{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:34:06Z","timestamp":1793504046286,"version":"4.5.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.isci.2024.108804","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T18:59:02Z","timestamp":1704394742000},"page":"108804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-5286","authenticated-orcid":false,"given":"Kathryn A.","family":"Bowman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine D.","family":"Wiggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"DeRiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffan","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klemen","family":"Strle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Branda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Steere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Lauffenburger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.108804_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6622a1","article-title":"Surveillance for Lyme Disease - United States, 2008-2015","volume":"66","author":"Schwartz","year":"2017","journal-title":"MMWR. Surveill. Summ."},{"key":"10.1016\/j.isci.2024.108804_bib2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1093\/cid\/ciu397","article-title":"Lyme disease testing by large commercial laboratories in the United States","volume":"59","author":"Hinckley","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2024.108804_bib3","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1056\/NEJM200306123482423","article-title":"The presenting manifestations of Lyme disease and the outcomes of treatment","volume":"348","author":"Steere","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2024.108804_bib4","first-page":"269","article-title":"Diagnosis and treatment of Lyme arthritis","volume":"29","author":"Arvikar","year":"2015","journal-title":"Infect. Dis. Clin."},{"key":"10.1016\/j.isci.2024.108804_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/ciaa1215","article-title":"Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease","volume":"72","author":"Lantos","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2024.108804_bib6","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1002\/art.22131","article-title":"Therapy for Lyme arthritis: strategies for the treatment of antibiotic-refractory arthritis","volume":"54","author":"Steere","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib7","doi-asserted-by":"crossref","first-page":"e12954","DOI":"10.1111\/cmi.12954","article-title":"Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with postinfectious, Borrelia burgdorferi-induced Lyme arthritis","volume":"21","author":"Lochhead","year":"2019","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.isci.2024.108804_bib8","first-page":"26","article-title":"Lyme arthritis. Spirochetes found in synovial microangiopathic lesions","volume":"118","author":"Johnston","year":"1985","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2024.108804_bib9","first-page":"563","article-title":"Lyme Arthritis","volume":"36","author":"Arvikar","year":"2022","journal-title":"Infect. Dis. Clin."},{"key":"10.1016\/j.isci.2024.108804_bib10","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1002\/art.30384","article-title":"Burden and viability of Borrelia burgdorferi in skin and joints of patients with erythema migrans or lyme arthritis","volume":"63","author":"Li","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib11","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1073\/pnas.1904170116","article-title":"Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis","volume":"116","author":"Jutras","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.108804_bib12","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41584-021-00648-5","article-title":"Lyme arthritis: linking infection, inflammation and autoimmunity","volume":"17","author":"Lochhead","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.isci.2024.108804_bib13","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/art.38618","article-title":"Antibodies to endothelial cell growth factor and obliterative microvascular lesions in the synovium of patients with antibiotic-refractory lyme arthritis","volume":"66","author":"Londo\u00f1o","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.isci.2024.108804_bib14","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/art.42408","article-title":"Cell-Mediated Cytotoxicity in Lyme Arthritis","volume":"75","author":"Ord\u00f3\u00f1ez","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.isci.2024.108804_bib15","doi-asserted-by":"crossref","first-page":"e55319","DOI":"10.7554\/eLife.55319","article-title":"Human Fcgamma-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis","volume":"9","author":"Danzer","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.isci.2024.108804_bib16","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1128\/IAI.00048-08","article-title":"A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi","volume":"76","author":"Barbour","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2024.108804_bib17","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1002\/art.23135","article-title":"Antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis","volume":"56","author":"Kannian","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib18","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/art.40566","article-title":"Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis","volume":"70","author":"Sulka","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.isci.2024.108804_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2016.08.072","article-title":"A Functional Role for Antibodies in Tuberculosis","volume":"167","author":"Lu","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108804_bib20","doi-asserted-by":"crossref","first-page":"996","DOI":"10.3389\/fimmu.2019.00996","article-title":"A Case for Antibodies as Mechanistic Correlates of Immunity in Tuberculosis","volume":"10","author":"Kawahara","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib21","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/s41590-018-0228-6","article-title":"Malaria prevention: from immunological concepts to effective vaccines and protective antibodies","volume":"19","author":"Cockburn","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib22","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/art.34383","article-title":"Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis","volume":"64","author":"Strle","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib23","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/art.37910","article-title":"Dysregulation of CD4+CD25(high) T\u00a0cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis","volume":"65","author":"Vudattu","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib24","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/cid\/cix002","article-title":"T-Helper 