{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:46:25Z","timestamp":1793148385199,"version":"4.5.0"},"reference-count":170,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.isci.2024.110726","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T16:59:17Z","timestamp":1723654757000},"page":"110726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Protective role of acetylcholine and the cholinergic system in the injured heart"],"prefix":"10.1016","volume":"27","author":[{"given":"Clara","family":"Liu Chung Ming","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3689-4275","authenticated-orcid":false,"given":"Carmine","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.110726_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.devcel.2015.06.017","article-title":"Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration","volume":"34","author":"Mahmoud","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.isci.2024.110726_bib3","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.3390\/ijms19092466","article-title":"Revisiting the Cardioprotective Effects of Acetylcholine Receptor Activation against Myocardial Ischemia\/Reperfusion Injury","volume":"19","author":"Intachai","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.110726_bib4","doi-asserted-by":"crossref","first-page":"C155","DOI":"10.1152\/ajpcell.00315.2020","article-title":"Protective and anti-inflammatory effects of acetylcholine in the heart","volume":"320","author":"Rocha-Resende","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib5","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1152\/jappl.1998.84.4.1234","article-title":"Time course of sympathovagal imbalance and left ventricular dysfunction in conscious dogs with heart failure","volume":"84","author":"Ishise","year":"1998","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0140-6736(97)11144-8","article-title":"Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction","volume":"351","author":"Rovere","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2024.110726_bib7","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1161\/01.CIR.103.10.1428","article-title":"Heart Rate and Cardiac Rhythm Relationships With Bisoprolol Benefit in Chronic Heart Failure in CIBIS II Trial","volume":"103","author":"Lechat","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2024.110726_bib8","doi-asserted-by":"crossref","first-page":"C794","DOI":"10.1152\/ajpcell.00031.2022","article-title":"Neuronal cholinergic signaling constrains norepinephrine activity in the heart","volume":"322","author":"Guimar\u00e3es","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-50088-2","article-title":"Increased GIRK channel activity prevents arrhythmia in mice with heart failure by enhancing ventricular repolarization","volume":"13","author":"An","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.110726_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.621769","article-title":"Role of the \u03b17 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis","volume":"11","author":"Vieira-Alves","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/oxfordjournals.eurheartj.a059668","article-title":"Effect of acetylcholine on arterial and venous grafts and coronary arteries in patients with coronary artery disease","volume":"11","author":"Werner","year":"1990","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2024.110726_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14021-8","article-title":"Cholinergic Stimulation Improves Oxidative Stress and Inflammation in Experimental Myocardial Infarction","volume":"7","author":"Bezerra","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.110726_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113300","article-title":"Loss of \u03b17nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-\u03baB activation","volume":"419","author":"Li","year":"2022","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.isci.2024.110726_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehad655.3090","article-title":"Non-neuronal acetylcholine is causal for cardioprotection by hypoxic preconditioning in adult rat cardiomyocytes","volume":"44","author":"Braczko","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2024.110726_bib15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/FJC.0b013e31822b7204","article-title":"Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion","volume":"58","author":"Calvillo","year":"2011","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.isci.2024.110726_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.trsl.2021.12.005","article-title":"Acetylcholine receptor agonists provide cardioprotection in doxorubicin-induced cardiotoxicity via modulating muscarinic M2 and \u03b17 nicotinic receptor expression","volume":"243","author":"Prathumsap","year":"2022","journal-title":"Transl. Res."},{"key":"10.1016\/j.isci.2024.110726_bib17","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cardfail.2009.05.008","article-title":"Anti-Alzheimer's Drug, Donepezil, Markedly Improves Long-Term Survival After Chronic Heart Failure in Mice","volume":"15","author":"Handa","year":"2009","journal-title":"J.\u00a0Card. Fail."},{"key":"10.1016\/j.isci.2024.110726_bib18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2018.10.013","article-title":"The non-neuronal cholinergic system in the heart: A comprehensive review","volume":"125","author":"Saw","year":"2018","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01085","article-title":"Expression and Function of the Cholinergic System in Immune Cells","volume":"8","author":"Fujii","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2024.110726_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphs.2017.05.002","article-title":"Physiological functions of the cholinergic system in immune cells","volume":"134","author":"Fujii","year":"2017","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.isci.2024.110726_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1566-0702(00)00233-2","article-title":"Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation","volume":"85","author":"Borovikova","year":"2000","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.isci.2024.110726_bib22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/cne.901000108","article-title":"The