{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:46:13Z","timestamp":1782539173627,"version":"3.54.5"},"reference-count":85,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3606300"],"award-info":[{"award-number":["2023YFC3606300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20404"],"award-info":[{"award-number":["U22A20404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","award":["2023KY0093"],"award-info":[{"award-number":["2023KY0093"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","award":["AD23026163"],"award-info":[{"award-number":["AD23026163"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","award":["2021AB07015"],"award-info":[{"award-number":["2021AB07015"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","award":["2020YFE0201600"],"award-info":[{"award-number":["2020YFE0201600"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018571","name":"Specific Research Project of Guangxi for Research Bases and Talents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.isci.2024.109961","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T11:38:00Z","timestamp":1716205080000},"page":"109961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis"],"prefix":"10.1016","volume":"27","author":[{"given":"Qinghua","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5075-6248","authenticated-orcid":false,"given":"Shifeng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuming","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hancheng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangtai","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-7724","authenticated-orcid":false,"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.109961_bib1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0140-6736(23)00020-X","article-title":"Thyroid cancer","volume":"401","author":"Chen","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2024.109961_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000486422","article-title":"Heterogeneity of Thyroid Cancer","volume":"85","author":"Chmielik","year":"2018","journal-title":"Pathobiology"},{"key":"10.1016\/j.isci.2024.109961_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ecl.2018.10.002","article-title":"Evolving Understanding of the Epidemiology of Thyroid Cancer","volume":"48","author":"Seib","year":"2019","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.isci.2024.109961_bib4","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.isci.2024.109961_bib5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S2213-8587(22)00035-3","article-title":"The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020","volume":"10","author":"Pizzato","year":"2022","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.isci.2024.109961_bib6","doi-asserted-by":"crossref","first-page":"423","DOI":"10.5603\/EP.a2019.0027","article-title":"Clinical implications of GWAS variants associated with differentiated thyroid cancer","volume":"70","author":"Jendrzejewski","year":"2019","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.isci.2024.109961_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14517","article-title":"A genome-wide association study yields five novel thyroid cancer risk loci","volume":"8","author":"Gudmundsson","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109961_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/srep26037","article-title":"Functional evaluation of TERT-CLPTM1L genetic variants associated with susceptibility of papillary thyroid carcinoma","volume":"6","author":"Ge","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109961_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nature19949","article-title":"Mass-spectrometric exploration of proteome structure and function","volume":"537","author":"Aebersold","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.109961_bib10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1080\/10408363.2017.1394266","article-title":"High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers","volume":"54","author":"Navas-Carrillo","year":"2017","journal-title":"Crit. Rev. Clin. Lab Sci."},{"key":"10.1016\/j.isci.2024.109961_bib11","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/jcp.22187","article-title":"Thyroid tumor marker genomics and proteomics: diagnostic and clinical implications","volume":"224","author":"Carpi","year":"2010","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.isci.2024.109961_bib12","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mce.2017.11.020","article-title":"Proteome profiles of different types of thyroid cancers","volume":"472","author":"Gawin","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.isci.2024.109961_bib13","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1039\/D3MO00142C","article-title":"Integrated proteomic and metabolomic analysis of plasma reveals regulatory pathways and key elements in thyroid cancer","volume":"19","author":"Sun","year":"2023","journal-title":"Mol. Omics"},{"key":"10.1016\/j.isci.2024.109961_bib14","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41588-021-00978-w","article-title":"Large-scale integration of the plasma proteome with genetics and disease","volume":"53","author":"Ferkingstad","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41586-023-06592-6","article-title":"Plasma proteomic associations with genetics and health in the UK Biobank","volume":"622","author":"Sun","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.109961_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41588-022-01051-w","article-title":"Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies","volume":"54","author":"Zhang","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1126\/science.aaq1327","article-title":"Co-regulatory networks of human serum proteins link genetics to disease","volume":"361","author":"Emilsson","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.109961_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-018-0175-2","article-title":"Genomic atlas of the human plasma proteome","volume":"558","author":"Sun","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.109961_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.46311","article-title":"Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk","volume":"5","author":"Feng","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.isci.2024.109961_bib20","doi-asserted-by":"crossref","first-page":"E1674","DOI":"10.1210\/jc.2013-1941","article-title":"Genome-wide association study on differentiated thyroid cancer","volume":"98","author":"K\u00f6hler","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.isci.2024.109961_bib21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2018.03.035","article-title":"Oncogenic Signaling Pathways in The Cancer Genome Atlas","volume":"173","author":"Sanchez-Vega","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.109961_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature24267","article-title":"The impact of rare variation on gene expression across tissues","volume":"550","author":"Li","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.109961_bib23","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1038\/onc.2011.626","article-title":"A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic","volume":"31","author":"Tom\u00e1s","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2024.109961_bib24","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/bjc.2014.665","article-title":"Revisiting the transcriptional analysis of primary tumours