{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:37:53Z","timestamp":1792708673191,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL134766"],"award-info":[{"award-number":["U01HL134766"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31HL162493"],"award-info":[{"award-number":["F31HL162493"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1TR001410"],"award-info":[{"award-number":["TL1TR001410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.isci.2024.110169","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T10:43:00Z","timestamp":1717584180000},"page":"110169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism"],"prefix":"10.1016","volume":"27","author":[{"given":"Alexandra B.","family":"Ysasi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpinder Singh","family":"Bawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regan D.","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony K.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Rock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Beane-Ebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Mazzilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Mizgerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3464-793X","authenticated-orcid":false,"given":"George J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.110169_bib1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.immuni.2022.08.010","article-title":"Biology of lung macrophages in health and disease","volume":"55","author":"Aegerter","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2024.110169_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.613116","article-title":"Non-genetic Heterogeneity of Macrophages in Diseases\u2014A Medical Perspective","volume":"8","author":"Gessain","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2024.110169_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41385-021-00480-w","article-title":"The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity","volume":"15","author":"Bain","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004053","article-title":"Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection","volume":"10","author":"Schneider","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.isci.2024.110169_bib5","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0964","article-title":"Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches","volume":"363","author":"Chakarov","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.110169_bib6","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.1038\/s41467-019-11843-0","article-title":"Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung","volume":"10","author":"Schyns","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110169_bib7","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.150239","article-title":"Recruitment and training of alveolar macrophages after pneumococcal pneumonia","volume":"7","author":"Arafa","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2024.110169_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133042","article-title":"Pneumonia recovery reprograms the alveolar macrophage pool","volume":"5","author":"Guillon","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2024.110169_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.642285","article-title":"Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes","volume":"12","author":"Ricketts","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib10","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.isci.2024.110169_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.734008","article-title":"Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus","volume":"12","author":"Ahamada","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib12","series-title":"Macrophages: Origin, Functions and Biointervention Results and Problems in Cell Differentiation","first-page":"299","article-title":"Macrophage Dysfunction in Respiratory Disease","author":"Belchamber","year":"2017"},{"key":"10.1016\/j.isci.2024.110169_bib13","doi-asserted-by":"crossref","first-page":"L601","DOI":"10.1152\/ajplung.00320.2007","article-title":"Apoptosis in the lung: induction, clearance and detection","volume":"294","author":"Henson","year":"2008","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.isci.2024.110169_bib14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/thoraxjnl-2011-201183","article-title":"Significance of the microbiome in obstructive lung disease","volume":"67","author":"Han","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.isci.2024.110169_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108553","article-title":"Airway-Associated Macrophages in Homeostasis and Repair","volume":"33","author":"Engler","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.110169_bib16","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.stem.2020.03.009","article-title":"The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future","volume":"26","author":"Basil","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2024.110169_bib17","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1016\/S0021-9258(18)37889-X","article-title":"Molecular and biochemical characterization of a novel gamma-interferon-inducible protein","volume":"263","author":"Luster","year":"1988","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.110169_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.imbio.2005.05.010","article-title":"The macrophage scavenger receptor CD163","volume":"210","author":"Fabriek","year":"2005","journal-title":"Immunobiology"},{"key":"10.1016\/j.isci.2024.110169_bib19","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1002\/jbm.a.36113","article-title":"Galectin-1 Promotes an M2 Macrophage Response to Polydioxanone Scaffolds","volume":"105","author":"Abebayehu","year":"2017","journal-title":"J.\u00a0Biomed. Mater. Res."},{"key":"10.1016\/j.isci.2024.110169_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.00901","article-title":"Galectin-1 Facilitates Macrophage Reprogramming and Resolution of Inflammation Through IFN-\u03b2","volume":"11","author":"Yaseen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2024.110169_bib21","doi-asserted-by":"crossref","first-page":"14147","DOI":"10.1074\/jbc.M112.448589","article-title":"Dysferlin Regulates Cell Adhesion in Human Monocytes","volume":"288","author":"de Morr\u00e9e","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.110169_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106392","article-title":"The Interferon-Induced Gene Ifi27l2a is Active in Lung Macrophages and Lymphocytes After Influenza A Infection but Deletion of Ifi27l2a in Mice Does Not Increase Susceptibility to Infection","volume":"9","author":"Tantawy","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110169_bib23","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00262-017-2023-x","article-title":"LILRB receptor-mediated regulation of myeloid cell maturation and function","volume":"66","author":"van der Touw","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.isci.2024.110169_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1189\/jlb.0812429","article-title":"Insights into the role of progranulin in immunity, infection, and inflammation","volume":"93","author":"Jian","year":"2013","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.isci.2024.110169_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1165\/rcmb.2016-0361OC","article-title":"Three Unique Interstitial Macrophages in the Murine Lung at Steady State","volume":"57","author":"Gibbings","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2024.110169_bib26","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.4049\/jimmunol.177.9.6480","article-title":"Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia","volume":"177","author":"Marriott","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib27","first-page":"1318","article-title":"Developmental origin of lung macrophage