histochemical localization of cholinesterases in the central nervous system of the rat","volume":"100","author":"Koelle","year":"1954","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.isci.2024.110726_bib23","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.ijcard.2011.12.082","article-title":"Preischemic efferent vagal stimulation increases the size of myocardial infarction in rabbits. Role of the sympathetic nervous system","volume":"155","author":"Buchholz","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/jnc.15821","article-title":"\u03b17 nicotinic receptors play a role in regulation of cardiac hemodynamics","volume":"168","author":"Targosova","year":"2024","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.isci.2024.110726_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104810","article-title":"Modulation of sodium-coupled choline transporter CHT function in health and disease","volume":"140","author":"Ojiakor","year":"2020","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.isci.2024.110726_bib26","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.yjmcc.2012.05.003","article-title":"Non-neuronal cholinergic machinery present in cardiomyocytes offsets hypertrophic signals","volume":"53","author":"Rocha-Resende","year":"2012","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0014-5793(77)81068-5","article-title":"The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents","volume":"84","author":"Cavey","year":"1977","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2024.110726_bib28","doi-asserted-by":"crossref","first-page":"11749","DOI":"10.1074\/jbc.270.20.11749","article-title":"Identification of a new component of the agonist binding site of the nicotinic \u03b17 homooligomeric receptor","volume":"270","author":"Corringer","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.isci.2024.110726_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/BF02505755","article-title":"Functional architecture of the nicotinic acetylcholine receptor: a prototype of ligand-gated ion channels","volume":"136","author":"Devillers-Thi\u00e9ry","year":"1993","journal-title":"J.\u00a0Membr. Biol."},{"key":"10.1016\/j.isci.2024.110726_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0306-4522(01)00613-3","article-title":"Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine","volume":"110","author":"Mesulam","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.isci.2024.110726_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1471-4159.1978.tb07029.x","article-title":"Sodium-dependent, high affinity choline uptake","volume":"30","author":"Kuhar","year":"1978","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.isci.2024.110726_bib32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2212476120","article-title":"Cholinergic regulation of vascular endothelial function by human ChAT+ T\u00a0cells","volume":"120","author":"Tarnawski","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110726_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jneuroim.2019.01.008","article-title":"Modulation of the extraneuronal cholinergic system on main innate response leukocytes","volume":"327","author":"Eduardo","year":"2019","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.isci.2024.110726_bib34","article-title":"Non-neuronal cholinergic system in the heart influences its homeostasis and an extra-cardiac site, the blood-brain barrier","volume":"11","author":"Kakinuma","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.isci.2024.110726_bib35","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1111\/j.1742-4658.2009.07208.x","article-title":"Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium","volume":"276","author":"Kakinuma","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.isci.2024.110726_bib36","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.autneu.2010.04.011","article-title":"Acetylcholine as an age-dependent non-neuronal source in the heart","volume":"156","author":"Rana","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.isci.2024.110726_bib37","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1096\/fj.13-238279","article-title":"Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart","volume":"27","author":"Roy","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.isci.2024.110726_bib38","doi-asserted-by":"crossref","first-page":"e100179","DOI":"10.1371\/journal.pone.0100179","article-title":"Cholinergic signaling exerts protective effects in models of sympathetic hyperactivity-induced cardiac dysfunction","volume":"9","author":"Gavioli","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110726_bib39","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1128\/MCB.00996-09","article-title":"Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure","volume":"30","author":"Lara","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2024.110726_bib40","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1096\/fj.15-277046","article-title":"Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions","volume":"30","author":"Roy","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.isci.2024.110726_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050761","article-title":"A non-neuronal cardiac cholinergic system plays a protective role in myocardium salvage during ischemic insults","volume":"7","author":"Kakinuma","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110726_bib42","doi-asserted-by":"crossref","first-page":"e004887","DOI":"10.1161\/JAHA.112.004887","article-title":"Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1\u03b1-related defense mechanisms","volume":"2","author":"Kakinuma","year":"2013","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.isci.2024.110726_bib43","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1073\/pnas.1221655110","article-title":"Lymphocyte-derived ACh regulates local innate but not adaptive immunity","volume":"110","author":"Reardon","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.110726_bib44","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1042\/CS20160277","article-title":"Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity","volume":"130","author":"Oikawa","year":"2016","journal-title":"Clin. Sci."