{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:47:21Z","timestamp":1793738841320,"version":"4.6.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012371","name":"Faculty of Science and Engineering, University of Manchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012371","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.isci.2024.110303","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:11:47Z","timestamp":1718669507000},"page":"110303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biomolecular alterations temporally anticipate microarchitectural modifications of collagen in oral tongue squamous cell carcinoma"],"prefix":"10.1016","volume":"27","author":[{"given":"Lucrezia","family":"Togni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Furlani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Belloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Riberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Notarstefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Santoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Giorgini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Rubini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Santarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Mascitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.110303_bib1","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.cell.2012.11.034","article-title":"Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration","volume":"151","author":"Plotnikov","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.110303_bib2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-3495(00)76279-5","article-title":"Cell movement is guided by the rigidity of the substrate","volume":"79","author":"Lo","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.isci.2024.110303_bib3","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.3390\/cancers14153571","article-title":"The Emerging Impact of Tumor Budding in Oral Squamous Cell Carcinoma: Main Issues and Clinical Relevance of a New Prognostic Marker","volume":"14","author":"Togni","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.isci.2024.110303_bib4","doi-asserted-by":"crossref","first-page":"8333","DOI":"10.1002\/cam4.3440","article-title":"The immune phenotype of tongue squamous cell carcinoma predicts early relapse and poor prognosis","volume":"9","author":"Troiano","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.isci.2024.110303_bib5","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/lary.27490","article-title":"Does anatomic subsite influence oral cavity cancer mortality? A SEER database analysis","volume":"129","author":"Farhood","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.isci.2024.110303_bib6","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/his.14202","article-title":"Addition of the tumour-stroma ratio to the 8th edition American Joint Committee on Cancer staging system improves survival prediction for patients with oral tongue squamous cell carcinoma","volume":"77","author":"Mascitti","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.isci.2024.110303_bib7","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s12885-021-08222-8","article-title":"Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis","volume":"21","author":"Almangush","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.isci.2024.110303_bib8","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/his.13481","article-title":"Prognostic impact of tumour-stroma ratio in early-stage oral tongue cancers","volume":"72","author":"Almangush","year":"2018","journal-title":"Histopathology"},{"key":"10.1016\/j.isci.2024.110303_bib9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13058-016-0740-2","article-title":"Tumor-associated stromal cells as key contributors to the tumor microenvironment","volume":"18","author":"Bussard","year":"2016","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.isci.2024.110303_bib10","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.4317\/medoral.24922","article-title":"Prognostic and clinicopathological significance of tumor-stroma ratio in head and neck squamous cell carcinoma: A systematic review","volume":"27","author":"Morais","year":"2022","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"10.1016\/j.isci.2024.110303_bib11","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.yexcr.2010.02.045","article-title":"Hallmarks of cancer: interactions with the tumor stroma","volume":"316","author":"Pietras","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2024.110303_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41571-018-0007-1","article-title":"Targeting the tumour stroma to improve cancer therapy","volume":"15","author":"Valkenburg","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.isci.2024.110303_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/medicina56010015","article-title":"Tumor Microenvironment","volume":"56","author":"Arneth","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.isci.2024.110303_bib14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1349-7006.2009.01357.x","article-title":"Tumor-host histopathologic variables, stromal myofibroblasts and risk score, are significantly associated with recurrent disease in tongue cancer","volume":"101","author":"Vered","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.isci.2024.110303_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.859144","article-title":"Clinicopathological and Prognostic Significance of Stromal Patterns in Oral Squamous Cell Carcinoma","volume":"9","author":"Amano","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.isci.2024.110303_bib16","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/odi.14193","article-title":"Prognostic significance of tumor budding thresholds in oral tongue squamous cell carcinoma","volume":"29","author":"Mascitti","year":"2022","journal-title":"Oral Dis."