{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T23:29:14Z","timestamp":1794526154133,"version":"4.9.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H06267"],"award-info":[{"award-number":["JP17H06267"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K07655"],"award-info":[{"award-number":["JP19K07655"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K20305"],"award-info":[{"award-number":["JP20K20305"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H02908"],"award-info":[{"award-number":["JP22H02908"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K19412"],"award-info":[{"award-number":["JP22K19412"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","award":["29-E-1"],"award-info":[{"award-number":["29-E-1"]}],"id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","award":["30-A-3"],"award-info":[{"award-number":["30-A-3"]}],"id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016211","name":"The Naito Science and Engineering Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.isci.2024.108916","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T21:03:59Z","timestamp":1705439039000},"page":"108916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mieap forms membrane-less organelles involved in cardiolipin metabolism"],"prefix":"10.1016","volume":"27","author":[{"given":"Naoki","family":"Ikari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuko","family":"Honjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Sagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6077-0638","authenticated-orcid":false,"given":"Hirofumi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.108916_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf4382","article-title":"Liquid phase condensation in cell physiology and disease","volume":"357","author":"Shin","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.tcb.2018.02.004","article-title":"Protein Phase Separation: A New Phase in Cell Biology","volume":"28","author":"Boeynaems","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.isci.2024.108916_bib3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2018.12.035","article-title":"Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates","volume":"176","author":"Alberti","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108916_bib4","doi-asserted-by":"crossref","first-page":"eaar3958","DOI":"10.1126\/science.aar3958","article-title":"Coactivator condensation at super-enhancers links phase separation and gene control","volume":"361","author":"Sabari","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.aau6313","article-title":"Stoichiometry controls activity of phase-separated clusters of actin signaling proteins","volume":"363","author":"Case","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib6","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1126\/science.aau5721","article-title":"A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS","volume":"363","author":"Huang","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib7","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1126\/science.aat1022","article-title":"DNA-induced liquid phase condensation of cGAS activates innate immune signaling","volume":"361","author":"Du","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib8","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2017.05.028","article-title":"The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin","volume":"169","author":"Woodruff","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108916_bib9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-018-0279-8","article-title":"Kinase-controlled phase transition of membraneless organelles in mitosis","volume":"559","author":"Rai","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.108916_bib10","series-title":"Prog. Biophys. Mol. Biol.","first-page":"103","article-title":"On the role of organized multienzyme systems in cellular metabolism: a general synthesis","author":"Welch","year":"1977"},{"key":"10.1016\/j.isci.2024.108916_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.bi.56.070187.000513","article-title":"Complexes of sequenctial metabolic enzymes","volume":"56","author":"Srere","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.isci.2024.108916_bib12","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.celrep.2017.06.082","article-title":"Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress","volume":"20","author":"Jin","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.108916_bib13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ymben.2011.09.003","article-title":"Spatial organization of enzymes for metabolic engineering","volume":"14","author":"Lee","year":"2012","journal-title":"Metab. Eng."},{"key":"10.1016\/j.isci.2024.108916_bib14","doi-asserted-by":"crossref","first-page":"9191","DOI":"10.1074\/jbc.M117.783050","article-title":"Identification of a multienzyme complex for glucose metabolism in living cells","volume":"292","author":"Kohnhorst","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.108916_bib15","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1021\/acs.biochem.7b00249","article-title":"Spatial Organization of Metabolic Enzyme Complexes in Cells","volume":"56","author":"Schmitt","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.isci.2024.108916_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1126\/science.1152241","article-title":"Reversible compartmentalization of de novo purine biosynthetic complexes in living cells","volume":"320","author":"An","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib17","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/182946a0","article-title":"Structure of cardiolipin","volume":"182","author":"Macfarlane","year":"1958","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.108916_bib18","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.bbamem.2017.03.013","article-title":"Cardiolipin and mitochondrial cristae organization","volume":"1859","author":"Ikon","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.isci.2024.108916_bib19","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbabio.2013.10.006","article-title":"Functional role of cardiolipin in mitochondrial bioenergetics","volume":"1837","author":"Paradies","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2024.108916_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2014.04.001","article-title":"Metabolism and function of mitochondrial cardiolipin","volume":"55","author":"Ren","year":"2014","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.isci.2024.108916_bib21","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/cells8070728","article-title":"Role of cardiolipin in mitochondrial function and dynamics in health and disease: Molecular and pharmacological aspects","volume":"8","author":"Paradies","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.isci.2024.108916_bib22","first-page":"359","article-title":"Barth syndrome: from mitochondrial dysfunctions associated with aberrant production of reactive oxygen species to pluripotent stem cell studies","volume":"6","author":"Saric","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.108916_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/labinvest.3700480","article-title":"Comparison of lymphoblast mitochondria from normal subjects and patients with Barth syndrome using electron microscopic tomography","volume":"87","author":"Acehan","year":"2007","journal-title":"Lab. Invest."