{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:51:20Z","timestamp":1781358680653,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007569","name":"Carl Zeiss Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007653","name":"Universit\u00e4tsklinikum Jena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007653","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012957","name":"Friedrich-Schiller-Universit\u00e4t Jena","doi-asserted-by":"publisher","award":["498523371"],"award-info":[{"award-number":["498523371"]}],"id":[{"id":"10.13039\/100012957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.isci.2024.110133","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T08:16:36Z","timestamp":1717661796000},"page":"110133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased peritoneal B1-like cells during acute phase of human septic peritonitis"],"prefix":"10.1016","volume":"27","author":[{"given":"Christian","family":"von Loeffelholz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Weigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Piskor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Vivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Rauchfu\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utz","family":"Settmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus H.","family":"Gr\u00e4ler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-3653","authenticated-orcid":false,"given":"Christian","family":"Kosan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.110133_bib1","article-title":"Sepsis: pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ (Clinical research ed.)"},{"key":"10.1016\/j.isci.2024.110133_bib2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2024.110133_bib3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.isci.2024.110133_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00390-010-0249-3","article-title":"Sepsis","volume":"48","author":"Hagel","year":"2011","journal-title":"Intensivmed."},{"key":"10.1016\/j.isci.2024.110133_bib5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.isci.2024.110133_bib6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/MMBR.05015-11","article-title":"Into the eye of the cytokine storm","volume":"76","author":"Tisoncik","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.isci.2024.110133_bib7","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1001\/jama.2011.1831","article-title":"Immunosuppression in sepsis","volume":"306","author":"Ward","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2024.110133_bib8","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00003246-199907000-00002","article-title":"Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction","volume":"27","author":"Hotchkiss","year":"1999","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.isci.2024.110133_bib9","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.4049\/jimmunol.166.11.6952","article-title":"Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans","volume":"166","author":"Hotchkiss","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib10","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1182\/blood.V87.10.4261.bloodjournal87104261","article-title":"Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators","volume":"87","author":"Ayala","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.isci.2024.110133_bib11","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/00003246-199708000-00015","article-title":"Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice","volume":"25","author":"Hotchkiss","year":"1997","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.isci.2024.110133_bib12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ccc.2016.12.001","article-title":"Persistent Inflammation, Immunosuppression and Catabolism Syndrome","volume":"33","author":"Mira","year":"2017","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.isci.2024.110133_bib13","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"Boomer","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2024.110133_bib14","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/00005373-199312000-00007","article-title":"Lymphocyte subset responses to trauma and sepsis","volume":"35","author":"Cheadle","year":"1993","journal-title":"J.\u00a0Trauma"},{"key":"10.1016\/j.isci.2024.110133_bib15","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/S0140-6736(14)60687-5","article-title":"The systemic immune response to trauma: an overview of pathophysiology and treatment","volume":"384","author":"Lord","year":"2014","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.isci.2024.110133_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/clin.1996.4289","article-title":"Only a subset of trauma patients with depressed mitogen responses have true T\u00a0cell dysfunctions","volume":"82","author":"De","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.isci.2024.110133_bib17","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.4049\/jimmunol.1700142","article-title":"Chronic Critical Illness from Sepsis Is Associated with an Enhanced TCR Response","volume":"198","author":"Borken","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/SHK.0000000000000234","article-title":"Persistent lymphopenia after diagnosis of sepsis predicts mortality","volume":"42","author":"Drewry","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.isci.2024.110133_bib19","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/jsre.1999.5797","article-title":"Relationships between T lymphocyte apoptosis and anergy following trauma","volume":"88","author":"Pellegrini","year":"2000","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.isci.2024.110133_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10495-016-1325-3","article-title":"Apoptosis-induced lymphopenia in sepsis and other severe injuries","volume":"22","author":"Girardot","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.isci.2024.110133_bib21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/JLB.MR0618-227R","article-title":"Innate-like B cell subsets during immune responses: Beyond antibody production","volume":"105","author":"Romero-Ram\u00edrez","year":"2019","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.isci.2024.110133_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/science.abo0510","article-title":"Mapping the developing human immune system across organs","volume":"376","author":"Suo","year":"2022","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.isci.2024.110133_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2901","article-title":"The double life of a B-1 cell: self-reactivity selects for protective effector functions","volume":"11","author":"Baumgarth","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.immuni.2004.06.019","article-title":"B1b lymphocytes confer T\u00a0cell-independent long-lasting