},{"key":"10.1016\/j.isci.2024.110303_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101807","article-title":"Integrating Quantitative Assays with Biologically Based Mathematical Modeling for Predictive Oncology","volume":"23","author":"Kazerouni","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.isci.2024.110303_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102475","article-title":"Emerging technologies provide insights on cancer extracellular matrix biology and therapeutics","volume":"24","author":"Cruz-Acuna","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.isci.2024.110303_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166494","article-title":"Uterine leiomyoma as useful model to unveil morphometric and macromolecular collagen state and impairment in fibrotic diseases: An ex-vivo human study","volume":"1868","author":"Belloni","year":"2022","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.isci.2024.110303_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47048-0","article-title":"Advanced 3D Imaging of Uterine Leiomyoma's Morphology by Propagation-based Phase-Contrast Microtomography","volume":"9","author":"Giuliani","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.110303_bib21","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.3390\/app13063954","article-title":"Novel Insights from Fourier-Transform InfraRed Imaging onthe Morpho-Chemical Profile of Human Corpus Callosum","volume":"13","author":"Alessia Belloni","year":"2023","journal-title":"Appl. Sci."},{"key":"10.1016\/j.isci.2024.110303_bib22","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/odi.12635","article-title":"Fourier Transform Infrared Imaging analysis of dental pulp inflammatory diseases","volume":"23","author":"Giorgini","year":"2017","journal-title":"Oral Dis."},{"key":"10.1016\/j.isci.2024.110303_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.micron.2010.09.010","article-title":"Collagen type I amide I band infrared spectroscopy","volume":"42","author":"Vidal Bde","year":"2011","journal-title":"Micron"},{"key":"10.1016\/j.isci.2024.110303_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.118006","article-title":"FTIR investigation of the secondary structure of type I collagen: New insight into the amide III band","volume":"229","author":"Stani","year":"2020","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.isci.2024.110303_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00216-009-3019-y","article-title":"Collagen types analysis and differentiation by FTIR spectroscopy","volume":"395","author":"Belbachir","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.isci.2024.110303_bib26","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/biof.1870","article-title":"Altered type I collagen networking in osteoporotic human femoral head revealed by histomorphometric and Fourier transform infrared imaging correlated analyses","volume":"48","author":"Licini","year":"2022","journal-title":"Biofactors"},{"key":"10.1016\/j.isci.2024.110303_bib27","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.3390\/ma12182884","article-title":"Vibrational Spectroscopy Fingerprinting in Medicine: from Molecular to Clinical Practice","volume":"12","author":"Balan","year":"2019","journal-title":"Materials"},{"key":"10.1016\/j.isci.2024.110303_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74993-y","article-title":"Linking structural and compositional changes in archaeological human bone collagen: an FTIR-ATR approach","volume":"10","author":"Martinez Cortizas","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.110303_bib29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12967-024-04906-4","article-title":"New insights on collagen structural organization and spatial distribution around dental implants: a comparison between machined and laser-treated surfaces","volume":"22","author":"Belloni","year":"2024","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.isci.2024.110303_bib30","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.3390\/ijms21207714","article-title":"Impact of the Stroma on the Biological Characteristics of the Parenchyma in Oral Squamous Cell Carcinoma","volume":"21","author":"Takabatake","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.110303_bib31","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/path.2830","article-title":"Stromal features are predictive of disease mortality in oral cancer patients","volume":"223","author":"Marsh","year":"2011","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.isci.2024.110303_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/jso.23821","article-title":"Perineural invasion in oral squamous cell carcinoma: quantitative subcategorisation of perineural invasion and prognostication","volume":"111","author":"Aivazian","year":"2015","journal-title":"J.\u00a0Surg. Oncol."