{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:47:39Z","timestamp":1792842459359,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900756"],"award-info":[{"award-number":["81900756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200915"],"award-info":[{"award-number":["82200915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270845"],"award-info":[{"award-number":["82270845"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH003"],"award-info":[{"award-number":["ZR2022MH003"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH232"],"award-info":[{"award-number":["ZR2022QH232"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.isci.2023.108446","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T16:50:52Z","timestamp":1699980652000},"page":"108446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions"],"prefix":"10.1016","volume":"26","author":[{"given":"Xinghong","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinguo","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7670-8062","authenticated-orcid":false,"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2023.108446_bib1","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/s00125-016-3940-5","article-title":"Hepatic glucose and lipid metabolism","volume":"59","author":"Jones","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2023.108446_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrgastro.2017.32","article-title":"Lipid droplets and liver disease: from basic biology to clinical implications","volume":"14","author":"Gluchowski","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2023.108446_bib3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrgastro.2016.147","article-title":"NAFLD and diabetes mellitus","volume":"14","author":"Tilg","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2023.108446_bib4","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s00125-020-05334-x","article-title":"The liver-alpha cell axis associates with liver fat and insulin resistance: a validation study in women with non-steatotic liver fat levels","volume":"64","author":"Gar","year":"2021","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2023.108446_bib5","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.cmet.2017.05.011","article-title":"Interrupted Glucagon Signaling Reveals Hepatic \u03b1 Cell Axis and Role for L-Glutamine in \u03b1 Cell Proliferation","volume":"25","author":"Dean","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2023.108446_bib6","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/er.2018-00251","article-title":"The Liver-\u03b1-Cell Axis and Type 2 Diabetes","volume":"40","author":"Wewer Albrechtsen","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.isci.2023.108446_bib7","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.isci.2023.108446_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/gutjnl-2020-323323","article-title":"Integrative study of diet-induced mouse models of NAFLD identifies PPAR\u03b1 as a sexually dimorphic drug target","volume":"71","author":"Smati","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.isci.2023.108446_bib9","doi-asserted-by":"crossref","first-page":"eabf8271","DOI":"10.1126\/science.abf8271","article-title":"Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1","volume":"376","author":"Gosis","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.isci.2023.108446_bib10","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.isci.2023.108446_bib11","doi-asserted-by":"crossref","first-page":"50237","DOI":"10.1074\/jbc.M201208200","article-title":"Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production","volume":"277","author":"Xu","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.108446_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13238-017-0409-3","article-title":"mTORC1 signaling in hepatic lipid metabolism","volume":"9","author":"Han","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.isci.2023.108446_bib13","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1073\/pnas.0914798107","article-title":"Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2023.108446_bib14","doi-asserted-by":"crossref","first-page":"6798","DOI":"10.1128\/MCB.25.15.6798-6810.2005","article-title":"hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells","volume":"25","author":"Taipale","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2023.108446_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00232-20","article-title":"Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development","volume":"40","author":"Singh","year":"2020","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2023.108446_bib16","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/nature12313","article-title":"The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy","volume":"500","author":"F\u00fcllgrabe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.isci.2023.108446_bib17","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1084\/jem.20181773","article-title":"KAT8 selectively inhibits antiviral immunity by acetylating IRF3","volume":"216","author":"Huai","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2023.108446_bib18","doi-asserted-by":"crossref","first-page":"20197","DOI":"10.1074\/jbc.M109.026096","article-title":"Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53","volume":"284","author":"Sykes","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.108446_bib19","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1111\/bph.12661","article-title":"The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer","volume":"171","author":"Chen","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2023.108446_bib20","doi-asserted-by":"crossref","first-page":"e1009736","DOI":"10.1371\/journal.pgen.1009736","article-title":"Genes in human obesity loci are causal obesity genes in C. elegans","volume":"17","author":"Ke","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.isci.2023.108446_bib21","first-page":"229","article-title":"Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome","volume":"17","author":"Du","year":"2019","journal-title":"Dev. Reprod. Biol."},{"key":"10.1016\/j.isci.2023.108446_bib22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.cell.2016.09.052","article-title":"MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria","volume":"167","author":"Chatterjee","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2023.108446_bib23","doi-asserted-by":"crossref","first-page":"6212","DOI":"10.1038\/s41467-021-26277-w","article-title":"Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice","volume":"12","author":"Pessoa Rodrigues","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2023.108446_bib24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.stem.2020.06.005","article-title":"Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation","volume":"27","author":"Khoa","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2023.108446_bib25","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/s41556-020-0526-8","article-title":"Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature","volume":"22","author":"Sheikh","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2023.108446_bib26","doi-asserted-by":"crossref","first-page":"154290","DOI":"10.1016\/j.metabol.2020.154290","article-title":"Mof regulates glucose level via altering different \u0251-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion","volume":"109","author":"Guo","year":"2020","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2023.108446_bib27","doi-asserted-by":"crossref","first-page":"111425","DOI":"10.1016\/j.mce.2021.111425","article-title":"Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic \u03b1-cells","volume":"537","author":"Guo","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.isci.2023.108446_bib28","doi-asserted-by":"crossref","first-page":"100235","DOI":"10.1074\/jbc.RA120.016079","article-title":"Dysregulation