{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:03:08Z","timestamp":1789052588379,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700414"],"award-info":[{"award-number":["81700414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070481"],"award-info":[{"award-number":["82070481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.isci.2024.110594","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T23:21:53Z","timestamp":1722036113000},"page":"110594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Stearic acid alleviates aortic medial degeneration through maintaining mitochondrial dynamics homeostasis via inhibiting JNK\/MAPK signaling"],"prefix":"10.1016","volume":"27","author":[{"given":"Kexin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.110594_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0003-4975(10)65594-4","article-title":"Management of acute aortic dissections","volume":"10","author":"Daily","year":"1970","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.isci.2024.110594_bib2","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jacc.2015.05.029","article-title":"Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends From the International Registry of Acute Aortic Dissection","volume":"66","author":"Pape","year":"2015","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2024.110594_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jtcvs.2004.09.005","article-title":"Contemporary results of surgery in acute type A aortic dissection: The International Registry of Acute Aortic Dissection experience","volume":"129","author":"Trimarchi","year":"2005","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.isci.2024.110594_bib4","first-page":"1","article-title":"Aortic dissection","volume":"2","author":"Nienaber","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.isci.2024.110594_bib5","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1161\/ATVBAHA.116.307909","article-title":"Role of Microvascular Tone and Extracellular Matrix Contraction in the Regulation of Interstitial Fluid: Implications for Aortic Dissection","volume":"36","author":"Mallat","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2024.110594_bib6","first-page":"e37","article-title":"Aortic aneurysms and dissections series","volume":"40","author":"Shen","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2024.110594_bib7","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1093\/eurheartj\/ehaa352","article-title":"Prevention of aortic dissection and aneurysm via an ALDH2-mediated switch in vascular smooth muscle cell phenotype","volume":"41","author":"Yang","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2024.110594_bib8","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s11745-005-1484-z","article-title":"The fate and intermediary metabolism of stearic acid","volume":"40","author":"Sampath","year":"2005","journal-title":"Lipids"},{"key":"10.1016\/j.isci.2024.110594_bib9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature14601","article-title":"Regulation of mitochondrial morphology and function by stearoylation of TFR1","volume":"525","author":"Senyilmaz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.110594_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/resp.13949","article-title":"Stearic acid attenuates profibrotic signalling in idiopathic pulmonary fibrosis","volume":"26","author":"Kim","year":"2021","journal-title":"Respirology"},{"key":"10.1016\/j.isci.2024.110594_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1745-7254.2007.00512.x","article-title":"Stearic acid protects primary cultured cortical neurons against oxidative stress","volume":"28","author":"Wang","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.isci.2024.110594_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/eurheartj\/ehx319","article-title":"Acute aortic syndromes: diagnosis and management, an update","volume":"39","author":"Bossone","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2024.110594_bib13","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/ajcn\/23.9.1184","article-title":"Comparison of effects of palmitic and stearic acids in the diet on serum cholesterol in man","volume":"23","author":"Grande","year":"1970","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2024.110594_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3945\/ajcn.2009.27661","article-title":"Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review","volume":"91","author":"Hunter","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2024.110594_bib15","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11883-010-0131-6","article-title":"Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients","volume":"12","author":"Siri-Tarino","year":"2010","journal-title":"Curr. Atherosclerosis Rep."},{"key":"10.1016\/j.isci.2024.110594_bib16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11745-005-1485-y","article-title":"Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption","volume":"40","author":"Kris-Etherton","year":"2005","journal-title":"Lipids"},{"key":"10.1016\/j.isci.2024.110594_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12916-016-0552-3","article-title":"Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study","volume":"14","author":"Kuhn","year":"2016","journal-title":"BMC Med."},{"key":"10.1016\/j.isci.2024.110594_bib18","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1038\/s41467-018-05614-6","article-title":"Dietary stearic acid regulates mitochondria in\u00a0vivo in humans","volume":"9","author":"Senyilmaz-Tiebe","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.110594_bib19","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physrev.00030.2008","article-title":"Mitochondrial dynamics in mammalian health and disease","volume":"89","author":"Liesa","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2024.110594_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0968-0004(00)01609-1","article-title":"The internal structure of mitochondria","volume":"25","author":"Frey","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.isci.2024.110594_bib21","article-title":"Mitochondrial dynamics in vascular remodeling and target-organ damage","volume":"10","author":"Zhu","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.isci.2024.110594_bib22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/sj.embor.7400488","article-title":"Separate fusion of outer and inner mitochondrial membranes","volume":"6","author":"Malka","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.isci.2024.110594_bib23","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100067R","article-title":"Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis","volume":"35","author":"Adebayo","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.isci.2024.110594_bib24","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1080\/15548627.2016.1166318","article-title":"Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways","volume":"12","author":"Huang","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.isci.2024.110594_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.isci.2024.110594_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1530\/JOE-16-0111","article-title":"Precise expression of Fis1 is important for glucose responsiveness of beta cells","volume":"230","author":"Schultz","year":"2016","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.isci.2024.110594_bib27","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41569-022-00703-y","article-title":"The role of mitochondrial fission in cardiovascular health and disease","volume":"19","author":"Quiles","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.isci.2024.110594_bib28","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/cvr\/cvaa133","article-title":"Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm","volume":"117","author":"Cooper","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2024.110594_bib29","doi-asserted-by":"crossref","first-page":"7666","DOI":"10.1039\/D2FO01084D","article-title":"Iron deficiency exacerbates aortic medial degeneration by inducing excessive mitochondrial fission","volume":"13","author":"Zhong","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.isci.2024.110594_bib30","article-title":"Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells","volume":"11","author":"Li","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.isci.2024.110594_bib31","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13419","article-title":"Alterations in mitochondrial dynamics with age-related Sirtuin1\/Sirtuin3 deficiency impair cardiomyocyte contractility","volume":"20","author":"Zhang","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.isci.2024.110594_bib32","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jtcvs.2009.07.075","article-title":"Smooth muscle phenotypic modulation is an early event in aortic aneurysms","volume":"138","author":"Ailawadi","year":"2009","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.isci.2024.110594_bib33","doi-asserted-by":"crossref","first-page":"9677","DOI":"10.3390\/ijms21249677","article-title":"c-Jun N-terminal kinase inhibitors as potential leads for new therapeutics for Alzheimer\u2019s diseases","volume":"21","author":"Hepp Rehfeldt","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.110594_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106366","article-title":"Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway","volume":"183","author":"Shi","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.isci.2024.110594_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122061","article-title":"Omentin-1 enhances the inhibitory effect of endothelial progenitor cells on neointimal hyperplasia by inhibiting the p38 MAPK\/CREB pathway","volume":"331","author":"Xiang","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.isci.2024.110594_bib36","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.jvs.2019.04.467","article-title":"A systematic review and meta-analysis of isolated abdominal aortic dissection","volume":"70","author":"Wu","year":"2019","journal-title":"J.\u00a0Vasc. Surg."},{"key":"10.1016\/j.isci.2024.110594_bib37","first-page":"172","article-title":"Correlation between ABCA1 gene polymorphism and aopA-I and HDL-C in abdominal aortic aneurysm","volume":"22","author":"Zhao","year":"2016","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.isci.2024.110594_bib38","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJM198805123181905","article-title":"Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels","volume":"318","author":"Bonanome","year":"1988","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2024.110594_bib39","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.clnu.2020.08.016","article-title":"Dietary stearic acid and palmitic acid do not differently affect ABCA1-mediated cholesterol efflux capacity in healthy men and postmenopausal women: A randomized controlled trial","volume":"40","author":"van Rooijen","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.isci.2024.110594_bib40","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1093\/ajcn\/85.6.1486","article-title":"The solid fat content of stearic acid\u2013rich fats determines their postprandial effects","volume":"85","author":"Berry","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.isci.2024.110594_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104083","article-title":"Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice","volume":"9","author":"Shen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110594_bib42","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1161\/01.CIR.0000087597.59169.8D","article-title":"Visceral adiposity and the prevalence of hypertension in Japanese Americans","volume":"108","author":"Hayashi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2024.110594_bib43","doi-asserted-by":"crossref","first-page":"657","DOI":"10.5551\/jat.13037","article-title":"Coexistence of visceral fat and multiple risk factor accumulations is strongly associated with coronary artery disease in Japanese (the VACATION-J study)","volume":"19","author":"Hiuge-Shimizu","year":"2012","journal-title":"J.\u00a0Atherosclerosis Thromb."