},{"key":"10.1016\/j.isci.2024.110303_bib33","doi-asserted-by":"crossref","DOI":"10.3892\/or.2022.8292","article-title":"Significance of cancer stroma for bone destruction in oral squamous cell carcinoma using different cancer stroma subtypes","volume":"47","author":"Shan","year":"2022","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.isci.2024.110303_bib34","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2021.5252","article-title":"Stromal cells in the tumor microenvironment promote the progression of oral squamous cell carcinoma","volume":"59","author":"Shan","year":"2021","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.isci.2024.110303_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/jop.12143","article-title":"\u03b1-Smooth muscle actin-positive myofibroblasts, in association with epithelial\u2013mesenchymal transition and lymphogenesis, is a critical prognostic parameter in patients with oral tongue squamous cell carcinoma","volume":"43","author":"Ding","year":"2014","journal-title":"J.\u00a0Oral Pathol. Med."},{"key":"10.1016\/j.isci.2024.110303_bib36","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/s41416-019-0705-1","article-title":"The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome","volume":"122","author":"D'Arcangelo","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.isci.2024.110303_bib37","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1111\/odi.14203","article-title":"Prognostic value of tumor-stroma ratio in oral carcinoma: Role of cancer-associated fibroblasts","volume":"29","author":"Qiu","year":"2022","journal-title":"Oral Dis."},{"key":"10.1016\/j.isci.2024.110303_bib38","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/jop.12927","article-title":"The prognostic role of tumour-infiltrating lymphocytes in oral squamous cell carcinoma: A meta-analysis","volume":"48","author":"Huang","year":"2019","journal-title":"J.\u00a0Oral Pathol. Med."},{"key":"10.1016\/j.isci.2024.110303_bib39","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.oooo.2018.07.052","article-title":"American Joint Committee on Cancer staging system 7th edition versus 8th edition: any improvement for patients with squamous cell carcinoma of the tongue?","volume":"126","author":"Mascitti","year":"2018","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"10.1016\/j.isci.2024.110303_bib40","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4103\/0973-1482.193113","article-title":"Clinicopathological correlation of tumor-stroma ratio and inflammatory cell infiltrate with tumor grade and lymph node metastasis in squamous cell carcinoma of buccal mucosa and tongue in 41 cases with review of literature","volume":"16","author":"Rani","year":"2020","journal-title":"J.\u00a0Cancer Res. Therapeut."},{"key":"10.1016\/j.isci.2024.110303_bib41","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/his.14070","article-title":"Prognostication for oral squamous cell carcinoma patients based on the tumour-stroma ratio and tumour budding","volume":"76","author":"Dourado","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.isci.2024.110303_bib42","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ijom.2021.06.011","article-title":"Tumor-stroma ratio is a crucial histological predictor of occult cervical lymph node metastasis and survival in early-stage (cT1\/2N0) oral squamous cell carcinoma","volume":"51","author":"Huang","year":"2022","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.isci.2024.110303_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.oraloncology.2010.10.013","article-title":"Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer","volume":"47","author":"Bello","year":"2011","journal-title":"Oral Oncol."},{"key":"10.1016\/j.isci.2024.110303_bib44","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/ijc.25358","article-title":"Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma","volume":"127","author":"Vered","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.isci.2024.110303_bib45","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1432-0436.2005.00017.x","article-title":"Fibroblast control on epithelial differentiation is gradually lost during in\u00a0vitro tumor progression","volume":"73","author":"Costea","year":"2005","journal-title":"Differentiation"},{"key":"10.1016\/j.isci.2024.110303_bib46","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yexcr.2013.12.029","article-title":"Insights into the role of components of the tumor microenvironment in oral carcinoma call for new therapeutic approaches","volume":"325","author":"Salo","year":"2014","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2024.110303_bib47","doi-asserted-by":"crossref","first-page":"e12283","DOI":"10.1111\/jicd.12283","article-title":"Histochemical analysis of collagen reorganization at the invasive front of oral squamous cell carcinoma tumors","volume":"9","author":"Devendra","year":"2018","journal-title":"J.\u00a0Investig. Clin. Dent."},{"key":"10.1016\/j.isci.2024.110303_bib48","doi-asserted-by":"crossref","first-page":"14348","DOI":"10.1002\/jcb.28669","article-title":"Upregulated LOX and increased collagen content associated with aggressive clinicopathological features and unfavorable outcome in oral squamous cell carcinoma","volume":"120","author":"Yu","year":"2019","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.isci.2024.110303_bib49","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.31557\/APJCP.2022.23.8.2829","article-title":"An Evaluation of the Prognosticative Value of Hyalinization in the Biological Behaviour of Oral Lesions Using Image Analysis","volume":"23","author":"Samyukta","year":"2022","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.isci.2024.110303_bib50","first-page":"EC13","article-title":"Architectural Analysis of Picrosirius Red Stained Collagen in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma using Polarization Microscopy","volume":"9","author":"Sharma","year":"2015","journal-title":"J.