{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:00:40Z","timestamp":1784761240706,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP20wm0325011h0001"],"award-info":[{"award-number":["JP20wm0325011h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR20HA"],"award-info":[{"award-number":["JPMJCR20HA"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","award":["19H04834"],"award-info":[{"award-number":["19H04834"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020954","name":"Program for Creating STart-ups from Advanced Research and Technology","doi-asserted-by":"publisher","award":["JPMJST2113"],"award-info":[{"award-number":["JPMJST2113"]}],"id":[{"id":"10.13039\/501100020954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JPJSCCA20190008"],"award-info":[{"award-number":["JPJSCCA20190008"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20H00662"],"award-info":[{"award-number":["JP20H00662"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K19909"],"award-info":[{"award-number":["JP21K19909"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19K22530"],"award-info":[{"award-number":["JP19K22530"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K05991"],"award-info":[{"award-number":["18K05991"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.isci.2024.110475","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T12:15:26Z","timestamp":1720440926000},"page":"110475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection"],"prefix":"10.1016","volume":"27","author":[{"given":"Madoka","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tarumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugo","family":"Tsunoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Komorizono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Yusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Tomonaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9628-2126","authenticated-orcid":false,"given":"Akiko","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.110475_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cell.2020.10.030","article-title":"Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells","volume":"184","author":"Daniloski","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.110475_bib2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/s41467-021-21213-4","article-title":"A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry","volume":"12","author":"Zhu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110475_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112076","article-title":"CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication","volume":"42","author":"Rehfeld","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.110475_bib4","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41588-022-01110-2","article-title":"Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs","volume":"54","author":"Rebendenne","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.110475_bib5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.chom.2020.12.009","article-title":"Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors","volume":"29","author":"Hoffmann","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.isci.2024.110475_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2020.12.004","article-title":"Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.110475_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.cell.2020.12.006","article-title":"Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks","volume":"184","author":"Schneider","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.110475_bib8","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41588-022-01131-x","article-title":"Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection","volume":"54","author":"Biering","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.110475_bib9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41588-021-00805-2","article-title":"Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2","volume":"53","author":"Baggen","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.110475_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cell.2020.10.028","article-title":"Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection","volume":"184","author":"Wei","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.110475_bib11","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1038\/s41467-022-30134-9","article-title":"Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR\/Cas9 screen","volume":"13","author":"Mac Kain","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110475_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e12744","article-title":"Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors","volume":"9","author":"Chan","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.isci.2024.110475_bib13","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41564-021-00958-0","article-title":"Cellular host factors for SARS-CoV-2 infection","volume":"6","author":"Baggen","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.isci.2024.110475_bib14","first-page":"S313","article-title":"THE CONCISE GUIDE TO PHARMACOLOGY 2021\/22: Enzymes","volume":"178","author":"Alexander","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.isci.2024.110475_bib15","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1038\/emboj.2008.192","article-title":"G9a\/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription","volume":"27","author":"Tachibana","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.isci.2024.110475_bib16","doi-asserted-by":"crossref","first-page":"20120","DOI":"10.1074\/jbc.M603087200","article-title":"Zinc finger protein Wiz links G9a\/GLP histone methyltransferases to the co-repressor molecule CtBP","volume":"281","author":"Ueda","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.110475_bib17","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.celrep.2016.09.079","article-title":"A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia","volume":"17","author":"Tzelepis","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.110475_bib18","doi-asserted-by":"crossref","first-page":"7384","DOI":"10.1038\/s41598-017-07827-z","article-title":"Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries","volume":"7","author":"Ong","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.110475_bib19","doi-asserted-by":"crossref","first-page":"16587","DOI":"10.1073\/pnas.2009799117","article-title":"Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development","volume":"117","author":"Imai","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110475_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110064","article-title":"TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2","volume":"85","author":"Wang","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.isci.2024.110475_bib21","doi-asserted-by":"crossref","first-page":"8900","DOI":"10.1038\/ncomms9900","article-title":"TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation","volume":"6","author":"Ferri","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110475_bib22","first-page":"1","article-title":"TRIM28 is a SUMO E3 Ligase and Negative Regulator of Interferon Regulatory Factor 7","volume":"23","author":"Vahid","year":"2012","journal-title":"NIH public acess"},{"key":"10.1016\/j.isci.2024.110475_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02229","article-title":"Phosphorylation of TRIM28 Enhances the Expression of IFN-\u03b2 and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells","volume":"9","author":"Krischuns","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.110475_bib24","article-title":"Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma","volume":"9","author":"Seier","year":"2021","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.isci.2024.110475_bib25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1084\/jem.20100363","article-title":"Activating and inhibitory functions for the histone lysine methyltransferase G9a in T helper cell differentiation and function","volume":"207","author":"Lehnertz","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.isci.2024.110475_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1089\/jir.2015.0006","article-title":"Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells","volume":"36","author":"Singh","year":"2016","journal-title":"J.\u00a0Interferon Cytokine Res."