17 Cell Cytokine Responses in Lyme Disease Correlate With Borrelia burgdorferi Antibodies During Early Infection and With Autoantibodies Late in the Illness in Patients With Antibiotic-Refractory Lyme Arthritis","volume":"64","author":"Strle","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.isci.2024.108804_bib25","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/art.42465","article-title":"Heightened Pro-inflammatory Glycosylation of Borrelia burgdorferi IgG Antibodies in Synovial Fluid in Patients with Antibiotic-Refractory Lyme Arthritis","volume":"75","author":"Sanes","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.isci.2024.108804_bib26","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1038\/ncomms11205","article-title":"Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis","volume":"7","author":"Ohmi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.108804_bib27","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3","article-title":"The lasso method for variable selection in the Cox model","volume":"16","author":"Tibshirani","year":"1997","journal-title":"Stat. Med."},{"key":"10.1016\/j.isci.2024.108804_bib28","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cell.2019.03.016","article-title":"B Cell Responses: Cell Interaction Dynamics and Decisions","volume":"177","author":"Cyster","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108804_bib29","first-page":"473","article-title":"Lyme Disease Pathogenesis","volume":"42","author":"Coburn","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.isci.2024.108804_bib30","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.tim.2020.05.004","article-title":"Complement Evasion by Lyme Disease Spirochetes","volume":"28","author":"Skare","year":"2020","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.isci.2024.108804_bib31","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/1529-0131(199909)42:9<1813::AID-ANR4>3.0.CO;2-0","article-title":"Association of antibiotic treatment-resistant Lyme arthritis with T\u00a0cell responses to dominant epitopes of outer surface protein A of Borrelia burgdorferi","volume":"42","author":"Chen","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib32","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1128\/iai.63.6.2228-2235.1995","article-title":"Early and late antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease","volume":"63","author":"Kalish","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2024.108804_bib33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nm0395-237","article-title":"Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein","volume":"1","author":"Malhotra","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2024.108804_bib34","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3389\/fmicb.2017.00328","article-title":"There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes","volume":"8","author":"Marcinkiewicz","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.isci.2024.108804_bib35","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.pt.2020.04.011","article-title":"Complement Evasion Contributes to Lyme Borreliae-Host Associations","volume":"36","author":"Lin","year":"2020","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.isci.2024.108804_bib36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fimmu.2016.00442","article-title":"Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion","volume":"7","author":"Caine","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib37","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3389\/fimmu.2016.00385","article-title":"Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack","volume":"7","author":"Kraiczy","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib38","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.3389\/fimmu.2018.01057","article-title":"Complement in the Initiation and Evolution of Rheumatoid Arthritis","volume":"9","author":"Holers","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/ar1761","article-title":"The role of the complement and the Fc gamma R system in the pathogenesis of arthritis","volume":"7","author":"Solomon","year":"2005","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.isci.2024.108804_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.1780230102","article-title":"Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells","volume":"23","author":"Theofilopoulos","year":"1980","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib41","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1128\/IAI.71.8.4432-4440.2003","article-title":"Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice","volume":"71","author":"Lawrenz","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2024.108804_bib42","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1172\/JCI65708","article-title":"Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity","volume":"123","author":"Ackerman","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2024.108804_bib43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/01.aids.0000161767.21405.68","article-title":"Increased levels of galactose-deficient IgG in sera of HIV-1-infected individuals","volume":"19","author":"Moore","year":"2005","journal-title":"AIDS"},{"key":"10.1016\/j.isci.2024.108804_bib44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41590-020-00828-7","article-title":"Proinflammatory IgG Fc structures in patients with severe COVID-19","volume":"22","author":"Chakraborty","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib45","first-page":"372","article-title":"Composition of the immunoglobulin G glycome associates with the severity of COVID-19","volume":"31","author":"Petrovi\u0107","year":"2021","journal-title":"Glycobiology"},{"key":"10.1016\/j.isci.2024.108804_bib46","doi-asserted-by":"crossref","first-page":"eabf8654","DOI":"10.1126\/scitranslmed.abf8654","article-title":"High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages","volume":"13","author":"Hoepel","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2024.108804_bib47","doi-asserted-by":"crossref","first-page":"eabc8378","DOI":"10.1126\/science.abc8378","article-title":"Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity","volume":"371","author":"Larsen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108804_bib48","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","article-title":"Glycosylation in health and disease","volume":"15","author":"Reily","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.isci.2024.108804_bib49","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00302151","article-title":"Abnormal galactosylation of serum IgG in patients with systemic lupus erythematosus and members of families with high frequency of autoimmune