},{"key":"10.1016\/j.isci.2024.110594_bib44","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1194\/jlr.M010371","article-title":"Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells","volume":"51","author":"Harvey","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.isci.2024.110594_bib45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41419-017-0257-3","article-title":"Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2024.110594_bib46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial Dynamics and Its Involvement in Disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.isci.2024.110594_bib47","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1083\/jcb.201611194","article-title":"A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space","volume":"217","author":"Mattie","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.isci.2024.110594_bib48","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"10.1016\/j.isci.2024.110594_bib49","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00018-017-2603-0","article-title":"The ever-growing complexity of the mitochondrial fission machinery","volume":"75","author":"Pagliuso","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.isci.2024.110594_bib50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/jb\/mvz106","article-title":"Mitochondrial division, fusion and degradation","volume":"167","author":"Murata","year":"2020","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.isci.2024.110594_bib51","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1161\/ATVBAHA.119.312787","article-title":"Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation: Involvement of vitamin K-dependent processes","volume":"39","author":"Petsophonsakul","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.isci.2024.110594_bib52","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1152\/physrev.1995.75.3.487","article-title":"Regulation of differentiation of vascular smooth muscle cells","volume":"75","author":"Owens","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2024.110594_bib53","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/CIRCRESAHA.117.310692","article-title":"ARHGAP18 Protects Against Thoracic Aortic Aneurysm Formation by Mitigating the Synthetic and Proinflammatory Smooth Muscle Cell Phenotype","volume":"121","author":"Liu","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2024.110594_bib54","article-title":"Elongation of Long-Chain Fatty Acid Family Member 6 (Elovl6)-Driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype Through AMP-Activated Protein Kinase\/Kr\u00fcppel-Like Factor 4 (AMPK\/KLF 4) Signaling","volume":"5","author":"Sunaga","year":"2016","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.isci.2024.110594_bib55","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.redox.2013.10.011","article-title":"Mitochondrial fission induced by platelet-derived growth factor regulates vascular smooth muscle cell bioenergetics and cell proliferation","volume":"1","author":"Salabei","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2024.110594_bib56","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bcp.2016.01.013","article-title":"Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics regulation","volume":"104","author":"Torres","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.isci.2024.110594_bib57","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.110594_bib58","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1017\/S1461145711000897","article-title":"Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation","volume":"15","author":"Galeotti","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.isci.2024.110594_bib59","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.288.5467.870","article-title":"Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway","volume":"288","author":"Tournier","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.isci.2024.110594_bib60","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jphs.2014.11.002","article-title":"Olmesartan inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch through the inhibition of the c-Jun N-terminal kinase and p38 signaling pathways","volume":"127","author":"Ito","year":"2015","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.isci.2024.110594_bib61","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.biopha.2018.09.129","article-title":"Mechanical stretch aggravates aortic dissection by regulating\u00a0MAPK pathway and the expression of MMP-9 and inflammation factors","volume":"108","author":"Hu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.isci.2024.110594_bib62","article-title":"Angiotensin II Type 1 Receptor Blocker Prevents Abdominal Aortic Aneurysm Progression in Osteoprotegerin-Deficient Mice via Upregulation of Angiotensin (1-7)","volume":"12","author":"Karasaki","year":"2023","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.isci.2024.110594_bib63","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.atherosclerosis.2017.09.004","article-title":"Stearic acid at physiologic concentrations induces in\u00a0vitro lipotoxicity in circulating angiogenic cells","volume":"265","author":"Spigoni","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.isci.2024.110594_bib64","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1142\/S0192415X21500488","article-title":"Serum Starvation Sensitizes Anticancer Effect of Anemarrhena asphodeloides via p38\/JNK-Induced Cell Cycle Arrest and Apoptosis in Colorectal Cancer Cells","volume":"49","author":"Ji","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.isci.2024.110594_bib65","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1631\/jzus.B2000022","article-title":"Induction of thoracic aortic dissection: a mini-review of beta-aminopropionitrile-related mouse models","volume":"21","author":"Zheng","year":"2020","journal-title":"J.\u00a0Zhejiang Univ. - Sci. B"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224018194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224018194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:47:42Z","timestamp":1748911662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224018194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S2589004224018194"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.110594","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stearic acid alleviates aortic medial degeneration through maintaining mitochondrial dynamics homeostasis via inhibiting JNK\/MAPK signaling","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.110594","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110594"}}