{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:29:14Z","timestamp":1793413754165,"version":"4.5.0"},"reference-count":126,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011501","name":"Qinghai Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.isci.2024.109174","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T03:47:35Z","timestamp":1707450455000},"page":"109174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota"],"prefix":"10.1016","volume":"27","author":[{"given":"Xinyi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-8065","authenticated-orcid":false,"given":"Daozhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.109174_bib1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41591-018-0104-9","article-title":"Mechanisms of NAFLD development and therapeutic strategies","volume":"24","author":"Friedman","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2024.109174_bib2","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/hep.31150","article-title":"Epidemiological Features of NAFLD From 1999 to 2018 in China","volume":"71","author":"Zhou","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2024.109174_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12902-022-00980-1","article-title":"Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss","volume":"22","author":"Pouwels","year":"2022","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.isci.2024.109174_bib4","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.isci.2024.109174_bib5","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/CIRCULATIONAHA.121.056589","article-title":"NAD(+) Metabolism in Cardiac Health, Aging, and Disease","volume":"144","author":"Abdellatif","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2024.109174_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101388","article-title":"Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis\u2013like phenotypes","volume":"297","author":"Dall","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.109174_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101117","article-title":"PARPs in lipid metabolism and related diseases","volume":"84","author":"Sz\u00e1nt\u00f3","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.isci.2024.109174_bib8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000455862","article-title":"Association between Nicotinamide Phosphoribosyltransferase and de novo Lipogenesis in Nonalcoholic Fatty Liver Disease","volume":"26","author":"Amirkalali","year":"2017","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.isci.2024.109174_bib9","doi-asserted-by":"crossref","first-page":"E117","DOI":"10.1152\/ajpendo.00318.2009","article-title":"Skeletal muscle NAMPT is induced by exercise in humans","volume":"298","author":"Costford","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib10","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1210\/jc.2015-3054","article-title":"Weight Loss Is Associated With Increased NAD+\/SIRT1 Expression But Reduced PARP Activity in White Adipose Tissue","volume":"101","author":"Rappou","year":"2016","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib11","article-title":"Nicotinamide mononucleotide induces lipolysis by regulating ATGL expression via the SIRT1-AMPK axis in adipocytes","volume":"34","author":"Imi","year":"2023","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.isci.2024.109174_bib12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12944-017-0464-z","article-title":"Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1\/AMPK\u03b1\/SREBP1 signaling pathway","volume":"16","author":"Wang","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.isci.2024.109174_bib13","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1097\/FJC.0000000000000332","article-title":"NAMPT and NAMPT-controlled NAD Metabolism in Vascular Repair","volume":"67","author":"Wang","year":"2016","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.isci.2024.109174_bib102","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000351162","article-title":"Effect of Weight Reduction Following Bariatric Surgery on Serum Visfatin and Adiponectin Levels in Morbidly Obese Subjects","volume":"6","author":"Hosseinzadeh-Attar","year":"2013","journal-title":"Obes. Facts"},{"key":"10.1016\/j.isci.2024.109174_bib103","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1210\/jc.2009-2148","article-title":"Intracellular Nicotinamide Phosphoribosyltransferase Protects against Hepatocyte Apoptosis and Is Down-Regulated in Nonalcoholic Fatty Liver Disease","volume":"95","author":"Dahl","year":"2010","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib104","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1665-2681(19)31635-7","article-title":"Visceral adipose tissue visfatin in nonalcoholic fatty liver disease","volume":"9","author":"Gaddipati","year":"2010","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.isci.2024.109174_bib105","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000495215","article-title":"Association of Circulating Adipsin, Visfatin, and Adiponectin with Nonalcoholic Fatty Liver Disease in Adults: A Case-Control Study","volume":"74","author":"Qiu","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib106","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.clinbiochem.2012.11.006","article-title":"Plasma visfatin levels and gene expression in morbidly obese women with associated fatty liver disease","volume":"46","author":"Auguet","year":"2013","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.isci.2024.109174_bib107","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1139\/gen-2014-0022","article-title":"Visfatin \u2212948G\/T and resistin \u2212420C\/G polymorphisms in Egyptian type 2 diabetic patients with and without cardiovascular diseases","volume":"57","author":"Motawi","year":"2014","journal-title":"Genome"},{"key":"10.1016\/j.isci.2024.109174_bib108","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jcla.21491","article-title":"Visfatin Levels in Nonalcoholic Fatty Liver Disease","volume":"26","author":"Akbal","year":"2012","journal-title":"J.