of intercellular signaling by MOF deletion leads to liver injury","volume":"296","author":"Lei","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2023.108446_bib29","doi-asserted-by":"crossref","first-page":"G462","DOI":"10.1152\/ajpgi.00358.2018","article-title":"Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals","volume":"316","author":"Suppli","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.isci.2023.108446_bib30","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1038\/s41467-021-24601-y","article-title":"TGF\u03b2 promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy","volume":"12","author":"Zehender","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2023.108446_bib31","doi-asserted-by":"crossref","first-page":"831879","DOI":"10.3389\/fnut.2022.831879","article-title":"Hepatic PPAR\u03b1 Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice","volume":"9","author":"Suh","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.isci.2023.108446_bib32","doi-asserted-by":"crossref","first-page":"39787","DOI":"10.1038\/srep39787","article-title":"GPS-PAIL: prediction of lysine acetyltransferase-specific modification sites from protein sequences","volume":"6","author":"Deng","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2023.108446_bib33","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.bbrc.2006.08.199","article-title":"Prediction of Nepsilon-acetylation on internal lysines implemented in Bayesian Discriminant Method","volume":"350","author":"Li","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2023.108446_bib34","doi-asserted-by":"crossref","first-page":"607605","DOI":"10.3389\/fphar.2020.607605","article-title":"MOF Regulates TNK2 Transcription Expression to Promote Cell Proliferation in Thyroid Cancer","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2023.108446_bib35","first-page":"D440","article-title":"MetaboLights: a resource evolving in response to the needs of its scientific community","volume":"48","author":"Haug","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2023.108446_bib36","doi-asserted-by":"crossref","first-page":"115923","DOI":"10.1016\/j.taap.2022.115923","article-title":"Lactobacillus rhamnosus GG combined with inosine ameliorates alcohol-induced liver injury through regulation of intestinal barrier and Treg\/Th1 cells","volume":"439","author":"Zhu","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.isci.2023.108446_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3892\/ijmm.2012.1203","article-title":"Adenosine and inosine exert cytoprotective effects in an in\u00a0vitro model of liver ischemia-reperfusion injury","volume":"31","author":"M\u00f3dis","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.isci.2023.108446_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/jdv.16635","article-title":"Disparate effects of adalimumab and fumaric acid esters on cardiovascular risk factors in psoriasis patients: results from a prospective, randomized, observer-blinded head-to-head trial","volume":"35","author":"Holzer","year":"2021","journal-title":"J.\u00a0Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.isci.2023.108446_bib39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.lfs.2018.12.013","article-title":"Dimethyl fumarate ameliorates acetaminophen-induced hepatic injury in mice dependent of Nrf-2\/HO-1 pathway","volume":"217","author":"Abdelrahman","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.isci.2023.108446_bib40","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.3748\/wjg.v23.i25.4508","article-title":"Treatment with dimethyl fumarate ameliorates liver ischemia\/reperfusion injury","volume":"23","author":"Takasu","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2023.108446_bib41","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1194\/jlr.M047514","article-title":"Hydroxyeicosapentaenoic acids from the Pacific krill show high ligand activities for PPARs","volume":"55","author":"Yamada","year":"2014","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.isci.2023.108446_bib42","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.cmet.2019.07.001","article-title":"12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat","volume":"30","author":"Leiria","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2023.108446_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrendo.2015.181","article-title":"Protein acetylation in metabolism - metabolites and cofactors","volume":"12","author":"Menzies","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.isci.2023.108446_bib44","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev.biochem.76.052705.162114","article-title":"Functions of site-specific histone acetylation and deacetylation","volume":"76","author":"Shahbazian","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.isci.2023.108446_bib45","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cmet.2022.05.004","article-title":"Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia","volume":"34","author":"Morrow","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.isci.2023.108446_bib46","doi-asserted-by":"crossref","first-page":"10084","DOI":"10.3748\/wjg.v22.i46.10084","article-title":"Sirtuins and nonalcoholic fatty liver disease","volume":"22","author":"Nassir","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2023.108446_bib47","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00125-017-4535-5","article-title":"Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids","volume":"61","author":"Wewer Albrechtsen","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2023.108446_bib48","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1172\/JCI106716","article-title":"The effect of alanine on glucagon secretion","volume":"50","author":"M\u00fcller","year":"1971","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2023.108446_bib49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41556-018-0205-1","article-title":"mTOR as a central hub of nutrient signalling and cell growth","volume":"21","author":"Kim","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2023.108446_bib50","doi-asserted-by":"crossref","first-page":"jcs222570","DOI":"10.1242\/jcs.222570","article-title":"Nutrient regulation of mTORC1 at a glance","volume":"132","author":"Condon","year":"2019","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.isci.2023.108446_bib51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41419-023-05582-w","article-title":"KAT8 acetylation-controlled lipolysis affects the invasive and migratory potential of colorectal cancer cells","volume":"14","author":"Qiu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2023.108446_bib52","doi-asserted-by":"crossref","first-page":"166103","DOI":"10.1016\/j.bbadis.2021.166103","article-title":"KAT8, lysine acetyltransferase 8, is required for adipocyte differentiation in\u00a0vitro","volume":"1867","author":"Burrell","year":"2021","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.isci.2023.108446_bib53","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nature01667","article-title":"Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction","volume":"423","author":"Puigserver","year":"2003","journal-title":"Nature"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223025233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004223025233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T01:10:28Z","timestamp":1753146628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004223025233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S2589004223025233"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2023.108446","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2023.108446","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108446"}}