},{"key":"10.1016\/j.isci.2024.110475_bib27","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1038\/s41467-020-19619-7","article-title":"SARS-CoV-2 structure and replication characterized by in\u00a0situ cryo-electron tomography","volume":"11","author":"Klein","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110475_bib28","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.016175","article-title":"The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles","volume":"296","author":"Boson","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.110475_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-25589-1","article-title":"Sequences in the cytoplasmic tail of SARS-CoV-2 Spike facilitate expression at the cell surface and syncytia formation","volume":"12","author":"Cattin-Ortol\u00e1","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110475_bib30","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl4895","article-title":"SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi\/ERGIC and lysosome-mediated egress","volume":"8","author":"Scherer","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2024.110475_bib31","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13072-022-00468-1","article-title":"De novo methylation of histone H3K23 by the methyltransferases EHMT1\/GLP and EHMT2\/G9a","volume":"15","author":"Vinson","year":"2022","journal-title":"Epigenet. Chromatin"},{"key":"10.1016\/j.isci.2024.110475_bib32","doi-asserted-by":"crossref","first-page":"579636","DOI":"10.3389\/fgene.2020.579636","article-title":"Hypoxia-Inducible Lysine Methyltransferases: G9a and GLP Hypoxic Regulation, Non-histone Substrate Modification, and Pathological Relevance","volume":"11","author":"Chopra","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.110475_bib33","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1101\/gad.2027411","article-title":"H3K9 methyltransferase G9a and the related molecule GLP","volume":"25","author":"Shinkai","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2024.110475_bib34","first-page":"1","article-title":"Discovery of an in\u00a0vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP","volume":"23","author":"Coates","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.isci.2024.110475_bib35","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41401-018-0205-5","article-title":"Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells","volume":"40","author":"Cao","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.isci.2024.110475_bib36","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature17180","article-title":"Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys","volume":"531","author":"Warren","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.110475_bib37","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1074\/jbc.RA120.013679","article-title":"Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency","volume":"295","author":"Gordon","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.110475_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj3789","article-title":"Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern","volume":"13","author":"Tostanoski","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2024.110475_bib39","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/03009858221095794","article-title":"Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments","volume":"59","author":"Piedra-Mora","year":"2022","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.isci.2024.110475_bib40","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.4049\/jimmunol.1401448","article-title":"The E3\u00a0Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA\u2013Induced NLRP3 Inflammasome Activation","volume":"193","author":"Weng","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.isci.2024.110475_bib41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3390\/v13030369","article-title":"The role of the host ubiquitin system in promoting replication of emergent viruses","volume":"13","author":"Valerdi","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.isci.2024.110475_bib42","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1021\/acs.jproteome.0c00758","article-title":"Ubiquitin-Modified Proteome of SARS-CoV-2-Infected Host Cells Reveals Insights into Virus-Host Interaction and Pathogenesis","volume":"20","author":"Zhang","year":"2021","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.isci.2024.110475_bib43","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41423-020-00603-6","article-title":"Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response","volume":"18","author":"Cao","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.isci.2024.110475_bib44","article-title":"The E3\u00a0Ubiquitin Ligase RNF5 Facilitates SARS-CoV-2 Membrane Protein-Mediated Virion Release","volume":"13","author":"Yuan","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.isci.2024.110475_bib45","article-title":"Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2","volume":"7","author":"Xu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.isci.2024.110475_bib46","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/s41591-020-1021-2","article-title":"Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection","volume":"26","author":"Ramlall","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2024.110475_bib47","article-title":"Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics","author":"Wang","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2024.110475_bib48","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-022-05282-z","article-title":"SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry","volume":"610","author":"Kee","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.110475_bib53","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s41590-021-00942-0","article-title":"RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells","volume":"22","author":"Yamada","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.isci.2024.110475_bib54","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.antiviral.2017.04.018","article-title":"Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses","volume":"143","author":"Tokunaga","year":"2017","journal-title":"Antiviral Res."},{"key":"10.1016\/j.isci.2024.110475_bib55","doi-asserted-by":"crossref","first-page":"5737","DOI":"10.1128\/JVI.02443-06","article-title":"Inhibition of Transcription of the Beta Interferon Gene by the Human Herpesvirus 6 Immediate-Early 1 Protein","volume":"81","author":"Jaworska","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.isci.2024.110475_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106712","article-title":"Synthesis and evaluation of alkoxy-substituted enamides against influenza A virus in\u00a0vitro and in\u00a0vivo","volume":"139","author":"Liu","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.isci.2024.110475_bib57","article-title":"Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies","volume":"11","author":"Suresh","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2024.110475_bib58","article-title":"SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters","volume":"13","author":"Qiao","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110475_bib59","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.2147\/JIR.S323026","article-title":"Characterization of virus replication, pathogenesis, and cytokine responses in syrian hamsters inoculated with sars-cov-2","volume":"14","author":"Yang","year":"2021","journal-title":"J.\u00a0Inflamm. Res."},{"key":"10.1016\/j.isci.2024.110475_bib49","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1186\/s13059-014-0554-4","article-title":"MAGeCK enables robust identification of essential genes from genome-scale CRISPR\/Cas9 knockout screens","volume":"15","author":"Li","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2024.110475_bib50","unstructured":"National Institutes of Health (NIH). Turning Discovery Into Health https:\/\/www.nih.gov\/."},{"key":"10.1016\/j.isci.2024.110475_bib51","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.110475_bib52","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01062-20","article-title":"Optimized Pseudotyping Conditions for the SARS-COV-2 Spike Glycoprotein","volume":"94","author":"Johnson","year":"2020","journal-title":"J.\u00a0Virol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224017000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224017000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:14:04Z","timestamp":1778901244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224017000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S2589004224017000"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.110475","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.03.06.531431","asserted-by":"object"}]},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.110475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110475"}}