{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:06:16Z","timestamp":1790820376947,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002738","name":"APHP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim International GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.isci.2024.109260","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T12:58:59Z","timestamp":1708088339000},"page":"109260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Linking genotype to trophoblast phenotype in preeclampsia and HELLP syndrome associated with STOX1 genetic variants"],"prefix":"10.1016","volume":"27","author":[{"given":"Lorenzo","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bermudez-Guzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Benouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Laissue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Marcela","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Stouvenel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"M\u00e9hats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Miralles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-0717","authenticated-orcid":false,"given":"Daniel","family":"Vaiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.109260_bib1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ng1541","article-title":"Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family","volume":"37","author":"van Dijk","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.109260_bib2","doi-asserted-by":"crossref","first-page":"101086","DOI":"10.1016\/j.isci.2020.101086","article-title":"Molecular Mechanisms of Trophoblast Dysfunction Mediated by Imbalance between STOX1 Isoforms","volume":"23","author":"Ducat","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.isci.2024.109260_bib3","doi-asserted-by":"crossref","first-page":"e3905","DOI":"10.1371\/journal.pone.0003905","article-title":"STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas","volume":"3","author":"Rigourd","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.109260_bib4","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/j.1471-0528.2007.01414.x","article-title":"STOX1 gene in pre-eclampsia and intrauterine growth restriction","volume":"114","author":"Berends","year":"2007","journal-title":"BJOG"},{"key":"10.1016\/j.isci.2024.109260_bib5","doi-asserted-by":"crossref","first-page":"144894","DOI":"10.1016\/j.gene.2020.144894","article-title":"STOX1 gene Y153H polymorphism is associated with early-onset preeclampsia in Turkish population","volume":"754","author":"Pinarbasi","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.isci.2024.109260_bib6","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1093\/hmg\/ddq152","article-title":"The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation","volume":"19","author":"van Dijk","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2024.109260_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.preghy.2020.09.003","article-title":"Identifying new potential genetic biomarkers for HELLP syndrome using massive parallel sequencing","volume":"22","author":"Jim\u00e9nez","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.isci.2024.109260_bib8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1161\/HYPERTENSIONAHA.120.15619","article-title":"Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth","volume":"77","author":"Dunk","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.isci.2024.109260_bib9","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/HYPERTENSIONAHA.111.202994","article-title":"Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment","volume":"61","author":"Doridot","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.isci.2024.109260_bib10","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/HJH.0000000000001695","article-title":"Preeclampsia induced by STOX1 overexpression in mice induces intrauterine growth restriction, abnormal ultrasonography and BOLD MRI signatures","volume":"36","author":"Collinot","year":"2018","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.isci.2024.109260_bib11","doi-asserted-by":"crossref","first-page":"19196","DOI":"10.1038\/srep19196","article-title":"Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia","volume":"6","author":"Ducat","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109260_bib12","doi-asserted-by":"crossref","first-page":"11918","DOI":"10.1038\/s41598-019-48427-3","article-title":"Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia","volume":"9","author":"Miralles","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109260_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fgene.2013.00248","article-title":"Trophoblasts, invasion, and microRNA","volume":"4","author":"Doridot","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.109260_bib14","doi-asserted-by":"crossref","first-page":"8561","DOI":"10.1038\/s41598-019-44639-9","article-title":"Alpha-1 microglobulin as a potential therapeutic candidate for treatment of hypertension and oxidative stress in the STOX1 preeclampsia mouse model","volume":"9","author":"Erlandsson","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109260_bib15","doi-asserted-by":"crossref","first-page":"102406","DOI":"10.1016\/j.redox.2022.102406","article-title":"Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia\/IUGR consequences","volume":"55","author":"Chatre","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2024.109260_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.biochi.2018.02.010","article-title":"Profile of CYP19A1 mRNA expression and aromatase activity during syncytialization of primary human villous trophoblast cells at term","volume":"148","author":"Hudon Thibeault","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.isci.2024.109260_bib17","doi-asserted-by":"crossref","first-page":"633937","DOI":"10.3389\/fcell.2021.633937","article-title":"Urothelial Cancer Associated 1 (UCA1) and miR-193 Are Two Non-coding RNAs Involved in Trophoblast Fusion and Placental Diseases","volume":"9","author":"Apicella","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2024.109260_bib18","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1002\/jcp.29643","article-title":"Upregulated lncRNA UCA1 inhibits trophoblast cell invasion and proliferation by downregulating JAK2","volume":"235","author":"Liu","year":"2020","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.isci.2024.109260_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbrc.2019.09.099","article-title":"Treatment with metformin prevents pre-eclampsia by suppressing migration of trophoblast cells via modulating the signaling pathway of UCA1\/miR-204\/MMP-9","volume":"520","author":"Ding","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2024.109260_bib20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.placenta.2019.01.016","article-title":"A simple and robust fluorescent labeling method to quantify trophoblast fusion","volume":"77","author":"Zhang","year":"2019","journal-title":"Placenta"},{"key":"10.1016\/j.isci.2024.109260_bib21","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1089\/ars.2013.5661","article-title":"Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene","volume":"21","author":"Doridot","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.isci.2024.109260_bib22","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1080\/01443615.2022.2141612","article-title":"STOX1 promotor region -922\u00a0T\u00a0>\u00a0C polymorphism is associated with Early-Onset preeclampsia","volume":"42","author":"Akin","year":"2022","journal-title":"J.