{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:14:01Z","timestamp":1791335641357,"version":"4.3.1"},"reference-count":80,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011025","name":"Government of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023931","name":"Harry Perkins Institute of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023931","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001801","name":"University of Western Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1163861"],"award-info":[{"award-number":["APP1163861"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023560","name":"Bioplatforms Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000947","name":"Australian Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023759","name":"Telethon Kids Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.isci.2024.111011","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T12:07:02Z","timestamp":1727093222000},"page":"111011","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mesothelioma survival prediction based on a six-gene transcriptomic signature"],"prefix":"10.1016","volume":"27","author":[{"given":"Kiarash","family":"Behrouzfar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve E.","family":"Mutsaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Loong","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Patrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac Trinstern","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona J.","family":"Pixley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Morahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Lake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1551-5579","authenticated-orcid":false,"given":"Scott A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2024.111011_bib1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0140-6736(20)32714-8","article-title":"First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial","volume":"397","author":"Baas","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2024.111011_bib2","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0140-6736(15)01238-6","article-title":"Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial","volume":"387","author":"Zalcman","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2024.111011_bib3","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMra1912719","article-title":"Perspectives on the Treatment of Malignant Pleural Mesothelioma","volume":"385","author":"Janes","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.isci.2024.111011_bib4","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thoraxjnl-2017-211321","article-title":"British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma","volume":"73","author":"Woolhouse","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.isci.2024.111011_bib5","article-title":"Integrative transcriptome analysis of malignant pleural mesothelioma reveals a clinically relevant immune-based classification","volume":"9","author":"Alay","year":"2021","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.isci.2024.111011_bib6","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1101\/pdb.top084970","article-title":"RNA Sequencing and Analysis","volume":"2015","author":"Kukurba","year":"2015","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.isci.2024.111011_bib7","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3389\/fgene.2020.00899","article-title":"Identification of a Five-Gene Signature for Predicting Survival in Malignant Pleural Mesothelioma Patients","volume":"11","author":"Bai","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.111011_bib8","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1158\/2159-8290.CD-18-0804","article-title":"Integrative Molecular Characterization of Malignant Pleural Mesothelioma","volume":"8","author":"Hmeljak","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.isci.2024.111011_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ht7030020","article-title":"Genomics and Epigenetics of Malignant Mesothelioma","volume":"7","author":"Sage","year":"2018","journal-title":"High. Throughput."},{"key":"10.1016\/j.isci.2024.111011_bib10","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s00335-008-9135-8","article-title":"The Collaborative Cross at Oak Ridge National Laboratory: developing a powerful resource for systems genetics","volume":"19","author":"Chesler","year":"2008","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.isci.2024.111011_bib11","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ng1104-1133","article-title":"The Collaborative Cross, a community resource for the genetic analysis of complex traits","volume":"36","author":"Churchill","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.111011_bib12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1534\/genetics.111.132639","article-title":"The genome architecture of the Collaborative Cross mouse genetic reference population","volume":"190","year":"2012","journal-title":"Genetics"},{"key":"10.1016\/j.isci.2024.111011_bib13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00335-008-9113-1","article-title":"The Collaborative Cross, developing a resource for mammalian systems genetics: a status report of the Wellcome Trust cohort","volume":"19","author":"Iraqi","year":"2008","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.isci.2024.111011_bib14","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00335-008-9134-9","article-title":"Establishment of \"The Gene Mine\": a resource for rapid identification of complex trait genes","volume":"19","author":"Morahan","year":"2008","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.isci.2024.111011_bib15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1534\/genetics.114.163014","article-title":"Rapid identification of major-effect genes using the collaborative cross","volume":"198","author":"Ram","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.isci.2024.111011_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061848","article-title":"Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma","volume":"8","author":"Patel","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.111011_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4939-6427-7_5","article-title":"Complex Trait Analyses of the Collaborative Cross: Tools and Databases","volume":"1488","author":"Ram","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2024.111011_bib18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00335-007-9045-1","article-title":"The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics","volume":"18","author":"Roberts","year":"2007","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.isci.2024.111011_bib19","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1158\/0008-5472.CAN-05-4668","article-title":"A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent","volume":"66","author":"Robinson","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.isci.2024.111011_bib20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejca.2010.08.015","article-title":"MexTAg mice exposed to asbestos develop cancer that faithfully replicates key features of the pathogenesis of human mesothelioma","volume":"47","author":"Robinson","year":"2011","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.isci.2024.111011_bib21","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1186\/s12885-015-1953-y","article-title":"Consistent gene expression profiles in MexTAg transgenic mouse and wild type mouse asbestos-induced mesothelioma","volume":"15","author":"Robinson","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.isci.2024.111011_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2024.1373003","article-title":"The MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop","volume":"6","author":"Fisher","year":"2024","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.isci.2024.111011_bib23","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1038\/onc.2014.227","article-title":"Melanoma susceptibility as a complex trait: genetic variation controls all stages of tumor progression","volume":"34","author":"Ferguson","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2024.111011_bib24","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s00125-020-05137-0","article-title":"E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia","volume":"63","author":"Yang","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.isci.2024.111011_bib25","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fgene.2019.00288","article-title":"Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human","volume":"10","author":"Yuan","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.isci.2024.111011_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.679609","article-title":"How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers","volume":"11","author":"Behrouzfar","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2024.111011_bib27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.3520","article-title":"Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations","volume":"48","author":"Bueno","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.111011_bib28","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","article-title":"Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade","volume":"18","author":"Charoentong","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.111011_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s40425-018-0367-1","article-title":"Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)","volume":"6","author":"Danaher","year":"2018","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.isci.2024.111011_bib30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.isci.2024.111011_bib31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s13059-016-1092-z","article-title":"Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures","volume":"17","author":"\u015eenbabao\u011flu","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2024.111011_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lungcan.2019.10.012","article-title":"Gene signatures of tumor inflammation and epithelial-to-mesenchymal transition (EMT) predict responses to immune checkpoint blockade in lung cancer with high accuracy","volume":"139","author":"Thompson","year":"2020","journal-title":"Lung Cancer"},{"key":"10.1016\/j.isci.2024.111011_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1056152","article-title":"Identification of glycolysis genes signature for predicting prognosis in malignant pleural mesothelioma by bioinformatics and machine learning","volume":"13","author":"Xiao","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.isci.2024.111011_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13073-022-01050-w","article-title":"Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response","volume":"14","author":"Zhang","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.isci.2024.111011_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111874","article-title":"CD4+ T\u00a0cells drive an inflammatory, TNF-alpha\/IFN-rich tumor microenvironment responsive to chemotherapy","volume":"41","author":"Tilsed","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.111011_bib36","article-title":"Genomic and transcriptomic analyses identify a prognostic gene signature and predict response to therapy in pleural and peritoneal mesothelioma","volume":"4","author":"Nair","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.isci.2024.111011_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105786","article-title":"Epithelioid Pleural Mesothelioma Is Characterized by Tertiary Lymphoid Structures in Long Survivors: Results from the MATCH Study","volume":"23","author":"Mannarino","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.isci.2024.111011_bib38","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13073-022-01060-8","article-title":"Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma","volume":"14","author":"Creaney","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.isci.2024.111011_bib39","doi-asserted-by":"crossref","first-page":"12089","DOI":"10.1007\/s00432-023-05128-9","article-title":"An anoikis-based gene signature for predicting prognosis in malignant pleural mesothelioma and revealing immune infiltration","volume":"149","author":"Shi","year":"2023","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.isci.2024.111011_bib40","doi-asserted-by":"crossref","first-page":"200","DOI":"10.21037\/atm-22-527","article-title":"Establishment and validation of a novel immune-related prognostic signature in malignant pleural mesothelioma","volume":"10","author":"Zhang","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.isci.2024.111011_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fonc.2019.00078","article-title":"Development and Validation of a Prognostic Signature for Malignant Pleural Mesothelioma","volume":"9","author":"Zhou","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2024.111011_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ebiom.2019.09.003","article-title":"Redefining malignant pleural mesothelioma types as a continuum uncovers immune-vascular interactions","volume":"48","author":"Alcala","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.isci.2024.111011_bib43","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.11145","article-title":"COL1A1 is a prognostic biomarker and correlated with immune infiltrates in lung cancer","volume":"9","author":"Geng","year":"2021","journal-title":"PeerJ"},{"key":"10.1016\/j.isci.2024.111011_bib44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.coi.2021.09.006","article-title":"Exploiting ECM remodelling to promote immune-mediated tumour destruction","volume":"74","author":"Pires","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.isci.2024.111011_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269533","article-title":"Identification of COL1A1 associated with immune infiltration in brain lower grade glioma","volume":"17","author":"Ren","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2024.111011_bib46","article-title":"Bioinformatics