024_bib4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.exer.2016.07.009","article-title":"The many faces of the trabecular meshwork cell","volume":"158","author":"Stamer","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2023.108024_bib5","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.exer.2009.02.007","article-title":"The trabecular meshwork outflow pathways: structural and functional aspects","volume":"88","author":"Tamm","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2023.108024_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11095-018-2557-4","article-title":"Glaucoma - Next Generation Therapeutics: Impossible to Possible","volume":"36","author":"Adams","year":"2018","journal-title":"Pharm. Res. (N. Y.)"},{"key":"10.1016\/j.isci.2023.108024_bib7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/ICU.0b013e32834ff23e","article-title":"Current understanding of conventional outflow dysfunction in glaucoma","volume":"23","author":"Stamer","year":"2012","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.isci.2023.108024_bib8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/j.2040-4603.2015.tb00603.x","article-title":"Autonomic control of the eye","volume":"5","author":"McDougal","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.isci.2023.108024_bib9","doi-asserted-by":"crossref","first-page":"e217","DOI":"10.1016\/j.jfo.2020.05.002","article-title":"The trabecular meshwork: Structure, function and clinical implications. A review of the literature","volume":"43","author":"Buffault","year":"2020","journal-title":"J.\u00a0Fr. Ophtalmol."},{"key":"10.1016\/j.isci.2023.108024_bib10","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.cell.2015.04.044","article-title":"Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells","volume":"161","author":"Klein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.108024_bib11","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1126\/science.1247651","article-title":"Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types","volume":"343","author":"Jaitin","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.108024_bib12","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1167\/iovs.18-25922","article-title":"Association of Gene Polymorphisms With Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis","volume":"60","author":"Chen","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2023.108024_bib13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/APO.0000000000000229","article-title":"Glaucoma Genetics: Recent Advances and Future Directions","volume":"5","author":"Aung","year":"2016","journal-title":"Asia. Pac. J. Ophthalmol."},{"key":"10.1016\/j.isci.2023.108024_bib14","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2023.108024_bib15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10974-014-9389-6","article-title":"A systematic nomenclature for mammalian tropomyosin isoforms","volume":"36","author":"Geeves","year":"2015","journal-title":"J.\u00a0Muscle Res. Cell Motil."},{"key":"10.1016\/j.isci.2023.108024_bib16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.chemosphere.2018.03.053","article-title":"Ca(2+) metabolic disorder and abnormal expression of cardiac troponin involved in fluoride-induced cardiomyocyte damage","volume":"201","author":"Wang","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.isci.2023.108024_bib17","doi-asserted-by":"crossref","first-page":"6960","DOI":"10.18632\/aging.102231","article-title":"TPM2 as a potential predictive biomarker for atherosclerosis","volume":"11","author":"Meng","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.isci.2023.108024_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0077100","article-title":"Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model","volume":"8","author":"Deng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.108024_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12868-017-0346-3","article-title":"Upregulation of the endothelin A (ETA) receptor and its association with neurodegeneration in a rodent model of glaucoma","volume":"18","author":"McGrady","year":"2017","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.isci.2023.108024_bib20","doi-asserted-by":"crossref","first-page":"12856","DOI":"10.1073\/pnas.2001896117","article-title":"Molecular taxonomy of human ocular outflow tissues defined by single-cell transcriptomics","volume":"117","author":"Patel","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.108024_bib21","doi-asserted-by":"crossref","first-page":"10339","DOI":"10.1073\/pnas.2001250117","article-title":"Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis","volume":"117","author":"van Zyl","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.108024_bib22","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/s41598-017-00845-x","article-title":"TGF-beta induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma","volume":"7","author":"Tellios","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2023.108024_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-95768-z","article-title":"Effects of selective EP2 receptor agonist, omidenepag, on trabecular meshwork cells, Schlemm's canal endothelial cells and ciliary muscle contraction","volume":"11","author":"Nakamura","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2023.108024_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023070","article-title":"Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility","volume":"6","author":"Goel","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.108024_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.exer.2016.07.007","article-title":"Age-related posterior ciliary muscle restriction - A link between trabecular meshwork and optic nerve head pathophysiology","volume":"158","author":"Croft","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2023.108024_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108272","article-title":"Corneal myofibroblasts and fibrosis","volume":"201","author":"Wilson","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2023.108024_bib27","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.bbadis.2016.11.006","article-title":"The role of alpha-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling","volume":"1863","author":"Shinde","year":"2017","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.isci.2023.108024_bib28","article-title":"Identification of a novel missense mutation in the TPM1 gene via exome sequencing in a Chinese family with dilated cardiomyopathy: A case report and literature review","volume":"101","author":"Man","year":"2022","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.isci.2023.108024_bib29","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1091\/mbc.E19-10-0586","article-title":"Dynamics of Tpm1.8 domains on actin filaments with single-molecule resolution","volume":"31","author":"Bareja","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.isci.2023.108024_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/127807","article-title":"Congenital heart defects are rarely caused by mutations in cardiac and smooth muscle actin genes","volume":"2015","author":"Khodyuchenko","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.isci.2023.108024_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/jcmm.13889","article-title":"Bmi-1 high-expressing cells enrich cardiac stem\/progenitor cells and respond to heart injury","volume":"23","author":"Song","year":"2019","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.isci.2023.108024_bib32","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/cm.20291","article-title":"Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle","volume":"65","author":"Moran","year":"2008","journal-title":"Cell Motil Cytoskeleton"},{"key":"10.1016\/j.isci.2023.108024_bib33","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/ar.22978","article-title":"Translational control of tropomyosin expression in vertebrate hearts","volume":"297","author":"Dube","year":"2014","journal-title":"Anat. Rec."},{"key":"10.1016\/j.isci.2023.108024_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1247\/csf.15007","article-title":"Morphological Modifications in Myofibrils by Suppressing Tropomyosin 4alpha in Chicken Cardiac Myocytes","volume":"41","author":"Toyota","year":"2016","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.isci.2023.108024_bib35","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3390\/cells10040863","article-title":"Role of Decorin in Posterior Capsule Opacification and Eye Lens Development","volume":"10","author":"Shibata","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.isci.2023.108024_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14720-2","article-title":"Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model","volume":"7","author":"Raghunathan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2023.108024_bib37","first-page":"171","article-title":"Acute and chronic structural effects of pilocarpine on monkey outflow tissues","volume":"96","author":"L\u00fctjen-Drecoll","year":"1998","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.isci.2023.108024_bib38","article-title":"Ex-vivo cultured human corneoscleral segment model to study the effects of glaucoma factors on trabecular meshwork","volume":"15","author":"Kasetti","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2023.108024_bib39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2018.03.001","article-title":"Consensus recommendations for trabecular meshwork cell isolation, characterization and culture","volume":"171","author":"Keller","year":"2018","journal-title":"Exp. Eye Res."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223021016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223021016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T19:40:50Z","timestamp":1762630850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223021016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2589004223021016"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.108024","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell atlas of trabecular meshwork in glaucomatous non-human primates and DEGs related to tissue contract based on single-cell transcriptomics","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.108024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"108024"}}