},{"key":"10.1016\/j.isci.2024.108916_bib24","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.scr.2013.05.005","article-title":"Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome","volume":"11","author":"Dudek","year":"2013","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.isci.2024.108916_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016054","article-title":"Possible Existence of Lysosome-Like Organella within Mitochondria and Its Role in Mitochondrial Quality Control","volume":"6","author":"Miyamoto","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.108916_bib26","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1038\/oncsis.2015.43","article-title":"Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer","volume":"4","author":"Kamino","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.isci.2024.108916_bib27","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1038\/s41598-019-39563-x","article-title":"Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation","volume":"9","author":"Okuyama","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.108916_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/srep12472","article-title":"Mieap suppresses murine intestinal tumor via its mitochondrial quality control","volume":"5","author":"Tsuneki","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.108916_bib29","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1111\/cas.14501","article-title":"Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors","volume":"111","author":"Mussazhanova","year":"2020","journal-title":"Cancer Sci."},{"key":"10.1016\/j.isci.2024.108916_bib30","doi-asserted-by":"crossref","first-page":"3910","DOI":"10.1111\/cas.13824","article-title":"Possible role of p53\/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer","volume":"109","author":"Gaowa","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.isci.2024.108916_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016060","article-title":"Mieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria","volume":"6","author":"Kitamura","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.108916_bib32","doi-asserted-by":"crossref","first-page":"D807","DOI":"10.1093\/nar\/gky1053","article-title":"OrthoDB v10: sampling the diversity of animal, plant, fungal, protist, bacterial and viral genomes for evolutionary and functional annotations of orthologs","volume":"47","author":"Kriventseva","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.108916_bib33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-62703-691-7_1","article-title":"DisMeta: a meta server for construct design and optimization","volume":"1091","author":"Huang","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2024.108916_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-59745-547-3_5","article-title":"Prediction of intrinsic disorder and its use in functional proteomics","volume":"408","author":"Uversky","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2024.108916_bib35","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.252.5009.1162","article-title":"Predicting coiled coils from protein sequences","volume":"252","author":"Lupas","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bpj.2016.11.3200","article-title":"CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins","volume":"112","author":"Holehouse","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2024.108916_bib37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.isci.2024.108916_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46883","article-title":"Proteome-wide signatures of function in highly diverged intrinsically disordered regions","volume":"8","author":"Zarin","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.isci.2024.108916_bib39","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1007\/s00216-007-1135-0","article-title":"Fluorescent determination of cardiolipin using 10-N-nonyl acridine orange","volume":"387","author":"Kaewsuya","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.isci.2024.108916_bib40","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.bpj.2015.07.034","article-title":"Cardiolipin Interactions with Proteins","volume":"109","author":"Planas-Iglesias","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2024.108916_bib41","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.bbamem.2016.03.007","article-title":"The ionization properties of cardiolipin and its variants in model bilayers","volume":"1858","author":"Sathappa","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2024.108916_bib42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00418-009-0587-z","article-title":"Chemical analysis of osmium tetroxide staining in adipose tissue using imaging ToF-SIMS","volume":"132","author":"Belazi","year":"2009","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.isci.2024.108916_bib43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-62703-401-2_23","article-title":"Lipid-binding analysis using a fat blot assay","volume":"1009","author":"Munnik","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2024.108916_bib44","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.cmet.2013.07.008","article-title":"TRIAP1\/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid","volume":"18","author":"Potting","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.108916_bib45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10863-014-9591-7","article-title":"Cardiolipin remodeling: a regulatory hub for modulating cardiolipin metabolism and function","volume":"48","author":"Ye","year":"2016","journal-title":"J.\u00a0Bioenerg. Biomembr."},{"key":"10.1016\/j.isci.2024.108916_bib46","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/ncb836","article-title":"Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism","volume":"4","author":"Bota","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2024.108916_bib47","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/ncb1487","article-title":"A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis","volume":"8","author":"Choi","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.isci.2024.108916_bib48","doi-asserted-by":"crossref","first-page":"W337","DOI":"10.1093\/nar\/gkac386","article-title":"FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins","volume":"50","author":"Hatos","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.108916_bib49","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2016.06.010","article-title":"Compositional Control of Phase-Separated Cellular Bodies","volume":"166","author":"Banani","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108916_bib50","doi-asserted-by":"crossref","first-page":"4924","DOI":"10.3390\/ijms20194924","article-title":"The role of adipose tissue mitochondria: Regulation of mitochondrial function for the treatment of\u00a0metabolic diseases","volume":"20","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.108916_bib51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1172\/JCI78362","article-title":"Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis","volume":"125","author":"Sidossis","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2024.108916_bib52","first-page":"25","article-title":"Brown