\u00a0Clin. Lab. Anal."},{"key":"10.1016\/j.isci.2024.109174_bib109","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/MEG.0000000000001608","article-title":"Serum visfatin level as a noninvasive marker for nonalcoholic fatty liver disease in children and adolescents with obesity: relation to transient elastography with controlled attenuation parameter","volume":"32","author":"Elkabany","year":"2020","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2024.109174_bib110","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/ijo.2010.280","article-title":"Serum visfatin and vaspin levels in prepubertal children: effect of obesity and weight loss after behavior modifications on their secretion and relationship with glucose metabolism","volume":"35","author":"Martos-Moreno","year":"2011","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.isci.2024.109174_bib111","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.bbadis.2019.06.009","article-title":"Nicotinamide riboside, an NAD+ precursor, attenuates the development of liver fibrosis in a diet-induced mouse model of liver fibrosis","volume":"1865","author":"Pham","year":"2019","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.isci.2024.109174_bib112","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/jcsm.12887","article-title":"Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators","volume":"13","author":"Manickam","year":"2022","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.isci.2024.109174_bib113","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib114","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity","volume":"15","author":"Cant\u00f3","year":"2012","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib115","doi-asserted-by":"crossref","DOI":"10.1038\/srep26933","article-title":"Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice","volume":"6","author":"Trammell","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109174_bib116","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1089\/jmf.2015.3439","article-title":"Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes","volume":"18","author":"Lee","year":"2015","journal-title":"J.\u00a0Med. Food"},{"key":"10.1016\/j.isci.2024.109174_bib117","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cmet.2018.02.001","article-title":"Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice","volume":"27","author":"Mitchell","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib14","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1210\/clinem\/dgad027","article-title":"Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study","volume":"108","author":"Pencina","year":"2023","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib15","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.32778","article-title":"Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial","volume":"78","author":"Dellinger","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2024.109174_bib16","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.abe9985","article-title":"Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women","volume":"372","author":"Yoshino","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.109174_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ajcn\/nqy132","article-title":"A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects","volume":"108","author":"Dollerup","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.freeradbiomed.2023.05.032","article-title":"The acute effect of different NAD+ precursors included in the combined metabolic activators","volume":"205","author":"Li","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2024.109174_bib19","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/ajcn\/nqaa072","article-title":"Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans","volume":"112","author":"Remie","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib20","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.3390\/nu12103087","article-title":"Why Are Branched-Chain Amino Acids Increased in Starvation and Diabetes?","volume":"12","author":"Hole\u010dek","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2024.109174_bib21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jare.2021.08.003","article-title":"Nicotinamide mononucleotide (NMN) as an anti-aging health product\u00a0\u2013 Promises and safety concerns","volume":"37","author":"Nadeeshani","year":"2022","journal-title":"J.\u00a0Adv. Res."},{"key":"10.1016\/j.isci.2024.109174_bib22","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201972RR","article-title":"Involvement of eNAMPT\/TLR4 inflammatory signaling in progression of non-alcoholic fatty liver disease, steatohepatitis, and fibrosis","volume":"37","author":"Sun","year":"2023","journal-title":"Faseb. J."},{"key":"10.1016\/j.isci.2024.109174_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109199","article-title":"High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms","volume":"330","author":"Lian","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.isci.2024.109174_bib118","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/gutjnl-2019-319664","article-title":"Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites","volume":"70","author":"Zhang","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.isci.2024.109174_bib119","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1053\/j.gastro.2019.06.028","article-title":"Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease","volume":"157","author":"Schwimmer","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2024.109174_bib120","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/hep.28356","article-title":"The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota","volume":"63","author":"Boursier","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2024.109174_bib121","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1038\/srep08096","article-title":"Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease","volume":"5","author":"Jiang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109174_bib122","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1499-3872(17)60019-5","article-title":"Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease","volume":"16","author":"Shen","year":"2017","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.isci.2024.109174_bib123","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/jgh.16147","article-title":"A