and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer","volume":"112","author":"Tarabichi","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.isci.2024.109961_bib25","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/modpathol.2009.38","article-title":"Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma","volume":"22","author":"Bai","year":"2009","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.isci.2024.109961_bib26","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s12020-022-03175-9","article-title":"Identification of the collagen family as prognostic biomarkers in papillary thyroid carcinoma","volume":"78","author":"Niu","year":"2022","journal-title":"Endocrine"},{"key":"10.1016\/j.isci.2024.109961_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49247-1","article-title":"Validation of Reference Genes for Normalization of Relative qRT-PCR Studies in Papillary Thyroid Carcinoma","volume":"9","author":"Razavi","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109961_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.787485","article-title":"Targeting Tumor-Stromal Interactions in Pancreatic Cancer: Impact of Collagens and Mechanical Traits","volume":"9","author":"Maneshi","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2024.109961_bib29","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.2174\/1381612826666201125111625","article-title":"An Overview of Targeting Legumain for Inhibiting Cancers","volume":"27","author":"Reddy","year":"2021","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.isci.2024.109961_bib30","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.biocel.2016.04.001","article-title":"PLEKHA7: Cytoskeletal adaptor protein at center stage in junctional organization and signaling","volume":"75","author":"Shah","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.isci.2024.109961_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041057","article-title":"Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer","volume":"19","author":"Kong","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.109961_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1121964","article-title":"Role of LGMN in tumor development and its progression and connection with the tumor microenvironment","volume":"10","author":"Khan","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.isci.2024.109961_bib33","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3892\/ol.2021.12877","article-title":"Pseudogene legumain promotes thyroid carcinoma progression via the microRNA-495\/autophagy pathway","volume":"22","author":"Sun","year":"2021","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.isci.2024.109961_bib34","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tranon.2019.10.007","article-title":"VCAM-1\u00a0Upregulation Contributes to Insensitivity of Vemurafenib in BRAF-Mutant Thyroid Cancer","volume":"13","author":"Chen","year":"2020","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.isci.2024.109961_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.729444","article-title":"WW, PH and C-Terminal Domains Cooperate to Direct the Subcellular Localizations of PLEKHA5, PLEKHA6 and PLEKHA7","volume":"9","author":"Sluysmans","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2024.109961_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7899961","article-title":"An Analysis of BMP1 Associated with m6A Modification and Immune Infiltration in Pancancer","volume":"2022","author":"Zhou","year":"2022","journal-title":"Dis. Markers"},{"key":"10.1016\/j.isci.2024.109961_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.883523","article-title":"Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years","volume":"10","author":"Ehata","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2024.109961_bib38","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.ygeno.2020.11.012","article-title":"High expression of bone morphogenetic protein 1 (BMP1) is associated with a poor survival rate in human gastric cancer, a dataset approaches","volume":"113","author":"Rafi","year":"2021","journal-title":"Genomics"},{"key":"10.1016\/j.isci.2024.109961_bib39","doi-asserted-by":"crossref","first-page":"9978","DOI":"10.3390\/ijms22189978","article-title":"Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model","volume":"22","author":"Mart\u00ednez-Nieto","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.109961_bib40","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1093\/hmg\/ddt365","article-title":"Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis","volume":"22","author":"Connelly","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib41","article-title":"Collagen XV, a multifaceted multiplexin present across tissues and species","volume":"6\u20137","author":"Bretaud","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.isci.2024.109961_bib42","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1038\/s41467-019-10167-3","article-title":"The structural basis of translational control by eIF2 phosphorylation","volume":"10","author":"Adomavicius","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109961_bib43","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The Role of Oxidative Stress and Antioxidants in Liver Diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.109961_bib44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/000992288902800607","article-title":"Measures of attention deficit. Part II: Clinical perspectives and test interpretation","volume":"28","author":"Blondis","year":"1989","journal-title":"Clin. Pediatr."},{"key":"10.1016\/j.isci.2024.109961_bib45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fphar.2016.00237","article-title":"Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase","volume":"7","author":"S\u00e1nchez-G\u00f3mez","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2024.109961_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/biom13040688","article-title":"The Multifaceted Role of Glutathione S-Transferases in Health and Disease","volume":"13","author":"Mazari","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.isci.2024.109961_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12964-020-0530-4","article-title":"Tumor microenvironment complexity and therapeutic implications at a glance","volume":"18","author":"Baghban","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.isci.2024.109961_bib48","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12967-022-03554-w","article-title":"IDO\/kynurenine pathway in cancer: possible therapeutic approaches","volume":"20","author":"Abd El-Fattah","year":"2022","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.isci.2024.109961_bib49","doi-asserted-by":"crossref","first-page":"8528","DOI":"10.1038\/s41598-023-35378-z","article-title":"IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma","volume":"13","author":"Xu","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.109961_bib50","article-title":"Molecular Analysis of IL-5 Receptor Subunit Alpha as a Possible Pharmacogenetic Biomarker in Asthma","volume":"7","author":"Elena-P\u00e9rez","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.isci.2024.109961_bib51","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12974-021-02175-2","article-title":"Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease","volume":"18","author":"Chen","year":"2021","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.isci.2024.109961_bib52","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00726-022-03123-x","article-title":"Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function","volume":"54","author":"Hyland","year":"2022","journal-title":"Amino