},{"key":"10.1016\/j.isci.2024.110726_bib45","doi-asserted-by":"crossref","first-page":"e128961","DOI":"10.1172\/jci.insight.128961","article-title":"Immunomodulatory role of nonneuronal cholinergic signaling in myocardial injury","volume":"5","author":"Rocha-Resende","year":"2019","journal-title":"JCI insight"},{"key":"10.1016\/j.isci.2024.110726_bib46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12933-021-01231-8","article-title":"Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications","volume":"20","author":"Saw","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.isci.2024.110726_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e17434","article-title":"Non-neuronal cholinergic system delays cardiac remodelling in type 1 diabetes","volume":"9","author":"Munasinghe","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.isci.2024.110726_bib48","first-page":"H70","article-title":"The Non-Neuronal Cholinergic System is Causal for Cardioprotection by Hypoxic Preconditioning in Isolated Adult Rat Cardiomyocytes","volume":"327","author":"Braczko","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.isci.2024.110726_bib49","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1159\/000363042","article-title":"A non-neuronal cholinergic system regulates cellular ATP levels to maintain cell viability","volume":"34","author":"Oikawa","year":"2014","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.isci.2024.110726_bib50","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbi.2019.06.005","article-title":"Potentiating a non-neuronal cardiac cholinergic system reinforces the functional integrity of the blood brain barrier associated with systemic anti-inflammatory responses","volume":"81","author":"Oikawa","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.isci.2024.110726_bib51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1136\/hrt.62.3.165","article-title":"Cardiac parasympathetic activity during the early hours of acute myocardial infarction","volume":"62","author":"McAreavey","year":"1989","journal-title":"Br. Heart J."},{"key":"10.1016\/j.isci.2024.110726_bib52","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13396","article-title":"The effects of acetylcholinesterase inhibitors on the heart in acute myocardial infarction and heart failure: From cells to patient reports","volume":"228","author":"Khuanjing","year":"2020","journal-title":"Acta Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib53","doi-asserted-by":"crossref","first-page":"H810","DOI":"10.1152\/ajpheart.00724.2007","article-title":"Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress","volume":"294","author":"LaCroix","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib54","first-page":"101","article-title":"Cardiovascular responses to acetylcholine: Effects of pentobarbital and autonomic blocking agents","volume":"6","author":"Tettelbaum","year":"1971","journal-title":"Cond. Reflex Pavlovian J. Res. Therapy"},{"key":"10.1016\/j.isci.2024.110726_bib55","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1172\/JCI117664","article-title":"Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs","volume":"95","author":"Hare","year":"1995","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.isci.2024.110726_bib56","first-page":"H1470","article-title":"Vagal stimulation attenuates sympathetic enhancement of left ventricular function","volume":"258","author":"Henning","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib57","doi-asserted-by":"crossref","first-page":"46","DOI":"10.7150\/ijbs.16404","article-title":"The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism","volume":"13","author":"Ren","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.isci.2024.110726_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.811220","article-title":"Cholinesterases in Tripartite Neuromuscular Synapse","volume":"14","author":"Petrov","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.isci.2024.110726_bib59","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1134\/S1068162023010211","article-title":"Muscarinic and nicotinic acetylcholine receptors in the regulation of the cardiovascular system","volume":"49","author":"Osipov","year":"2023","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.isci.2024.110726_bib60","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034173","article-title":"Vagus Nerve Stimulation and the Cardiovascular System","volume":"10","author":"Capilupi","year":"2020","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"10.1016\/j.isci.2024.110726_bib61","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.hrthm.2020.07.036","article-title":"Simultaneous activation of the small conductance calcium-activated potassium current by acetylcholine and inhibition of sodium current by ajmaline cause J-wave syndrome in Langendorff-perfused rabbit ventricles","volume":"18","author":"Fei","year":"2021","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.isci.2024.110726_bib62","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.febslet.2005.02.065","article-title":"Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1\u03b1","volume":"579","author":"Kakinuma","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2024.110726_bib63","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s00380-013-0333-2","article-title":"Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein","volume":"28","author":"Soeki","year":"2013","journal-title":"Heart Ves."