metagenomic study identifies a Prevotella copri enriched microbial profile associated with non-alcoholic steatohepatitis in subjects with obesity","volume":"38","author":"Moran-Ramos","year":"2023","journal-title":"J.\u00a0Gastroenterol. Hepatol."},{"key":"10.1016\/j.isci.2024.109174_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41514-023-00106-4","article-title":"Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans","volume":"9","author":"Peluso","year":"2023","journal-title":"NPJ Aging"},{"key":"10.1016\/j.isci.2024.109174_bib25","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00230-21","article-title":"Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice","volume":"7","author":"Lozada-Fern\u00e1ndez","year":"2022","journal-title":"mSystems"},{"key":"10.1016\/j.isci.2024.109174_bib26","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1053\/j.gastro.2017.05.022","article-title":"Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota","volume":"153","author":"Wellman","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.isci.2024.109174_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102495","article-title":"Loss of Sirt1 Function Improves Intestinal Anti-Bacterial Defense and Protects from Colitis-Induced Colorectal Cancer","volume":"9","author":"Lo Sasso","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.109174_bib28","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fgene.2015.00148","article-title":"Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes","volume":"6","author":"Magn\u00fasd\u00f3ttir","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.109174_bib29","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/yea.810","article-title":"Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene","volume":"19","author":"Ghislain","year":"2002","journal-title":"Yeast"},{"key":"10.1016\/j.isci.2024.109174_bib30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/MMBR.00042-08","article-title":"Microbial NAD metabolism: lessons from comparative genomics","volume":"73","author":"Gazzaniga","year":"2009","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.isci.2024.109174_bib31","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.cmet.2020.02.001","article-title":"Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway","volume":"31","author":"Shats","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib32","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.cmet.2022.11.004","article-title":"NAD precursors cycle between host tissues and the gut microbiome","volume":"34","author":"Chellappa","year":"2022","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s42003-023-04613-8","article-title":"Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid","volume":"6","author":"Feng","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.isci.2024.109174_bib34","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"de Vos","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.isci.2024.109174_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/science.abp9960","article-title":"The microbiome and gut homeostasis","volume":"377","author":"Lee","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.109174_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.873160","article-title":"Hepatocellular Carcinoma: How the Gut Microbiota Contributes to Pathogenesis, Diagnosis, and Therapy","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.isci.2024.109174_bib37","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/gutjnl-2015-309990","article-title":"The gut microbiota and host health: a new clinical frontier","volume":"65","author":"Marchesi","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.isci.2024.109174_bib38","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1016\/j.cell.2022.07.020","article-title":"Gut bacterial nutrient preferences quantified in\u00a0vivo","volume":"185","author":"Zeng","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.109174_bib39","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.cmet.2015.10.001","article-title":"Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella","volume":"22","author":"Kovatcheva-Datchary","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib40","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13073-021-00921-y","article-title":"Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men","volume":"13","author":"Ma","year":"2021","journal-title":"Genome Med."},{"key":"10.1016\/j.isci.2024.109174_bib41","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s42255-022-00649-y","article-title":"Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism","volume":"4","author":"Qiao","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat9076","article-title":"Colonocyte metabolism shapes the gut microbiota","volume":"362","author":"Litvak","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.109174_bib43","doi-asserted-by":"crossref","first-page":"e00939-19","DOI":"10.1128\/IAI.00939-19","article-title":"Gut Epithelial Metabolism as a Key Driver of Intestinal Dysbiosis Associated with Noncommunicable Diseases","volume":"88","author":"Shelton","year":"2020","journal-title":"Infect. Immun."