analysis identifies COL1A1, THBS2 and SPP1 as potential predictors of patient prognosis and immunotherapy response in gastric cancer","volume":"41","author":"Wang","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.isci.2024.111011_bib47","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbrc.2019.01.057","article-title":"Inhibition of collagen production delays malignant mesothelioma tumor growth in a murine model","volume":"510","author":"Abayasiriwardana","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.isci.2024.111011_bib48","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/s41467-019-09307-6","article-title":"Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications","volume":"10","author":"Blum","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2024.111011_bib49","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.ajpath.2010.12.014","article-title":"Identification of novel markers for the diagnosis of malignant pleural mesothelioma","volume":"178","author":"Gueugnon","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2024.111011_bib50","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jtho.2017.09.1968","article-title":"Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma","volume":"13","author":"Patil","year":"2018","journal-title":"J.\u00a0Thorac. Oncol."},{"key":"10.1016\/j.isci.2024.111011_bib51","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41598-022-04973-x","article-title":"A panel of emerging EMT genes identified in malignant mesothelioma","volume":"12","author":"Wu","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.isci.2024.111011_bib52","first-page":"5084","article-title":"A gene expression signature of TREM2(hi) macrophages and gammadelta T\u00a0cells predicts immunotherapy response Nat Commun. 2020; 11 (1): 5084","volume":"11","author":"Xiong","year":"2020","journal-title":"Theor. Biosci."},{"key":"10.1016\/j.isci.2024.111011_bib53","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.cell.2021.03.030","article-title":"Synthetic lethality-mediated precision oncology via the tumor transcriptome","volume":"184","author":"Lee","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.isci.2024.111011_bib54","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.celrep.2018.03.042","article-title":"Global Cancer Transcriptome Quantifies Repeat Element Polarization between Immunotherapy Responsive and T Cell Suppressive Classes","volume":"23","author":"Solovyov","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.isci.2024.111011_bib55","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s12864-019-5850-7","article-title":"Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks","volume":"20","author":"Walters","year":"2019","journal-title":"BMC Genom."},{"key":"10.1016\/j.isci.2024.111011_bib56","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1080\/15476286.2019.1679585","article-title":"Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA","volume":"17","author":"Ye","year":"2020","journal-title":"RNA Biol."},{"key":"10.1016\/j.isci.2024.111011_bib57","series-title":"Australian Code for the Care and Use of Animals for Scientific Purposes","author":"Council","year":"2013"},{"key":"10.1016\/j.isci.2024.111011_bib58","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nbt0816-888d","article-title":"Erratum: Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2024.111011_bib59","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Res."},{"key":"10.1016\/j.isci.2024.111011_bib60","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2024.111011_bib61","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.111011_bib62","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.111011_bib63","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav7816","article-title":"Sensitization to immune checkpoint blockade through activation of a STAT1\/NK axis in the tumor microenvironment","volume":"11","author":"Zemek","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2024.111011_bib64","doi-asserted-by":"crossref","first-page":"D587","DOI":"10.1093\/nar\/gkac963","article-title":"KEGG for taxonomy-based analysis of pathways and genomes","volume":"51","author":"Kanehisa","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2024.111011_bib65","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2024.111011_bib66","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1093\/bioinformatics\/btm369","article-title":"GSEA-P: a desktop application for Gene Set Enrichment Analysis","volume":"23","author":"Subramanian","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.111011_bib67","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2024.111011_bib68","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.isci.2024.111011_bib69","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.isci.2024.111011_bib70","article-title":"Fast R Functions for Robust Correlations and Hierarchical Clustering","volume":"46","author":"Langfelder","year":"2012","journal-title":"J.\u00a0Stat. Software"},{"key":"10.1016\/j.isci.2024.111011_bib71","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.isci.2024.111011_bib72","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.isci.2024.111011_bib73","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.isci.2024.111011_bib74","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.111011_bib75","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2024.111011_bib76","article-title":"A package for survival analysis in S","volume":"2","author":"Therneau","year":"2015","journal-title":"R package version"},{"key":"10.1016\/j.isci.2024.111011_bib77","series-title":"Modeling Survival Data: Extending the Cox Model","first-page":"39","article-title":"The Cox Model","author":"Therneau","year":"2000"},{"key":"10.1016\/j.isci.2024.111011_bib78","first-page":"1","article-title":"Regularization Paths for Generalized Linear Models via Coordinate Descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J.\u00a0Stat. Software"},{"key":"10.1016\/j.isci.2024.111011_bib79","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1002\/sim.5958","article-title":"Estimating and comparing time-dependent areas under receiver operating characteristic curves for censored event times with competing risks","volume":"32","author":"Blanche","year":"2013","journal-title":"Stat. Med."},{"key":"10.1016\/j.isci.2024.111011_bib80","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224022363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004224022363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:47:22Z","timestamp":1783385242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004224022363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":80,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S2589004224022363"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2024.111011","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesothelioma survival prediction based on a six-gene transcriptomic signature","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2024.111011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"111011"}}