\u00a0Clin. Diagn. Res."},{"key":"10.1016\/j.isci.2024.110303_bib51","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/hed.26009","article-title":"Association between immunohistochemical expression of matrix metalloproteinases and metastasis in oral squamous cell carcinoma: Systematic review and meta-analysis","volume":"42","author":"Miguel","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.isci.2024.110303_bib52","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<627::AID-HED7>3.0.CO;2-2","article-title":"Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis","volume":"21","author":"Kurahara","year":"1999","journal-title":"Head Neck"},{"key":"10.1016\/j.isci.2024.110303_bib53","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/0278-2391(95)90065-9","article-title":"Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity","volume":"53","author":"Kusukawa","year":"1995","journal-title":"J.\u00a0Oral Maxillofac. Surg."},{"key":"10.1016\/j.isci.2024.110303_bib54","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.bjoms.2005.10.005","article-title":"The matrix metalloproteinase system in oral squamous cell carcinoma","volume":"44","author":"Baker","year":"2006","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.isci.2024.110303_bib55","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1834-7819.2012.01705.x","article-title":"Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma","volume":"57","author":"Suarez-Roa","year":"2012","journal-title":"Aust. Dent. J."},{"key":"10.1016\/j.isci.2024.110303_bib56","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.oooo.2012.04.009","article-title":"The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma","volume":"114","author":"Mashhadiabbas","year":"2012","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"10.1016\/j.isci.2024.110303_bib57","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jop.12044","article-title":"Expression of \u03b1v\u03b26 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications","volume":"42","author":"Li","year":"2013","journal-title":"J.\u00a0Oral Pathol. Med."},{"key":"10.1016\/j.isci.2024.110303_bib58","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41586-022-05169-z","article-title":"Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome","volume":"610","author":"Su","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.110303_bib59","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.trecan.2023.06.002","article-title":"Collagen architecture and signaling orchestrate cancer development","volume":"9","author":"Su","year":"2023","journal-title":"Trends Cancer"},{"key":"10.1016\/j.isci.2024.110303_bib60","first-page":"135","article-title":"[The Helsinki Declaration]","volume":"100","author":"Snaedal","year":"2014","journal-title":"Laeknabladid"},{"key":"10.1016\/j.isci.2024.110303_bib61","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2024.110303_bib62","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/cncy.20147","article-title":"Biospecimen reporting for improved study quality (BRISQ)","volume":"119","author":"Moore","year":"2011","journal-title":"Cancer Cytopathol."},{"key":"10.1016\/j.isci.2024.110303_bib63","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3322\/caac.21388","article-title":"The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.isci.2024.110303_bib64","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jnci.2017.03.003","article-title":"Editor's perspective on the 4th edition of the WHO head and neck tumor classification","volume":"29","author":"El-Naggar","year":"2017","journal-title":"J.\u00a0Egypt Natl. Cancer Inst."},{"key":"10.1016\/j.isci.2024.110303_bib65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40679-016-0036-8","article-title":"SYRMEP Tomo Project: a graphical user interface for customizing CT reconstruction workflows","volume":"3","author":"Brun","year":"2017","journal-title":"Adv. Struct. Chem. Imag."},{"key":"10.1016\/j.isci.2024.110303_bib66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1046\/j.1365-2818.2002.01010.x","article-title":"Simultaneous phase and amplitude extraction from a single defocused image of a homogeneous object","volume":"206","author":"Paganin","year":"2002","journal-title":"J.\u00a0Microsc."},{"key":"10.1016\/j.isci.2024.110303_bib67","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/(SICI)1096-9896(199601)178:1<100::AID-PATH429>3.0.CO;2-K","article-title":"Fractal dimension and architecture of trabecular bone","volume":"178","author":"Fazzalari","year":"1996","journal-title":"J.\u00a0Pathol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224015281?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224015281?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:54:11Z","timestamp":1747457651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224015281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":67,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2589004224015281"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.110303","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomolecular alterations temporally anticipate microarchitectural modifications of collagen in oral tongue squamous cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.110303","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110303"}}