immunity","volume":"21","author":"Alugupalli","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2024.110133_bib25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1084\/jem.20101499","article-title":"Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-","volume":"208","author":"Griffin","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2024.110133_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.surge.2010.07.011","article-title":"Surgery induced immunosuppression","volume":"9","author":"Hogan","year":"2011","journal-title":"Surgeon"},{"key":"10.1016\/j.isci.2024.110133_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fimmu.2015.00080","article-title":"Metabolic control of B cells: more questions than answers","volume":"6","author":"Capasso","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/486403","article-title":"Stress hyperglycemia, insulin treatment, and innate immune cells","volume":"2014","author":"Xiu","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.isci.2024.110133_bib29","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.4049\/jimmunol.2100880","article-title":"Cell Cycle-Mediated Regulation of Secondary Ig Diversification","volume":"210","author":"Bello","year":"2023","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib30","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.110133_bib31","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jcrc.2015.10.001","article-title":"Postoperative sepsis in cancer patients undergoing major elective digestive surgery is associated with increased long-term mortality","volume":"31","author":"Mokart","year":"2016","journal-title":"J.\u00a0Crit. Care"},{"key":"10.1016\/j.isci.2024.110133_bib32","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s001340050482","article-title":"Lymphocyte counts and the development of nosocomial sepsis","volume":"23","author":"Rajan","year":"1997","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.isci.2024.110133_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/nu10050597","article-title":"Current Evidence about Nutrition Support in Cardiac Surgery Patients-What Do We Know?","volume":"10","author":"Hill","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.isci.2024.110133_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0256205","article-title":"Lymphopenia in hospitalized patients and its relationship with severity of illness and mortality","volume":"16","author":"Andreu-Ballester","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110133_bib35","doi-asserted-by":"crossref","first-page":"14541","DOI":"10.1073\/pnas.96.25.14541","article-title":"Prevention of lymphocyte cell death in sepsis improves survival in mice","volume":"96","author":"Hotchkiss","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110133_bib36","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.4049\/jimmunol.1202062","article-title":"IL-7 restores lymphocyte functions in septic patients","volume":"189","author":"Venet","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cimid.2017.08.002","article-title":"Development, phenotype, and function of non-conventional B cells","volume":"54","author":"Prieto","year":"2017","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.isci.2024.110133_bib38","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.immuni.2011.11.017","article-title":"B-1 B cell development in the fetus and adult","volume":"36","author":"Montecino-Rodriguez","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2024.110133_bib39","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1084\/jem.20131471","article-title":"Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis","volume":"211","author":"Weber","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2024.110133_bib40","article-title":"Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.814857","article-title":"The Role of B1 Cells in Systemic Lupus Erythematosus","volume":"13","author":"She","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.110133_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104408","article-title":"Emerging role of innate B1 cells in the pathophysiology of autoimmune and neuroimmune diseases: Association with inflammation, oxidative and nitrosative stress and autoimmune responses","volume":"148","author":"Morris","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.isci.2024.110133_bib43","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1749-6632.2009.04616.x","article-title":"IL-10 production by B cells expressing CD5 with the alternative exon 1B","volume":"1173","author":"Garaud","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.isci.2024.110133_bib44","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1126\/science.1215173","article-title":"Innate response activator B cells protect against microbial sepsis","volume":"335","author":"Rauch","year":"2012","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.isci.2024.110133_bib46","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1016\/j.jss.2011.05.019","article-title":"Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model","volume":"170","author":"Gonnert","year":"2011","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.isci.2024.110133_bib45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5644\/ama2006-124.165","article-title":"Predictive value of SAPS II and APACHE II scoring systems for patient outcome in a medical intensive care unit","volume":"45","author":"Godinjak","year":"2016","journal-title":"Acta Med. Acad."},{"key":"10.1016\/j.isci.2024.110133_bib47","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/liv.12012","article-title":"Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats","volume":"33","author":"Recknagel","year":"2013","journal-title":"Liver Int."},{"key":"10.1016\/j.isci.2024.110133_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6412682","article-title":"Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis","volume":"2017","author":"Rademann","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.isci.2024.110133_bib49","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2017.05.031","article-title":"Metabolic Adaptation Establishes Disease Tolerance to Sepsis","volume":"169","author":"Weis","year":"2017","journal-title":"Cell"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224013580?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224013580?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T19:53:21Z","timestamp":1762631601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224013580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2589004224013580"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.110133","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased peritoneal B1-like cells during acute phase of human septic peritonitis","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.110133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110133"}}