},{"key":"10.1016\/j.isci.2024.110726_bib64","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/cvr\/cvm092","article-title":"Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction","volume":"77","author":"Tsutsumi","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2024.110726_bib65","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00395-018-0683-0","article-title":"Vagus nerve stimulation exerts cardioprotection against myocardial ischemia\/reperfusion injury predominantly through its efferent vagal fibers","volume":"113","author":"Nuntaphum","year":"2018","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105882","article-title":"Acetylcholinesterase inhibitor ameliorates doxorubicin-induced cardiotoxicity through reducing RIP1-mediated necroptosis","volume":"173","author":"Khuanjing","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.isci.2024.110726_bib67","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10495-010-0549-x","article-title":"Acetylcholine prevents angiotensin II-induced oxidative stress and apoptosis in H9c2 cells","volume":"16","author":"Liu","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.isci.2024.110726_bib68","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvy217","article-title":"Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway","volume":"115","author":"Xu","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2024.110726_bib69","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2019.09.025","article-title":"Regulation of mitochondrial cristae remodelling by acetylcholine alleviates palmitate-induced cardiomyocyte hypertrophy","volume":"145","author":"Xue","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.isci.2024.110726_bib70","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jtcvs.2008.08.020","article-title":"Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect","volume":"137","author":"Katare","year":"2009","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.isci.2024.110726_bib71","first-page":"9334","article-title":"Unilateral vagus nerve stimulation improves ventricular autonomic nerve distribution and functional imbalance in a canine heart failure model","volume":"8","author":"Sun","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.isci.2024.110726_bib72","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab045","article-title":"Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK\/NF-\u03baB pathway","volume":"27","author":"Wang","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.isci.2024.110726_bib73","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10495-022-01715-2","article-title":"Acetylcholine exerts cytoprotection against hypoxia\/reoxygenation-induced apoptosis, autophagy and mitochondrial impairment through both muscarinic and nicotinic receptors","volume":"27","author":"Intachai","year":"2022","journal-title":"Apoptosis"},{"key":"10.1016\/j.isci.2024.110726_bib74","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1016\/j.hrthm.2014.08.001","article-title":"Vagus nerve stimulation initiated late during ischemia, but not reperfusion, exerts cardioprotection via amelioration of cardiac mitochondrial dysfunction","volume":"11","author":"Shinlapawittayatorn","year":"2014","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.isci.2024.110726_bib75","article-title":"Vagal modulation of high mobility group box-1 protein mediates electroacupuncture-induced cardioprotection in ischemia-reperfusion injury","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.110726_bib76","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11010-020-03811-w","article-title":"Protective effects of acetylcholine on hypoxia-induced endothelial-to-mesenchymal transition in human cardiac microvascular endothelial cells","volume":"473","author":"Li","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.isci.2024.110726_bib77","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.3389\/fphar.2019.01386","article-title":"Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor","volume":"10","author":"Zhao","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2024.110726_bib78","doi-asserted-by":"crossref","first-page":"759.e1","DOI":"10.1016\/j.ahj.2008.07.009","article-title":"Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men","volume":"156","author":"Lampert","year":"2008","journal-title":"Am. Heart J."},{"key":"10.1016\/j.isci.2024.110726_bib79","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.isci.2024.110726_bib80","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2119\/2008-00079.Parrish","article-title":"Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling","volume":"14","author":"Parrish","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.isci.2024.110726_bib81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.redox.2017.11.013","article-title":"Cholinergic anti-inflammatory pathway inhibits neointimal hyperplasia by suppressing inflammation and oxidative stress","volume":"15","author":"Li","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.isci.2024.110726_bib82","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2796.2010.02321.x","article-title":"The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy","volume":"269","author":"Huston","year":"2011","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.isci.2024.110726_bib83","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2024.110726_bib84","doi-asserted-by":"crossref","first-page":"e000804","DOI":"10.1161\/JAHA.114.000804","article-title":"Arterial Baroreflex Dysfunction Impairs Ischemia-Induced Angiogenesis","volume":"3","author":"Hao","year":"2014","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.isci.2024.110726_bib85","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0025-6196(12)65280-X","article-title":"Spasm of the Coronary Arteries: Causes and Consequences (the Scientist's Viewpoint)","volume":"60","author":"Shepherd","year":"1985","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.isci.2024.110726_bib86","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s12928-020-00720-z","article-title":"Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease","volume":"36","author":"Suzuki","year":"2021","journal-title":"Cardiovasc. Interv. Ther."