adipose tissue and thermogenesis","volume":"19","author":"Fenzl","year":"2014","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"key":"10.1016\/j.isci.2024.108916_bib53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.biochi.2016.12.016","article-title":"The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism","volume":"134","author":"Crichton","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.isci.2024.108916_bib54","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/nbt.3018","article-title":"Enzyme clustering accelerates processing of intermediates through metabolic channeling","volume":"32","author":"Castellana","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2024.108916_bib55","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3390\/biom8040160","article-title":"Regulation of Cellular Metabolism through Phase Separation of Enzymes","volume":"8","author":"Prouteau","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.isci.2024.108916_bib56","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nchem.1466","article-title":"RNA catalysis through compartmentalization","volume":"4","author":"Strulson","year":"2012","journal-title":"Nat. Chem."},{"key":"10.1016\/j.isci.2024.108916_bib57","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/s41587-019-0341-6","article-title":"Probing and engineering liquid-phase organelles","volume":"37","author":"Bracha","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2024.108916_bib58","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41589-019-0284-8","article-title":"Light-based control of metabolic flux through assembly of synthetic organelles","volume":"15","author":"Zhao","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2024.108916_bib59","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bpj.2016.11.3194","article-title":"Optimal Compartmentalization Strategies for Metabolic Microcompartments","volume":"112","author":"Hinzpeter","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2024.108916_bib60","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1126\/science.aad9964","article-title":"Phase separation of signaling molecules promotes T\u00a0cell receptor signaltransduction","volume":"352","author":"Su","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib61","series-title":"Uversky V. Droplets of life","first-page":"431","article-title":"MLOs and control of metabolic pathways","volume":"Chapter14","author":"Arakawa","year":"2023"},{"key":"10.1016\/j.isci.2024.108916_bib62","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.aax4240","article-title":"Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation","volume":"365","author":"Kim","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.108916_bib63","doi-asserted-by":"crossref","first-page":"32782","DOI":"10.1021\/acsami.8b07573","article-title":"Membraneless Compartmentalization Facilitates Enzymatic Cascade Reactions and Reduces Substrate Inhibition","volume":"10","author":"Kojima","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.isci.2024.108916_bib64","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.cell.2016.04.047","article-title":"Coexisting liquid phases underlie nucleolar subcompartments","volume":"165","author":"Feric","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108916_bib65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41589-021-00801-x","article-title":"Mechanistic dissection of increased enzymatic rate in a phase-separated compartment","volume":"17","author":"Peeples","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.isci.2024.108916_bib66","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/sj.emboj.7601972","article-title":"Quality control of mitochondria: protection against neurodegeneration and aging","volume":"27","author":"Tatsuta","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2024.108916_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.932754","article-title":"Mieap and ATG5 are tumor suppressors in a mouse model of BRAFV600E-positive thyroid cancer","volume":"13","author":"Hamada","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2024.108916_bib68","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.bbalip.2018.01.007","article-title":"Cardiolipin synthesizing enzymes form a complex that interacts with cardiolipin-dependent membrane organizing proteins","volume":"1863","author":"Serricchio","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.isci.2024.108916_bib69","first-page":"375","article-title":"The matrix granules of mitochondria: A review","volume":"1","author":"Barnard","year":"1972","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.isci.2024.108916_bib70","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jemt.1070270406","article-title":"Mitochondrial matrix granules: their behavior during changing metabolic situations and their relationship to contact sites between inner and outer mitochondrial membranes","volume":"27","author":"Jacob","year":"1994","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.isci.2024.108916_bib74","first-page":"531","article-title":"Protein identification and analysis tools in the ExPASy server","volume":"112","author":"Wilkins","year":"1999","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2024.108916_bib78","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2024.108916_bib71","first-page":"3313","article-title":"Enhanced proliferative potential in culture of cells from p53-deficient mice","volume":"8","author":"Tsukada","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2024.108916_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030767","article-title":"BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria","volume":"7","author":"Nakamura","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.108916_bib73","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0092-8674(00)00073-8","article-title":"p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53","volume":"102","author":"Oda","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.108916_bib75","doi-asserted-by":"crossref","first-page":"12054","DOI":"10.1074\/jbc.M117.790568","article-title":"Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells","volume":"292","author":"Shindou","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.108916_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208396","article-title":"Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction","volume":"13","author":"Yamamoto","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.108916_bib77","first-page":"911","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224001378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224001378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T23:30:46Z","timestamp":1739662246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224001378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2589004224001378"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.108916","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.10.26.354365","asserted-by":"object"}]},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mieap forms membrane-less organelles involved in cardiolipin metabolism","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.108916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108916"}}