{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:45:56Z","timestamp":1784673956844,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/36\/T\/NZ3\/00132"],"award-info":[{"award-number":["2020\/36\/T\/NZ3\/00132"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/37\/B\/NZ3\/02345"],"award-info":[{"award-number":["2020\/37\/B\/NZ3\/02345"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014069","name":"Funda\u00e7\u00e3o Champalimaud","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.isci.2024.110149","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T17:54:08Z","timestamp":1716918848000},"page":"110149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hyperactive mTORC1 disrupts habenula function and light preference in zebrafish model of Tuberous sclerosis complex"],"prefix":"10.1016","volume":"27","author":[{"given":"Olga","family":"Doszyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Zmorzynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.110149_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuroscience.2016.11.017","article-title":"Molecular neurobiology of mTOR","volume":"341","author":"Switon","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2024.110149_bib2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1523\/JNEUROSCI.3696-09.2010","article-title":"Dysregulation of mTOR Signaling in Fragile X Syndrome","volume":"30","author":"Sharma","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2024.110149_bib3","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1523\/JNEUROSCI.4276-14.2015","article-title":"Imbalanced mechanistic target of rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function","volume":"35","author":"Sun","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2024.110149_bib4","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1523\/JNEUROSCI.5685-08.2009","article-title":"Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice","volume":"29","author":"Zhou","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.isci.2024.110149_bib5","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/ncomms2295","article-title":"Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex","volume":"3","author":"Sato","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110149_bib6","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/mp.2014.124","article-title":"Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates Mtor","volume":"20","author":"Oguro-Ando","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.isci.2024.110149_bib7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature11628","article-title":"Autism-related deficits via dysregulated eIF4E-dependent translational control","volume":"493","author":"Gkogkas","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.110149_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40478-015-0184-4","article-title":"Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid","volume":"3","author":"Nicolini","year":"2015","journal-title":"Acta Neuropath. Commun."},{"key":"10.1016\/j.isci.2024.110149_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13229-015-0066-4","article-title":"Increased expression of the PI3K catalytic subunit p110\u03b4 underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family","volume":"7","author":"Poopal","year":"2016","journal-title":"Mol. Autism."},{"key":"10.1016\/j.isci.2024.110149_bib10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/aur.2696","article-title":"Global prevalence of autism: A systematic review update","volume":"15","author":"Zeidan","year":"2022","journal-title":"Autism Res."},{"key":"10.1016\/j.isci.2024.110149_bib11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ijdevneu.2013.02.008","article-title":"A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits","volume":"31","author":"Feliciano","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.isci.2024.110149_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/YCO.0000000000000136","article-title":"Advances in the treatment of tuberous sclerosis complex","volume":"28","author":"Leclezio","year":"2015","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.isci.2024.110149_bib13","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/01942638.2017.1390809","article-title":"Sensory Processing Patterns in Autism, Attention Deficit Hyperactivity Disorder, and Typical Development","volume":"38","author":"Little","year":"2018","journal-title":"Phys. Occup. Ther. Pediatr."},{"key":"10.1016\/j.isci.2024.110149_bib14","doi-asserted-by":"crossref","first-page":"48R","DOI":"10.1203\/PDR.0b013e3182130c54","article-title":"Sensory Processing in Autism: A Review of Neurophysiologic Findings","volume":"69","author":"Marco","year":"2011","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.isci.2024.110149_bib15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1242\/dmm.005587","article-title":"Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin","volume":"4","author":"Kim","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.isci.2024.110149_bib16","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1590\/S0100-879X1999001200016","article-title":"Natural preference of zebrafish (Danio rerio) for a dark environment","volume":"32","author":"Serra","year":"1999","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.isci.2024.110149_bib17","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1073\/pnas.1018275108","article-title":"Identification of a brain center whose activity discriminates a choice behavior in zebrafish","volume":"108","author":"Lau","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110149_bib18","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1073\/pnas.1910834117","article-title":"TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex","volume":"117","author":"Kedra","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110149_bib19","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1098\/rstb.2008.0213","article-title":"The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain","volume":"364","author":"Bianco","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.isci.2024.110149_bib20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.cub.2014.01.016","article-title":"Left-Right Asymmetry Is Required for the Habenulae to Respond to Both Visual and Olfactory Stimuli","volume":"24","author":"Dreosti","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.isci.2024.110149_bib21","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.neuron.2017.01.011","article-title":"Left Habenula Mediates Light-Preference Behavior in Zebrafish via an Asymmetrical Visual Pathway","volume":"93","author":"Zhang","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2024.110149_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2014.00018","article-title":"Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation","volume":"7","author":"LaSarge","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.isci.2024.110149_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115397","article-title":"Toxic effects of sirolimus and everolimus on the development and behavior of zebrafish embryos","volume":"166","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.isci.2024.110149_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064455","article-title":"Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment","volume":"8","author":"Macias","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110149_bib25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/annonc\/mdi113","article-title":"mTOR-targeted therapy of cancer with rapamycin derivatives","volume":"16","author":"Vignot","year":"2005","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.isci.2024.110149_bib26","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/archderm.135.5.553","article-title":"Systemic Toxicity Following Administration of Sirolimus (Formerly Rapamycin) for Psoriasis: Association of Capillary Leak Syndrome With Apoptosis of Lesional Lymphocytes","volume":"135","author":"Kaplan","year":"1999","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.isci.2024.110149_bib27","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.2337\/db13-0106","article-title":"Evidence for Rapamycin Toxicity in Pancreatic \u03b2-Cells and a Review of the Underlying Molecular Mechanisms","volume":"62","author":"Barlow","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.isci.2024.110149_bib29","series-title":"Handbook of Animal Models in Neurological Disorders","first-page":"227","article-title":"The zebrafish model of Tuberous sclerosis complex to study epilepsy","author":"Doszyn","year":"2023"},{"key":"10.1016\/j.isci.2024.110149_bib30","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2024.110149_bib28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nmeth.2434","article-title":"Whole-brain functional imaging at cellular resolution using light-sheet microscopy","volume":"10","author":"Ahrens","year":"2013","journal-title":"Nat. Methods"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224013749?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224013749?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:14:18Z","timestamp":1782537258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224013749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S2589004224013749"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.110149","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperactive mTORC1 disrupts habenula function and light preference in zebrafish model of Tuberous sclerosis complex","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.110149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110149"}}