},{"key":"10.1016\/j.isci.2024.110726_bib87","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jacc.2015.06.1324","article-title":"Acetylcholine-Provoked Coronary Spasm at Site of Significant Organic Stenosis Predicts Poor Prognosis in Patients With Coronary Vasospastic Angina","volume":"66","author":"Ishii","year":"2015","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib88","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/clc.22369","article-title":"Serious cardiac complications in coronary spasm provocation tests using acetylcholine or ergonovine: analysis of 21 512 patients from the diagnosis procedure combination database in Japan","volume":"38","author":"Isogai","year":"2015","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib89","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1177\/106002809102501104","article-title":"Hypotension and bradycardia possibly associated with intraocular injection of acetylcholine","volume":"25","author":"Erickson","year":"1991","journal-title":"DICP"},{"key":"10.1016\/j.isci.2024.110726_bib90","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.617459","article-title":"Autonomic modulation for cardiovascular disease","volume":"11","author":"Hadaya","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib91","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1007\/s00424-014-1591-2","article-title":"Changes in the loading conditions induced by vagal stimulation modify the myocardial infarct size through sympathetic-parasympathetic interactions","volume":"467","author":"Buchholz","year":"2015","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.isci.2024.110726_bib92","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13663","article-title":"Benefits of pharmacological and electrical cholinergic stimulation in hypertension and heart failure","volume":"232","author":"Cavalcante","year":"2021","journal-title":"Acta Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib93","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4740931","article-title":"Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2\/HO-1 Pathway","volume":"2022","author":"Guo","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.isci.2024.110726_bib94","doi-asserted-by":"crossref","first-page":"e073548","DOI":"10.1002\/alz.073548","article-title":"Vagus Nerve Stimulation Provides Neuroprotection Against Doxorubicin-induced Chemobrain Via Activations of Both Muscarinic and Nicotinic Acetylcholine Receptors","volume":"19","author":"Siripakkaphant","year":"2023","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.isci.2024.110726_bib95","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00395-015-0508-3","article-title":"Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow","volume":"110","author":"Uitterdijk","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib96","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/0003319712474336","article-title":"No-reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. A review of the current literature and future perspectives","volume":"65","author":"Galasso","year":"2014","journal-title":"Angiology"},{"key":"10.1016\/j.isci.2024.110726_bib97","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.yjmcc.2011.06.009","article-title":"Coronary no reflow","volume":"52","author":"Schwartz","year":"2012","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib98","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00395-013-0345-1","article-title":"Vagal stimulation triggers peripheral vascular protection through the cholinergic anti-inflammatory pathway in a rat model of myocardial ischemia\/reperfusion","volume":"108","author":"Zhao","year":"2013","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib99","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/01.CIR.0000105721.71640.DA","article-title":"Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats","volume":"109","author":"Li","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2024.110726_bib100","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3390\/cells10040899","article-title":"Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease","volume":"10","author":"Liu Chung Ming","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.isci.2024.110726_bib101","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s42234-022-00092-0","article-title":"Threshold adjusted vagus nerve stimulation after asphyxial cardiac arrest results in neuroprotection and improved survival","volume":"8","author":"Choudhary","year":"2022","journal-title":"Bioelectron. Med."},{"key":"10.1016\/j.isci.2024.110726_bib102","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/SHK.0000000000000962","article-title":"Improved Outcomes of Cardiopulmonary Resuscitation in Rats Treated With Vagus Nerve Stimulation and Its Potential Mechanism","volume":"49","author":"Sun","year":"2018","journal-title":"Shock"},{"key":"10.1016\/j.isci.2024.110726_bib103","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5847\/wjem.j.1920-8642.2021.04.010","article-title":"Left-sided vagus nerve stimulation improves cardiopulmonary resuscitation outcomes in rats as effectively as right-sided vagus nerve stimulation","volume":"12","author":"Shao","year":"2021","journal-title":"World J. Emerg. Med."},{"key":"10.1016\/j.isci.2024.110726_bib104","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jcmm.12938","article-title":"Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor\/CaMKK\u03b2\/AMPK pathway in isoproterenol-induced myocardial ischaemia","volume":"21","author":"Xue","year":"2017","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.isci.2024.110726_bib105","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/eurheartj\/ehq391","article-title":"Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure","volume":"32","author":"De Ferrari","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2024.110726_bib106","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.tcm.2023.07.003","article-title":"Vagus nerve stimulation for cardiovascular diseases: Is there light at the end of the tunnel?","volume":"34","author":"Zafeiropoulos","year":"2024","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.isci.2024.110726_bib107","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jacc.2016.03.525","article-title":"Vagus Nerve Stimulation for the Treatment of Heart Failure","volume":"68","author":"Gold","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib108","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cardfail.2014.08.009","article-title":"Autonomic Regulation Therapy via Left or Right Cervical Vagus Nerve Stimulation in Patients With Chronic Heart Failure: Results of the ANTHEM-HF Trial","volume":"20","author":"Premchand","year":"2014","journal-title":"J.\u00a0Card. Fail."