},{"key":"10.1016\/j.isci.2024.109174_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.freeradbiomed.2016.09.022","article-title":"Oxygen as a driver of gut dysbiosis","volume":"105","author":"Rivera-Ch\u00e1vez","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2024.109174_bib45","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/hep.32705","article-title":"Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression","volume":"77","author":"Ju\u00e1rez-Fern\u00e1ndez","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2024.109174_bib46","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1136\/gutjnl-2012-303816","article-title":"Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice","volume":"62","author":"Le Roy","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.isci.2024.109174_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113436","article-title":"Lactobacillus sakei MJM60958 as a Potential Probiotic Alleviated Non-Alcoholic Fatty Liver Disease in Mice Fed a High-Fat Diet by Modulating Lipid Metabolism, Inflammation, and Gut Microbiota","volume":"23","author":"Nguyen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.109174_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.746601","article-title":"Oral Administration of Latilactobacillus sakei ADM14 Improves Lipid Metabolism and Fecal Microbiota Profile Associated With Metabolic Dysfunction in a High-Fat Diet Mouse Model","volume":"12","author":"Won","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.isci.2024.109174_bib49","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.3390\/nu12123703","article-title":"Lactobacillus sakei ADM14 Induces Anti-Obesity Effects and Changes in Gut Microbiome in High-Fat Diet-Induced Obese Mice","volume":"12","author":"Won","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2024.109174_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105673","article-title":"Prevotella: An insight into its characteristics and associated virulence factors","volume":"169","author":"Sharma","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.isci.2024.109174_bib51","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1038\/s41467-023-38778-x","article-title":"Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial","volume":"14","author":"Corbin","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109174_bib52","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1136\/gutjnl-2015-309957","article-title":"High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome","volume":"65","author":"De Filippis","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.isci.2024.109174_bib53","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1681\/ASN.2019101029","article-title":"Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid\u2013Mediated Activation of G Protein\u2013Coupled Receptors GPR43 and GPR109A","volume":"31","author":"Li","year":"2020","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.isci.2024.109174_bib54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3748\/wjg.v27.i1.107","article-title":"Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults","volume":"27","author":"Rahayu","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.isci.2024.109174_bib55","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1038\/s41598-019-42183-0","article-title":"Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota","volume":"9","author":"Kang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109174_bib56","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1021\/acs.jafc.1c07711","article-title":"Lactobacillus plantarum DP189 Reduces \u03b1-SYN Aggravation in MPTP-Induced Parkinson\u2019s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder","volume":"70","author":"Wang","year":"2022","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.isci.2024.109174_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162188","article-title":"Colonic mechanism of serum NAD+ depletion induced by DEHP during pregnancy","volume":"872","author":"Hong","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.isci.2024.109174_bib58","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/mmi.14058","article-title":"Physiology and central carbon metabolism of the gut bacteriumPrevotella copri","volume":"109","author":"Franke","year":"2018","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.isci.2024.109174_bib59","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1530\/JOE-17-0542","article-title":"Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate","volume":"236","author":"de Vadder","year":"2018","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.isci.2024.109174_bib60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/nu11010025","article-title":"The Role of Succinate in the Regulation of Intestinal Inflammation","volume":"11","author":"Connors","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2024.109174_bib61","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.tcb.2013.11.008","article-title":"Succinate: a metabolic signal in inflammation","volume":"24","author":"Mills","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.isci.2024.109174_bib62","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmet.2016.06.013","article-title":"Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis","volume":"24","author":"De Vadder","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib63","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3389\/fendo.2020.00567","article-title":"Exercise-Induced Improvements to Whole Body Glucose Metabolism in Type 2 Diabetes: The Essential Role of the Liver","volume":"11","author":"Warner","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2024.109174_bib64","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13435","article-title":"Insulin regulation of gluconeogenesis","volume":"1411","author":"Hatting","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2024.109174_bib65","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2190300","article-title":"Succinate metabolism and its regulation of host-microbe interactions","volume":"15","author":"Wei","year":"2023","journal-title":"Gut Microb."