diseases","volume":"12","author":"Tomana","year":"1992","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.isci.2024.108804_bib50","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1002\/art.39273","article-title":"Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome","volume":"67","author":"Vu\u010dkovi\u0107","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.isci.2024.108804_bib51","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/annrheumdis-2013-203565","article-title":"Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis","volume":"74","author":"Rombouts","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.isci.2024.108804_bib52","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/art.27533","article-title":"Aberrant IgG galactosylation precedes disease onset, correlates with disease activity, and is prevalent in autoantibodies in rheumatoid arthritis","volume":"62","author":"Ercan","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.isci.2024.108804_bib53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/rheumatology\/33.1.36","article-title":"Early agalactosylation of IgG is associated with a more progressive disease course in patients with rheumatoid arthritis:\u00a0results of a follow-up study","volume":"33","author":"van Zeben","year":"1994","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.isci.2024.108804_bib54","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3389\/fimmu.2018.01183","article-title":"Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis","volume":"9","author":"Bartsch","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib55","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/intimm\/dxx053","article-title":"Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation","volume":"29","author":"Br\u00fcckner","year":"2017","journal-title":"Int. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib56","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cell.2017.11.041","article-title":"Engineered Sialylation of Pathogenic Antibodies In\u00a0Vivo Attenuates Autoimmune Disease","volume":"172","author":"Pagan","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108804_bib57","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/iai.61.7.2774-2779.1993","article-title":"Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi","volume":"61","author":"Kalish","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2024.108804_bib58","doi-asserted-by":"crossref","first-page":"R168","DOI":"10.1186\/ar3128","article-title":"Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis","volume":"12","author":"Shin","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.isci.2024.108804_bib59","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fimmu.2019.00553","article-title":"IgA and FcalphaRI: Pathological Roles and Therapeutic Opportunities","volume":"10","author":"Breedveld","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib60","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.4049\/jimmunol.1300261","article-title":"IgA enhances NETosis and release of neutrophil extracellular traps by polymorphonuclear cells via Fcalpha receptor I","volume":"192","author":"Aleyd","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib61","doi-asserted-by":"crossref","first-page":"732977","DOI":"10.3389\/fimmu.2022.732977","article-title":"Anti-FcalphaRI Monoclonal Antibodies Resolve IgA Autoantibody-Mediated Disease","volume":"13","author":"Bos","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.108804_bib62","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1128\/CMR.18.3.484-509.2005","article-title":"Diagnosis of lyme borreliosis","volume":"18","author":"Aguero-Rosenfeld","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.isci.2024.108804_bib63","first-page":"1","article-title":"Case definitions for public health surveillance","volume":"39","author":"Wharton","year":"1990","journal-title":"MMWR Recomm. Rep. (Morb. Mortal. Wkly. Rep.)"},{"key":"10.1016\/j.isci.2024.108804_bib64","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1056\/NEJM198303313081301","article-title":"The spirochetal etiology of Lyme disease","volume":"308","author":"Steere","year":"1983","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2024.108804_bib65","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1128\/iai.62.8.3213-3221.1994","article-title":"Humoral immune response to outer surface protein C of Borrelia burgdorferi in Lyme disease: role of the immunoglobulin M response in the serodiagnosis of early infection","volume":"62","author":"Fung","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2024.108804_bib66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jim.2017.01.010","article-title":"Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles","volume":"443","author":"Brown","year":"2017","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.isci.2024.108804_bib67","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jim.2012.09.007","article-title":"High-throughput, multiplexed IgG subclassing of antigen-specific antibodies from clinical samples","volume":"386","author":"Brown","year":"2012","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.isci.2024.108804_bib68","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jim.2010.12.016","article-title":"A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples","volume":"366","author":"Ackerman","year":"2011","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.isci.2024.108804_bib69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jim.2019.05.006","article-title":"A versatile high-throughput assay to characterize antibody-mediated neutrophil phagocytosis","volume":"471","author":"Karsten","year":"2019","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.isci.2024.108804_bib70","doi-asserted-by":"crossref","first-page":"112630","DOI":"10.1016\/j.jim.2019.07.002","article-title":"A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation","volume":"473","author":"Fischinger","year":"2019","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.isci.2024.108804_bib71","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11306-009-0185-z","article-title":"Multivariate paired data analysis: multilevel PLSDA versus OPLSDA","volume":"6","author":"Westerhuis","year":"2010","journal-title":"Metabolomics"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224000257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224000257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T04:24:10Z","timestamp":1739679850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224000257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2589004224000257"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.108804","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Borrelia-specific antibody profiles and complement deposition in joint fluid distinguish antibiotic-refractory from -responsive Lyme arthritis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.108804","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"108804"}}