},{"key":"10.1016\/j.isci.2024.110726_bib109","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(21)00475-X","article-title":"Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial","volume":"397","author":"Dawson","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2024.110726_bib110","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnins.2020.00284","article-title":"Critical Review of Transcutaneous Vagus Nerve Stimulation: Challenges for Translation to Clinical Practice","volume":"14","author":"Yap","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.isci.2024.110726_bib111","article-title":"Vagus Nerve Stimulation and Its Cardioprotective Abilities: A Systematic Review","volume":"12","author":"Elamin","year":"2023","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.isci.2024.110726_bib112","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jacep.2019.11.008","article-title":"TREAT AF (Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation)","volume":"6","author":"Stavrakis","year":"2020","journal-title":"JACC. Clin. Electrophysiol."},{"key":"10.1016\/j.isci.2024.110726_bib113","first-page":"588","article-title":"The anatomical basis for transcutaneous auricular vagus nerve stimulation","volume":"236","author":"Butt","year":"2020","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.isci.2024.110726_bib114","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s13311-015-0348-8","article-title":"Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage (\"Neuroprotection\")","volume":"12","author":"Wiendl","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.isci.2024.110726_bib115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165975","article-title":"Donepezil provides neuroprotective effects against brain injury and Alzheimer's pathology under conditions of cardiac ischemia\/reperfusion injury","volume":"1867","author":"Ongnok","year":"2021","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.isci.2024.110726_bib116","first-page":"Cd001190","article-title":"Donepezil for dementia due to Alzheimer's disease","volume":"6","author":"Birks","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.isci.2024.110726_bib117","first-page":"CD013306","article-title":"Cholinesterase inhibitors for vascular dementia and other vascular cognitive impairments: a network meta-analysis","volume":"2","author":"Battle","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.isci.2024.110726_bib118","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41401-019-0334-5","article-title":"Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation","volume":"41","author":"Jian","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.isci.2024.110726_bib119","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/1533317518775044","article-title":"The Impact of a Long-Term Rivastigmine and Donepezil Treatment on All-Cause Mortality in Patients With Alzheimer\u2019s Disease","volume":"33","author":"Kazmierski","year":"2018","journal-title":"Am. J. Alzheimers Dis. Other Demen."},{"key":"10.1016\/j.isci.2024.110726_bib120","article-title":"Impact of acetylcholinesterase inhibitors on the occurrence of acute coronary syndrome in patients with dementia","volume":"5","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.110726_bib121","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1111\/jgs.15415","article-title":"Cardiovascular Outcomes of Cholinesterase Inhibitors in Individuals with Dementia: A Meta-Analysis and Systematic Review","volume":"66","author":"Isik","year":"2018","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.isci.2024.110726_bib122","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/eurheartj\/eht182","article-title":"The use of cholinesterase inhibitors and the risk of myocardial infarction and death: a nationwide cohort study in subjects with Alzheimer's disease","volume":"34","author":"Nordstr\u00f6m","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2024.110726_bib123","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/14740338.2022.2027905","article-title":"Compared of efficacy and safety of high-dose donepezil vs standard-dose donepezil among elderly patients with Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"21","author":"Wang","year":"2022","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.isci.2024.110726_bib124","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/s41440-024-01629-3","article-title":"Donepezil attenuates progression of cardiovascular remodeling and improves prognosis in spontaneously hypertensive rats with chronic myocardial infarction","volume":"47","author":"Li","year":"2024","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.isci.2024.110726_bib125","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.trsl.2020.10.010","article-title":"Donepezil attenuated cardiac ischemia\/reperfusion injury through balancing mitochondrial dynamics, mitophagy, and autophagy","volume":"230","author":"Khuanjing","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.isci.2024.110726_bib126","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.yjmcc.2009.11.010","article-title":"Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model","volume":"48","author":"Kakinuma","year":"2010","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2024.110726_bib127","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1177\/1060028015602274","article-title":"Adverse Drug Reactions Reported With Cholinesterase Inhibitors:An Analysis of 16 Years of Individual Case Safety Reports From VigiBase","volume":"49","author":"Kr\u00f6ger","year":"2015","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.isci.2024.110726_bib128","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3233\/JAD-201551","article-title":"Bradycardia Due to Donepezil in Adults: Systematic Analysis of FDA Adverse Event Reporting System","volume":"81","author":"Morris","year":"2021","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.isci.2024.110726_bib129","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2165\/00023210-200620050-00005","article-title":"Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer\u2019s disease","volume":"20","author":"Bordier","year":"2006","journal-title":"CNS Drugs"},{"key":"10.1016\/j.isci.2024.110726_bib130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5414\/CP203257","article-title":"Donepezil decreases heart rate in elderly patients with Alzheimer\u2019s disease","volume":"57","author":"Pu","year":"2019","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.isci.2024.110726_bib131","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/emj.2006.036251","article-title":"Complete atrioventricular block and ventricular tachyarrhythmia associated with donepezil","volume":"23","author":"Suleyman","year":"2006","journal-title":"Emerg. Med. J."