},{"key":"10.1016\/j.isci.2024.109174_bib66","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109174_bib67","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s40168-021-01125-7","article-title":"Commensal microbe-derived acetate suppresses NAFLD\/NASH development via hepatic FFAR2 signalling in mice","volume":"9","author":"Aoki","year":"2021","journal-title":"Microbiome"},{"key":"10.1016\/j.isci.2024.109174_bib68","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000452560","article-title":"Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells","volume":"40","author":"Zeng","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.isci.2024.109174_bib69","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41586-021-03727-5","article-title":"Acetate differentially regulates IgA reactivity to commensal bacteria","volume":"595","author":"Takeuchi","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.109174_bib70","doi-asserted-by":"crossref","first-page":"giz004","DOI":"10.1093\/gigascience\/giz004","article-title":"The unique composition of Indian gut microbiome, gene catalogue, and associated fecal metabolome deciphered using multi-omics approaches","volume":"8","author":"Dhakan","year":"2019","journal-title":"GigaScience"},{"key":"10.1016\/j.isci.2024.109174_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.789325","article-title":"Uncovering the Role of Gut Microbiota in Amino Acid Metabolic Disturbances in Heart Failure Through Metagenomic Analysis","volume":"8","author":"Hayashi","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.isci.2024.109174_bib72","doi-asserted-by":"crossref","first-page":"207S-11S","DOI":"10.1093\/jn\/136.1.207S","article-title":"Branched-Chain Amino Acids: Enzyme and Substrate Regulation","volume":"136","author":"Brosnan","year":"2006","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib73","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1096\/fj.201802842RR","article-title":"Role of branched-chain amino acid\u2013catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis","volume":"33","author":"Biswas","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.isci.2024.109174_bib74","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.3390\/biomedicines10061444","article-title":"The Emerging Role of Branched-Chain Amino Acids in Liver Diseases","volume":"10","author":"Lo","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.isci.2024.109174_bib75","doi-asserted-by":"crossref","first-page":"7851","DOI":"10.1038\/s41598-017-08463-3","article-title":"Metabolic networks for nitrogen utilization in Prevotella ruminicola 23","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109174_bib76","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/JB.05916-11","article-title":"Purification, Characterization, and Expression of Multiple Glutamine Synthetases from Prevotella ruminicola 23","volume":"194","author":"Kim","year":"2012","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.isci.2024.109174_bib77","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41467-018-05470-4","article-title":"Microbial tryptophan catabolites in health and disease","volume":"9","author":"Roager","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109174_bib78","doi-asserted-by":"crossref","first-page":"5202","DOI":"10.1038\/s41467-022-32788-x","article-title":"Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109174_bib79","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159204","article-title":"Altered branched-chain \u03b1-keto acid metabolism is a feature of NAFLD in individuals with severe obesity","volume":"7","author":"Grenier-Larouche","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2024.109174_bib80","doi-asserted-by":"crossref","first-page":"E311","DOI":"10.1152\/ajpendo.00161.2015","article-title":"Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease","volume":"309","author":"Sunny","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib81","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.14309\/ajg.0000000000001375","article-title":"Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease","volume":"116","author":"Harrison","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.isci.2024.109174_bib124","article-title":"Effects of Amino Acids Supplementation on Lipid and Glucose Metabolism in HepG2 Cells","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2024.109174_bib82","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3945\/jn.109.108977","article-title":"Isoleucine Prevents the Accumulation of Tissue Triglycerides and Upregulates the Expression of PPAR\u03b1 and Uncoupling Protein in Diet-Induced Obese Mice","volume":"140","author":"Nishimura","year":"2010","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib125","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.metabol.2016.12.013","article-title":"Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice","volume":"69","author":"Honda","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.isci.2024.109174_bib126","doi-asserted-by":"crossref","first-page":"bqab062","DOI":"10.1210\/endocr\/bqab062","article-title":"BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis","volume":"162","author":"Lee","year":"2021","journal-title":"Endocrinology"},{"key":"10.1016\/j.isci.2024.109174_bib83","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.biochi.2021.11.004","article-title":"AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes","volume":"195","author":"Hinkle","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.isci.2024.109174_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.640720","article-title":"UCP2 