\u00a0Obstet. Gynaecol."},{"key":"10.1016\/j.isci.2024.109260_bib23","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.3390\/biomedicines10061253","article-title":"Identification of LOC101927355 as a Novel Biomarker for Preeclampsia","volume":"10","author":"Pe\u00f1ailillo","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.isci.2024.109260_bib24","doi-asserted-by":"crossref","first-page":"2198923","DOI":"10.1155\/2022\/2198923","article-title":"Trophoblast Exosomal UCA1 Induces Endothelial Injury through the PFN1-RhoA\/ROCK Pathway in Preeclampsia: A Human-Specific Adaptive Pathogenic Mechanism","volume":"2022","author":"Wu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.isci.2024.109260_bib25","doi-asserted-by":"crossref","first-page":"830446","DOI":"10.3389\/fgene.2022.830446","article-title":"Genetic Variations in Metallothionein Genes and Susceptibility to Hypertensive Disorders of Pregnancy: A Case-Control Study","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.109260_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.placenta.2020.09.069","article-title":"Transgenic expression of human C19MC miRNAs impacts placental morphogenesis","volume":"101","author":"Mouillet","year":"2020","journal-title":"Placenta"},{"key":"10.1016\/j.isci.2024.109260_bib27","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1210\/en.2014-1501","article-title":"C19MC microRNAs regulate the migration of human trophoblasts","volume":"155","author":"Xie","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.isci.2024.109260_bib28","doi-asserted-by":"crossref","first-page":"13836","DOI":"10.3390\/ijms232213836","article-title":"The Role of Cluster C19MC in Pre-Eclampsia Development","volume":"23","author":"Jaszczuk","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.109260_bib29","doi-asserted-by":"crossref","first-page":"11451","DOI":"10.1073\/pnas.1303707110","article-title":"Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia","volume":"110","author":"Freitag","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.109260_bib30","first-page":"170","article-title":"Maternal Nodal inversely affects NODAL and STOX1 expression in the fetal placenta","volume":"4","author":"Thulluru","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.109260_bib31","doi-asserted-by":"crossref","first-page":"e0202190","DOI":"10.1371\/journal.pone.0202190","article-title":"The effect of maternal NODAL on STOX1 expression in extravillous trophoblasts is mediated by IGF1","volume":"13","author":"Visser","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.109260_bib32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jcb.20558","article-title":"TGF-beta control of cell proliferation","volume":"96","author":"Huang","year":"2005","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.isci.2024.109260_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-023-05869-0","article-title":"Spatial multiomics map of trophoblast development in early pregnancy","volume":"616","author":"Arutyunyan","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.109260_bib34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.mehy.2013.04.034","article-title":"Why preeclampsia still exists?","volume":"81","author":"Chelbi","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.isci.2024.109260_bib35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbagrm.2015.11.009","article-title":"Hydrogen peroxide-mediated induction of SOD1 gene transcription is independent from Nrf2 in a cellular model of neurodegeneration","volume":"1859","author":"Dell'Orco","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.isci.2024.109260_bib36","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.bbrc.2004.09.066","article-title":"Accelerated CuZn-SOD-mediated oxidation and reduction in the presence of hydrogen peroxide","volume":"324","author":"Johnson","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2024.109260_bib37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ajmg.a.30257","article-title":"Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study","volume":"130A","author":"Cnattingius","year":"2004","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.isci.2024.109260_bib38","doi-asserted-by":"crossref","first-page":"W425","DOI":"10.1093\/nar\/gkv493","article-title":"NPDock: a web server for protein-nucleic acid docking","volume":"43","author":"Tuszynska","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.109260_bib39","doi-asserted-by":"crossref","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.109260_bib40","doi-asserted-by":"crossref","first-page":"W365","DOI":"10.1093\/nar\/gkx407","article-title":"HDOCK: a web server for protein-protein and protein-DNA\/RNA docking based on a hybrid strategy","volume":"45","author":"Yan","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.109260_bib41","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nprot.2010.32","article-title":"The HADDOCK web server for data-driven biomolecular docking","volume":"5","author":"de Vries","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2024.109260_bib42","doi-asserted-by":"crossref","first-page":"W241","DOI":"10.1093\/nar\/gkx236","article-title":"mCSM-NA: predicting the effects of mutations on protein-nucleic acids interactions","volume":"45","author":"Pires","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.109260_bib43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/pro.3942","article-title":"DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations","volume":"30","author":"Rodrigues","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.isci.2024.109260_bib44","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00439-020-02248-x","article-title":"Alternative splicing in normal and pathological human placentas is correlated to genetic variants","volume":"140","author":"Ruano","year":"2021","journal-title":"Hum. Genet."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224004814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224004814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:52:05Z","timestamp":1753869125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224004814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S2589004224004814"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.109260","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linking genotype to trophoblast phenotype in preeclampsia and HELLP syndrome associated with STOX1 genetic variants","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.109260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024","name":"copyright","label":"Copyright"}],"article-number":"109260"}}