},{"key":"10.1016\/j.isci.2024.110726_bib132","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/j.jccase.2013.05.004","article-title":"Donepezil-induced torsades de pointes without QT prolongation","volume":"8","author":"Hadano","year":"2013","journal-title":"J.\u00a0Cardiol. Cases"},{"key":"10.1016\/j.isci.2024.110726_bib133","article-title":"Correlation between donepezil and QTc prolongation and torsades de pointes: a very rare phenomenon","volume":"11","author":"Malik","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.isci.2024.110726_bib134","first-page":"1","article-title":"Proarrhythmic major adverse cardiac events with donepezil: A systematic review with meta-analysis","volume":"1","author":"Nham","year":"2024","journal-title":"J.\u00a0Am. Geriatrics Soc"},{"key":"10.1016\/j.isci.2024.110726_bib135","article-title":"Extrapyramidal side effect of donepezil hydrochloride in an elderly patient: a case report","volume":"99","author":"Li","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.isci.2024.110726_bib136","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12894","article-title":"Bone marrow-derived mononuclear cell therapy for nonischaemic dilated cardiomyopathy\u2014A meta-analysis","volume":"48","author":"Wen","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.isci.2024.110726_bib137","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/eurheartj\/ehu007","article-title":"Autologous CD133+ bone marrow cells and bypass grafting for regeneration of ischaemic myocardium: the Cardio133 trial","volume":"35","author":"Nasseri","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2024.110726_bib138","series-title":"Advanced Technologies in Cardiovascular Bioengineering","first-page":"281","article-title":"Stem Cell-Based 3D Bioprinting for Cardiovascular Tissue Regeneration","author":"Liu Chung Ming","year":"2022"},{"key":"10.1016\/j.isci.2024.110726_bib139","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/heartjnl-2012-302230","article-title":"Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a meta-analysis of randomised controlled clinical trials","volume":"99","author":"Delewi","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.isci.2024.110726_bib140","doi-asserted-by":"crossref","first-page":"H207","DOI":"10.1152\/ajpheart.00239.2016","article-title":"Improving stem cell therapy in cardiovascular diseases: the potential role of microRNA","volume":"311","author":"Nollet","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2024.110726_bib141","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1161\/CIRCRESAHA.114.304792","article-title":"Adult bone marrow cell therapy for ischemic heart disease: evidence and insights from randomized controlled trials","volume":"117","author":"Afzal","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2024.110726_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110813","article-title":"Current situation and future of stem cells in cardiovascular medicine","volume":"132","author":"Nasser","year":"2020","journal-title":"Biomed. Pharmaco."},{"key":"10.1016\/j.isci.2024.110726_bib143","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ydbio.2018.11.020","article-title":"Derivation of pluripotent stem cells from nascent undifferentiated teratoma","volume":"446","author":"An","year":"2019","journal-title":"Dev. Biol."},{"key":"10.1016\/j.isci.2024.110726_bib144","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/cvr\/cvv205","article-title":"Gene therapy for cardiovascular disease: advances in vector development, targeting, and delivery for clinical translation","volume":"108","author":"Rincon","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.isci.2024.110726_bib145","article-title":"Targeted therapy in cardiovascular disease: A precision therapy era","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.isci.2024.110726_bib146","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1479-5876-11-209","article-title":"Upregulation of M3 muscarinic receptor inhibits cardiac hypertrophy induced by angiotensin II","volume":"11","author":"Liu","year":"2013","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.isci.2024.110726_bib147","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12265-017-9750-4","article-title":"Various regulatory modes for circadian rhythmicity and sexual dimorphism in the non-neuronal cardiac cholinergic system","volume":"10","author":"Oikawa","year":"2017","journal-title":"J.\u00a0Cardiovasc. Transl. Res."},{"key":"10.1016\/j.isci.2024.110726_bib148","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.immuni.2009.09.019","article-title":"MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase","volume":"31","author":"Shaked","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2024.110726_bib149","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2011.00028","article-title":"Cholinesterase-Targeting microRNAs Identified in\u00a0silico Affect Specific Biological Processes","volume":"4","author":"Hanin","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.isci.2024.110726_bib150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2006.11.005","article-title":"A medical health report on individuals with silent butyrylcholinesterase in the Vysya community of India","volume":"378","author":"Manoharan","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.isci.2024.110726_bib151","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharep.2016.09.016","article-title":"Effect of intensive lipid-lowering therapies on cholinesterase activity in patients with coronary artery disease","volume":"69","author":"Pytel","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.isci.2024.110726_bib152","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000065054","article-title":"The