as a Potential Biomarker for Adjunctive Metabolic Therapies in Tumor Management","volume":"11","author":"Vallejo","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2024.109174_bib85","doi-asserted-by":"crossref","first-page":"E1234","DOI":"10.1152\/ajpendo.00198.2012","article-title":"Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice","volume":"303","author":"Li","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib86","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s13098-015-0064-x","article-title":"Regulation of hepatic TRB3\/Akt interaction induced by physical exercise and its effect on the hepatic glucose production in an insulin resistance state","volume":"7","author":"Marinho","year":"2015","journal-title":"Diabetol. Metab. Syndrome"},{"key":"10.1016\/j.isci.2024.109174_bib87","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2337\/db19-0920","article-title":"Branched-Chain Amino Acids Exacerbate Obesity-Related Hepatic Glucose and Lipid Metabolic Disorders via Attenuating Akt2 Signaling","volume":"69","author":"Zhao","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2024.109174_bib88","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cmet.2011.03.009","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice","volume":"13","author":"Li","year":"2011","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib89","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75542-3","article-title":"Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid","volume":"10","author":"Iwao","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109174_bib90","doi-asserted-by":"crossref","first-page":"G1292","DOI":"10.1152\/ajpgi.00510.2003","article-title":"Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis","volume":"288","author":"Nishitani","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.isci.2024.109174_bib91","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.clnu.2022.03.027","article-title":"Efficacy of branched chain amino acids supplementation in liver cirrhosis: A systematic review and meta-analysis","volume":"41","author":"Konstantis","year":"2022","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib92","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/hep.32197","article-title":"Gut microbiome features associated with liver fibrosis in Hispanics, a population at high risk for fatty liver disease","volume":"75","author":"Kwan","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.isci.2024.109174_bib93","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/19490976.2019.1595300","article-title":"Intestinal and hepatic microbiota changes associated with chronic ethanol administration in mice","volume":"11","author":"Bluemel","year":"2020","journal-title":"Gut Microb."},{"key":"10.1016\/j.isci.2024.109174_bib94","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/s41396-018-0068-2","article-title":"Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota","volume":"12","author":"Serena","year":"2018","journal-title":"ISME J."},{"key":"10.1016\/j.isci.2024.109174_bib95","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1016\/j.clnu.2020.02.014","article-title":"Overweight and underweight status are linked to specific gut microbiota and intestinal tricarboxylic acid cycle intermediates","volume":"39","author":"Wan","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib96","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/ajcn\/nqac286","article-title":"A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition","volume":"116","author":"Haas","year":"2022","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib97","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1007\/s00394-020-02370-6","article-title":"Dietary intake of specific amino acids and liver status in subjects with nonalcoholic fatty liver disease: fatty liver in obesity (FLiO) study","volume":"60","author":"Galarregui","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.isci.2024.109174_bib98","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3390\/nu11030705","article-title":"Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids","volume":"11","author":"van den Berg","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2024.109174_bib99","doi-asserted-by":"crossref","first-page":"dgaa175","DOI":"10.1210\/clinem\/dgaa175","article-title":"Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent","volume":"105","author":"Grzych","year":"2020","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109174_bib100","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cmet.2021.03.025","article-title":"The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine","volume":"33","author":"Yu","year":"2021","journal-title":"Cell Metabol."},{"key":"10.1016\/j.isci.2024.109174_bib101","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.immuni.2022.04.017","article-title":"Leucine-tRNA-synthetase-2-expressing B cells contribute to colorectal cancer immunoevasion","volume":"55","author":"Wang","year":"2022","journal-title":"Immunity"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422400395X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S258900422400395X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:35:39Z","timestamp":1753868139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S258900422400395X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":126,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S258900422400395X"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.109174","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAD metabolic therapy in metabolic dysfunction-associated steatotic liver disease: Possible roles of gut microbiota","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.109174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"109174"}}