Acids"},{"key":"10.1016\/j.isci.2024.109961_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.955705","article-title":"Amino acid metabolism genes associated with immunotherapy responses and clinical prognosis of colorectal cancer","volume":"9","author":"Peng","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.isci.2024.109961_bib54","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181662","article-title":"As a downstream target of the AKT pathway, NPTX1 inhibits proliferation and promotes apoptosis in hepatocellular carcinoma","volume":"39","author":"Zhao","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.isci.2024.109961_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.672441","article-title":"The Role of Semaphorins and Their Receptors in Innate Immune Responses and Clinical Diseases of Acute Inflammation","volume":"12","author":"Kanth","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.109961_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.878123","article-title":"Clinical significance of SPOCK2 expression signature for high-grade serous ovarian cancer patients","volume":"13","author":"Jiao","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00702-021-02411-2","article-title":"Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration","volume":"129","author":"G\u00f3mez de San Jos\u00e9","year":"2022","journal-title":"J.\u00a0Neural. Transm."},{"key":"10.1016\/j.isci.2024.109961_bib58","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s12094-022-02918-4","article-title":"TNFAIP3 mediates FGFR1 activation-induced breast cancer angiogenesis by promoting VEGFA expression and secretion","volume":"24","author":"Gao","year":"2022","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.isci.2024.109961_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.804401","article-title":"Identification of a Novel Mutation in TNFAIP3 in a Family With Poly-Autoimmunity","volume":"13","author":"Rossi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.109961_bib60","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00011-016-0983-5","article-title":"Semaphorins 4A and 4D in chronic inflammatory diseases","volume":"66","author":"Chapoval","year":"2017","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.isci.2024.109961_bib61","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fimmu.2018.00104","article-title":"A20\/Tumor Necrosis Factor \u03b1-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models","volume":"9","author":"Das","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.109961_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.876048","article-title":"Over-Expression of GUSB Leads to Primary Resistance of Anti-PD1 Therapy in Hepatocellular Carcinoma","volume":"13","author":"Kong","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.109961_bib63","article-title":"INHBA is a Prognostic Biomarker and Correlated With Immune Cell Infiltration in Cervical Cancer","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib64","doi-asserted-by":"crossref","first-page":"15946","DOI":"10.1016\/S0021-9258(18)37540-9","article-title":"Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase","volume":"263","author":"Hum","year":"1988","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.109961_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185792","article-title":"One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation","volume":"12","author":"Moruzzi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.109961_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082589","article-title":"Proteomic profiling of exosomes leads to the identification of novel biomarkers for prostate cancer","volume":"8","author":"Duijvesz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.109961_bib67","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.isci.2024.109961_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian test for colocalisation between pairs of genetic association studies using summary statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.isci.2024.109961_bib69","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.isci.2024.109961_bib70","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib71","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.109961_bib72","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib73","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.109961_bib74","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2024.109961_bib75","article-title":"Connecting genetic risk to disease end points through the human blood plasma proteome","volume":"8","author":"Suhre","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109961_bib76","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/ng.3396","article-title":"A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease","volume":"47","author":"Nikpay","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib77","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/ije\/dyt179","article-title":"Calculating statistical power in Mendelian randomization studies","volume":"42","author":"Brion","year":"2013","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.isci.2024.109961_bib78","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41467-020-20885-8","article-title":"A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits","volume":"12","author":"Foley","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109961_bib79","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41467-018-03209-9","article-title":"Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms","volume":"9","author":"Pierce","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109961_bib80","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41588-019-0404-0","article-title":"Abundant associations with gene expression complicate GWAS follow-up","volume":"51","author":"Liu","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.109961_bib81","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.109961_bib82","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1093\/bioinformatics\/btab665","article-title":"MungeSumstats: a Bioconductor package for the standardization and quality control of many GWAS summary statistics","volume":"37","author":"Murphy","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.109961_bib83","article-title":"Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses","volume":"4","author":"Yuan","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.isci.2024.109961_bib84","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41467-020-14389-8","article-title":"Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis","volume":"11","author":"Papadimitriou","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.109961_bib85","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13073-023-01229-9","article-title":"Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome","volume":"15","author":"Sun","year":"2023","journal-title":"Genome Med."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224011830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224011830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:59:00Z","timestamp":1782536340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224011830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":85,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S2589004224011830"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.109961","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.109961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109961"}}