Origin of the Molecular Diversity and Functional Anchoring of Cholinesterases","volume":"11","author":"Massouli\u00e9","year":"2002","journal-title":"Neurosignals"},{"key":"10.1016\/j.isci.2024.110726_bib153","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0896-6273(01)00584-0","article-title":"PRiMA: the membrane anchor of acetylcholinesterase in the brain","volume":"33","author":"Perrier","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2024.110726_bib154","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1139\/cjpp-2019-0565","article-title":"Expression of cholinesterases and their anchoring proteins in rat heart","volume":"98","author":"Kilianova","year":"2020","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.isci.2024.110726_bib155","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0024-3205(98)00258-6","article-title":"Acetylcholinesterase: An enzymatic marker of human red blood cell aging","volume":"63","author":"Prall","year":"1998","journal-title":"Life Sci."},{"key":"10.1016\/j.isci.2024.110726_bib156","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0009-2797(99)00013-7","article-title":"Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus","volume":"119","author":"Altamirano","year":"1999","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.isci.2024.110726_bib157","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1742-4658.2008.06756.x","article-title":"Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase","volume":"276","author":"Liang","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.isci.2024.110726_bib158","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1124\/jpet.107.133330","article-title":"The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency","volume":"324","author":"Li","year":"2008","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.isci.2024.110726_bib159","first-page":"113","article-title":"Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk","volume":"21","author":"Lockridge","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.isci.2024.110726_bib160","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0022-3565(25)20479-7","article-title":"Protection by butyrylcholinesterase against organophosphorus poisoning in nonhuman primates","volume":"259","author":"Broomfield","year":"1991","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.isci.2024.110726_bib161","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1016\/j.vaccine.2014.05.067","article-title":"Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice","volume":"32","author":"Murthy","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.isci.2024.110726_bib162","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/j.1471-4159.2006.04347.x","article-title":"Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity","volume":"100","author":"Hartmann","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.isci.2024.110726_bib163","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/bj2600625","article-title":"Comparison of butyrylcholinesterase and acetylcholinesterase","volume":"260","author":"Chatonnet","year":"1989","journal-title":"Biochem. J."},{"key":"10.1016\/j.isci.2024.110726_bib164","first-page":"2024","article-title":"Cardiac acetylcholinesterase and butyrylcholinesterase have distinct localization and function","volume":"1","author":"Dingov\u00e1","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.isci.2024.110726_bib165","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s10904-023-02690-0","article-title":"Synthesis and Characterization of Chitosan Acetylcholine Nanoparticles for Neural Disorders Associated with Cancer Treatment","volume":"33","author":"Sankar","year":"2023","journal-title":"J.\u00a0Inorg. Organomet. Polym."},{"key":"10.1016\/j.isci.2024.110726_bib166","doi-asserted-by":"crossref","first-page":"e0257071","DOI":"10.1371\/journal.pone.0257071","article-title":"Acetylcholine esterase inhibitory activity of green synthesized nanosilver by naphthopyrones isolated from marine-derived Aspergillus niger","volume":"16","author":"Abdelwahab","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.110726_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.sintl.2020.100007","article-title":"Acetylcholine and acetylcholinesterase inhibitors detection using gold nanoparticles coupled with dynamic light scattering","volume":"1","author":"Alami","year":"2020","journal-title":"Sensors Int."},{"key":"10.1016\/j.isci.2024.110726_bib168","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2119\/molmed.2014.00125","article-title":"Cholinergic Activity as a New Target in Diseases of the Heart","volume":"20","author":"Roy","year":"2015","journal-title":"Mol. Med."},{"key":"10.1016\/j.isci.2024.110726_bib169","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuron.2017.03.016","article-title":"Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders","volume":"94","author":"Foster","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.isci.2024.110726_bib170","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S1474-4422(03)00622-7","article-title":"Antimuscarinics for treatment of overactive bladder","volume":"3","author":"Andersson","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.isci.2024.110726_bib171","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.physbeh.2016.12.010","article-title":"Anticholinergic activity in the nervous system: Consequences for visuomotor function","volume":"170","author":"Naicker","year":"2017","journal-title":"Physiol. Behav."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224019515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224019515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:53:19Z","timestamp":1748911999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224019515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":170,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S2589004224019515"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.110726","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective role of acetylcholine and the cholinergic system in the injured heart","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.110726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"110726"}}