diversity","volume":"143","author":"Tan","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.isci.2024.110169_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2011.04.021","article-title":"All hematopoietic cells develop from hematopoietic stem cells through Flk2\/Flt3-positive progenitor cells","volume":"9","author":"Boyer","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.isci.2024.110169_bib29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41588-022-01243-4","article-title":"A spatially resolved atlas of the human lung characterizes a gland-associated immune niche","volume":"55","author":"Madissoon","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.110169_bib30","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1073\/pnas.87.15.5613","article-title":"Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms\/CSF-1 receptor cDNA","volume":"87","author":"Pierce","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110169_bib31","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/501962","article-title":"Macrophage Migration and Its Regulation by CSF-1","volume":"2012","author":"Pixley","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.isci.2024.110169_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.615031","article-title":"Molecular Basis for CCRL2 Regulation of Leukocyte Migration","volume":"8","author":"Schioppa","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2024.110169_bib33","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of Wound Healing by Growth Factors and Cytokines","volume":"83","author":"Werner","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2024.110169_bib34","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.3390\/ijms19103217","article-title":"The Role of Chemokines in Wound Healing","volume":"19","author":"Ridiandries","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.110169_bib35","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/s41385-022-00563-2","article-title":"Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation","volume":"15","author":"Stakenborg","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013693","article-title":"Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice","volume":"5","author":"Saederup","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110169_bib37","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","article-title":"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2","volume":"94","author":"Kuziel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110169_bib38","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2024.110169_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib40","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2024.110169_bib41","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.1701230","article-title":"Cutting Edge: CCR2 Is Not Required for Ly6Chi Monocyte Egress from the Bone Marrow but Is Necessary for Migration within the Brain in La Crosse Virus Encephalitis","volume":"200","author":"Winkler","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib42","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.immuni.2019.01.009","article-title":"Chemokine Receptor Redundancy and Specificity Are Context Dependent","volume":"50","author":"Dyer","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2024.110169_bib43","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2024.110169_bib44","article-title":"De-Novo Hematopoiesis from the Fetal Lung","author":"Yeung","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2024.110169_bib45","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.celrep.2014.09.032","article-title":"Non-classical Ly6C\u2212 monocytes drive the development of inflammatory arthritis in mice","volume":"9","author":"Misharin","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.110169_bib46","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1084\/jem.20162152","article-title":"Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span","volume":"214","author":"Misharin","year":"2017","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2024.110169_bib47","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41385-022-00526-7","article-title":"Correction to: Mild COVID-19 imprints a long-term inflammatory eicosanoid- and chemokine memory in monocyte-derived macrophages","volume":"15","author":"Bohnacker","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib48","first-page":"231","article-title":"Prolonged monocyte accumulation in the lung during bleomycin-induced pulmonary fibrosis. A noninvasive assessment of monocyte kinetics by scintigraphy","volume":"66","author":"Doherty","year":"1992","journal-title":"Lab. Invest."},{"key":"10.1016\/j.isci.2024.110169_bib49","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/ni.3857","article-title":"A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes","volume":"18","author":"Machiels","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib50","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41590-022-01216-z","article-title":"Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation","volume":"23","author":"Mirchandani","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2024.110169_bib51","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1165\/ajrcmb.24.6.4217","article-title":"Evidence for Stem-Cell Niches in the Tracheal Epithelium","volume":"24","author":"Borthwick","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.isci.2024.110169_bib52","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nprot.2014.005","article-title":"Intravascular staining for discrimination of vascular and tissue leukocytes","volume":"9","author":"Anderson","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.isci.2024.110169_bib53","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","article-title":"MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2024.110169_bib54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.110169_bib55","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: enriching a GOld mine","volume":"49","author":"Carbon","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.110169_bib56","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2024.110169_bib57","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13059-019-1850-9","article-title":"A benchmark of batch-effect correction methods for single-cell RNA sequencing data","volume":"21","author":"Tran","year":"2020","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2024.110169_bib58","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/bioinformatics\/btw777","article-title":"Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R","volume":"33","author":"McCarthy","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.110169_bib59","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/bioinformatics\/bti525","article-title":"BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis","volume":"21","author":"Durinck","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.110169_bib60","article-title":"Interactive analysis of single-cell data using flexible workflows with SCTK2","volume":"4","author":"Wang","year":"2023","journal-title":"Patterns (N Y)"},{"key":"10.1016\/j.isci.2024.110169_bib61","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1093\/nar\/gkaa582","article-title":"Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring","volume":"48","author":"Frost","year":"2020","journal-title":"Nucleic Acids Res."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224013944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224013944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T19:42:03Z","timestamp":1762630923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224013944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2589004224013944"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.110169","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.110169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110169"}}